DavidRobertPhillipsDO

PubMed

• A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa.
  Lu, G.,Deguzman, F. R.,Hollenbach, S. J.,Karbarz, M. J.,Abe, K.,Lee, G.,Luan, P.,Hutchaleelaha, A.,Inagaki, M.,Conley, P. B.,Phillips, D. R.,Sinha, U.> ;Nat. Med.. 2013 Apr
• Critical role for Syk in responses to vascular injury.
  Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, ...> ;Blood. 2011-11-03
• Specific Inhibition of Syk Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis.
  Coffey, G., Deguzman, F., Inagaki, M., Pak, Y., Delaney, S.M., Ives, D., Betz, A., Jia, Z.J., Pandey, A., Baker, D., Hollenbach, S.J., Phillips, D.R., Sinha, U.> ;J Pharmacol Exp Ther. 2012 Feb
• A CLOPIDOGREL-INSENSITIVE POOL OF P2Y12 RECEPTORS CONTRIBUTES TO THROMBUS FORMATION;INHIBITION BY ELINOGREL, A DIRECT-ACTING, REVERSIBLE P2Y12 ANTAGONIST.
  Haberstock-Debic, H., Andre, P., Mills, S., Phillips, D.R., Conley, P.B.> ;J Pharmacol Exp Ther. 2011 Oct
• Thienopyridines, but not elinogrel, result in off-target effects at the vessel wall that contribute to bleeding.
  André, P., DeGuzman, F., Haberstock-Debic, H., Mills, S., Pak, Y., Inagaki, M., Pandey, A., Hollenbach, S., Phillips, D. R., Conley, P. B.> ;J Pharmacol Exp Ther. 2011 Jul
• The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
  Feng, W., McCabe, N.P., Mahabeleshwar, G.H., Somanath, P.R., Phillips, D.R., Byzova, T.V.> ;J Cell Biol. 2008-12-15
• Integrin signaling is critical for pathological angiogenesis.
  Mahabeleshwar, G.H., Feng, W., Phillips, D.R., Byzova, T.V.> ;J Exp Med. 2006 Oct 30
• Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.
  Xi, X., Flevaris, P., Stojanovic, A., Chishti, A., Phillips, D.R., Lam, S.T., Du, X.> ;J Biol Chem. 2006 Oct 6
• Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses.
  Treanor B, Lanigan PMP, Kumar S, Dunsby C, Munro I, Auksorius E, Culley FJ, Purbhoo MA, Phillips D, Neil MAA, Burshtyn DN, French PMW, Davis DM> ;J. Cell Biol.. 2006-07-03
• Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation.
  Lee, S.P., Ataga, K.I., Orringer, E.P., Phillips, D.R., Parise, L.V.> ;Arterioscler Thromb Vasc Biol. 2006 Jul
• Novel targets for antithrombotic drug discovery.
  Nanda, N., Phillips, D.R.> ;Blood Cells Mol Dis. 2006-03-01
• Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.
  Nanda, N., Andre, P., Bao, M., Clauser, K., Deguzman, F., Howie, D., Conley, P.B., Terhorst, C., Phillips, D.R.> ;Blood. 2005 Nov 1
• Synergistic induction of tissue factor by coagulation factor Xa and TNF: evidence for involvement of negative regulatory signaling cascades.
  Hezi-Yamit, A., Wong, P.W., Bien-Ly, N., Komuves, L.G., Prasad, K.S., Phillips, D.R., Sinha, U.> ;Proc Natl Acad Sci U S A. 2005 Aug 23
• Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced...
  Nanda, N.,Bao, M.,Lin, H.,Clauser, K.,Komuves, L.,Quertermous, T.,Conley, P. B.,Phillips, D. R.,Hart, M. J.> ;J Biol Chem. 2005 Jul 1
• Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen.
  Stephens, G., Yan, Y., Jandrot-Perrus, M., Villeval, J., Clemetson, K.J., Phillips, D.R.> ;Blood. 2005 Jan 1
• PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
  Fang, L., Yan, Y., Komuves, L.G., Yonkovich, S., Sullivan, C.M., Stringer, B., Galbraith, S., Lokker, N.A., Hwang, S.S., Nurden, P., Phillips, D.R., Giese, N.A.> ;Arterioscler Thromb Vasc Biol. 2004 Apr
• GP IIb/IIIa inhibition with eptifibatide lowers levels of soluble CD40L and RANTES after percutaneous coronary intervention.
  Welt, F.P., Rogers, S.D., Zhang, X., Ehlers, R., Chen, Z., Nannizzi-Alaimo, L., Phillips, D.R., Simon, D.I.> ;Catheter Cardiovasc Interv. 2004 Feb
• Platelet and osteoclast beta3 integrins are critical for bone metastasis.
  Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN> ;Proc. Natl. Acad. Sci. U.S.A.. 2003-11-25
• Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis.
  André, P., LaRocca, T., Delaney, S.M., Lin, P.H., Vincent, D., Sinha, U., Conley, P.B., Phillips, D.R.> ;Circulation. 2003 Nov 25
• Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling.
  Prasad, K.S., Andre, P., He, M., Bao, M., Manganello, J., Phillips, D.R.> ;Proc Natl Acad Sci U S A. 2003 Oct 14
• The platelet CD40L/GP IIb-IIIa axis in atherothrombotic disease.
  Prasad, K.S., Andre, P., Yan, Y., Phillips, D.R.> ;Curr Opin Hematol. 2003 Sep
• P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.
  Andre, P., Delaney, S.M., LaRocca, T., Vincent, D., DeGuzman, F., Jurek, M., Koller, B., Phillips, D.R., Conley, P.B.> ;J Clin Invest. 2003 Aug
• Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation.
  Nannizzi-Alaimo, L., Alves, V.L., Phillips, D.R.> ;Circulation. 2003 Mar 4
• Age differences in safety attitudes and safety performance in Hong Kong construction workers.
  Siu, O., Phillips, D.R., Leung, T.> ;J Safety Res. 2003
• Platelet-derived CD40L: the switch-hitting player of cardiovascular disease.
  André, P., Nannizzi-Alaimo, L., Prasad, S.K., Phillips, D.R.> ;Circulation. 2002 Aug 20
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