DeborahWenkertMD

PubMed

• Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin Bmetabolism.
  Whyte, M., Zhang, F., Mack, K., Ericson, K., Cole, J., Coburn, S., Wenkert, D., Gottesman, G.> ;Bone. 2024 Apr 1
• Effects of food, fasting, and exercise on plasma pyrophosphate levels and ENPP1 activity in healthy adults.
  Gus Khursigara, Pedro Huertas, Deborah Wenkert, Kevin O'Brien, Yves Sabbagh> ;Bone. 2023 Jun 1
• 3 citations
  Why are There not More Bayesian Clinical Trials? Ability to Interpret Bayesian and Conventional Statistics Among Medical Researchers.
  , Ross Bray, Andrew Hartley, Deborah Wenkert, Natalia Muehlemann, Fanni Natanegara, Frank E Harrell Jr, Fei Wang, Jennifer Clark> ;Therapeutic Innovation & Regulatory Science. 2023 May 1
• 10 citations
  Why are not There More Bayesian Clinical Trials? Perceived Barriers and Educational Preferences Among Medical Researchers Involved in Drug Development.
  , Jennifer Clark, Natalia Muhlemann, Fanni Natanegara, Andrew Hartley, Deborah Wenkert, Fei Wang, Frank E Harrell Jr, Ross Bray> ;Therapeutic Innovation & Regulatory Science. 2023 May 1
• 8 citations
  Hypophosphatasia: Vitamin B6 status of affected children and adults.
  Michael P. Whyte, Fan Zhang, Deborah Wenkert, Karen E. Mack, Vinieth N. Bijanki, Karen L. Ericson, Stephen P. Coburn> ;Bone. 2022 Jan 1
• 5 citations
  Coalescing expansile skeletal disease: Delineation of an extraordinary osteopathy involving the IFITM5 mutation of osteogenesis imperfecta type V.
  Michael P. Whyte, James Aronson, William H. McAlister, Robert S. Weinstein, Deborah Wenkert, Karen L. Clements, Gary S. Gottesman, Katherine L Madson, Marina Stolina, ...> ;Bone. 2021 Apr 1
• 2 citations
  Utility of genetic testing for prenatal presentations of hypophosphatasia.
  Brian Sperelakis-Beedham, Agnès Taillandier, Christelle Domingues, Mihelaiti Guberto, Estelle Colin, Valérie Porquet-Bordes, Anya Rothenbuhler, Jean-Pierre Salles, Deb...> ;Molecular Genetics and Metabolism. 2021 Jan 27
• 12 citations
  Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review).
  Fiona J. Cook, Maighan Seagrove-Guffey, Steven Mumm, Deborah J. Veis, William H. McAlister, Vinieth N. Bijanki, Deborah Wenkert, Michael P. Whyte> ;Bone. 2021 Apr 1
• 9 citations
  X-Linked Hypophosphatemia: Uniquely Mild Disease Associated With PHEX 3′-UTR Mutation c.*231A>G (A Retrospective Case–Control Study)
  Pamela S Smith, Gary S. Gottesman, Fan Zhang, Fiona J. Cook, Beatriz Francesca Ramirez, Deborah Wenkert, Valerie A. Wollberg, Margaret Huskey, Steven Mumm, Michael P. ...> ;Journal of Bone and Mineral Research. 2020 May 1
• 10 citations
  Hyperphosphatemia with low FGF7 and normal FGF23 and sFRP4 levels in the circulation characterizes pediatric hypophosphatasia.
  Michael P. Whyte, Fan Zhang, Deborah Wenkert, Steven Mumm, Theresa J. Berndt, Rajiv Kumar> ;Bone. 2020 Feb 26
• 13 citations
  Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
  Steven Mumm, Gary S. Gottesman, Deborah Wenkert, Philippe M. Campeau, Angela Nenninger, Margaret Huskey, Vinieth N. Bijanki, Deborah J. Veis, Aileen M. Barnes, Joan C....> ;Bone. 2020 Jan 1
• 177 citations
  Risk of subsequent fracture after prior fracture among older women
  Akhila Balasubramanian, Jie Zhang, Lang Chen, Deborah Wenkert, Shanette G. Daigle, Andreas Grauer, Jeffrey R. Curtis> ;Osteoporosis International. 2019 Jan 1
• 48 citations
  Hypophosphatasia: Natural history study of 101 affected children investigated at one research center
  Michael P. Whyte, Deborah Wenkert, Fan Zhang> ;Bone. 2016 Dec 1
• 40 citations
  Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated s...
  Voraluck Phatarakijnirund, Steven Mumm, William H. McAlister, Deborah V. Novack, Deborah Wenkert, Karen L. Clements, Michael P. Whyte> ;Bone. 2016 Mar 1
• 6 citations
  Auricular ossification: A newly recognized feature of osteoprotegerin-deficiency juvenile Paget disease.
  Gary S. Gottesman, Katherine L Madson, William H. McAlister, Angela Nenninger, Deborah Wenkert, Steven Mumm, Michael P. Whyte> ;American Journal of Medical Genetics. Part A. 2016 Jan 14
• 59 citations
  Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease-Modifying Antirheumatic Drugs.
  Dimitrios A. Pappas, Michele Hooper, Joel M. Kremer, George W. Reed, Ying Shan, Deborah Wenkert, Jeff Greenberg, Jeffrey R. Curtis> ;Arthritis Care & Research. 2015 Dec 1
• 155 citations
  Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients.
  Michael P. Whyte, Fan Zhang, Deborah Wenkert, William H. McAlister, Karen E. Mack, Marci C. Benigno, Stephen P. Coburn, Susan Wagy, Donna Griffin, Karen L. Ericson, St...> ;Bone. 2015 Jun 1
• 17 citations
  PHEX 3′-UTR c.*231A>G Near The Polyadenylation Signal Is a Relatively Common, Mild, American Mutation That Masquerades as Sporadic or X-Linked Recessive Hypophosphatem...
  Steven Mumm, Margaret Huskey, Adela Cajic, Valerie Wollberg, Fan Zhang, Katherine L Madson, Deborah Wenkert, William H. McAlister, Gary S. Gottesman, Michael P. Whyte> ;Journal of Bone and Mineral Research. 2015 Jan 1
• 31 citations
  Multicentric carpotarsal osteolysis syndrome is caused by only a few domain‐specific mutations in MAFB, a negative regulator of RANKL‐induced osteoclastogenesis
  Steven Mumm, Margaret Huskey, Shenghui Duan, Deborah Wenkert, Katherine L Madson, Gary S. Gottesman, Angela Nenninger, Ronald M. Laxer, William H. McAlister, Michael P...> ;American Journal of Medical Genetics. Part A. 2014 Sep 1
• 18 citations
  Pregnancy-Associated Osteoporosis With a Heterozygous Deactivating LDL Receptor-Related Protein 5 (LRP5) Mutation and a Homozygous Methylenetetrahydrofolate Reductase ...
  Fiona J. Cook, Steven Mumm, Michael P. Whyte, Deborah Wenkert> ;Journal of Bone and Mineral Research. 2014 Apr 1
• 17 citations
  Malignancies in children and young adults on etanercept: summary of cases from clinical trials and post marketing reports
  Michele Hooper, Deborah Wenkert, Bojena Bitman, Virgil C Dias, Yessenia Bartley> ;Pediatric Rheumatology Online Journal. 2013 Oct 2
• 21 citations
  A randomized study to evaluate the efficacy and safety of adding topical therapy to etanercept in patients with moderate to severe plaque psoriasis.
  Mark Lebwohl, Leon H Kircik, Kristina Callis Duffin, David M. Pariser, Michele Hooper, Deborah Wenkert, Elizabeth H.Z. Thompson, Jun Yang, Greg Kricorian, John Koo> ;Journal of the American Academy of Dermatology. 2013 Sep 1
• 36 citations
  Rheumatoid Arthritis Disease Activity and Disability Affect the Risk of Serious Infection Events in RADIUS 1
  Arthur L. Weaver, Orrin Troum, Michele Hooper, Andrew S Koenig, Sandeep Chaudhari, JingYuan Feng, Deborah Wenkert> ;The Journal of Rheumatology. 2013 Aug 1
• 10 citations
  Dual-energy X-ray absorptiometry interpretation: a simple equation for height correction in preteenage children.
  Fan Zhang, Michael P. Whyte, Deborah Wenkert> ;Journal of Clinical Densitometry. 2012 Jul 1
• 326 citations
  Enzyme-replacement therapy in life-threatening hypophosphatasia.
  Michael P. Whyte, Cheryl R. Greenberg, Nada J. Salman, Michael B. Bober, William H. McAlister, Deborah Wenkert, Bradley J. Van Sickle, Jill H. Simmons, Terence S. Edga...> ;The New England Journal of Medicine. 2012 Mar 7
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Journal Articles

• Why are not There More Bayesian Clinical Trials? Perceived Barriers and Educational Preferences Among Medical Researchers Involved in Drug Development.  
  Clark J, Muhlemann N, Natanegara F, Hartley A, Wenkert D, Wang F, Harrell FE Jr, Bray R., Ther Innov Regul Sci., 1/3/2022
• Auricular Ossification: A Newly Recognized Feature of Osteoprotegerin-Deficiency Juvenile Paget Disease  
  Gottesman GS, Madson KL, McAlister WH, Nenninger AR, Wenkert D, Mumm S, Whyte MP, Am J Med Genetics, 1/1/2016
• Hypophosphatasia: Natural history study of 101 affected children investigated at one research center  
  Whyte MP, Wenkert D, Zhang F, Bone, 1/1/2016
• Hypophosphatasia: Validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients  
  Whyte MP, Zhang F, Wenkert D, McAlister WH, Mack KE, Benigno MC, Coburn SP, Wagy S, Griffin DM, Ericson KL, Mumm S, Bone, 1/1/2015
• Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease-Modifying Antirheumatic Drugs  
  Pappas DA, Hooper MM, Kremer JM, Reed G, Shan Y, Wenkert D, Greenberg JD, Curtis JR, Arthritis Care Res, 1/1/2015
• Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis  
  Mumm S, Huskey M, Duan S, Wenkert D, Madson KL, Gottesman GS, Nenninger AR, Laxer RM, McAlister WH, Whyte MP, Am J Med Genet A, 1/1/2014
• A randomized study to evaluate the efficacy and safety of adding topical therapy to etanercept in patients with moderate to severe plaque psoriasis  
  Lebwohl MG, Kircik L, Callis Duffin K, Pariser D, Hooper M, Wenkert D, Thompson EH, Yang J, Kricorian G, Koo J, J Am Acad Dermatol, 1/1/2013
• Rheumatoid Arthritis Disease Activity and Disability Affect the Risk of Serious Infection Events in RADIUS 1  
  Weaver A, Troum O, Hooper M, Koenig AS, Chaudhari S, Feng J, Wenkert D, J Rheumatol, 1/1/2013
• Pregnancy-associated osteoporosis with a heterozygous deactivating LDL receptor-related protein 5 (LRP5) mutation and a homozygous methylenetetrahydrofolate reductase ...  
  Cook FJ, Mumm S, Whyte MP, Wenkert D, J Bone Miner, 1/1/2013
• Malignancies in children and young adults on etanercept: summary of cases from clinical trials and postmarketing reports  
  Hooper M, Wenkert D, Bitman B, Dias VC, Bartley Y, Pediatr Rheumatol Online J, 1/1/2013
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  Whyte MP, Wenkert D, Demertzis JL, Dicarlo EF, Westenberg E, Mumm S, J Bone Miner Res, 1/1/2012
• Hypophosphatasia (HPP): Enzyme Replacement Therapy (EzRT) for Children Using Bone-Targeted, Tissue-Nonspecific Alkaline Phosphatase  
  Whyte MP, Greenberg CR, Salman NJ, Bober M, McAlister WH, Wenkert D et al, N Engl J Med, 1/1/2012
• Dual-Energy X-Ray Absorptiometry Interpretation: A Simple Equation for Height Correction in Preteenage Children  
  Zhang F, Whyte MP, Wenkert D, J Clin Densitom, 1/1/2012
• Camurati-Engelmann disease: Unique variant featuring a novel mutation in TGFBeta1 encoding transforming growth factor beta 1 and a missense change in TNFSF11 encoding ...  
  Whyte MP, Totty WG, Novack DV, Zhang X, Wenkert D, Mumm S, J Bone Miner Res, 1/1/2011
• Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia  
  Whyte MP, Wenkert D, McAlister WH, Mughal MZ, Freemont AJ, Whitehouse R,Baildam EM, Coburn SP, Ryan LM, Mumm S, J Bone Miner Res, 1/1/2009
• Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts  
  Cahill, R, Wenkert D, Perlman SA, Steele A, Coburn SP, McAlister WH, Mumm S, Whyte MP, Journal of Clinical Endocrinology and Metabolism, 1/1/2007
• Absence of MMP2 mutation in idiopathic multicentric osteolysis with nephropathy  
  Wenkert D, Mumm S, Wiegand SM, McAlister WH, Whyte MP, Clinical Orthopedics and Related Research, 1/1/2007
• Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis?  
  Heike CL, Cunningham ML, Steiner RD, Wenkert D, Hornung RL, Gruss JS, Gannon FH, McAlister WH, Mumm S, Whyte MP, American Journal of Medical Genetics, 1/1/2005
• Bisphosphonate-induced osteopetrosis  
  Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S, New England Journal of Medicine, 1/1/2003
• Bisphosphonates in children with bone diseases (Reply Letter)  
  Whyte MP, Wenkert D, McAlister WH, Mumm S, New England Journal of Medicine, 1/1/2003
• Modulation of linker histones during development in tetrahymena: selective elimination of linker histones during the differentiation of mew macronuclei  
  Chicoine LC, Wenkert D, Richmond R, Wiggins JC, Allis CD, Dev Biol, 1/1/1985
• Timing of the appearance of macronuclear specific histone variant hvl and gene expression in developing new macronuclei of tetrahymena thermophia  
  Wenkert D, Allis CD, J Cell Biol, 1/1/1984
• Lipoprotein (a) purification problems and structural properties  
  Morrisett, JD, Wenkert D, Gotto AM, Dahlen GH, Gianturco SH, Heideman C, Gaubatz JW, Proceedings of the Workshop on Apolipoprotein Quantifications, 1/1/1983
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Books/Book Chapters

• Textbook of Pediatric Rheumatology 
  Chapter: Primary Disorders of Bone and Connective Tissue 
  Page 742 - 765Wenkert DEditors: J Cassidy, R Petty, R Laxer, and C Lindsley.Elsevier2011
• Bone Disease in Rheumatology 
  Chapter: Heterotopic Ossification and Calcinosis 
  Page 197 - 202Wenkert D, Whyte MPEditors: MJ Maricic and O Gluck.Lippincott, Williams & Wilkins, Philadelphia, PA2005