DerekM.KlarinMD

PubMed

• Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease.
  Pranav Sharma, Benjamin F Voight, Philip S Tsao, Derek Klarin, Michael G Levin, Scott M Damrauer> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2024 Mar 28
• Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors.
  Gabrielle Shakt, Noah L Tsao, Michael G Levin, Venexia Walker, Rachel L Kember, Derek Klarin, Phil Tsao, Benjamin F Voight, Salvatore T Scali, Scott M Damrauer> ;Journal of the American Heart Association. 2024 Feb 20
• Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
  Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M Smith, Florian Thibord, Julia Barb...> ;Nature Communications. 2023 Nov 27
• 1 citations
  Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
  Tanmoy Roychowdhury, Derek Klarin, Michael G Levin, Joshua M Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A Headley, Noah L Tsao, Corry Gellatly, Verena Zuber, Fred Shen, ...> ;Nature Genetics. 2023 Nov 1
• 6 citations
  Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.
  Derek Klarin, Poornima Devineni, Anoop K Sendamarai, Anthony R Angueira, Sarah E Graham, Ying H Shen, Michael G Levin, James P Pirruccello, Ida Surakka, Purushotham R ...> ;Nature Genetics. 2023 Jul 1
• 4 citations
  Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
  Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M Smith, Florian Thibord, Julia Barb...> ;Nature Communications. 2023 Jun 7
• 2 citations
  Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
  Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W Winkler, Adam E L...> ;Nature. 2023 Jun 1
• Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.
  Shuai Yuan, Olga E Titova, Ke Zhang, Jie Chen, Xue Li, Derek Klarin, Agneta Åkesson, Scott M Damrauer, , Susanna C Larsson> ;European Heart Journal Open. 2023 May 1
• 3 citations
  Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses.
  Shuai Yuan, Olga E Titova, Ke Zhang, Wanglong Gou, Tessa Schillemans, Pradeep Natarajan, Jie Chen, Xue Li, Agneta Åkesson, Maria Bruzelius, Derek Klarin, Scott M Damra...> ;British Journal of Haematology. 2023 May 1
• 19 citations
  mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease.
  Seyedeh M Zekavat, Vanesa Viana-Huete, Nuria Matesanz, Saman Doroodgar Jorshery, María A Zuriaga, Md Mesbah Uddin, Mark Trinder, Kaavya Paruchuri, Virginia Zorita, Alb...> ;Nature Cardiovascular Research. 2023 Jan 16
• 2 citations
  Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35.
  Sinead Cullina, Genevieve L Wojcik, Ruhollah Shemirani, Derek Klarin, Bryan R Gorman, Elena P Sorokin, Christopher R Gignoux, Gillian M Belbin, Saiju Pyarajan, Samira ...> ;Frontiers in Genetics. 2023 Jan 1
• 21 citations
  Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
  Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W Winkler, Adam E L...> ;Genome Biology. 2022 Dec 27
• 18 citations
  Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.
  Florian Thibord, Derek Klarin, Jennifer A Brody, Ming-Huei Chen, Michael G Levin, Daniel I Chasman, Ellen L Goode, Kristian Hveem, Maris Teder-Laving, Angel Martinez-P...> ;Circulation. 2022 Oct 18
• 3 citations
  Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.
  Eliana Portilla-Fernandez, Derek Klarin, Shih-Jen Hwang, Mary L Biggs, Joshua C Bis, Stefan Weiss, Susanne Rospleszcz, Pradeep Natarajan, Udo Hoffmann, Ian S Rogers, Q...> ;Human Molecular Genetics. 2022 Oct 10
• 15 citations
  A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
  Shweta Ramdas, Jonathan Judd, Sarah E Graham, Stavroula Kanoni, Yuxuan Wang, Ida Surakka, Brandon Wenz, Shoa L Clarke, Alessandra Chesi, Andrew Wells, Konain Fatima Bh...> ;American Journal of Human Genetics. 2022 Aug 4
• 84 citations
  Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.
  Tcheandjieu, C., Zhu, X., Hilliard, A., Clarke, S., Napolioni, V., Ma, S., Lee, K., Fang, H., Chen, F., Lu, Y., Tsao, N., Raghavan, S., Koyama, S., Gorman, B., Vujkovi...> ;Nature Medicine. 2022 Aug 1
• 55 citations
  A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological v...
  Marijana Vujkovic, Shweta Ramdas, Kim M Lorenz, Xiuqing Guo, Rebecca Darlay, Heather J Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert P Myers, Carolin V Schne...> ;Nature Genetics. 2022 Jun 1
• 21 citations
  High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease.
  Catherine Tcheandjieu, Ke Xiao, Helio Tejeda, Julie A Lynch, Sanni Ruotsalainen, Tiffany Bellomo, Madhuri Palnati, Renae Judy, Derek Klarin, Rachel L Kember, Shefali V...> ;Nature Genetics. 2022 Jun 1
• 2 citations
  Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.
  Joseph H Breeyear, Jacob M Keaton, Eric S Torstenson, Andrew H Smith, Derek Klarin, Scott M Damrauer, Pradeep Natarajan, Sara L Van Driest, Jeffrey G Weiner, Prince J ...> ;Circulation Research. 2022 Apr 1
• 264 citations
  The power of genetic diversity in genome-wide association studies of lipids.
  Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W Winkler, Adam E L...> ;Nature. 2021 Dec 1
• 50 citations
  Clinical utility of polygenic risk scores for coronary artery disease.
  Derek Klarin, Pradeep Natarajan> ;Nature Reviews. Cardiology. 2021 Nov 22
• 6 citations
  A Missense Variant in the IL-6 Receptor and Protection from Peripheral Artery Disease
  Michael G. Levin, Derek Klarin, Marios K. Georgakis, Julie Lynch, Katherine P. Liao, Benjamin F. Voight, Christopher J. O'Donnell, Kyong-Mi Chang, Themistocles L. Assi...> ;Circulation Research. 2021 Oct 29
• 12 citations
  Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins
  Sumeet A. Khetarpal, Cecilia Vitali, Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V. Subbai...> ;Plos Genetics. 2021 Sep 20
• 12 citations
  Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm.
  Tanmoy Roychowdhury, Haocheng Lu, Whitney E. Hornsby, Bradley Crone, Gao Wang, Dongchuan Guo, Anoop K Sendamarai, Poornima Devineni, Maoxuan Lin, Wei Zhou, Sarah E. Gr...> ;American Journal of Human Genetics. 2021 Sep 2
• 8 citations
  Genetic Determinants of Peripheral Artery Disease.
  Derek Klarin, Philip S. Tsao, Scott M. Damrauer> ;Circulation Research. 2021 Jun 11
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Journal Articles

• DNA Sequence Variation in ACVR1C Encoding the Activin-Receptor like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes  
  Derek Klarin, Pradeep Natarajan, Ruth McPherson, Sekar Kathiresan, Krishna Aragam, Alexander Bick, Diabetes Care