DavidJosephSewardMD

PubMed

• Oncologic Outcomes for Squamous Cell Carcinoma In Situ With a Clinically Resolved Biopsy Site Managed by Watchful Waiting.
  Sam Logan, Hannah J Porter, Joy Lowry, Cari Carpenter, David J Seward, Todd Holmes, Glenn Goldman, Melanie R Bui> ;Dermatologic Surgery. 2024 May 9
• STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines.
  Sean M Lenahan, Hailey M Sarausky, Paula Deming, David J Seward> ;Cancer Gene Therapy. 2024 Jan 1
• 3 citations
  Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x.
  Reem Aboushousha, Jos van der Velden, Nicholas Hamilton, Zhihua Peng, Maximilian MacPherson, Cuixia Erickson, Sheryl White, Emiel F M Wouters, Niki L Reynaert, David J...> ;Science Advances. 2023 Sep 15
• Corrigendum to "Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progressi...
  Prachi N Ghule, Joseph R Boyd, Fleur Kabala, Andrew J Fritz, Nicole A Bouffard, Cong Gao, Kathleen Bright, Jill Macfarlane, David J Seward, Gianluca Pegoraro, Tom Mist...> ;Gene. 2023 Jul 15
• 1 citations
  Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression.
  Prachi N Ghule, Joseph R Boyd, Fleur Kabala, Andrew J Fritz, Nicole A Bouffard, Cong Gao, Kathleen Bright, Jill Macfarlane, David J Seward, Gianluca Pegoraro, Tom Mist...> ;Gene. 2023 Jul 1
• Investigation of discordant sibling pairs from hereditary breast cancer families and analysis of a rare PMS1 variant.
  KK Landry, DJ Seward, JA Dragon, M Slavik, K Xu, Wendy McKinnon, L Colello, Joann B. Sweasy, SS Wallace, M Cuke, ME Wood> ;Cancer Genetics. 2022 Jan 1
• 2 citations
  Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers.
  Liam Donnelly, Tyler C Hogan, Sean M. Lenahan, Gopika Nandagopal, Jenna G Eaton, Meagan A Lebeau, Cai L McCann, Hailey M. Sarausky, Kenneth J. Hampel, Jordan Armstrong...> ;Carcinogenesis. 2021 Nov 19
• 4 citations
  Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
  Caspar Schiffers, Lennart K. A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M. W. Janssen...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2021 May 5
• 6 citations
  Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells
  Reem Aboushousha, Evan Elko, Shi B. Chia, Allison M. Manuel, Cheryl van de Wetering, Jos van der Velden, Maximilian B. MacPherson, Cuixia Erickson, Julie A. Reisz, Ang...> ;FASEB Journal. 2021 May 1
• Cutaneous squamous cell carcinoma of the forearm: Clinical features and outcomes at a single academic tertiary care center in a rural setting.
  Margaret Johnston, Cari E. Carpenter, Kathryn A. Potter, Maxwell Knapp, Katelyn Shea, David J. Seward, Caitlyn Dayman, Melanie R. Bui> ;Journal of the American Academy of Dermatology. 2021 Sep 1
• 4 citations
  Diagnosing Calciphylaxis: A series of cases with both imaging and tissue biopsy.
  Dema T. Alniemi, Christopher Kanner, Anne M. Stowman, Maxwell Knapp, Laura McGevna, David J. Seward, Melanie R. Bui> ;Journal of the American Academy of Dermatology. 2020 Jun 8
• 32 citations
  Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.
  Shi B. Chia, Evan Elko, Reem Aboushousha, Allison M. Manuel, Cheryl van de Wetering, Joseph E Druso, Jos van der Velden, David J. Seward, Vikas Anathy, Charles G. Irvi...> ;American Journal of Physiology. Cell Physiology. 2020 Feb 1
• 21 citations
  Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease
  Evan Elko, Brian Cunniff, David J. Seward, Shi Biao Chia, Reem Aboushousha, Cheryl van de Wetering, Jos van der Velden, Allison M. Manuel, Arti Shukla, Nicholas H. Hei...> ;Antioxidants & Redox Signaling. 2019 Sep 27
• 11 citations
  Age-dependent dysregulation of redox genes may contribute to fibrotic pulmonary disease susceptibility.
  Evan Elko, J. Matthew Mahoney, Pamela M. Vacek, Albert van der Vliet, Vikas Anathy, Jos van der Velden, Yvonne M. W. Janssen-Heininger, David J. Seward> ;Free Radical Biology & Medicine. 2019 Jul 14
• 3 citations
  Active Surveillance for Medically Inoperable Stage IA Lung Cancer in the Elderly.
  Hyunsoo J. No, Nataniel H. Lester-Coll, David J. Seward, Nikoletta Sidiropoulos, Havaleh M. Gagne, Carl J. Nelson, Garth W. Garrison, C. Matthew Kinsey, Steven H. Lin,...> ;Cureus. 2018 Oct 22
• 9 citations
  Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition.
  Prachi N. Ghule, David J. Seward, Andrew J. Fritz, Joseph R. Boyd, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein> ;Journal of Cellular Physiology. 2018 May 10
• 74 citations
  Reducing protein oxidation reverses lung fibrosis
  Vikas Anathy, Karolyn G. Lahue, David G. Chapman, Shi B. Chia, Dylan T. Casey, Reem Aboushousha, Jos van der Velden, Evan Elko, Sidra M. Hoffman, David H. McMillan, Ja...> ;Nature Medicine. 2018 Jul 9
• 35 citations
  Paradoxical roles of dual oxidases in cancer biology.
  Andrew C. Little, Arvis Sulovari, Karamatullah Danyal, David E. Heppner, David J. Seward, Albert van der Vliet> ;Free Radical Biology & Medicine. 2017 Sep 1
• 175 citations
  Gene-specific RNA polymerase II phosphorylation and the CTD code.
  Hyunmin Kim, Benjamin Erickson, Weifei Luo, David J. Seward, Joel H. Graber, David D. Pollock, Paul C. Megee, David Bentley> ;Nature Structural & Molecular Biology. 2010 Oct 1
• 146 citations
  Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
  David J. Seward, Gabrielle Cubberley, Soojin Kim, Matt Schonewald, Lian Zhang, Brian Tripet, David Bentley> ;Nature Structural & Molecular Biology. 2007 Feb 18
• 6 citations
  Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis
  Nazzareno Ballatori, John H. Henson, David J. Seward, Shi-Ying Cai, Maria T. Runnegar, Gert Fricker, David S. Miller, James L. Boyer> ;Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 2006 Jun 1
• 12 citations
  Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters
  Ronald P.J. Oude Elferink, Roelof Ottenhoff, Gert Fricker, David J. Seward, Nazzareno Ballatori, James L. Boyer> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2004 May 1
• 131 citations
  Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ
  David J. Seward, Albert S. Koh, James L. Boyer, Nazzareno Ballatori> ;The Journal of Biological Chemistry. 2003 Jul 25
• 91 citations
  Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate
  Wei Wang, David J. Seward, Liqiong Li, James L. Boyer, Nazzareno Ballatori> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Jul 31
• 47 citations
  bHLH transcription factor MyoD affects myosin heavy chain expression pattern in a muscle-specific fashion
  David J. Seward, John C. Haney, Michael A. Rudnicki, Steven J. Swoap> ;American Journal of Physiology. Cell Physiology. 2001 Feb 1
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Journal Articles

• Reducing Protein Oxidation Reverses Lung Fibrosis  
  David J Seward, Ralph C Budd, Charles G Irvin, Kevin K Brown, Kelly J Butnor, Naftali Kaminski, Nature