DavidPSchenkeinMD

PubMed

• 2 citations
  US immigration order strikes against biotech
  Jeremy M Levin, Steven H Holtzman, John M. Maraganore, Paul Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall,...> ;Nature Biotechnology. 2017 Mar 7
• O11.2AG-221 offers a survival advantage in a primary human IDH2 mutant AML xenograft model.
  Yen, K.,Wang, F.,Travins, J.,Chen, Y.,Yang, H.,Straley, K.,Choe, S.,Dorsch, M.,Agresta, S.,Schenkein, D.,Biller, S.,Su, M.> ;Ann. Oncol.. 2015 Mar 22
• 121 citations
  IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
  Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, Davi...> ;Blood. 2015 Jan 8
• 52 citations
  Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate
  Amir T. Fathi, Hossein Sadrzadeh, Amy Comander, Michaela J. Higgins, Aditya Bardia, Ashley M. Perry, Meghan Burke, Regina Silver, Christina R. Matulis, Kimberly Strale...> ;The Oncologist. 2014 Jun 1
• 91 citations
  Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma
  Darrell R. Borger, Lipika Goyal, Thomas Yau, Ronnie T.P. Poon, Marek Ancukiewicz, Vikram Deshpande, David C. Christiani, Hannah M. Liebman, Hua Yang, Hyeryun Kim, Kath...> ;Clinical Cancer Research. 2014 Apr 1
• 46 citations
  Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
  Jane Fridlyand, Richard M. Simon, Jessica C. Walrath, Nancy Roach, Richard Buller, David P. Schenkein, Keith T. Flaherty, Jeff Allen, Ellen V. Sigal, Howard I. Scher> ;Nature Reviews. Drug Discovery. 2013 Oct 1
• 13 citations
  Reevaluating the Accelerated Approval Process for Oncology Drugs
  Wyndham H. Wilson, David P. Schenkein, Cheryl L. Jernigan, Janet Woodcock, Richard L. Schilsky> ;Clinical Cancer Research. 2013 Jun 1
• 603 citations
  Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
  Fang Wang, Jeremy Travins, Byron DeLaBarre, Virginie Penard-Lacronique, Stefanie Schalm, Erica Hansen, Kimberly Straley, Andrew Kernytsky, Wei Liu, Camelia Gliser, Hua...> ;Science. 2013 May 3
• 19 citations
  2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylc...
  Daniel A. Pollyea, Holbrook E Kohrt, James L. Zehnder, David P. Schenkein, Valeria Fantin, Kimberly Straley, Aparna Vasanthakumar, Omar Abdel-Wahab, Ross L. Levine, Lu...> ;Leukemia & Lymphoma. 2013 Feb 1
• 96 citations
  Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
  Amir T. Fathi, Hossein Sadrzadeh, Darrell R. Borger, Karen K. Ballen, Philip C. Amrein, Eyal C. Attar, Julia Foster, Meghan Burke, Hector U. Lopez, Christina R. Matuli...> ;Blood. 2012 Nov 29
• 240 citations
  Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
  Whitney B. Pope, Robert M. Prins, M. Albert Thomas, Rajakumar Nagarajan, Katharine E. Yen, Mark A. Bittinger, Noriko Salamon, Arthur P. Chou, William H. Yong, Horacio ...> ;Journal of Neuro-Oncology. 2012 Mar 1
• 14 citations
  Cancer-Associated Isocitrate Dehydrogenase Mutations
  Katharine E. Yen, David P. Schenkein> ;The Oncologist. 2012 Jan 1
• 556 citations
  Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
  Darrell R. Borger, Kenneth K. Tanabe, Kenneth C. Fan, Hector U. Lopez, Valeria Fantin, Kimberly Straley, David P. Schenkein, Aram F. Hezel, Marek Ancukiewicz, Hannah M...> ;The Oncologist. 2012 Jan 1
• 574 citations
  Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
  Stefan Gross, Rob A. Cairns, Mark D. Minden, Edward M. Driggers, Mark A. Bittinger, Hyun Gyung Jang, Masato Sasaki, Shengfang Jin, David P. Schenkein, Shinsan M. Su, L...> ;The Journal of Experimental Medicine. 2010 Feb 15
• 93 citations
  Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute myelogenous leukemia
  Eyal C. Attar, Daniel J. DeAngelo, Jeffrey G. Supko, Ferdinando D’Amato, David Zahrieh, Andres Sirulnik, Martha Wadleigh, Karen K. Ballen, Steve McAfee, Kenneth B. Mil...> ;Clinical Cancer Research. 2008 Mar 1
• 28 citations
  The Proteasome Inhibitor Bortezomib in Combination with Gemcitabine and Carboplatin in Advanced Non-small Cell Lung Cancer: A California Cancer Consortium Phase I Study
  Angela M. Davies, Christopher Ruel, Primo N. Lara, Derick H Lau, Paul H. Gumerlock, Richard J. Bold, Stephen Shibata, Heinz-Josef Lenz, David P. Schenkein, David R. Ga...> ;Journal of Thoracic Oncology. 2008 Jan 1
• 399 citations
  Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial.
  Paul G. Richardson, Pieter Sonneveld, Michael W. Schuster, David Irwin, Edward A. Stadtmauer, Thierry Facon, Jean-Luc Harousseau, Dina Ben-Yehuda, Sagar Lonial, Hartmu...> ;Blood. 2007 Nov 15
• 285 citations
  Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
  George Mulligan, Constantine S. Mitsiades, Barb Bryant, Fenghuang Zhan, Wee Chng, Steven Roels, Erik Koenig, Andrew Fergus, Yongsheng Huang, Paul G. Richardson, Willia...> ;Blood. 2007 Apr 15
• 78 citations
  The Proteasome Inhibitor Bortezomib Acts Independently of p53 and Induces Cell Death via Apoptosis and Mitotic Catastrophe in B-Cell Lymphoma Cell Lines
  Sandra J. Strauss, Karen Higginbottom, Simone Jüliger, Lenushka Maharaj, Paul D. Allen, David P. Schenkein, T. Andrew Lister, Simon P. Joel> ;Cancer Research. 2007 Mar 15
• 99 citations
  MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo
  Teru Hideshima, Paola Neri, Pierfranchesco Tassone, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine S. Mitsiades, Lenny Dang,...> ;Clinical Cancer Research. 2006 Oct 1
• 103 citations
  Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
  Jennifer Rocnik, Rachel Okabe, Jin-Chen Yu, Benjamin H. Lee, Neill Giese, David P. Schenkein, D. Gary Gilliland> ;Blood. 2006 Aug 15
• 41 citations
  Drug-induced cutaneous vasculitis in patients with non-Hodgkin lymphoma treated with the novel proteasome inhibitor bortezomib: a possible surrogate marker of response?
  John F. Gerecitano, Andre Goy, John J. Wright, Barbara MacGregor-Cortelli, Ellen Neylon, Mithat Gonen, Dixie Lee Esseltine, Anthony Boral, David P. Schenkein, Klaus J....> ;British Journal of Haematology. 2006 Aug 1
• 15 citations
  An electrodiagnostic evaluation of the effect of pre-existing peripheral nervous system disorders in patients treated with the novel proteasome inhibitor bortezomib.
  Michael D. Stubblefield, Susan F. Slovin, Barbara MacGregor-Cortelli, Jamie Muzzy, Howard I. Scher, John J. Wright, Dixie Lee Esseltine, David P. Schenkein, Owen A. O'...> ;Clinical Oncology. 2006 Jun 1
• 126 citations
  Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezom...
  Sundar Jagannath, Paul G Richardson, Bart Barlogie, James R Berenson, Seema Singhal, David Irwin, Gordan Srkalovic, David P Schenkein, Dixie L Esseltine, Kenneth C And...> ;Haematologica. 2006 Jul 1
• 172 citations
  Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines
  Belén Blanco, José A. Pérez-Simón, Luis Ignacio Sánchez-Abarca, Xonia Carvajal-Vergara, Juan Mateos, Belén Vidriales, Natalia Lopez-Holgado, Patricia Maiso, Mercedes A...> ;Blood. 2006 May 1
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