DavidMccaugheySpencerMD

PubMed

• 11 citations
  Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins.
  Xiaomei Wang, Fabricio G. Cabrera, Kelly L. Sharp, David M. Spencer, Aaron E. Foster, J. Henri Bayle> ;Molecular Therapy. 2021 Feb 3
• 45 citations
  Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells
  Xiaomei Wang, Daniel L. Jasinski, Jan L. Medina, David M. Spencer, Aaron E. Foster, J. Henri Bayle> ;Blood Advances. 2020 May 12
• 54 citations
  Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches.
  My Linh T. Duong, Matthew R. Collinson-Pautz, Eva Morschl, An Lu, Slawomir P. Szymanski, Ming Zhang, Mary E. Brandt, Wei-Chun Chang, Kelly L. Sharp, Steven M. Toler, K...> ;Molecular Therapy Oncolytics. 2019 Mar 29
• 50 citations
  Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies.
  Matthew R. Collinson-Pautz, Wei-Chun Chang, An Lu, Mariam Khalil, Jeannette Crisostomo, Pei-Yi Lin, Aruna Mahendravada, Nicholas P. Shinners, Mary E. Brandt, Ming Zhan...> ;Leukemia. 2019 Feb 28
• 15 citations
  Effectiveness of Implemented Interventions on Pathologic Nodal Staging of Non-Small Cell Lung Cancer
  Meredith Ray, Nicholas Faris, Matthew P. Smeltzer, Carrie Fehnel, Cheryl Houston-Harris, P. Levy, Lynn Wiggins, Vishal Sachdev, Todd Robbins, David M. Spencer, Raymond...> ;The Annals of Thoracic Surgery. 2018 Jul 1
• 109 citations
  Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models
  Melinda Mata, Claudia Gerken, Phuong Nguyen, Giedre Krenciute, David M. Spencer, Stephen Gottschalk> ;Cancer Discovery. 2017 Nov 1
• 75 citations
  Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
  Aaron E. Foster, Aruna Mahendravada, Nicholas P. Shinners, Wei-Chun Chang, Jeannette Crisostomo, An Lu, Mariam Khalil, Eva Morschl, Joanne L. Shaw, Sunandan Saha, My L...> ;Molecular Therapy. 2017 Sep 6
• 20 citations
  Phase I trial of antigen-targeted autologous dendritic cell-based vaccine with in vivo activation of inducible CD40 for advanced prostate cancer.
  Guru Sonpavde, John McMannis, Yu Bai, Mamatha Seethammagari, Joan M C Bull, Victoria E Hawkins, Theresa K. Dancsak, Natasha Lapteva, Jonathan M. Levitt, Annemarie Mose...> ;Cancer Immunology, Immunotherapy. 2017 Jun 12
• 7 citations
  Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study
  Liset Westera, Tanja van Viegen, Jenny Jeyarajah, Azar Azad, Janine Bilsborough, Gijs R. van den Brink, Jonathan Cremer, Silvio Danese, Geert R. D'Haens, Lars Eckmann,...> ;Clinical and Translational Gastroenterology. 2017 Nov 2
• Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.
  Nobuyuki Ono, Kiichi Murakami, Olivia Chan, Håkan Hall, Alisha R. Elford, Patty Yen, Thomas Calzascia, David M. Spencer, Pamela S. Ohashi, Salim Dhanji> ;Plos One. 2017 Mar 3
• 3 citations
  MyD88/CD40 Genetic Adjuvant Function in Cutaneous Atypical Antigen-Presenting Cells Contributes to DNA Vaccine Immunogenicity.
  Matthew R. Collinson-Pautz, Kevin M. Slawin, Jonathan M. Levitt, David M. Spencer> ;Plos One. 2016 Oct 14
• 166 citations
  Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
  Xiaoou Zhou, Gianpietro Dotti, Robert A. Krance, Caridad Martinez, Swati Naik, Rammurti T. Kamble, April G. Durett, Olga Dakhova, Barbara Savoldo, Antonio Di Stasi, Da...> ;Blood. 2015 Jun 25
• 11 citations
  Improving the pathologic evaluation of lung cancer resection specimens
  Raymond U. Osarogiagbon, Holly L. Hilsenbeck, Elizabeth Sales, Allen Berry, Robert W. Jarrett Jr, Christopher S. Giampapa, Clara N. Finch-Cruz, David M. Spencer> ;Translational Lung Cancer Research. 2015 Jan 8
• 24 citations
  Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.
  Cecilia Barese, Tania C. Felizardo, Stephanie Sellers, Keyvan Keyvanfar, Antonio Di Stasi, Mark E. Metzger, Allen E. Krouse, Robert E. Donahue, David M. Spencer, Cynth...> ;Stem Cells. 2015 Jan 1
• 19 citations
  The impact of a novel lung gross dissection protocol on intrapulmonary lymph node retrieval from lung cancer resection specimens.
  Raymond U. Osarogiagbon, Ransome Eke, Srishti Sareen, Cynthia D Leary, LaShundra Coleman, Nicholas Faris, Xinhua Yu, David M. Spencer> ;Annals of Diagnostic Pathology. 2014 Aug 1
• 24 citations
  Tobacco mosaic virus efficiently targets DC uptake, activation and antigen-specific T cell responses in vivo.
  Jan Ole Kemnade, Mamatha Seethammagari, Mathew Collinson-Pautz, Hardeep Kaur, David M. Spencer, Alison A. McCormick> ;Vaccine. 2014 Jul 16
• 128 citations
  Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene.
  Xiaoou Zhou, Antonio Di Stasi, Siok-Keen Tey, Robert A. Krance, Caridad Martinez, Kathryn S. Leung, April G. Durett, Meng Fen Wu, Hao Liu, Ann M. Leen, Barbara Savoldo...> ;Blood. 2014 Jun 19
• 30 citations
  FGFR1–WNT–TGF-β Signaling in Prostate Cancer Mouse Models Recapitulates Human Reactive Stroma
  Julienne L. Carstens, Payam Shahi, Susan Van Tsang, Billie Smith, Chad J. Creighton, Yiqun Zhang, Amber Seamans, Mamatha Seethammagari, Indira Vedula, Jonathan M. Levi...> ;Cancer Research. 2014 Jan 15
• 146 citations
  Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.
  Lihua E. Budde, Carolina Berger, Yukang Lin, Jinjuan Wang, Xubin Lin, Shani E. Frayo, Shaunda A. Brouns, David M. Spencer, Brian G. Till, Michael C. Jensen, Stanley R....> ;Plos One. 2013 Dec 17
• 72 citations
  Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity
  Joseph M. Valdez, Li Zhang, Qingtai Su, Olga Dakhova, Yiqun Zhang, Payam Shahi, David M. Spencer, Chad J. Creighton, Michael Ittmann, Li Xin> ;Cell Stem Cell. 2012 Nov 2
• 5 citations
  Off-the-shelf Adenoviral-mediated Immunotherapy via Bicistronic Expression of Tumor Antigen and iMyD88/CD40 Adjuvant
  Jan Ole Kemnade, Mamatha Seethammagari, Priya Narayanan, Jonathan M. Levitt, Alison A. McCormick, David M. Spencer> ;Molecular Therapy. 2012 Jul 1
• The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers.
  Harrill, A. H., Roach, J., Fier, I., Eaddy, J. S., Kurtz, C. L., Antoine, D. J., Spencer, D. M., Kishimoto, T. K., Pisetsky, D. S., Park, B. K., Watkins, P. B.> ;Clin Pharmacol Ther. 2012 Aug
• 1039 citations
  Inducible apoptosis as a safety switch for adoptive cell therapy
  Antonio Di Stasi, Siok-Keen Tey, Gianpietro Dotti, Yuriko Fujita, Alana A. Kennedy-Nasser, Caridad Martinez, Karin Straathof, Enli Liu, April G. Durett, Bambi Grilley,...> ;The New England Journal of Medicine. 2011 Nov 2
• 85 citations
  Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling.
  William M. Rockey, Frank J. Hernandez, Sheng-You Huang, Song Cao, Craig A. Howell, Gregory S. Thomas, Xiu Ying Liu, Natalia Lapteva, David M. Spencer, James O. McNamar...> ;Nucleic Acid Therapeutics. 2011 Oct 17
• 15 citations
  The E3 ligase c‐Cbl regulates dendritic cell activation
  Shin Heng Chiou, Payam Shahi, Ryan T. Wagner, Hongbo Hu, Natalia Lapteva, Mamatha Seethammagari, Shao Cong Sun, Jonathan M. Levitt, David M. Spencer> ;EMBO Reports. 2011 Sep 1
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