DemetriosThomasBraddockMD

PubMed

• Hypophosphatemic rickets: An unexplained early feature of craniometaphyseal dysplasia.
  Julio Soto Barros, Demetrios Braddock, Thomas O Carpenter> ;Bone Reports. 2023 Dec 1
• 1 citations
  ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency.
  Carlos R Ferreira, Thomas O Carpenter, Demetrios T Braddock> ;Annual Review of Pathology. 2024 Jan 24
• Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments.
  Hajime Kato, Demetrios T Braddock, Nobuaki Ito> ;Current Osteoporosis Reports. 2023 Oct 1
• IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression.
  Gauri Panse, Demetrios Braddock, Sudhir Perincheri, Mina L Xu, Jennifer M McNiff, Tang, H.> ;Journal of Cutaneous Pathology. 2023 Jul 1
• 3 citations
  Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome.
  Sae-Il Murtada, Nicole Mikush, Mo Wang, Pengwei Ren, Yuki Kawamura, Abhay B Ramachandra, David S Li, Demetrios T Braddock, George Tellides, Leslie B Gordon, Jay D Hump...> ;Elife. 2023 Mar 17
• 1 citations
  Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI).
  Elizabeth H Theng, Carmen C Brewer, Ralf Oheim, Christopher K Zalewski, Kelly A King, Maximillian M Delsmann, Tim Rolvien, Rachel I Gafni, Demetrios T Braddock, H Jeff...> ;Orphanet Journal of Rare Diseases. 2022 Jul 19
• 5 citations
  Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.
  Kristin Zimmerman, Xiaochen Liu, Simon von Kroge, Paul Stabach, Ethan R Lester, Emily Y Chu, Shivani Srivastava, Martha J Somerman, Steven M Tommasini, Björn Busse, Th...> ;Journal of Bone and Mineral Research. 2022 Sep 1
• 13 citations
  Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early-Onset Osteoporosis.
  Hajime Kato, Anenya J Ansh, Ethan R Lester, Yuka Kinoshita, Naoko Hidaka, Yoshitomo Hoshino, Minae Koga, Yuki Taniguchi, Taisuke Uchida, Hideki Yamaguchi, Yo Niida, Ma...> ;Journal of Bone and Mineral Research. 2022 Jun 1
• 10 citations
  Musculoskeletal Comorbidities and Quality of Life in ENPP1-Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models.
  Carlos R Ferreira, Anenya Jai Ansh, Catherine Nester, Christine O'Brien, Paul R Stabach, Sae-Il Murtada, Ethan R Lester, Gus Khursigara, Liz Molloy, Thomas O Carpenter...> ;Journal of Bone and Mineral Research. 2022 Mar 1
• 21 citations
  Strategies for Glycoengineering Therapeutic Proteins.
  Kris Dammen-Brower, Paige Epler, Stanley Zhu, Zachary J Bernstein, Paul R Stabach, Demetrios T Braddock, Jamie B Spangler, Kevin J Yarema> ;Frontiers in Chemistry. 2022 Jan 1
• 12 citations
  The cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair
  Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie ...> ;The Journal of Clinical Investigation. 2021 Nov 23
• 12 citations
  Direct targeting of amplified gene loci for proapoptotic anticancer therapy
  Meetu Kaushik Tiwari, Daniel A. Colon-Rios, Hemanta C. Rao Tumu, Yanfeng Liu, Elias Quijano, Adam Krysztofiak, Cynthia Chan, Eric Song, Demetrios T. Braddock, Hee-Won ...> ;Nature Biotechnology. 2021 Oct 28
• 11 citations
  Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection
  Jiahui Ding, Paulomi Aldo, Cai M. Roberts, Paul R. Stabach, Hong Liu, Yuan You, Xuemin Qiu, Jiwon Jeong, Anthony Maxwell, Brett D. Lindenbach, Demetrios T. Braddock, A...> ;EMBO Reports. 2021 Oct 5
• 11 citations
  Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice
  Carlos Ferreira, Dillon Kavanagh, Ralf Oheim, Kristin Zimmerman, Julian Stürznickel, Xiaofeng Li, Paul R. Stabach, R. Luke Rettig, Logan Calderone, Colin MacKichan, Aa...> ;Journal of Bone and Mineral Research. 2021 May 1
• 18 citations
  Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization
  Nathan D. Maulding, Dillon Kavanagh, Kristin Zimmerman, Gianfilippo Coppola, Thomas O. Carpenter, Nathaniel K. Jue, Demetrios T. Braddock> ;Bone. 2021 Jan 1
• 3 citations
  Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
  Hsin-Hao T Hsiao, Gregg V. Crichlow, James W. Murphy, Ewa Folta-Stogniew, Elias Lolis, Demetrios T. Braddock> ;Plos One. 2020 Nov 30
• 10 citations
  Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering
  Paul R. Stabach, Kristin Zimmerman, Aaron Adame, Dillon Kavanagh, Christopher T. Saeui, Christian Agatemor, Shawn Gray, Wenxiang Cao, Enrique M. De La Cruz, Kevin J. Y...> ;Clinical and Translational Science. 2021 Jan 1
• 6 citations
  Phylogeny and chemistry of biological mineral transport.
  Paul H. Schlesinger, Demetrios T. Braddock, Quitterie C. Larrouture, Evan C. Ray, Vladimir Riazanski, Deborah J. Nelson, Irina L. Tourkova, Harry C. Blair> ;Bone. 2020 Aug 26
• 26 citations
  Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles.
  Shipra Malik, Frank J. Slack, Demetrios T. Braddock, Raman Bahal, Jihoon Lim> ;Journal of Controlled Release. 2020 Nov 10
• 15 citations
  Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome
  Sae-Il Murtada, Y. Kawamura, Alexander W. Caulk, Hossein Ahmadzadeh, N. Mikush, Kristin Zimmerman, Dillon Kavanagh, Dar Weiss, Marcos Latorre, Zhen W. Zhuang, Gerald S...> ;Journal of the Royal Society, Interface. 2020 May 27
• 12 citations
  Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators.
  Emily Y. Chu, T.D. Vo, Michael B. Chavez, A Nagasaki, E.L. Mertz, Francisco Humberto Nociti, S.F. Aitken, Dillon Kavanagh, Kristin Zimmerman, Xiaofeng Li, Paul R. Stab...> ;Bone. 2020 Mar 26
• 34 citations
  Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency.
  Ralf Oheim, Kristin Zimmerman, Nathan D. Maulding, Julian Stürznickel, Simon von Kroge, Dillon Kavanagh, Paul R. Stabach, Uwe Kornak, Steven M. Tommasini, Mark C. Horo...> ;Journal of Bone and Mineral Research. 2020 Mar 1
• 29 citations
  Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations
  Anupam Kotwal, Alejandro Ferrer, Rajiv Kumar, Ravinder J. Singh, Vishakantha Murthy, Laura Schultz-Rogers, Michael T. Zimmermann, Brendan C. Lanpher, Kristin Zimmerman...> ;Journal of Bone and Mineral Research. 2020 Apr 1
• Research on physical activity and disability: an emerging national priority.
  Rimmer, J. H., Braddock, D., Pitetti, K. H.> ;Med Sci Sports Exerc. 1996 Nov
• 4 citations
  Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
  Catherine M. Gordon, Robert H. Cleveland, Kristin Baltrusaitis, Joseph M. Massaro, Ralph B. D'Agostino, Marilyn G. Liang, Brian D. Snyder, Michele Walters, X. Li, Deme...> ;Bone. 2019 May 8
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Journal Articles

• "In vivo correction of anaemia in Beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery"  
  Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, Lopez-Giraldez F, Ricciardi A, Beloor J, K..., Nature Communications, 1/26/2016
• "pHLIP® targeting of PNA to silence MicroRNA in tumors"  
  Cheng, C.J., Bahal, R., Babar, I.A., Pincus, Z., Barrera, F., Liu, C., Svoronos, A., Braddock, D.T., Glazer, P.M., Engelman, D.M., Saltzman, W.M., Slack, F.J., Nature, 1/5/2015
• "ENPP1-Fc Fusion Protein Prevents Mortality and Vascular Calcifications in Rodent Model of Generalized Calcification of Infancy"  
  Albright, R.A., Stabach, P., Cao, W., Kavanagh, D., Mullen, I., Braddock, A.A., Covo M.S., Tehan, M., Yang, G., Cheng, Z., Bouchard, K., Zhao-Xue, Y., Thorn, S., Wang,..., Nature Communications, 1/1/2015
• "The Molecular Basis of Purinergic Signal Metabolism by Ecto-Nucleotide Phosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke"  
  Albright, R.A., Ornstein, D.L., Cao, W., Chang, W.C., Robert, D., Tehan, M., Stabach, P. R., Hoyer, D., Liu, L., Yang, G., De La Cruz, E. M., Braddock, D.T., J Biol Chem, 1/7/2014
• "Desmoplastic Melanoma: A 12-year experience with sentinel lymph node biopsy"  
  Broer, P.N., Walker, M.E., Goldberg, C., Buonocore, S., Braddock, D.T., Lazova, R., Narayan, D., Ariyan, S., Eur J. Surg Oncol., 1/1/2013
• "NPP4 is a procoagulant enzyme on the surface of vascular endothelium"  
  Albright, R.A., Chang, W.C., Robert, D., Ornstein, D.L., Cao, W., Redick, M.E., Young, J.I., De La Cruz, E. M., Braddock, D.T., Blood, 1/1/2012
• "Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution"  
  Saunders, L. P., Wenxiang Cao, W., Chang, W. C., Albright, W.A., Braddock, D. T.,* De La Cruz, E.M., Journal of Biological Chemistry, 1/1/2011
• "Autotaxin and lipid signaling pathways as anticancer targets"  
  Braddock, D.T., Current Opinion in Investigational Drugs, 1/1/2010
• "Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice"  
  Li, S., Ezhevsky, S., Dewin A., Cato, M.H., Scortegagna, M., Bhoumik A., Breitwieser W., Braddock, D., Eroshkin, A., Qi, J., Chen, M., Kim, J.-Y., Jones, S., Jones, N...., Genes and Cancer, 1/1/2010
• "Quantitative Characterization of the Interactions between c-myc Transcriptional Regulators FUSE, FBP and FIR"  
  Hsiao, H.-H., Nath, A., Lin, C.-Y., Folta-Stogniew, E.J., Rhoades, E. and Braddock, D.T., Biochemistry, 1/1/2010
• "Small molecule inhibitors of Autotaxin inhibit melanoma cell migration and invasion"  
  Saunders, L.P., Ouellette, A., Bandle, R., Chang, W.C., Zhou, H., Misra, R.N., De La Cruz, E. M. and Braddock, D.T., Molecular Cancer Therapeutics, 1/1/2008
• "Histopathologic and Molecular Aspects of CD56+ Natural Killer/T-Cell Lymphoma of the Testis"  
  Ornstein, D.L, Bifulco. C.B., Braddock D.T., and Howe, J.G., Int J Surg Pathol, 1/1/2008
• "Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition"  
  Crichlow, G. V., Zhou, H., Hsiao, H-H, Frederick, K. B., Debrosse, M., Yang, Y., Folta-Stogniew, E. J., Chung., H-J, Fan, C., De La Cruz, E. M., Levens, D.L., Lolis E...., EMBO, 1/1/2008
• "Benzoylanthranilic Acid Inhibitors of FBP Binding to the c-myc Promoter"  
  Huth, J.R., Liping, Y., Collins, I., Mack, Mendoza, R., Isaac, B., Braddock, D.T., Muchmore, S.W., Comess, K.M., Fesik, S.W., Clore, G.M., Levens, D., Hajduk, P.J., J. Med. Chem., 1/1/2004
• "The Solution Structure of a Complex between the KH3 domain of hnRNP K and Single Stranded DNA"  
  Braddock, D.T., Baber, J. L., Levens, D., and Clore, G. M., EMBO, 1/1/2002
• "Solution Structure and Dynamics of a Specific Complex Between the KH3 and KH4 Domains of FBP and the Single Stranded Far Upstream Element of C-Myc"  
  Braddock, D.T., Louis, J. M., Baber, J. L., Levens, D., and Clore, G. M., Nature, 1/1/2002
• "Rapid Identification of Medium to Large Scale Interdomain Motion in Modular Proteins using Dipolar Couplings"  
  Braddock,D.T., Cai, M., Baber, J. L., Huang, Y., and Clore, G. M., J. Am. Chem. Soc, 1/1/2001
• "Model for the molecular mechanism of HIV-associated neurological damage and dementia"  
  Caffrey, M., Braddock, D.T., Louis J.M., Abu-Asab, M.A., Kingma, D., Liotta, L., Tresser, N., Tsokos, M., Wingfield, P., and Clore, G.M., Journal of Biological Chemistry, 1/1/2000
• "Treatment of autoimmune premature ovarian failure"  
  Kalantaridou, S.N., Braddock, D.T., Patronas, N.J., and Nelson, L.M., Human Reproduction, 1/1/1999
• "Adrenal lymphocytic infiltration and adrenocortical tumors in a patient with 21-hydroxylase deficiency"  
  Merke D.P., Bornstein S.R., Braddock D., Chrousos G., New England Journal of Medicine, 1/1/1999
• "Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E"  
  Benzinger TLS, Braddock D.T., et. al, Biochemistry, 1/1/1998
• "A Conserved Anionic N Terminal Domain of Human Apolipoprotein E Increases the Binding of LDL to Cell Surface Receptors: Structure Function Relationships in Peptide Mo...  
  Braddock, D. T., Mercurius, K. O., Subramanian, R. M., Davies, P. F., Meredith, S. C., Biochemistry, 1/1/1996
• "Structural and Thermodynamic Characterization of a Bioactive Peptide Model of Apolipoprotein E: Side Chain Lactam Bridges To Constrain the Conformation"  
  Luo, P., Braddock, D. T., Subramanian, R. M., Meredith, S. C., and Lynn, D. G., Biochemistry, 1/1/1994
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Books/Book Chapters

• Proteomics in Cancer Research 
  Chapter: Structural Proteomics: High Throughput Determination of Whole Organismal Genomes 
  Braddock, D. T.Editors: Daniel C. Liebler.Wiley Press, Hoboken, NJ2005
• Molecular Biology of Atherosclerosis 
  Chapter: Secondary Structure of the Exon 3 Encoded Domain of Apolipoprotein E 
  Braddock, D. T., Kovatsits, P. G., and Meredith, S. C.Editors: Attie, A. D..Elsevier Science Publishing Co. Inc.1990