DavidSReynoldsMD

PubMed

• 16 citations
  Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
  Rachel Gurrell, Donal Gorman, Mark Whitlock, Adam Ogden, David S. Reynolds, Bree DiVentura, Bassel Abou-Khalil, Michael A. Gelfand, John R. Pollard, R. Edward Hogan, G...> ;Neurology. 2019 Apr 9
• 14 citations
  Tackling gaps in developing life-changing treatments for dementia.
  Rui Mauricio, Caroline L. Benn, John B. Davis, G. R. Dawson, Lee A. Dawson, Alison Evans, Nick C. Fox, John Gallacher, Michael Hutton, John Isaac, Declan N.C. Jones, L...> ;Alzheimer's & Dementia. 2019 Jan 1
• Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve perf...
  Ellard JM, Madin A, Philps O, Hopkin M, Henderson S, Birch L, O'Connor D, Arai T, Takase K, Morgan L, Reynolds D, Talma S, Howley E, Powney B, Payne AH, Hall A, Gartlo...> ;Bioorg. Med. Chem. Lett.. 2015-12-15
• Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At ?1 Subunit-Containing GABA(A) Receptor Subtypes in Midazolam- But Not Cocaine-Experienced Rhesus Monkeys.
  Shinday, N. M.,Sawyer, E. K.,Fischer, B. D.,Platt, D. M.,Licata, S. C.,Atack, J. R.,Dawson, G. R.,Reynolds, D. S.,Rowlett, J. K.> ;Neuropsychopharmacology. 2013 May
• Assessment of 'active investigation' as a potential measure of female sexual incentive motivation in a preclinical non-contact rodent model: observations with apomorph...
  Hawcock, A.B., Dawkins, T.E., Reynolds, D.S.> ;Pharmacol Biochem Behav. 2010 Apr
• The value of genetic and pharmacological approaches to understanding the complexities of GABA(A) receptor subtype functions: the anxiolytic effects of benzodiazepines.
  Reynolds, D.S.> ;Pharmacol Biochem Behav. 2008 Jul
• Guest editor's note.
  Reynolds, D.S., Dawson, G.R.> ;Pharmacol Biochem Behav. 2008 Jul
• 24 citations
  Alpha2-containing GABAA receptors are involved in mediating stimulant effects of cocaine
  H.V. Morris, G. R. Dawson, David S. Reynolds, John R. Atack, Thomas W. Rosahl, David N. Stephens> ;Pharmacology, Biochemistry, and Behavior. 2008 Jul 1
• 19 citations
  Designing drugs for the treatment of female sexual dysfunction
  Alan Daniel Brown, Julian Blagg, David S. Reynolds> ;Drug Discovery Today. 2007 Sep 1
• 36 citations
  Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
  Rosa L. Fradley, Martin R. Guscott, Sharlene Bull, David James Hallett, Simon Charles Goodacre, Keith A. Wafford, Elizabeth M. Garrett, Richard J. Newman, Gillian F. O...> ;Journal of Psychopharmacology. 2007 Jun 1
• Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm.
  Morris HV, Dawson GR, Reynolds DS, Atack JR, Stephens DN> ;Eur. J. Neurosci.. 2006-05-01
• A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
  Lewis, R.T., Blackaby, W.P., Blackburn, T., Jennings, A.R., Pike, A., Wilson, R.A., Hallett, D.J., Cook, S.M., Ferris, P., Marshall, G.R., Reynolds, D.S., Sheppard, W....> ;J Med Chem. 2006 Apr 20
• 8 citations
  Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety
  Andrew Stephen Robert Jennings, Richard Thomas Lewis, Michael G. N. Russell, David James Hallett, Leslie J. Street, José L. Castro, John R. Atack, Susan M. Cook, Racha...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Mar 15
• An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.
  Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA,...> ;J. Pharmacol. Exp. Ther.. 2006-03-01
• Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
  Russell, M.N., Carling, R.W., Street, L.J., Hallett, D.J., Goodacre, S., Mezzogori, E., Reader, M., Cook, S.M., Bromidge, F.A., Newman, R., Smith, A.J., Wafford, K.A.,...> ;J Med Chem. 2006 Feb 23
• Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
  Dias, R., Sheppard, W.A., Fradley, R.L., Garrett, E.M., Stanley, J.L., Tye, S.J., Goodacre, S., Lincoln, R.J., Cook, S.M., Conley, R., Hallett, D., Humphries, A.C., Th...> ;J Neurosci. 2005 Nov 16
• Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide.
  Leslie, J.C., Shaw, D., Gregg, G., McCormick, N., Reynolds, D.S., Dawson, G.R.> ;J Exp Anal Behav. 2005 Nov
• 95 citations
  STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating.
  Rosa L. Fradley, Gillian F. O'Meara, Richard J. Newman, Annie Andrieux, Didier Job, David S. Reynolds> ;Behavioural Brain Research. 2005 Sep 8
• The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines.
  Stanley, J. L.,Lincoln, R. J.,Brown, T. A.,McDonald, L. M.,Dawson, G. R.,Reynolds, D. S.> ;J Psychopharmacol. 2005 May
• 20 citations
  Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD
  Huw D. Lewis, Dirk Beher, Smith David W, Louise Hewson, Natalie J. Cookson, David S. Reynolds, Gerard R. Dawson, Michael Jiang, Lex H.T Van der Ploeg, Su Qian, Thomas ...> ;Neurobiology of Aging. 2004 Oct 1
• Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes.
  Wafford KA, Macaulay AJ, Fradley R, O'Meara GF, Reynolds DS, Rosahl TW> ;Biochem. Soc. Trans.. 2004-06-01
• Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice.
  Cirone, J., Rosahl, T.W., Reynolds, D.S., Newman, R.J., O'Meara, G.F., Hutson, P.H., Wafford, K.A.> ;Anesthesiology. 2004 Jun
• Effects of chlordiazepoxide on extinction and re-acquisition of operant behaviour in mice.
  Shaw D, Dawson GR, Reynolds DS, McCabe C, Leslie JC> ;Behav Pharmacol. 2004-05-01
• Effects of drugs that potentiate GABA on extinction of positively-reinforced operant behaviour.
  Leslie, J.C., Shaw, D., McCabe, C., Reynolds, D.S., Dawson, G.R.> ;Neurosci Biobehav Rev. 2004 May
• Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
  Reynolds, D.S., Rosahl, T.W., Cirone, J., O'Meara, G.F., Haythornthwaite, A., Newman, R.J., Myers, J., Sur, C., Howell, O., Rutter, A.R., Atack, J., Macaulay, A.J...> ;J Neurosci. 2003 Sep 17
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