DavidBSolitMD

PubMed

• Treatment Patterns and Clinical Outcomes Among Patients With Metastatic Prostate Cancer Harboring Homologous Recombination Repair Mutations.
  Priyanka J Bobbili, Jasmina Ivanova, David B Solit, Niharika B Mettu, Shannon J McCall, Mallika Dhawan, Maral DerSarkissian, Bhakti Arondekar, Jane Chang, Alexander Ni...> ;Clinical Genitourinary Cancer. 2024 Mar 23
• Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy.
  Walmsley, C., Jonsson, P., Cheng, M., McBride, S., Kaeser, C., Vargas, H., Laudone, V., Taylor, B., Kappagantula, R., Baez, P., Richards, A., Noronha, A., Perera, D., ...> ;NPJ Precision Oncology. 2024 Feb 14
• 2 citations
  BRAF - a tumour-agnostic drug target with lineage-specific dependencies.
  Hanrahan, A., Chen, Z., Rosen, N., Solit, D.> ;Nature Reviews. Clinical Oncology. 2024 Mar 1
• Targeting HER2-mutant metastatic cervical cancer with neratinib: Final results from the phase 2 SUMMIT basket trial.
  Friedman, C., D'Souza, A., Bello Roufai, D., Tinker, A., de Miguel, M., Gambardella, V., Goldman, J., Loi, S., Melisko, M., Oaknin, A., Spanggaard, I., Shapiro, G., El...> ;Gynecologic Oncology. 2024 Feb 1
• Mutant PIK3CA is a targetable driver alteration in histiocytic neoplasms.
  Benjamin H Durham, Oshrat Hershkovitz-Rokah, Omar Abdel-Wahab, Mariko Yabe, Young Rock Chung, Gilad Itchaki, Maayan Ben-Sasson, Vered A Asher-Guz, David Groshar, Seyra...> ;Blood Advances. 2023 Dec 12
• 2 citations
  Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma.
  Cristina Valero, Mahdi Golkaram, Joris L Vos, Bin Xu, Conall Fitzgerald, Mark Lee, Shannon Kaplan, Catherine Y Han, Xin Pei, Reith Sarkar, Lillian A Boe, Abhinav Pande...> ;The Journal of Clinical Investigation. 2023 Oct 2
• 2 citations
  Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade.
  Emily C Harrold, Michael B Foote, Benoit Rousseau, Henry Walch, Yelena Kemel, Allison L Richards, Fergus Keane, Andrea Cercek, Rona Yaeger, Dana Rathkopf, Neil H Segal...> ;Nature Medicine. 2023 Oct 1
• 2 citations
  Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience.
  Brendan J Guercio, Michal Sarfaty, Min Yuen Teo, Neha Ratna, Cihan Duzgol, Samuel A Funt, Chung-Han Lee, David H Aggen, Ashley M Regazzi, Ziyu Chen, Michael Lattanzi, ...> ;Clinical Cancer Research. 2023 Nov 14
• 3 citations
  First-line regorafenib with nivolumab and chemotherapy in advanced oesophageal, gastric, or gastro-oesophageal junction cancer in the USA: a single-arm, single-centre,...
  Samuel L Cytryn, Ryan H Moy, Darren Cowzer, Ronak H Shah, Joanne F Chou, Smita S Joshi, Geoffrey Y Ku, Steven B Maron, Avni Desai, Jessica Yang, Ryan Sugarman, Devika ...> ;The Lancet. Oncology. 2023 Oct 1
• Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Advanced Hepatocellular Carcinoma.
  Darren Cowzer, Jessica B White, Joanne F Chou, Pin-Jung Chen, Tae-Hyung Kim, Danny N Khalil, Imane H El Dika, Katrina Columna, Amin Yaqubie, Joseph S Light, Jinru Shia...> ;JCO Precision Oncology. 2023 Sep 1
• Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets.
  Claire F Friedman, Vignesh Ravichandran, Kathryn Miller, Chad Vanderbilt, Qin Zhou, Alexia Iasonos, Malavika Vivek, Pamela Mishra, Mario M Leitao Jr, Vance Broach, Yuk...> ;Clinical Cancer Research. 2023 Nov 14
• Feasibility and tissue concordance of genomic sequencing of urinary cytology in upper tract urothelial carcinoma.
  Andrew B Katims, Christopher Gaffney, Sanaz Firouzi, Wesley Yip, Andreas Aulitzky, Eugene J Pietzak, S Machele Donat, Bernard H Bochner, Timothy F Donahue, Harry W Her...> ;Urologic Oncology. 2023 Oct 1
• 1 citations
  Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer.
  Steven B Maron, Walid Chatila, Henry Walch, Joanne F Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S Lewis,...> ;Clinical Cancer Research. 2023 Sep 15
• 1 citations
  Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach.
  Glade Bender, J., Seyram A Doe-Tetteh, Sabrina Y Camp, Dalicia Reales, Jett Crowdis, Anne Marie Noronha, Bernadette Wolff, Tina Alano, Jesse Galle, S Duygu Selcuklu, A...> ;Clinical Cancer Research. 2023 Jul 5
• 3 citations
  Clonal evolution during metastatic spread in high-risk neuroblastoma.
  Gundem, G., Levine, M., Roberts, S., Cheung, I., Medina-Martínez, J., Feng, Y., Arango-Ossa, J., Chadoutaud, L., Rita, M., Asimomitis, G., Zhou, J., You, D., Bouvier, ...> ;Nature Genetics. 2023 Jun 1
• 14 citations
  Genomic mapping of metastatic organotropism in lung adenocarcinoma.
  Harry B Lengel, Brooke Mastrogiacomo, James G Connolly, Kay See Tan, Yuan Liu, Cameron N Fick, Elizabeth G Dunne, Di He, Manendra B Lankadasari, Baby Anusha Satravada,...> ;Cancer Cell. 2023 May 8
• 4 citations
  KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer.
  Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah Wise, Daniel Kim, Varna Thayaparan, Daniel J Lin...> ;Cancer Research. 2023 Mar 15
• 13 citations
  Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers.
  James J Harding, Sarina A Piha-Paul, Ronak H Shah, Jessica J Murphy, James M Cleary, Geoffrey I Shapiro, David I Quinn, Irene Braña, Victor Moreno, Mitesh Borad, Shere...> ;Nature Communications. 2023 Feb 6
• 2 citations
  Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma.
  Wesley Yip, Daniel D Sjoberg, Lucas M Nogueira, Andrew T Tracey, Ricardo G Alvim, Peter A Reisz, Quinlan Demac, Nicole E Benfante, Rand W Vanden Berg, Kwanghee Kim, Hi...> ;The Journal of Urology. 2023 May 1
• 13 citations
  Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer.
  Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chav...> ;Cancer Discovery. 2023 Jan 9
• 1 citations
  Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation.
  Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Os...> ;Nature Communications. 2022 Dec 23
• 6 citations
  Genomic heterogeneity as a barrier to precision oncology in urothelial cancer.
  Timothy N Clinton, Ziyu Chen, Hannah Wise, Andrew T Lenis, Shweta Chavan, Mark T A Donoghue, Nima Almassi, Carissa E Chu, Shawn Dason, Pavitra Rao, James A Rodrigues, ...> ;Cell Reports. 2022 Dec 20
• 8 citations
  Molecular Classification of Appendiceal Adenocarcinoma.
  Michael B Foote, Henry Walch, Walid Chatila, Efsevia Vakiani, Chris Chandler, Felix Steinruecke, Garrett M Nash, Zsofia Stadler, Sebastian Chung, Rona Yaeger, Maria Ig...> ;Journal of Clinical Oncology. 2023 Mar 10
• 9 citations
  FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation.
  Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Os...> ;Nature Communications. 2022 Nov 2
• 40 citations
  Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer.
  Justin Jee, Emily S Lebow, Randy Yeh, Jeeban P Das, Azadeh Namakydoust, Paul K Paik, Jamie E Chaft, Gowtham Jayakumaran, A Rose Brannon, Ryma Benayed, Ahmet Zehir, Mar...> ;Nature Medicine. 2022 Nov 1
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Journal Articles

• Article Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer  
  Sarat Chandarlapaty, Alison M Schram, David M Hyman, David B Solit, ScienceDirect
• Neratinib Is Effective in Breast Tumors Bearing Both Amplification and Mutation of ERBB2 (HER2)  
  José Baselga, Kyriakos P. Papadopoulos, Sarat Chandarlapaty, David B. Solit, Science Magazine
• Genome Doubling Shapes the Evolution and Prognosis of Advanced Cancers  
  Alison M Schram, Jose Baselga, Mark E Robson, David B Solit, Zsofia K Stadler, Nature

Abstracts/Posters

• Annotation of Somatic Genomic Variants in Hematologic Diseases Using OncoKB, a Precision Oncology Knowledgebase
  David B. Solit, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

• Drugging the Undruggable 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Activating Mutations in CSF1R and Additional Receptor Tyrosine Kinases in Sporadic and Familial Histiocytic Neoplasms 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Role of cfDNA in the Treatment of Patients With Advanced Cancer 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018