DavidAPearceMD

Orthopaedic Surgery • Jackson, TN

Hip & Knee Reconstructive Surgery, Orthopedic Sports Medicine

Physician

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Office
24 Physicians Dr
Jackson, TN 38305
Phone+1 731-661-9825

Fax+1 731-668-6757
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Summary

Dr. David Pearce is an orthopedic surgeon in Jackson, TN and is affiliated with multiple hospitals in the area, including Jackson-Madison County General Hospital, Tennova Healthcare Regional Hospital of Jackson, and Baptist Memorial Hospital-Union City. He received his medical degree from Georgetown University School of Medicine and has been in practice 22 years. He specializes in hip & knee reconstructive surgery and orthopedic sports medicine and is experienced in sports medicine, hip and knee surgery, shoulder and elbow sports medicine, foot and ankle sports medicine, and hip and knee traumatology.

Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHFellowship, Orthopaedic Sports Medicine, 2000 - 2001
Virginia Commonwealth University Health SystemResidency, Orthopaedic Surgery, 1995 - 2000
Georgetown University School of MedicineClass of 1995

Certifications & Licensure

TN State Medical License 2004 - 2026
KY State Medical License 2001 - 2005
VA State Medical License 1998 - 2002
PA State Medical License 2000 - 2002
American Board of Orthopaedic Surgery Orthopaedic Surgery
American Board of Orthopaedic Surgery Orthopaedic Sports Medicine

Clinical Trials

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Start of enrollment: 2010 Jul 01
Recruiting

Publications & Presentations

PubMed

Evaluating the effectiveness of a laboratory-based professional development program for science educators.
Amolins, M. W.,Ezrailson, C. M.,Pearce, D. A.,Elliott, A. J.,Vitiello, P. F.> ;Adv Physiol Educ. 2015 Dec 03
Tissue-specific variation in nonsense mutant transcript level and drug-induced read-through efficiency in the Cln1(R151X) mouse model of INCL.
Thada, V.,Miller, J. N.,Kovács, A. D.,Pearce, D. A.> ;J. Cell. Mol. Med.. 2015 Dec 10
Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis.
Hersrud, S. L.,Geraets, R. D.,Weber, K. L.,Chan, C. H.,Pearce, D. A.> ;FEBS J.. 2015 Nov 14
Lysosome dysfunction in the pathogenesis of kidney diseases.
Surendran, K.,Vitiello, S. P.,Pearce, D. A.> ;Pediatr. Nephrol.. 2013 Nov 13
The novel Cln1R151X mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.
Miller, J. N.,Kovács, A. D.,Pearce, D. A.> ;Hum. Mol. Genet.. 2014 Sep 11
18 citations
Batten Disease Clinical Aspects, Molecular Mechanisms, Translational Science, and Future Directions
Sarah-Bianca Dolisca, Mitali Mehta, David A. Pearce, Jonathan W. Mink, Bernard L. Maria> ;Journal of Child Neurology. 2013 Jul 9
The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.
Miller, J. N.,Chan, C. H.,Pearce, D. A.> ;Hum. Mol. Genet.. 2013 Jul 1
Seizure Susceptibility, Phenotype, and Resultant Growth Delay in the nclf and mnd Mouse Models of Neuronal Ceroid Lipofuscinoses.
Kriscenski-Perry, E.,Kovács, A. D.,Pearce, D. A.> ;J. Child Neurol.. 2013 Sep
28 citations
Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.
Amanda L. Getty, Attila D. Kovács, Tímea Lengyel-Nelson, Andrew L. Cardillo, Caitlin Hof, Chun-Hung Chan, David A. Pearce> ;Plos One. 2013 Jun 20
Neuronal ceroid lipofuscinosis type CLN2: a new rationale for the construction of phenotypic subgroups based on a survey of 25 cases in South America.
Kohan, R.,Carabelos, M. N.,Xin, W.,Sims, K.,Guelbert, N.,Cismondi, I. A.,Pons, P.,Alonso, G. I.,Troncoso, M.,Witting, S.,Pearce, D. A.,Dodelson de Kremer, R.,Oller-Ram...> ;Gene. 2013 Mar 1
Patterns of marine bacterioplankton biodiversity in the surface waters of the Scotia Arc, Southern Ocean.
Jamieson, R.E., Rogers, A.D., Billett, D.M., Smale, D.A., Pearce, D.A.> ;FEMS Microbiol Ecol. 2012 May
The discovery of new deep-sea hydrothermal vent communities in the southern ocean and implications for biogeography.
Rogers, A.D., Tyler, P.A., Connelly, D.P., Copley, J.T., James, R., Larter, R.D., Linse, K., Mills, R.A., Garabato, A.N., Pancost, R.D., Pearce, D.A., Polunin, N.C., G...> ;PLoS Biol. 2012 Jan
BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution.
Padilla-López, S., Langager, D., Chan, C. H., Pearce, D. A.> ;Dis Model Mech. 2012 Mar
Altered glutamate receptor function in the cerebellum of the Ppt1(-/-) mouse, a murine model of infantile neuronal ceroid lipofuscinosis.
Finn, R., Kovács, A. D., Pearce, D. A.> ;J Neurosci Res. 2012 Feb
A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3(-/-) cells.
Getty, A.L., Benedict, J.W., Pearce, D.A.> ;Exp Cell Res. 2011 Jan 1
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains.
Finn, R., Kovács, A.D., Pearce, D.A.> ;J Neurosci Res. 2010 Sep
34 citations
Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na+ Channel
Kenneth R. Hallows, Vivek Bhalla, Nicholas M. Oyster, Marjolein A. Wijngaarden, Jeffrey K. Lee, Hui Li, Sindhu Chandran, Xiaoyu Xia, Zhirong Huang, Robert J. Chalkley,...> ;The Journal of Biological Chemistry. 2010 Jul 9
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2.
Benedict, J.W., Getty, A.L., Wishart, T.M., Gillingwater, T.H., Pearce, D.A.> ;J Neurosci Res. 2009 Jul
Juvenile neuronal ceroid lipofuscinosis (JNCL) and the eye.
Bozorg, S., Ramirez-Montealegre, D., Chung, M., Pearce, D.A.> ;Surv Ophthalmol. 2009-07-01
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2.
Schmidt, K., Wolfe, D.M., Stiller, B., Pearce, D.A.> ;Biochem Biophys Res Commun. 2009-05-29
Spectral properties and mechanisms that underlie autofluorescent accumulations in Batten disease.
Seehafer, S.S., Pearce, D.A.> ;Biochem Biophys Res Commun. 2009 May 1
178 citations
Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders.
S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, Hao Huang, Kenichi Oishi, Susumu Mori, Donald F. Smee, David A. Pearce, Christine Winter, Reinhard Sohr, Georg ...> ;Schizophrenia Research. 2008 Feb 1
Identification of alpha-fetoprotein as an autoantigen in juvenile Batten disease.
Castaneda, J.A., Pearce, D.A.> ;Neurobiol Dis. 2008 Jan
Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease.
Kovács, A.D., Pearce, D.A.> ;Exp Neurol. 2008 Jan
Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease.
Benedict, J.W., Sommers, C.A., Pearce, D.A.> ;J Neurosci Res. 2007 Oct
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Grant Support

Sanford Research/Usd Science Educator Pediatric Health And Research FellowshipEunice Kennedy Shriver National Institute Of Child Health &Human Development2012
13th International NCL Congress: Supporting US Based ScientistsNational Institute Of Neurological Disorders And Stroke2011–2012
The Autoimmune Response Of Battens DiseaseNational Institute Of Neurological Disorders And Stroke2009–2011
Gilz Regulation Of ENACNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Regulation Of Ubiquitin Ligase Nedd4-2 By PhosphorylationNational Center For Research Resources2007–2011
SGK Regulation Of Epithelial Sodium TransportNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2011
Studies Of Yeast Btn1p And Human Cln3p In YeastNational Institute Of Neurological Disorders And Stroke2009–2010
AMPA Receptor Attenuation As A New Therapeutic Approach For Batten DiseaseNational Institute Of Neurological Disorders And Stroke2009–2010
Are Ncls Atypical In Latin America? Phenotypic And Genotypic Analyses.Fogarty International Center2009–2010
The Autoimmune Response Of Battens DiseaseNational Institute Of Neurological Disorders And Stroke2009
12th International NCL CongressNational Institute Of Neurological Disorders And Stroke2009
Are Ncls Atypical In Latin America? Phenotypic And Genotypic Analyses.Fogarty International Center2009
Studies Of Yeast Btn1p And Human Cln3p In YeastNational Institute Of Neurological Disorders And Stroke2007–2009
Mechanisms Of Mineralcorticoid Receptor FunctionNational Institute Of Diabetes And Digestive And Kidney Diseases2008
Serum Proteomics For Biomarker Discovery In Batten DiseaseNational Institute Of Neurological Disorders And Stroke2007–2008
The Autoimmune Response In Batten DiseaseNational Institute Of Neurological Disorders And Stroke2003–2008
11th International Congress On Neuronal Ceroid LipofuscinosisNational Institute Of Neurological Disorders And Stroke2007
Studies Of Yeast Btnlp And Human Cln3p In YeastNational Institute Of Neurological Disorders And Stroke2001–2006
Mechanisms Of Mineralcorticoid Receptor FunctionNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2005
Mineralocorticoid-Regulated Epithelial Sodium TransportNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2003
Retinal Cell Model For Batten DiseaseNational Institute Of Neurological Disorders And Stroke2000–2002
Mechanisms Of Corticosteroid Receptor Function In BrainNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2001
Yeast Btnlp And Human Cln3p In YeastNational Institute Of Neurological Disorders And Stroke1999–2000
Mechanisms Of Mineralocorticoid Receptor FunctionNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2000
Role Of Gene Regulation In Renal Physiologic ResponsesNational Institute Of Diabetes And Digestive And Kidney Diseases1988–1992

Hospital Affiliations

Jackson-Madison County General HospitalJackson, Tennessee
Tennova Healthcare Regional Hospital of JacksonJackson, Tennessee
Baptist Memorial Hospital-Union CityUnion City, Tennessee

DavidAPearceMD

Dr. Pearce is on Doximity

Summary

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Grant Support

Hospital Affiliations

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