DavidLeitenbergMD

PubMed

• 6 citations
  Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer.
  Stephanie Gomez, Olivia L Cox, Reddick R Walker 3rd, Uzma Rentia, Melissa Hadley, Elisa Arthofer, Noor Diab, Erin E Grundy, Tomas Kanholm, James I McDonald, Julie Koby...> ;Journal for Immunotherapy of Cancer. 2022 Nov 1
• 9 citations
  Major Histocompatibility Complex Class II Deficiency due to a Novel Mutation in RFXANK in a Child of Mexican Descent
  Katherine Clarridge, David Leitenberg, Brett Loechelt, Capuchine Picard, Michael A. Keller> ;Journal of Clinical Immunology. 2016 Jan 1
• 21 citations
  HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications
  Zaruhi Karabekian, Hao Ding, Gulnaz Stybayeva, Irina Ivanova, Narine Muselimyan, Amranul Haque, Ian Toma, Nikki Gillum Posnack, Alexander Revzin, David Leitenberg, Mic...> ;Tissue Engineering. Part A. 2015 Sep 8
• 8 citations
  Aspirin insensitive thrombophilia: Transcript profiling of blood identifies platelet abnormalities and HLA restriction
  Payam Fallahi, Richard J. Katz, Ian Toma, Ranyang Li, Jonathan S. Reiner, Kiersten VanHouten, Larry Carpio, Lorraine Marshall, Yi Lian, Sujata Bupp, Sidney W. Fu, Fred...> ;Gene. 2013 May 15
• 18 citations
  Ganglioside‐exposed dendritic cells inhibit T‐cell effector function by promoting regulatory cell activity
  Alessandra Jales, Rustom Falahati, Elisabeth Mari, Erik J. Stemmy, Weiping Shen, Cathy Southammakosane, Dallen Herzog, Stephan Ladisch, David Leitenberg> ;Immunology. 2011 Jan 1
• 1 citations
  CD4 co-receptor dependent signaling promotes competency for re-stimulation induced cell death of effector T cells.
  Kevin W. Tinsley, Dallen Herzog, David Leitenberg> ;Cellular Immunology. 2011 Jan 1
• 6 citations
  Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.
  Rustom Falahati, David Leitenberg> ;Journal of Immunology. 2008 Nov 1
• 35 citations
  Inhibition of TLR Activation and Up-Regulation of IL-1R-Associated Kinase-M Expression by Exogenous Gangliosides
  Weiping Shen, Kelly D. Stone, Alessandra Jales, David Leitenberg, Stephan Ladisch> ;Journal of Immunology. 2008 Apr 1
• 21 citations
  CD45-associated protein promotes the response of primary CD4 T cells to low-potency T-cell receptor (TCR) stimulation and facilitates CD45 association with CD3/TCR and...
  David Leitenberg, Rustom Falahati, Dan Dan Lu, Akiko Takeda> ;Immunology. 2007 Apr 12
• 21 citations
  Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development.
  Rustom Falahati, David Leitenberg> ;Journal of Immunology. 2007 Feb 15
• 98 citations
  Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention
  William M. Gwinn, Jesse M. Damsker, Rustom Falahati, Ifeanyi Okwumabua, Ann E. Kelly-Welch, Achsah D. Keegan, Christophe Vanpouille, James J. Lee, Lindsay A. Dent, Dav...> ;Journal of Immunology. 2006 Oct 1
• 1 citations
  CD4-Dependent Signaling Is Required for a Late Checkpoint during Th2 Development Associated with Resistance to Activation-Induced Cell Death
  Zohreh Tatari-Calderone, Jennifer L. Brogdon, Kevin W. Tinsley, Anahita Ramezani, David Leitenberg> ;Journal of Immunology. 2005 Nov 1
• 15 citations
  Modulation of CD4 Th Cell Differentiation by Ganglioside GD1a In Vitro
  Weiping Shen, Rustom Falahati, Ryan J. Stark, David Leitenberg, Stephan Ladisch> ;Journal of Immunology. 2005 Oct 15
• 1 citations
  Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia.
  Aurelia Meloni-Ehrig, Carlos A. Tirado, Kuoping Chen, Jennifer Jahn, Stephany Suchan, Jay Scheerle, Maria Gabriela Crosby, Holly J. Meany, Nita Seibel, David Leitenber...> ;Cancer Genetics and Cytogenetics. 2005 Aug 1
• 56 citations
  A Secreted Protein from the Human Hookworm Necator americanus Binds Selectively to NK Cells and Induces IFN-γ Production
  George C.-F. Hsieh, Alex Loukas, Allison M. Wahl, Monica Bhatia, Yan Wang, Angela L. Williamson, Kylene W. Kehn, Haruhiko Maruyama, Peter J. Hotez, David Leitenberg, J...> ;Journal of Immunology. 2004 Aug 15
• 100 citations
  The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells
  Jennifer L. Brogdon, David Leitenberg, Kim Bottomly> ;Journal of Immunology. 2002 Apr 15
• 160 citations
  CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans.
  Julie T. Nguyen, Douglas P. Evans, Marisa Galvan, Karen E. Pace, David Leitenberg, Thanhmy N. Bui, Linda G. Baum> ;Journal of Immunology. 2001 Nov 15
• 129 citations
  Distinct Patterns of Membrane Microdomain Partitioning in Th1 and Th2 Cells
  Fran Balamuth, David Leitenberg, Juli Unternaehrer, Ira Mellman, Kim Bottomly> ;Immunity. 2001 Nov 1
• 62 citations
  Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.
  Terrence L. Geiger, Phuong L. Nguyen, David Leitenberg, Richard A. Flavell> ;Blood. 2001 Oct 15
• 55 citations
  Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation.
  David Leitenberg, Fran Balamuth, Kim Bottomly> ;Seminars in Immunology. 2001 Apr 1
• 26 citations
  Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.
  Jan Czyzyk, David Leitenberg, Tom Taylor, Kim Bottomly> ;Molecular and Cellular Biology. 2000 Dec 1
• 78 citations
  Regulation of naive T cell differentiation by varying the potency of TCR signal transduction.
  David Leitenberg, Kim Bottomly> ;Seminars in Immunology. 1999 Aug 1
• 61 citations
  Biochemical Association of CD45 with the T Cell Receptor Complex: Regulation by CD45 Isoform and during T Cell Activation
  David Leitenberg, Yvan Boutin, Dan Dan Lu, Kim Bottomly> ;Immunity. 1999 Jun 1
• 42 citations
  The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
  Terrence L. Geiger, David Leitenberg, Richard A. Flavell> ;Journal of Immunology. 1999 May 15
• 109 citations
  STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation
  Thomas Welte, David Leitenberg, Bonnie N. Dittel, Basel K. al-Ramadi, Bing Xie, Yue E. Chin, Charles A. Janeway, Alfred L. M. Bothwell, Kim Bottomly, Xin-Yuan Fu> ;Science. 1999 Jan 8
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Journal Articles

• Major Histocompatibility Complex Class II Deficiency due to a Novel Mutation in RFXANK in a Child of Mexican Descent  
  Clarridge, K., D. Leitenberg, B. Loechelt, C. Picard, M. Keller, J Clinical Immunol, 1/1/2016
• HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications  
  Karabekian Z, Ding H, Stybayeva G, Ivanova I, Muselimyan N, Haque A, Toma I, Posnack NG, Revzin A, Leitenberg D, Laflamme MA, Sarvazyan N, Tissue Eng, 1/1/2015
• Ganglioside-treated dendritic cells inhibit T cell effector function by promoting regulatory T cell activity  
  Falahati, R., E. Mari, A. Jales, E.J. Stemy, W. Shen, C. Southammokasone, D. Herzog, S. Ladisch, D. Leitenberg, Immunology, 1/1/2011
• Selective Regulation of TCR Signaling Pathways in Primary Thymocytes by the CD45 tyrosine phosphatase  
  Falahati, R., and D. Leitenberg, J Immunol, 1/1/2008
• CD45-associated protein regulates the response to low-potency T cell stimulation and promotes CD45 association with CD3/TCR and lck  
  Leitenberg, D., Falahati, R., Lu, D., and Takeda, A, Immunology, 1/1/2007
• Changes in the role of the CD45 Protein Tyrosine Phosphatase in Regulating of Lck Tyrosine Phosphorylation During Thymic Development  
  Falahati, R., and D. Leitenberg, J Immunol, 1/1/2007
• CD4-dependent regulation of Activation-induced cell death promotes selection of Th2 effector cells  
  Tatari-Calderone, Z, Brogdon, J.L., Tinsley, K., Ramezani, A., and D. Leitenberg, J Immunol, 1/1/2005
• The modulation of CD4 T helper cell differentiation by tumor ganglioside  
  Shen, W., R. Falahati, R. Stark, D. Leitenberg, and S. Ladisch, J Immunol, 1/1/2005
• The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4(+) T Cells  
  Brogdon, J., D. Leitenberg, and K. Bottomly, J Immunol, 1/1/2002
• CD45 modulates galectin-1 induced T cell death: regulation by expression of core 2 O-glycans  
  Nguyen, J.T., D.P. Evans, M. Galvan, K.E. Pace, D. Leitenberg, T.N. Bui, and L.G. Baum, J Immunol, 1/1/2001
• Deficiency of small GTPase Rac2 GTPase affects T cell activation  
  Yu, H., D. Leitenberg, B. Li, D.A. Williams, and R.A. Flavell, J Exp Med, 1/1/2001
• Integrated src kinase activity enhances signal transduction through single chain chimeric receptors in T lymphocytes  
  Geiger, T.L., P. Nguyen, D. Leitenberg, and R.A. Flavell, Blood, 1/1/2001
• Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation  
  Leitenberg, D., F. Balamuth, and K. Bottomly, Seminars in Immunology, 1/1/2001
• Combinatorial effect of TCR ligation and CD45 isoform expression on the regulation of small GTPases ras and rap1  
  Czyzyk, J., D. Leitenberg, T. Taylor, K. Bottomly, Mol Cell Biol, 1/1/2000
• Specific biochemical association of CD45 with the T cell receptor: regulation by CD45 isoform and during T cell activation  
  Leitenberg, D., Y. Boutin, D. Lu, and K. Bottomly, Immunity, 1/1/1999
• The T cell receptor zeta chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes  
  Geiger, T.L., D. Leitenberg, and R.A. Flavell, J Immunol, 1/1/1999
• Regulation of naive T cell differentiation by varying the potency of TCR signal transduction  
  Leitenberg, D. and K. Bottomly, Seminars in Immunology, 1/1/1999
• CD4 regulation of T cell receptor signaling and T cell differentiation following stimulation with peptides of different affinities for the T cell receptor  
  Leitenberg, D., Y. Boutin, S. Constant, and K. Bottomly, J Immunol, 1/1/1998
• Distinct biochemical signals characterize agonist and altered peptide ligand-induced diferentiation of naive CD4 T cells into Th1 and Th2 subsets  
  Boutin, Y., D. Leitenberg, X. Tao, and K. Bottomly, J Immunol, 1/1/1997
• Epstein Barr virus suspension cell assay using in situ hybridization and flow cytometry  
  Crouch, J., D. Leitenberg, B.R. Smith, and J.G. Howe, Cytometry, 1/1/1997
• Deficient expression of p56lck in Th2 cells leads to partial TcR signaling and a dysregulation in lymphokine mRNA levels  
  Al-Ramadi, B.K., T. Nakamura, D. Leitenberg, and A.L.M. Bothwell, J Immunol, 1/1/1996
• The extracellular domain of CD45 controls association with the CD4/T cell receptor complex and the response to antigen-specific stimulation  
  Leitenberg D, T. Novak, D. Farber, B.R. Smith and K. Bottomly, J Exp Med, 1/1/1996
• Lymphocyte adhesion-dependent calcium signalling in human endothelial cells  
  Pfau S, D. Leitenberg, H Rinder, BR Smith, R Pardi, and JR Bender, J Cell Biol, 1/1/1995
• B-Cell precursor bone marrow reconstitution after bone marrow transplantation  
  Leitenberg D, JM Rappeport, BR Smith, Am J Clin Path, 1/1/1994
• Neutrophil but not monocyte activation inhibition of P-selectin mediated platelet adhesion  
  Rinder HM, JC Tracey, CS Rinder, D Leitenberg, and BR Smith, Thrombosis and Haemostasis, 1/1/1994
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Books/Book Chapters

• T cell dependent and independent B cell activation. 
  Chapter: T cell control of memory development. 
  Page 205 - 230Braley-Mullen H, D Leitenberg, and TL FeldbushEditors: EC Snow.1991

Lectures

• Tumor Immunology for PhD and MS level students 
  Multiple Locations, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019 - 1/1/2019
• Clinical Flow Cytometry 
  Georgetown University, 2018, 2019 - 1/1/2019
• Hypersensitivity Responses 
  Georgetown University, 2018, 2019 - 1/1/2019
• Immunodeficiency diagnosis 
  Georgetown University, 2018, 2019 - 1/1/2019
• Introduction to the Immune System 
  Multiple Locations, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 20 - 1/1/2018
• Tuning T cell activation: Role of the CD45 protein tyrosine phosphatase 
  Yale University, New Haven, CT, 2002, 2014 - 1/1/2014
• CD45 Regulation of T lymphocyte Activation 
  Bethesda, MD - 1/1/2012
• CD45 regulation of thymocyte development 
  Bethesda, MD, 2005; George Washington University, Washington, DC, 2008 - 1/1/2008
• CD45 regulation of T cell activation and development 
  University of Maryland School of Medicine, Baltimore, MD - 1/1/2007
• Effects of GD1a gangliosides on T cell Differentiation 
  Frederick, MD - 1/1/2006
• CD45 regulation of T lymphocyte activation and development 
  Georgetown University, Washington, DC - 1/1/2004
• CD4 Regulation of T lymphocyte effector function 
  Rockville, MD - 1/1/2003
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