Dennis Holmes, MD, Oncology, Santa Monica, CA, California Hospital Medical Center


Oncology Santa Monica, CA

Breast Cancer

Breast Surgeon; Director, Breast Program Adventist Health Glendale Medical Center; Breast Surgeon, Margie Petersen Breast Center, Providence St. John’s Health Center and Good Samaritan Hospital

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  • Office

    2121 Santa Monica Blvd
    Garden Level (Breast Center)
    Santa Monica, CA 90404
    Phone(180) 020-35515
    Fax(180) 020-35515
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  • EXPERT. Dr. Holmes is a dedicated breast surgeon and cancer researcher currently serving as Interim Director of the Margie Petersen Breast Center at St. John’s Health. Formerly, Dr. Holmes held the positions of Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health, and Chief Breast Cancer Surgeon, and Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center.

    LEADER. Dr. Holmes serves in the leadership of several national surgical societies and is a frequent lecturer at national conferences. For example, as a member of the education committee of the American Society of Breast Surgeons, Dr. Holmes recently led the development of national surgical practice guidelines for the use of preoperative chemotherapy prior to breast cancer surgery. Dr. Holmes is a Fellow of the American College of Surgeons and was also recently selected as Board Chair and President of the TARGIT Collaborative Group, a national research and education organization.

    INNOVATOR. Widely respected by colleagues for his innovative approach to breast cancer care, Dr. Holmes has gained worldwide acclaim for his pioneering research in intraoperative radiotherapy. He currently serves as National Co-Chair of the TARGIT U.S. Registry clinical trial, and is also National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation (tumor freezing) instead of surgery for the treatment of early stage breast cancer. In addition, he has been a pioneer in the field of minimally-invasive breast surgery, including intraoperative radiotherapy, cryoablation, and lymph node-sparing surgery.

    ADVOCATE. Dr. Holmes is a strong advocate for individualized or personalized cancer therapy that adapts the extent of care to the severity of the cancer, avoiding unnecessary side effects.
  • Ways to Help Prevent Breast Cancer | Reader's Digest - Reader's Digest

    Content continues below ad Content continues below ad Content continues below ad Research suggests that those with certain ethnic and socioeconomic backgrounds

    Surprising Signs of Breast Cancer in Men | Reader's Digest - Reader's Digest

    While incidences of breast cancer in men are rare, they're certainly there, which is why guys should know about the symptoms as well. In fact, the American Canc

    Zero Breast Cancer: How Should It Be Treated?

    Women with stage zero breast cancer may be getting more treatment than they need. Researchers are concerned about the effects of potential overtreatment, and ar

    Intraoperative radiotherapy: Patient selection, management, and follow-up. - Pub

    J Surg Oncol. 2017 Dec;116(7):824-830. doi: 10.1002/jso.24734. Epub 2017 Jul 17. Review

    Watchful Waiting | Stage 0 Breast Cancer

    Not all breast cancers require immediate treatment. Learn more about watchful waiting, including when it should be considered and who are the most appropriate c

    Gene Expression Score Identifies Ultralow-Risk Breast... : Oncology Times

    Using a 70-gene expression score may allow oncologists to identify women with ultralow-risk breast cancer, meaning indolent tumors that pose an "exceedingly low

    The 'Freckles' on This Woman's Chest Were Actually a Rare Sign of Breast Cancer

    Freckles are common, and you probably wouldn't think twice if you noticed a random new mark on your skin. That's what happened to Georgia mom Rebecca Hockaday-b

    Are Nipple Bumps Normal or Something to Worry About?

    At some point in your life, you've probably been told that any odd lumps and bumps on your breasts are generally worth checking out-especially if they don't go

    8 Reasons Your Boobs Are So Damn Itchy

    Itchy boobs can be such a predicament. Of course, one of the universal truths of having skin is that it's going to get itchy at some point. And that's usually n

Education & Training

  • University of Southern CaliforniaFellowship, Breast Fellowship, 2002 - 2003
  • Highland General Hospital - Alameda County Medical CenterResidency, General Surgery, 1999 - 2002
  • Washington University - Barnes-Jewish Hospital
    Washington University - Barnes-Jewish HospitalResidency, General Surgery, 1991 - 1997
  • Tulane University School of Medicine
    Tulane University School of MedicineClass of 1991
  • Loyola UniversityBachelor, Biology, Summa Cum Laude, 1987

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 1999 - 2021
  • MD State Medical License
    MD State Medical License 1998 - 2000
  • VA State Medical License
    VA State Medical License 1997 - 2000
  • DC State Medical License
    DC State Medical License 1997 - 2000
  • LA State Medical License
    LA State Medical License 1991 - 1992
  • American Board of Surgery Surgery

Awards, Honors, & Recognition

  • Top Doctors Los Angeles Magazine, 2016
  • Congressional Commendation 2012
  • Pasadena Top Doc in Breast Surgery 2010
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Clinical Trials

Publications & Presentations


Journal Articles

  • Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A r...  
    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Duoek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams N, Potyka I, Roberts N, B..., British Medical Journal, 9/19/2020
  • Breast cancer care during a pandemic: an opportune time for cryoablation?  
    Holmes, DR, Breast Cancer Research and Treatment, 6/11/2020
  • Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast  
    Rivera R, Banks A, Casillas-Lopez A, et al (Holmes DR), Breast Journal, 1/1/2016
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Books/Book Chapters

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  • Analysis of the impact of intraoperative margin assessment with adjunctive use of MARGINPROBE (R) vs. standard of care on tissue volume removed, results from a randomi...
    Holmes DR, Tafra L, Margin Probe Group, 13th Annual American Society of Breast Surgeons Annual Meeting, Phoenix, AZ, 1/4/2012
  • Mammographic findings after intraoperative radiotherapy.
    Holmes D, Rivera R, Sheth P, Villegas-Mendez S, Smith-Bronson V, Radiotherapy and Oncology, 1/1/2011
  • Beyond TARGIT: A pragmatic, risk-adaptive policy for expanding the indications for IORT in the management of invasive breast cancer.
    Holmes DR, Alvarado M, Harris H, Hoefer R, Small W, International Society of Intraoperative Radiotherapy, Tucson, AZ, 1/5/2010
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  • Personalized Approach to Breast Cancer Surgery. 
    William Beaumont Hospital, Detroit, MI - 1/19/2016
  • Oncoplastic Approaches to Intraoperative Radiotherapy. 
    Dallas, TX - 1/15/2016
  • Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast. 
    Mannheim, Germany - 1/1/2016
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  • Are Double Mastectomies Necessary for Breast Cancer Patients? 
    Holmes, DR, NBC Southern California
  • Interview about Hereditary Breast Cancer. 
    Holmes, DR, KTLA5
  • Breast Cancer Surgery Radio Clips from Dr. Holmes. Interview About Declining Cancer Death Rates in the US 
    Holmes, DR
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Press Mentions

  • 14 Causes of Itchy Boobs Everyone Should Know
    14 Causes of Itchy Boobs Everyone Should KnowJuly 3rd, 2019
  • 70 Things You Should Never Do for Your Health
    70 Things You Should Never Do for Your HealthJuly 2nd, 2019
  • 8 Reasons Your Boobs Are so Damn Itchy
    8 Reasons Your Boobs Are so Damn ItchyJune 8th, 2018
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Professional Memberships

Hospital Affiliations