DavidW.KohMD

PubMed

• 30 citations
  Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 ...
  David W. Koh, Daniel P. Powell, Steven D. Blake, Joy L. Hoffman, Mandi M. Hopkins, Xiaoxing Feng> ;Oncology Reports. 2015 Sep 1
• 39 citations
  Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells.
  Mandi M. Hopkins, Xiaoxing Feng, Mengwei Liu, Lauren P. Parker, David W. Koh> ;International Journal of Oncology. 2015 May 1
• 22 citations
  Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity
  Simon T. Dillon, Manoj Bhasin, Xiaoxing Feng, David W. Koh, Sayed S. Daoud> ;Journal of Translational Medicine. 2013 Oct 1
• 13 citations
  Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP‑ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeL...
  Xiaoxing Feng, David W. Koh> ;International Journal of Oncology. 2013 Feb 1
• 50 citations
  Roles of poly(ADP-ribose) glycohydrolase in DNA damage and apoptosis.
  Xiaoxing Feng, David W. Koh> ;International Review of Cell and Molecular Biology. 2013 Jan 1
• 18 citations
  Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy
  Xiaoxing Feng, Yiran Zhou, Alicia M Proctor, Mandi M. Hopkins, Mengwei Liu, David W. Koh> ;Molecular Cancer. 2012 Jul 29
• 5 citations
  Synergistic cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine and absence of poly(ADP-ribose) glycohydrolase involves chromatin decondensation.
  Yiran Zhou, Xiaoxing Feng, David W. Koh> ;International Journal of Oncology. 2011 Jul 1
• 32 citations
  Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase.
  Yiran Zhou, Xiaoxing Feng, David W. Koh> ;Biochemistry. 2011 Apr 12
• 1 citations
  Poly(ADP-ribosyl)ation Pathways in Mammals: The Advantage of Murine PARG Null Mutation
  Yiran Zhou, David W. Koh> ;Methods in Molecular Biology. 2011 Jan 1
• 26 citations
  Enhanced DNA accessibility and increased DNA damage induced by the absence of poly(ADP-ribose) hydrolysis.
  Yiran Zhou, Xiaoxing Feng, David W. Koh> ;Biochemistry. 2010 Aug 5
• 36 citations
  Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain
  Marc F. Poitras, David W. Koh, Seong-Woon Yu, Shaida A. Andrabi, Allen S. Mandir, Guy G. Poirier, Valina L. Dawson, Ted M. Dawson> ;Neuroscience. 2007 Aug 10
• 504 citations
  Poly(ADP-ribose) (PAR) polymer is a death signal
  Shaida A. Andrabi, No Soo Kim, Seong-Woon Yu, Hongmin Wang, David W. Koh, Masayuki Sasaki, Judith A. Klaus, Takashi Otsuka, Zhizheng Zhang, Raymond C. Koehler, Patrici...> ;Proceedings of the National Academy of Sciences of the United States of America. 2006 Nov 28
• 194 citations
  Mediation of cell death by poly(ADP-ribose) polymerase-1.
  David W. Koh, Ted M. Dawson, Valina L. Dawson> ;Pharmacological Research. 2005 Jul 1
• 52 citations
  Differential Effect of PARP-2 Deletion on Brain Injury after Focal and Global Cerebral Ischemia
  Julia Kofler, Takashi Otsuka, Zhizheng Zhang, Ruediger R. Noppens, Marjorie R. Grafe, David W. Koh, Valina L. Dawson, Josiane Ménissier-de Murcia, Patricia D. Hurn, Ri...> ;Journal of Cerebral Blood Flow and Metabolism. 2006 Jan 1
• 57 citations
  Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain
  Chandra Patel, David W. Koh, Myron K. Jacobson, Marcos A. Oliveira> ;The Biochemical Journal. 2005 Jun 1
• 17 citations
  The road to survival goes through PARG.
  David W. Koh, Valina L. Dawson, Ted M. Dawson> ;Cell Cycle. 2005 Feb 1
• 250 citations
  Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality
  David W. Koh, Ann M. Lawler, Marc F. Poitras, Masayuki Sasaki, Sigrid Wattler, Michael Nehls, Tobias Stöger, Guy G. Poirier, Valina L. Dawson, Ted M. Dawson> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Dec 21
• 227 citations
  Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
  Hongmin Wang, Seong-Woon Yu, David W. Koh, Jasmine Lew, Carmen Coombs, William J. Bowers, Howard J. Federoff, Guy G. Poirier, Ted M. Dawson, Valina L. Dawson> ;The Journal of Neuroscience. 2004 Dec 1
• 27 citations
  SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase
  David W. Koh, Donna L. Coyle, Nimish Mehta, Sushma Ramsinghani, Hyun-Tae Kim, James T. Slama, Myron K. Jacobson> ;Journal of Medicinal Chemistry. 2003 Aug 29
• 27 citations
  Identification of an inhibitor binding site of poly(ADP-ribose) glycohydrolase.
  David W. Koh, Chandra Patel, Sushma Ramsinghani, James T. Slama, Marcos A. Oliveira, Myron K. Jacobson> ;Biochemistry. 2003 May 6
• 9 citations
  Syntheses of photoactive analogues of adenosine diphosphate (hydroxymethyl)pyrrolidinediol and photoaffinity labeling of poly(ADP-ribose) glycohydrolase.
  Sushma Ramsinghani, David W. Koh, Jean-Christophe Amé, Mark Strohm, Myron K. Jacobson, James T. Slama> ;Biochemistry. 1998 May 6
• Postpneumonectomy lung growth: a model of reinitiation of tropoelastin and type I collagen production in a normal pattern in adult rat lung.
  Koh, D. W., Roby, J. D., Starcher, B., Senior, R. M., Pierce, R. A.> ;Am J Respir Cell Mol Biol. 1996 Nov
• Poly(ADP-ribosyl)ation regulation of life and death in the nervous system.
  Koh, D. W., Dawson, T. M., Dawson, V. L.> ;Cell Mol Life Sci. 2005 Apr
• Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.
  Shieh, W. M., Amé, J. C., Wilson, M. V., Wang, Z. Q., Koh, D. W., Jacobson, M. K., Jacobson, E. L.> ;J Biol Chem. 1998 Nov 13
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