DeborahAnneYoungMD

PubMed

• 34 citations
  AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy.
  Simon J. O'Carroll, William H Cook, Deborah Young> ;Frontiers in Molecular Neuroscience. 2021 Jan 11
• 1 citations
  Platelet-Reactive Antibodies in Patients after Ischaemic Stroke—An Epiphenomenon or a Natural Protective Mechanism
  Young-Eun Park, Rushi Penumarthy, Paul P. Sun, Caroline Y Kang, Marie-Christine Morel-Kopp, Jonathan Downing, Taryn N. Green, Tracey Immanuel, Chris Ward, Deborah Youn...> ;International Journal of Molecular Sciences. 2020 Nov 9
• 8 citations
  The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor.
  Deborah Young> ;Frontiers in Neurology. 2020 Jul 3
• 17 citations
  Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injury.
  Jarred M. Griffin, Barbara Fackelmeier, Connor A. Clemett, Dahna M. Fong, Alexandre Mouravlev, Deborah Young, Simon J. O'Carroll> ;Experimental Neurology. 2020 Feb 7
• 49 citations
  Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury.
  Jarred M. Griffin, Barbara Fackelmeier, Dahna M. Fong, Alexander Mouravlev, Deborah Young, Simon J. O'Carroll> ;Gene Therapy. 2019 Apr 8
• 37 citations
  Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics
  Mikail Weston, Teresa Kaserer, Angela Wu, Alexandre Mouravlev, Jenna C Carpenter, Albert Snowball, Samuel Knauss, Melanie J. von Schimmelmann, Matthew J. During, Gabri...> ;Science Advances. 2019 Apr 1
• 16 citations
  Effects of GnRH vaccination in wild and captive African Elephant bulls (Loxodonta africana) on reproductive organs and semen quality.
  Imke Lueders, Deborah Young, Liana Maree, Gerhard van der Horst, Ilse Luther, Stephan Botha, Brendan Tindall, Geoffrey T. Fosgate, Andre Ganswindt, Henk J. Bertschinger> ;Plos One. 2017 Sep 15
• 17 citations
  Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis.
  Taryn N. Green, Justin Raymond Hamilton, Marie-Christine Morel-Kopp, Zhaohua Zheng, Ting Yu T Chen, James I. Hearn, Peng P. Sun, Jack U. Flanagan, Deborah Young, P. Al...> ;Platelets. 2017 Feb 21
• 3 citations
  Standing sedation with medetomidine and butorphanol in captive African elephants (Loxodonta africana)
  I. Lüders, Brendan Tindall, Deborah Young, G. van der Horst, Stephan Botha, Ilse Luther, Liana Maree, Henk J. Bertschinger> ;Veterinary Journal. 2016 Mar 1
• 2 citations
  Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington’s Disease
  Deborah Young> ;Methods in Molecular Biology. 2016 Jan 1
• 14 citations
  Transcriptional activity of novel ALDH1L1 promoters in the rat brain following AAV vector-mediated gene transfer
  Janitha M Mudannayake, Alexandre Mouravlev, Dahna M. Fong, Deborah Young> ;Molecular Therapy. Methods & Clinical Development. 2016 Jan 1
• 7 citations
  A novel bicistronic sensor vector for detecting caspase-3 activation.
  Tatyana Vagner, Alexandre Mouravlev, Deborah Young> ;Journal of Pharmacological and Toxicological Methods. 2015 Mar 1
• 21 citations
  Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy
  Deborah Young, Dahna M. Fong, P. Lawlor, Angela Wu, Alexandre Mouravlev, Michelle McRae, Michelle Glass, Mike Dragunow, Matthew J. During> ;Gene Therapy. 2014 Sep 18
• 1 citations
  An Immunological Approach to Increase the Brain’s Resilience to Insults
  En-Ju D. Lin, C. Wymond Symes, Andrea Townsend-Nicholson, Matthias Klugmann, Claudia B. Klugmann, Klaus Lehnert, Dahna Fong, Deborah Young, Matthew J. During> ;ISRN Neuroscience. 2014 Apr 24
• 14 citations
  AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.
  Vicky W. K. Tsang, Deborah Young, Matthew J. During, Nigel P. Birch> ;Plos One. 2014 Mar 7
• 23 citations
  Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size
  Maggie L. Kalev-Zylinska, Wymond Symes, Kevin C. E. Little, Peng Sun, Daying Wen, Linzi Qiao, Deborah Young, Matthew J. During, P. Alan Barber> ;Stroke. 2013 Aug 1
• 169 citations
  Long-Term Follow-Up After Gene Therapy for Canavan Disease
  Paola Leone, David Shera, Scott W.J. McPhee, Jeremy S. Francis, Edwin H. Kolodny, Larissa T. Bilaniuk, Dah Jyuu Wang, Mitra Assadi, Olga Goldfarb, H. Warren Goldman, A...> ;Science Translational Medicine. 2012 Dec 19
• 73 citations
  IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
  Andrew L. Rankin, Heath Guay, Deborah Herber, Sarah A. Bertino, Tatyana A. Duzanski, Yijun Carrier, Sean Keegan, Mayra Senices, Nancy Stedman, Mark Ryan, Laird Bloom, ...> ;Journal of Immunology. 2012 Feb 15
• 7 citations
  Nucleic Acid-Based Therapy Approaches for Huntington's Disease.
  Tatyana Vagner, Deborah Young, Alexandre Mouravlev> ;Neurology Research International. 2012 Jan 11
• 21 citations
  Gene Regulation Systems for Gene Therapy Applications in the Central Nervous System
  Jerusha Naidoo, Deborah Young> ;Neurology Research International. 2012 Jan 5
• 25 citations
  IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
  Alessandra Petrelli, M. Carvello, Andrea Vergani, Kang Mi Lee, Sara Tezza, Ming Du, Sonja Kleffel, Liu Chengwen, Bechara Mfarrej, Patrick Hwu, Antonio Secchi, Warren J...> ;Diabetes. 2011 Dec 1
• 312 citations
  Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis
  Yijun Carrier, Hak-Ling Ma, Hilda E. Ramon, Lee Napierata, Clayton Small, Margot O'Toole, Deborah A. Young, Lynette A. Fouser, Cheryl Nickerson-Nutter, Mary Collins, K...> ;The Journal of Investigative Dermatology. 2011 Dec 1
• 58 citations
  IL-21 Receptor Is Critical for the Development of Memory B Cell Responses
  Andrew L. Rankin, Heather MacLeod, Sean Keegan, Tatyana Andreyeva, Leslie Lowe, Laird Bloom, Mary Collins, Cheryl Nickerson-Nutter, Deborah Young, Heath Guay> ;Journal of Immunology. 2011 Jan 15
• 11 citations
  Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood
  Maya Arai, Sadhana Jain, Amy A Weaver, Andrew A. Hill, Yongjing Guo, Andrea G Bree, Michael F Smith, Scott W Allen, Edward R. Lavallie, Deborah Young, Laird Bloom, Kar...> ;Journal of Translational Medicine. 2010 May 28
• 2 citations
  Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
  Yongjing Guo, Andrew A. Hill, Renee Ramsey, Immermann Frederick, Christopher John Corcoran, Deborah Young, Edward R. Lavallie, Mark Ryan, Theresa Bechard, Richard Pfei...> ;Journal of Translational Medicine. 2010 May 26
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