DeniseAWellsMD

PubMed

• 2 citations
  The impact of Down syndrome-specific non-malignant hematopoietic regeneration in the bone marrow on the detection of leukemic measurable residual disease.
  Fan-Chi Hsu, Elisabeth R Wilson, Laura M Pardo, Timothy P Singleton, Dongbin Xu, Barbara K Zehentner, Johann Hitzler, Jason Berman, Denise A Wells, Michael R Loken, Li...> ;Cytometry. Part B, Clinical Cytometry. 2023 Jul 1
• 7 citations
  Multiparameter flow cytometry in the evaluation of myelodysplasia: Analytical issues: Recommendations from the European LeukemiaNet/International Myelodysplastic Syndr...
  Anna Porwit, Marie C Béné, Carolien Duetz, Sergio Matarraz, Uta Oelschlaegel, Theresia M Westers, Orianne Wagner-Ballon, Shahram Kordasti, Peter Valent, Frank Preijers...> ;Cytometry. Part B, Clinical Cytometry. 2023 Jan 1
• 18 citations
  Flow cytometric analysis of myelodysplasia: Pre-analytical and technical issues-Recommendations from the European LeukemiaNet.
  Vincent H J van der Velden, Frank Preijers, Ulrika Johansson, Theresia M Westers, Alan Dunlop, Anna Porwit, Marie C Béné, Peter Valent, Jeroen Te Marvelde, Orianne Wag...> ;Cytometry. Part B, Clinical Cytometry. 2023 Jan 1
• 15 citations
  Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet Internationa...
  Arjan A van de Loosdrecht, Wolfgang Kern, Anna Porwit, Peter Valent, Sharham Kordasti, Eline Cremers, Canan Alhan, Carolien Duetz, Alan Dunlop, Willemijn Hobo, Frank P...> ;Cytometry. Part B, Clinical Cytometry. 2023 Jan 1
• 1 citations
  Integrated analysis of genotype and phenotype reveals clonal evolution and cytogenetically driven disruption of myeloid cell maturation in myelodysplastic syndromes.
  Jevon Cutler, Haley R. Pugsley, Richard Bennington, Wayne Fritschle, Luise Hartmann, Nigar Zaidi, Andrew J. Menssen, Timothy P. Singleton, Dongbin Xu, Michael R. Loken...> ;Cytometry. Part B, Clinical Cytometry. 2021 Nov 13
• 15 citations
  Deciphering the Significance of CD56 Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
  Laura Pardo, Andrew P. Voigt, Todd A. Alonzo, Elisabeth R. Wilson, Robert B. Gerbing, Dana Paine, Fangyan Dai, Andrew J. Menssen, Susana C. Raimondi, Betsy A. Hirsch, ...> ;Cytometry. Part B, Clinical Cytometry. 2020 Jan 1
• 15 citations
  Phenotype in combination with genotype improves outcome prediction in acute myeloid leukemia: a report from Children's Oncology Group protocol AAML0531.
  Voigt, A. P., Voigt, A. P., Eidenschink Brodersen, L., Brodersen, L. E., Alonzo, T. A., Alonzo, T. A., Gerbing, R. B., Gerbing, R. B., Menssen, A. J., Menssen, A. J., ...> ;Haematologica. 2017 Sep 9
• Assessment of erythroid dysplasia by "Difference from normal" in routine clinical flow cytometry workup.
  Eidenschink Brodersen, L.,Menssen, A. J.,Wangen, J. R.,Stephenson, C. F.,de Baca, M. E.,Zehentner, B. K.,Wells, D. A.,Loken, M. R.> ;Cytometry B Clin Cytom. 2014 Dec 11
• Detection of clonal evolution in hematopoietic malignancies by combining comparative genomic hybridization and single nucleotide polymorphism arrays.
  Hartmann, L., Stephenson, C. F., Verkamp, S. R., Johnson, K. R., Burnworth, B., Hammock, K., Brodersen, L. E., de Baca, M. E., Wells, D. A., Loken, M. R., Zehentner, B...> ;Clinical chemistry. 2014 Oct 17
• 34 citations
  Assessment of normal erythropoiesis by flow cytometry: important considerations for specimen preparation
  J. R. Wangen, L. Eidenschink Brodersen, T. T. Stolk, Denise A. Wells, Michael R. Loken> ;International Journal of Laboratory Hematology. 2014 Apr 1
• 98 citations
  Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European Leukemi...
  Anna Porwit, A.A. van de Loosdrecht, Peter Bettelheim, L Eidenschink Brodersen, Kate Burbury, Eline M. P. Cremers, M.G. Della Porta, Robin M. Ireland, Ulf Johansson, S...> ;Leukemia. 2014 Jan 1
• 8 citations
  Array-Based Karyotyping in Plasma Cell Neoplasia After Plasma Cell Enrichment Increases Detection of Genomic Aberrations
  Barbara K. Zehentner, Luise Hartmann, Krystal Johnson, Christine F. Stephenson, Douglas B. Chapman, Monica E. de Baca, Denise A. Wells, Michael R. Loken, Budi Tirtorah...> ;American Journal of Clinical Pathology. 2012 Oct 1
• 18 citations
  Basal levels of CD34 positive cells in peripheral blood differ between individuals and are stable for 18 months.
  Lisa Eidenschink, Gere S. diZerega, Kathy Rodgers, Mark Bartlett, Denise A. Wells, Michael R. Loken> ;Cytometry. Part B, Clinical Cytometry. 2012 Jan 1
• 2 citations
  A minority of concurrent monoclonal lymphocytes and plasmacytic cells sharing light chains are genetically related in putative lymphoplasmacytic lymphoma.
  Barbara K. Zehentner, Jevon Cutler, Wayne Fritschle, Richard Bennington, Collette Wentzel, Stephanie R. Smading, Eric W. Jeffery, Denise A. Wells, Michael R. Loken> ;Leukemia Research. 2011 Dec 1
• 27 citations
  Detection of Genomic Abnormalities in Multiple Myeloma The Application of FISH Analysis in Combination With Various Plasma Cell Enrichment Techniques
  Luise Hartmann, Julie Sanford Biggerstaff, Douglas B. Chapman, Janice M. Scott, Krystal Johnson, Keely M. Ghirardelli, Wayne Fritschle, Dolores L. Martinez, Richard Be...> ;American Journal of Clinical Pathology. 2011 Nov 1
• 11 citations
  Minimal residual disease detected prior to hematopoietic cell transplantation.
  Jennifer Foster, Douglas S. Hawkins, Michael R. Loken, Denise A. Wells, Blythe Thomson> ;Pediatric Blood & Cancer. 2011 Jul 15
• 54 citations
  Flow cytometric scoring system as a diagnostic and prognostic tool in myelodysplastic syndromes.
  Sung-Chao Chu, Tso Fu Wang, Chi Cheng Li, Ruey Ho Kao, Dian Kun Li, Yu-Chieh Su, Denise A. Wells, Michael R. Loken> ;Leukemia Research. 2011 Jul 1
• 18 citations
  Phenotypic abnormalities strongly reflect genotype in patients with unexplained cytopenias
  Jevon Cutler, Denise A. Wells, Arjan A. van de Loosdrecht, Monica E. de Baca, Michael Kalnoski, Barbara K. Zehentner, Lisa Eidenschink, Keely M. Ghirardelli, Julie San...> ;Cytometry. Part B, Clinical Cytometry. 2011 May 1
• Phenotypic abnormalities strongly reflect genotype in patients with unexplained cytopenias.
  Cutler, J.A., Wells, D.A., van de Loosdrecht, A.A., de Baca, M.E., Kalnoski, M.H., Zehentner, B.K., Eidenschink, L., Ghirardelli, K.M., Biggerstaff, J.S., Loken, M.R.> ;Cytometry B Clin Cytom. 2010-12-23
• 169 citations
  Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic synd...
  Arjan A. van de Loosdrecht, Canan Alhan, Marie C. Béné, Matteo G. Della Porta, Angelika M. Dräger, Jean Feuillard, Patricia Font, Ulrich Germing, Detlef Haase, Christa...> ;Haematologica. 2009 Aug 1
• 63 citations
  Normalization of bone marrow aspirates for hemodilution in flow cytometric analyses.
  Michael R. Loken, Sung-Chao Chu, Wayne Fritschle, Michael Kalnoski, Denise A. Wells> ;Cytometry. Part B, Clinical Cytometry. 2009 Jan 1
• 84 citations
  Validation of a flow cytometric scoring system as a prognostic indicator for posttransplantation outcome in patients with myelodysplastic syndrome.
  Bart L. Scott, Denise A. Wells, Michael R. Loken, David Myerson, Wendy M. Leisenring, H. Joachim Deeg> ;Blood. 2008 Oct 1
• 10 citations
  The role of flow cytometry in myelodysplastic syndromes.
  Michael R. Loken, Denise A. Wells> ;Journal of the National Comprehensive Cancer Network. 2008 Oct 1
• 4 citations
  On flow cytometry in myelodysplastic syndromes, with caveats.
  Denise A. Wells, Kiyoyuki Ogata> ;Leukemia Research. 2008 Feb 1
• 75 citations
  Flow cytometry in myelodysplastic syndromes: report from a working conference.
  Michael R. Loken, Arjan A. van de Loosdrecht, Kiyoyuki Ogata, Alberto Orfao, Denise A. Wells> ;Leukemia Research. 2008 Jan 1
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Journal Articles

• Intraclonal Heterogeneity in Concomitant Monoclonal Lymphocyte and Plasma Cell Populations: Combining Flow Cytometric Cell Sorting With Molecular Monoclonality Profiling  
  Zehentner BK, de Baca ME, Wells DA, Loken MR, Clinical lymphoma, myeloma and leukemia, 3/8/2013
• Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European Leu...  
  van de Loosdrecht AA, Ireland R, Kern W, Della Porta MG, Alhan C, Balleisen JS, Bettelheim P, Bowen DT, Burbury K, Eidenschink L, Cazzola M, Chu SS, Cullen M, Cutler J..., Leukemia & lymphoma, 1/1/2013
• Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group  
  Westers TM, Ireland R, Kern W, Alhan C, Balleisen JS, Bettelheim P, Burbury K, Cullen M, Cutler JA, Della Porta MG, Dräger AM, Feuillard J, Font P, Germing U, Haase D,..., Leukemia, 1/1/2012
• Array-based karyotyping in plasma cell neoplasia after plasma cell enrichment increases detection of genomic aberrations  
  Zehentner BK, Hartmann L, Johnson KR, Stephenson CF, Chapman DB, de Baca ME, Wells DA, Loken MR, Tirtorahardjo B, Gunn SR, Lim L, American journal of clinical pathology, 1/1/2012
• Basal levels of CD34 positive cells in peripheral blood differ between individuals and are stable for 18 months  
  Eidenschink L, DiZerega G, Rodgers K, Bartlett M, Wells DA, Loken MR, Cytometry. Part B, Clinical cytometry, 1/1/2012
• Phenotypic abnormalities strongly reflect genotype in patients with unexplained cytopenias  
  Cutler JA, Wells DA, van de Loosdrecht AA, de Baca ME, Kalnoski MH, Zehentner BK, Eidenschink L, Ghirardelli KM, Biggerstaff JS, Loken MR, Cytometry. Part B, Clinical cytometry, 1/1/2011
• A minority of concurrent monoclonal lymphocytes and plasmacytic cells sharing light chains are genetically related in putative lymphoplasmacytic lymphoma  
  Zehentner BK, Cutler JA, Fritschle WK, Bennington RK, Wentzel C, Smading SR, Jeffery EW, Wells DA, Loken MR, Leukemia Research, 1/1/2011
• Detection of genomic abnormalities in multiple myeloma: the application of FISH analysis in combination with various plasma cell enrichment techniques  
  Hartmann L, Biggerstaff JS, Chapman DB, Scott JM, Johnson KR, Ghirardelli KM, Fritschle WK, Martinez DL, Bennington RK, de Baca ME, Wells DA, Loken MR, Zehentner BK, American journal of clinical pathology, 1/1/2011
• Standardization of flow cytometry in myelodysplastic syndromes: Report from the first ELNet working conference on flow cytometry in myelodysplastic syndromes  
  van de Loosdrecht AA, Alhan C, Bene C, Dräger A, Della Porta M, Feuillard J, Font P, Germing U, Haase D, Homburg C, Ireland R, Jansen J, KernW, Loken M, Malcovati L, t..., Haematologica, 1/1/2009
• Validation of a Flow Cytometric Scoring System as a Prognostic Indicator for Post-Transplant Outcome in Patients with MDS  
  Scott BL, WellsDA, Loken MR, Myerson D, LeisenringWM, DeegHW, Blood, 10/1/2008
• The Role of Flow Cytometry in Myelodysplastic Syndromes  
  Loken MR, Wells DA, Journal of the National Comprehensive Cancer Network, 10/1/2008
• On flow cytometry in myelodysplastic syndromes, with caveats  
  Wells DA, Ogata K, Leukemia research, 2/1/2008
• Flow Cytometry in Myelodysplastic Syndromes: Report from a Working Conference  
  Michael R. Loken, Arjan van de Loosdrecht, Kiyoyuki Ogata, Alberto Orfao, Denise A. Wells, Leuk Res, 1/1/2008
• Flow Cytometry: Providing additional information in diagnosis, prognosis and monitoring treatment of MDS  
  Wells DA, Loken MR, MDS Foundation Newsletter, 1/1/2008
• Normalization of bone marrow aspirate for hemodilution in flow cytometric analyses  
  Loken, MR, Chu, SC, Fritschle, W, Kalnoski M, Wells DA, Cytometry B Clin Cytometry, 1/1/2008
• Minimal residual disease detected prior to hematopoietic cell transplantation  
  Foster JH, Hawkins DS, Loken MR, Wells DA, Thomson B, Pediatric blood & cancer, 1/1/2008
• Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference  
  Valent P, Horny HP, Bennett JM, Fonatsch C, Germing U, Greenberg P, Haferlach T, Haase D, Kolb HJ, Krieger O, Loken M, van de Loosdrecht A, Ogata K, Orfao A, Pfeilstoc..., Leuk Res, 6/1/2007
• 2006 Bethesda International Consensus recommendations on the flow cytometric immunophenotypic analysis of hematolymphoid neoplasia: medical indications  
  Davis BH, Holden JT, Bene MC, Borowitz MJ, Braylan RC, Cornfield D, Gorczyca W, Lee R, Maiese R, Orfao A, Wells D, Wood BL, Stetler-Stevenson M, Cytometry. Part B, Clinical cytometry, 1/1/2007
• JAK2V617F mutation can occur exclusively in the erythroid lineage and be absent in granulocytes and progenitor cells in classic myeloproliferative disorders  
  Zehentner, Barbara K., Michael R. Loken, Denise A. Wells, Am J Hematol, 10/1/2006
• Minimal disease detection and confirmation in hematologic malignancies: combining cell sorting with clonality profiling  
  Zehentner BK, Fritschle W, Stelzer T, Ghirardelli KM, Hunter K, Wentzel C, Bennington R, Hansen CL, Myerson D, Kalnoski M, Wells DA, Loken MR, Clin Chem, 3/1/2006
• Flow cytometric detection of nonneoplastic antigenic polymorphisms of donor origin after allogeneic marrow transplant: a report of two cases  
  Wang L, Wells DA, Deeg HJ, Loken MR, Am J Clin Pathol, 7/1/2004
• Flow Cytometry for Diagnosis and Assessment of Prognosis in Patients with Myelodysplastic Syndromes  
  Benesch, M, Deeg, HJ, Wells, DA, and Loken, MR, Hematology, 6/1/2004
• Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hemopoietic stem ...  
  Wells DA, Benesch M, Loken MR,Vallejo C, Myerson D, Leisenring WM, Deeg HJ, Blood, 7/1/2003
• Factors influencing B-lymphopoiesis after allogeneic hematopoietic cell transplantation  
  Storek, J; Wells, D; Dawson, M; Storer, B; Maloney, D, Blood, 1/1/2001
• Quantification of lymphoma in CD34+ enriched stem cell harvests: Evidence of non random, non specific contamination  
  Loken, MR; Rowley, S; McSweeney, P, Wells, DA, Cancer Research Therapy and Control, 1/1/2001
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Books/Book Chapters

• Myelodysplastic Syndromes: Pathobiology and Clinical Management 
  Chapter: Diagnostic and Prognostic Utility of Flow Cytometry in MDS 
  Page 247 - 266Wells DA, Loken MREditors: Steensma.Informa Healthcare USA, Inc.,, New York, NYEdition 2nd ,2009
• Clinical Flow Cytometry 
  Chapter: Normal antigen expression in hematopoiesis: Basis for interpreting leukemia phenotypes 
  Loken MR, Wells DAEditors: Stewart CC and Nickolson J.Wiley-Liss, Inc.2000
• Immunofluorescence of cell surface markers, in Flow Cytometry: A Practical Approach 
  Loken MR, and Wells DAEditors: MG Ormerod.Oxford University PressEdition 2nd ,1993

Abstracts/Posters

• Flow Cytometry and SNP/CGH Array can Definitively IdentifyMyelodysplastic Syndrome in Patients with Unexplained Cytopenias
  Lisa Eidenschink Brodersen, Barbara Zehentner, Luise Hartmann, Keely Ghirardelli,Michael R Loken and Denise A Wells, 12th International Symposium on Myelodysplastic Syndromes, 5/1/2013

Lectures

• Flow Cytometry in Myelodysplastic Syndromes: Problems and Pitfalls 
  St. Etienne, France - 9/1/2009
• What’s Beyond Morphology 
  Atlanta, GA - 12/1/2007
• Standards in flow cytometry in MDS 
  Vienna, Austria - 7/1/2007
• Prognostic Significance of Pretransplant Multidimensional Flow Cytometric Parameters for Posttransplant Survival and Relapse in 111 Patients with Myelodysplastic Syndr... 
  Philadelphia, PA - 12/6/2002
• Combining Diagnostic Modalities to Detect Residual Tumor Post Bone Marrow Transplant 
  Brugge, Belgium - 6/12/1997
• Special Education Session: State of the art in the laboratory diagnosis of leukemia and lymphoma 
  6/12/1997
• CD45 and Right AngleLight Scatter (RALS) Gating in a Three Color Analysis Differentiates Hairy Cell Leukemia from Myelodysplastic Syndrome 
  Chicago, IL - 4/8/1997
• Flow Cytometric Evaluation of Patients with Paroxysmal Nocturnal Hemoglobinuria 
  4/1/1997
• Quantification of malignant cells contaminating stem cell harvest 
  Orlando, FL - 10/1/1996
• Symposium on Flow Cytometry and CD34: New Technologies and Clinical Applications 
  Aarau, Switzerland - 5/1/1996
• Minimal disease detection in leukemia and clinical outcome 
  Banff, Alberta, Canada - 4/1/1996
• Multi-dimensional flow cytometry differentiates acute myeloblastic leukemia from normal myeloblasts and lymphoblasts in marrow from post chemotherapy and bone marrow t... 
  Washington, DC - 3/1/1996
• Five dimensional flow cytometry differentiates acute lymphoblastic leukemia from normal lymphoblasts and myeloblasts in marrow from post chemotherapy and bone marrow t... 
  Seattle, WA - 12/1/1995
• North American Consensus Conference on the use of flow cytometry in immunophenotyping of leukemias and lymphomas: Medical Indications Committee 
  Bethesda, MD - 12/1/1995
• Flow Cytometry in Hematology: Diagnosis of Lymphoma 
  Bellevue, WA - 10/13/1994
• Multi-dimensional flow cytometric antigenic comparison of bone marrow from normal, acute myeloid leukemia, and myelodysplastic patients 
  Chicago, IL - 10/2/1994
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