DavidHWittyMD

PubMed

• Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1.
  Kennedy, A. R., Todd, J. F., Dhillo, W. S., Seal, L. J., Ghatei, M. A., O'Toole, C. P., Jones, M., Witty, D., Winborne, K., Riley, G., Hervieu, G., Wilson, S., Bloom, ...> ;J Neuroendocrinol. 2003 Mar
• Society for Anti-infective Pharmacology--Ninth International Symposium. 3-4 July 1999, Birmingham, UK.
  Witty, D.> ;IDrugs. 1999 Sep
• Anti-infective research.
  Witty, D.> ;IDrugs. 1999 Sep
• 27th National Medicinal Chemistry Symposium.
  Witty, D.> ;IDrugs. 2000 Sep
• Appropriate selection of biochemical targets is one of the most important driver of cost-effectiveness in the discovery of new medicines. Preface.
  Lawton, G., Witty, D. R.> ;Prog Med Chem. 2008
• Beginning of the ''numbers'' era of medicinal chemistry. Preface.
  Lawton, G., Witty, D. R.> ;Prog Med Chem. 2009 Nov 28
• Progress in medicinal chemistry. Preface.
  Lawton, G., Witty, D. R.> ;Prog Med Chem. 2009
• Medicinial chemistry. Preface.
  Lawton, G., Witty, D. R.> ;Prog Med Chem. 2010
• Advances in the design of 5-HT6 receptor ligands with therapeutic potential.
  Witty, D., Ahmed, M., Chuang, T. T.> ;Prog Med Chem. 2009
• Drug discovery projects. Preface.
  Lawton, G., Witty, D. R.> ;Prog Med Chem. 2011
• Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine.
  Nichols, P. L., Brand, J., Briggs, M., D'Angeli, M., Farge, J., Garland, S. L., Goldsmith, P., Hutchings, R., Kilford, I., Li, H. Y., MacPherson, D., Nimmo, F., Sander...> ;Bioorg Med Chem Lett. 2010 Feb 15
• Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists.
  Trani, G., Baddeley, S. M., Briggs, M. A., Chuang, T. T., Deeks, N. J., Johnson, C. N., Khazragi, A. A., Mead, T. L., Medhurst, A. D., Milner, P. H., Quinn, L. P., Ray...> ;Bioorg Med Chem Lett. 2008 Oct 15
• The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
  Brown, M. J., Carter, P. S., Fenwick, A. S., Fosberry, A. P., Hamprecht, D. W., Hibbs, M. J., Jarvest, R. L., Mensah, L., Milner, P. H., O'Hanlon, P. J., Pope, A. J., ...> ;Bioorg Med Chem Lett. 2002 Nov 4
• Unified route to the palmarumycin and preussomerin natural products. Enantioselective synthesis of (-)-preussomerin G.
  Barrett, A. G., Blaney, F., Campbell, A. D., Hamprecht, D., Meyer, T., White, A. J., Witty, D., Williams, D. J.> ;J Org Chem. 2002 May 3
• Biphenyl amides and isosteres as MCH R1 antagonists.
  Hertzog, D. L., Witty, D. R.> ;Curr Top Med Chem. 2007
• Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.
  Witty, D. R., Bateson, J., Hervieu, G. J., Al-Barazanji, K., Jeffrey, P., Hamprecht, D., Haynes, A., Johnson, C. N., Muir, A. I., O'Hanlon, P. J., Stemp, G., Stevens, ...> ;Bioorg Med Chem Lett. 2006 Sep 15
• SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
  Witty, D. R., Bateson, J. H., Hervieu, G. J., Jeffrey, P., Johnson, C. N., Muir, A. I., O'Hanlon, P. J., Stemp, G., Stevens, A. J., Thewlis, K. M., Wilson, S., Winborn...> ;Bioorg Med Chem Lett. 2006 Sep 15
• Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.
  Ahmed, M., Briggs, M. A., Bromidge, S. M., Buck, T., Campbell, L., Deeks, N. J., Garner, A., Gordon, L., Hamprecht, D. W., Holland, V., Johnson, C. N., Medhurst, A. D....> ;Bioorg Med Chem Lett. 2005 Nov 1
• Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.
  Jarvest, R. L., Armstrong, S. A., Berge, J. M., Brown, P., Elder, J. S., Brown, M. J., Copley, R. C., Forrest, A. K., Hamprecht, D. W., O'Hanlon, P. J., Mitchell, D. J...> ;Bioorg Med Chem Lett. 2004 Aug 2
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