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Dennis Holmes, MD, Oncology, Glendale, CA

Dennis R Holmes MD F.A.C.S.

Breast Cancer


Breast Surgeon; Director, Breast Program Adventist Health Glendale Medical Center; Breast Surgeon, Providence St. John’s Health Center and Good Samaritan Hospital; CEO, XpediteMD, Inc.

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  • Physician Medical Terrace1505 Wilson Terrace, Suite 370Glendale, CA 91206

  • Phone+1 818-539-1985

  • Fax+1 818-539-1985

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Summary

  • Dennis R. Holmes, M.D., FACS is an internationally recognized breast surgeon, cancer researcher, and medical innovator credited with numerous methodological, technical, and device breakthroughs that are reshaping breast cancer care worldwide. His latest innovation is XpediteMD—a cloud-based, comprehensive digital oncology patient navigation and care management platform designed to streamline cancer care, eliminate treatment delays, close care gaps, and elevate care quality.
    For hospitals and insurers, XpediteMD has consistently reduced cancer treatment delays by over 70%, cut administrative overhead by more than 70%, and improved both patient and provider satisfaction. Based on his work with XpediteMD, Dr. Holmes was selected by the American College of Surgeons and American Society of Breast Surgeons as the joint 2023 Health Policy Scholar.

    In 2024, CMS introduced new CPT codes allowing cancer providers to bill for time-based patient navigation services performed by licensed clinicians (MDs, NPs, PAs) or their supervised staff (navigators, nurses, MAs). These services, which are often already being delivered, are now reimbursable monthly—including during the global period—and may be provided via telehealth.

    The challenge is cancer providers and their staff is how to easily track, document, and bill for each encounter. That’s where XpediteMD comes in.
    XpediteMD is an integratable, cloud-based platform that simplifies the tracking, documentation, coding, and billing of patient navigation services—transforming navigation from a cost center into a sustainable revenue stream. Built with the same tools proven to drive dramatic improvements for insurers, XpediteMD empowers providers to deliver high-quality, timely, and reimbursable navigation support with minimal administrative burden.

    Discover how XpediteMD can help your practice boost profitability and scale navigation services for you or your program
    .
    Request your personalized demo at www.XpediteMD.com/demo.
  • Increase Practice Revenue >$100K w/New CPT Codes for Cancer Patient Navigation

    XpediteMD is offered as a Software-as-a-Service platform that streamlines coding and billing for cancer patient navigation using new CPT codes released in 2024.

    Freezing away earlier stages of breast cancer? How a 30-minute procedure could h

    Getting rid of cancerous tumors without surgery? Doctors say extreme cold cryoablation treatment can be effective for early stage breast cancer.

    Newsletter about Breast Cancer cryoablation

    Latest developments in cryoablation for breast cancer and my contribution to ongoing research and innovation.

    Ways to Help Prevent Breast Cancer | Reader's Digest - Reader's Digest

    Content continues below ad Content continues below ad Content continues below ad Research suggests that those with certain ethnic and socioeconomic backgrounds

    Surprising Signs of Breast Cancer in Men | Reader's Digest - Reader's Digest

    While incidences of breast cancer in men are rare, they're certainly there, which is why guys should know about the symptoms as well. In fact, the American Canc

    Zero Breast Cancer: How Should It Be Treated?

    Women with stage zero breast cancer may be getting more treatment than they need. Researchers are concerned about the effects of potential overtreatment, and ar

    Intraoperative radiotherapy: Patient selection, management, and follow-up. - Pub

    J Surg Oncol. 2017 Dec;116(7):824-830. doi: 10.1002/jso.24734. Epub 2017 Jul 17. Review

    Watchful Waiting | Stage 0 Breast Cancer

    Not all breast cancers require immediate treatment. Learn more about watchful waiting, including when it should be considered and who are the most appropriate c

    Gene Expression Score Identifies Ultralow-Risk Breast... : Oncology Times

    Using a 70-gene expression score may allow oncologists to identify women with ultralow-risk breast cancer, meaning indolent tumors that pose an "exceedingly low

    The 'Freckles' on This Woman's Chest Were Actually a Rare Sign of Breast Cancer

    Freckles are common, and you probably wouldn't think twice if you noticed a random new mark on your skin. That's what happened to Georgia mom Rebecca Hockaday-b

    Are Nipple Bumps Normal or Something to Worry About?

    At some point in your life, you've probably been told that any odd lumps and bumps on your breasts are generally worth checking out-especially if they don't go

    8 Reasons Your Boobs Are So Damn Itchy

    Itchy boobs can be such a predicament. Of course, one of the universal truths of having skin is that it's going to get itchy at some point. And that's usually n

Education & Training

  • University of Southern California/LACUSC Medical Center
    University of Southern California/LACUSC Medical CenterFellowship, Breast Fellowship, 2002 - 2003
  • University of California San Francisco (East Bay)
    University of California San Francisco (East Bay)Residency, Surgery, 1999 - 2002
  • Washington University/B-JH/SLCH Consortium
    Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1991 - 1997
  • Tulane University School of Medicine
    Tulane University School of MedicineClass of 1991
  • Loyola University New Orleans
    Loyola University New OrleansBachelor, Biology, Summa Cum Laude, 1987

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 1999 - 2027
  • FL State Medical License
    FL State Medical License 2021 - 2023
  • DC State Medical License
    DC State Medical License 1997 - 2000
  • MD State Medical License
    MD State Medical License 1998 - 2000
  • VA State Medical License
    VA State Medical License 1997 - 2000
  • LA State Medical License
    LA State Medical License 1991 - 1992
  • Surgery
    American Board of Surgery Surgery

Awards, Honors, & Recognition

  • Top Doctors Los Angeles Magazine, 2016
  • Congressional Commendation 2012
  • Pasadena Top Doc in Breast Surgery 2010
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A r...  
    Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Duoek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams N, Potyka I, Roberts N, B..., British Medical Journal, 9/19/2020
  • Breast cancer care during a pandemic: an opportune time for cryoablation?  
    Holmes, DR, Breast Cancer Research and Treatment, 6/11/2020
  • Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast  
    Rivera R, Banks A, Casillas-Lopez A, et al (Holmes DR), Breast Journal, 1/1/2016
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Books/Book Chapters

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Abstracts/Posters

  • Analysis of the impact of intraoperative margin assessment with adjunctive use of MARGINPROBE (R) vs. standard of care on tissue volume removed, results from a randomi...
    Holmes DR, Tafra L, Margin Probe Group, 13th Annual American Society of Breast Surgeons Annual Meeting, Phoenix, AZ, 1/4/2012
  • Mammographic findings after intraoperative radiotherapy.
    Holmes D, Rivera R, Sheth P, Villegas-Mendez S, Smith-Bronson V, Radiotherapy and Oncology, 1/1/2011
  • Beyond TARGIT: A pragmatic, risk-adaptive policy for expanding the indications for IORT in the management of invasive breast cancer.
    Holmes DR, Alvarado M, Harris H, Hoefer R, Small W, International Society of Intraoperative Radiotherapy, Tucson, AZ, 1/5/2010
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Lectures

  • Personalized Approach to Breast Cancer Surgery. 
    William Beaumont Hospital, Detroit, MI - 1/19/2016
  • Oncoplastic Approaches to Intraoperative Radiotherapy. 
    Dallas, TX - 1/15/2016
  • Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast. 
    Mannheim, Germany - 1/1/2016
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Other

  • Are Double Mastectomies Necessary for Breast Cancer Patients? 
    Holmes, DR, NBC Southern California
    1/22/2013
  • Interview about Hereditary Breast Cancer. 
    Holmes, DR, KTLA5
    http://drholmesmd.com/press/tv/
    1/20/2013
  • Breast Cancer Surgery Radio Clips from Dr. Holmes. Interview About Declining Cancer Death Rates in the US 
    Holmes, DR
    http://drholmesmd.com/press/radio/
    1/17/2013
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Press Mentions

  • IceCure Medical to Provide Educational Support in a First-of-Its-Kind Cryotherapy Course at the American Society of Breast Surgeons' 24th Annual Meeting
    IceCure Medical to Provide Educational Support in a First-of-Its-Kind Cryotherapy Course at the American Society of Breast Surgeons' 24th Annual MeetingApril 24th, 2023
  • Everyday Habits That Shorten Your Life, According to Science
    Everyday Habits That Shorten Your Life, According to ScienceNovember 13th, 2021
  • Experts Answer Most Searched Questions About Breast Cancer
    Experts Answer Most Searched Questions About Breast CancerOctober 20th, 2021
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