DavidH.LynchDO

PubMed

• Excision of expanded GAA repeats alleviates the molecular phenotype of Friedreich's ataxia.
  Li, Y.,Polak, U.,Bhalla, A.,Rozwadowska, N.,Butler, J. S.,Lynch, D.,Dent, S. Y.,Napierala, M.> ;Mol. Ther.. 2015 Mar 12
• The CD95 receptor: apoptosis revisited.
  Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. M., Hueber, A. O., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J., Wajant, H., Wallach, D., Wiltrout, R. H....> ;Cell. 2007 May 4
• Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor.
  > ;J Clin Invest. 2005 Jul
• Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity.
  Lum, J.J., Schnepple, D.J., Nie, Z., Sanchez-Dardon, J., Mbisa, G.L., Mihowich, J., Hawley, N., Narayan, S., Kim, J.E., Lynch, D.H., Badley, A.D.> ;J Virol. 2004 Jun
• Distinguishing modes of cell death using the ImageStream multispectral imaging flow cytometer.
  George, T.C., Basiji, D.A., Hall, B.E., Lynch, D.H., Ortyn, W.E., Perry, D.J., Seo, M.J., Zimmerman, C.A., Morrissey, P.J.> ;Cytometry A. 2004 Jun
• A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.
  Bertram, E.M., Dawicki, W., Sedgmen, B., Bramson, J.L., Lynch, D.H., Watts, T.H.> ;J Immunol. 2004 Jan 15
• Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.
  Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao X, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD> ;J. Clin. Invest.. 2003-05-01
• 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner.
  Miller, R.E., Jones, J., Le, T., Whitmore, J., Boiani, N., Gliniak, B., Lynch, D.H.> ;J Immunol. 2002 Aug 15
• Therapeutic potential of ABX-EGF: a fully human anti-epidermal growth factor receptor monoclonal antibody for cancer treatment.
  Lynch, D.H., Yang, X.> ;Semin Oncol. 2002 Feb
• Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis.
  Vincent MS, Roessner K, Lynch D, Wilson D, Cooper SM, Tschopp J, Sigal LH, Budd RC> ;J. Exp. Med.. 1996-12-01
• Impaired nonrestricted cytolytic activity in systemic lupus erythematosus: involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP th...
  Stohl, W., Elliott, J. E., Li, L., Podack, E. R., Lynch, D. H., Jacob, C. O.> ;Arthritis Rheum. 1997 Jun
• Extensive apoptosis of lung T-lymphocytes maintained in vitro.
  Herry, I., Bonay, M., Bouchonnet, F., Schuller, M. P., Lecossier, D., Tazi, A., Lynch, D. H., Hance, A. J.> ;Am J Respir Cell Mol Biol. 1996 Sep
• Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice.
  Sakai, T., Kimura, Y., Inagaki-Ohara, K., Kusugami, K., Lynch, D. H., Yoshikai, Y.> ;Gastroenterology. 1997 Jul
• Inducible resistance to Fas-mediated apoptosis in primary B lymphocytes.
  Rothstein, T. L., Foote, L. C., Schneider, T. J., Fischer, G. M., Jacobson, B. A., Lynch, D. H., Ju, S. T., Marshak-Rothstein, A.> ;Adv Exp Med Biol. 1996
• CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells.
  Koppi, T. A., Tough-Bement, T., Lewinsohn, D. M., Lynch, D. H., Alderson, M. R.> ;Eur J Immunol. 1997 Dec
• Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine.
  Inagaki-Ohara, K., Nishimura, H., Sakai, T., Lynch, D. H., Yoshikai, Y.> ;Lab Invest. 1997 Nov
• Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis.
  Josefsen, D., Myklebust, J. H., Lynch, D. H., Stokke, T., Blomhoff, H. K., Smeland, E. B.> ;Exp Hematol. 1999 Sep
• Regulation of Fas and Fas-ligand expression in NK cells by cytokines and the involvement of Fas-ligand in NK/LAK cell-mediated cytotoxicity.
  Medvedev, A. E., Johnsen, A. C., Haux, J., Steinkjer, B., Egeberg, K., Lynch, D. H., Sundan, A., Espevik, T.> ;Cytokine. 1997 Jun
• Blocking of the B7-CD28 pathway increases apoptosis induced in activated T cells by in vitro-generated CD95L (FasL) positive dendritic cells.
  Lu, L., Qian, S., Hershberger, P., Rudert, W. A., Li, Y., Chambers, F. G., Starzl, T. E., Lynch, D. H., Thomson, A. W.> ;Transplant Proc. 1997 Feb 01
• An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro.
  Papoff, G., Cascino, I., Eramo, A., Starace, G., Lynch, D. H., Ruberti, G.> ;J Immunol. 1996 Jun 15
• Blocking of the B7-CD28 pathway increases the capacity of FasL+ (CD95L+) dendritic cells to kill alloactivated T cells.
  Lu, L., Qian, S., Starzl, T. E., Lynch, D. H., Thomson, A. W.> ;Adv Exp Med Biol. 1997
• HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid.
  Mitra, D., Steiner, M., Lynch, D. H., Staiano-Coico, L., Laurence, J.> ;Immunology. 1996 Apr
• Regulation of the Fas lytic pathway in cloned CTL.
  Glass, A., Walsh, C. M., Lynch, D. H., Clark, W. R.> ;J Immunol. 1996 May 15
• CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.
  Mollereau, B., Deckert, M., Déas, O., Rieux-Laucat, F., Hirsch, F., Bernard, A., Fischer, A., Lynch, D. H., Charpentier, B., Le Deist, F., Senik, A.> ;J Immunol. 1996 May 1
• Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells.
  Foote, L. C., Schneider, T. J., Fischer, G. M., Wang, J. K., Rasmussen, B., Campbell, K. A., Lynch, D. H., Ju, S. T., Marshak-Rothstein, A., Rothstein, T. L.> ;J Immunol. 1996 Sep 1
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