DavidBennerLombardMD

PubMed

• Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress.
  Ashley F Melnick, Carea Mullin, Karena Lin, Anna C McCarter, Shannon Liang, Yiran E Liu, Qing Wang, Nicole A Jerome, Elizabeth Choe, Nicholas Kunnath, Geethika Bodanap...> ;Blood. 2023 Dec 21
• variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
  Taolin Yuan, Surinder Kumar, Mary Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J Kunkel, Yanghan Liu, Elyse M Petrunak, Thomas L Sau...> ;Biorxiv. 2023 Dec 8
• 3 citations
  Biallelic variants in COQ7 cause distal hereditary motor neuropathy with upper motor neuron signs.
  Garret, M., Adriana P Rebelo, Pedro J Tomaselli, Jessica Medina, Ying Wang, Maike F Dohrn, Eva Nyvltova, Matt C Danzi, Mark Garrett, Sean E Smith, Alan Pestronk, Cheng...> ;Brain. 2023 Oct 3
• 3 citations
  PTEN is both an activator and a substrate of chaperone-mediated autophagy.
  Katherine K Zhang, Calvin M Burns, Mary E Skinner, Richard A Miller, S Joseph Endicott, David B Lombard> ;The Journal of Cell Biology. 2023 Sep 4
• 1 citations
  Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation.
  Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, Katrin Rietscher, Thomas M Magin, Qing Xie, Li Liu, M Bishr Omary, David B Lombard> ;JCI Insight. 2023 Jul 24
• 4 citations
  Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors.
  Jian Yao, Yudong Yin, Hong Han, Shaoting Chen, Yuxiang Zheng, Benji Liang, Mengyue Wu, Kangqi Shu, Bikash Debnath, Quande Wang, Keguang Cheng, Nouri Neamati, Yanghan L...> ;European Journal of Medicinal Chemistry. 2023 Feb 5
• 7 citations
  The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
  Judy Baek, Kelli Sas, Chenchen He, Viji Nair, William Giblin, Ayaka Inoki, Hongyu Zhang, Yang Yingbao, Jeffrey Hodgin, Robert G Nelson, Frank C Brosius 3rd, Matthias K...> ;The Journal of Biological Chemistry. 2023 Mar 1
• 4 citations
  Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.
  Xinna Li, Mary Hager, Madaline McPherson, Michael Lee, Riha Hagalwadi, Mary E Skinner, David Lombard, Richard A Miller> ;Geroscience. 2023 Apr 1
• 4 citations
  Epigenetic mechanisms of cadmium-induced nephrotoxicity.
  Angela H Guo, Surinder Kumar, David B Lombard> ;Current Opinion in Toxicology. 2022 Dec 1
• 16 citations
  Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
  Benjamin Suenkel, Sergio Valente, Clemens Zwergel, Sandra Weiss, Elisabetta Di Bello, Rossella Fioravanti, Michele Aventaggiato, João A Amorim, Neha Garg, Surinder Kum...> ;Journal of Medicinal Chemistry. 2022 Oct 27
• 15 citations
  Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.
  Randy Strong, Richard A Miller, Catherine J Cheng, James F Nelson, Jonathan Gelfond, Shailaja Kesaraju Allani, Vivian Diaz, Angela Olsen Dorigatti, Jonathan Dorigatti,...> ;Aging Cell. 2022 Dec 1
• 3 citations
  Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors.
  Yanghan Liu, Bikash Debnath, Surinder Kumar, David B Lombard, Nouri Neamati> ;European Journal of Medicinal Chemistry. 2022 Nov 5
• 6 citations
  Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload.
  Angela H Guo, Rachael Baliira, Mary E Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S Goldsmith, Shaday Michan, Norma J Davis, Sharlene M Day, David A Sinc...> ;Scientific Reports. 2022 Jul 18
• 23 citations
  Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
  Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, ...> ;Elife. 2022 Jul 11
• 4 citations
  Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer.
  Surinder Kumar, Morgan Jones, Qing Li, David B. Lombard> ;Journal of Visualized Experiments. 2021 Sep 24
• 7 citations
  Canagliflozin increases intestinal adenoma burden in female Apc Min/+ mice.
  Justin Korfhage, Mary E. Skinner, Jookta Basu, Joel K. Greenson, Richard A. Miller, David B. Lombard> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2021 Aug 27
• 1 citations
  SIRT5's GOT1 up on PDAC.
  Surinder Kumar, David B. Lombard> ;Gastroenterology. 2021 Jul 16
• 22 citations
  The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
  William Giblin, Lauren Bringman-Rodenbarger, Angela H. Guo, Surinder Kumar, Alexander C. Monovich, Ahmed Mostafa, Mary E. Skinner, Michelle Azar, Ahmed S.A. Mady, Caro...> ;The Journal of Clinical Investigation. 2021 Jun 15
• 3 citations
  ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection.
  Samanthi Narayanan, Srikanth Elesela, Andrew J. Rasky, Susan H. Morris, Surinder Kumar, David B. Lombard, Nicholas W. Lukacs> ;Journal of Leukocyte Biology. 2021 Apr 18
• 69 citations
  Melanoma models for the next generation of therapies
  E. Elizabeth Patton, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Christin E. Bu...> ;Cancer Cell. 2021 May 10
• 46 citations
  Canagliflozin extends life span in genetically heterogeneous male but not female mice
  Richard A. Miller, David E. Harrison, David B. Allison, Molly A. Bogue, Lucas Kniess Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej T. Galecki, W. Timothy Garvey, ...> ;JCI Insight. 2020 Nov 5
• 2 citations
  An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells
  Taolin Yuan, Jaap Keijer, Angela H. Guo, David B. Lombard, Vincent C. J. de Boer> ;Scientific Reports. 2020 Oct 12
• 8 citations
  High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.
  David B. Lombard, William J. Kohler, Angela H. Guo, Christi M. Gendron, Melissa Han, Weiqiao Ding, Yang Lyu, Tsui Ting Ching, Feng Yung Wang, Tuhin Subhra Chakraborty,...> ;Science Advances. 2020 Sep 30
• 31 citations
  High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions
  Andrew C. Little, Ilya Kovalenko, Laura E. Goo, Hanna Sungok Hong, Samuel A. Kerk, Joel A. Yates, Vinee Purohit, David B. Lombard, Sofia D. Merajver, Costas A. Lyssiotis> ;Communications Biology. 2020 May 29
• 16 citations
  A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.
  Kaylee Steen, Desu Chen, Fengrong Wang, Ritankar Majumdar, Song Chen, Surinder Kumar, David B. Lombard, Roberto Weigert, A.G. Zieman, Carole A. Parent, Pierre A. Coulombe> ;Molecular Biology of the Cell. 2020 Mar 26
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Journal Articles

• Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses After Experimental Allogeneic Hematopoietic Transplantation  
  David B Lombard, Pavan Reddy, Daniel C Peltier, The Journal of Immunology