DianeMHershockMDPhD

PubMed

• 9 citations
  Doxorubicin, paclitaxel, and cisplatin based chemotherapy for the treatment of angiosarcoma: Two case reports.
  Joseph A. Lewcun, Colette R. Pameijer, Rena Kass, Leah Cream, Diane Hershock, Ashton J. Brooks, Daleela Dodge> ;International Journal of Surgery Case Reports. 2020 Jan 1
• 2 citations
  Pharmacokinetics and excretion of 14C-omacetaxine in patients with advanced solid tumors
  C.M. Nijenhuis, Edward T. Hellriegel, Jos H. Beijnen, Diane Hershock, Alwin D. R. Huitema, L. Lucas, Marja Mergui-Roelvink, Mihaela C. Munteanu, Laura Rabinovich-Guila...> ;Investigational New Drugs. 2016 May 25
• 17 citations
  Long-term results of radiation therapy oncology group 9903: a randomized phase 3 trial to assess the effect of erythropoietin on local-regional control in anemic patie...
  George Shenouda, Qiang Zhang, K. Kian Ang, Mitchell Machtay, Matthew Parliament, Diane Hershock, Mohan Suntharalingam, Alexander Lin, Marvin Rotman, Abdenour Nabid, Su...> ;International Journal of Radiation Oncology, Biology, Physics. 2015 Apr 1
• 8 citations
  A phase 1 study of fixed dose rate gemcitabine and irinotecan in patients with advanced pancreatic and biliary cancer
  Weijing Sun, Maureen R. Hewitt, Marry R. Theobald, Diane Hershock, Daniel G. Haller> ;Cancer. 2007 Dec 15
• 84 citations
  Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: a randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03).
  Mitchell Machtay, Thomas F. Pajak, Mohan Suntharalingam, George Shenouda, Diane Hershock, Diana Stripp, Anthony J. Cmelak, Alan Schulsinger, Karen K. Fu> ;International Journal of Radiation Oncology, Biology, Physics. 2007 Nov 15
• 1152 citations
  Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.
  Marshall R. Posner, Diane Hershock, Cesar R. Blajman, Elizabeth Mickiewicz, Eric Winquist, Vera Gorbounova, Sergei Tjulandin, Dong M. Shin, Kevin J. Cullen, Thomas J. ...> ;The New England Journal of Medicine. 2007 Oct 25
• 19 citations
  Preliminary investigation of symptom distress in the head and neck patient population: validation of a measurement instrument.
  H. Jones, Diane Hershock, Mitchell Machtay, Ara A. Chalian, Randal S. Weber, Gregory S. Weinstein, Karen L. Schumacher, Morton M. Kligerman, Jessie A. Berlin, David I....> ;American Journal of Clinical Oncology. 2006 Apr 1
• 2 citations
  Esophagectomy and splenectomy in a patient with osteopetrosis
  Samantha K. Hendren, Jessica Wang, Joseph H. Gorman, Thomas Peacock, Diane Hershock, Ernest F. Rosato> ;The Journal of Thoracic and Cardiovascular Surgery. 2005 Jun 1
• 1 citations
  Genetics, prevention and screening for melanoma.
  Diane Hershock> ;Cancer Chemotherapy and Biological Response Modifiers. 2005 Jan 1
• 10 citations
  Final report of a pilot trial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer.
  Mary K. Bucci, David I. Rosenthal, Diane Hershock, James M. Metz, Pamela Devine, Morton M. Kligerman, Mitchell Machtay> ;American Journal of Clinical Oncology. 2004 Dec 1
• A phase I trial of fixed-dose-rate (FDR) gemcitabine and irinotecan combination in patients with advanced pancreatic and biliary cancer.
  Sun W, Theobald ME, Hershock D, Haller DG> ;J. Clin. Oncol.. 2004-07-15
• 52 citations
  Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer
  Mitchell Machtay, David I. Rosenthal, Ara A. Chalian, Robert H. Lustig, Diane Hershock, Linda Miller, Gregory S. Weinstein, Randal S. Weber> ;International Journal of Radiation Oncology, Biology, Physics. 2004 May 1
• 126 citations
  Merkel cell carcinoma
  Michael S. Lehrer, Diane Hershock, Michael E. Ming> ;Current Treatment Options in Oncology. 2004 Jun 1
• 2 citations
  Percutaneous placement of an implantable arm port through an internal mammary venous pathway: Case report.
  T. Urbania, Diane Hershock, Timothy Clark> ;The Journal of Vascular Access. 2003 Oct 1
• 176 citations
  Organ Preservation Therapy Using Induction Plus Concurrent Chemoradiation for Advanced Resectable Oropharyngeal Carcinoma: A University of Pennsylvania Phase II Trial
  Mitchell Machtay, David I. Rosenthal, Diane Hershock, H. Jones, Shirnett Williamson, Michael J. Greenberg, Gregory S. Weinstein, Victor M. Aviles, Ara A. Chalian, Rand...> ;Journal of Clinical Oncology. 2002 Oct 1
• 34 citations
  A phase I study of SPI-077 (Stealth liposomal cisplatin) concurrent with radiation therapy for locally advanced head and neck cancer.
  David I. Rosenthal, Sue S. Yom, Li Liu, Mitchell Machtay, Kenneth M. Algazy, Randal S. Weber, Gregory S. Weinstein, Ara A. Chalian, Linda Miller, Kenneth Rockwell, Mar...> ;Investigational New Drugs. 2002 Aug 1
• 13 citations
  Pilot study of organ preservation multimodality therapy for locally advanced resectable oropharyngeal carcinoma
  Mitchell Machtay, David I. Rosenthal, Kenneth M. Algazy, Victor M. Aviles, Ara A. Chalian, Diane Hershock, Robin Neubauer, Michael J. Greenberg, Natasha Mirza, Gregory...> ;American Journal of Clinical Oncology. 2000 Oct 1
• 13 citations
  Effects of adinazolam on plasma catecholamine, heart rate and blood pressure responses in stressed and non-stressed rats
  M. J. Krieman, Diane Hershock, I. J. Greenberg, Wolfgang H. Vogel> ;Neuropharmacology. 1992 Jan 1
• 25 citations
  The effects of immobilization stress on serum triglycerides, nonesterified fatty acids, and total cholesterol in male rats after dietary modifications.
  Diane Hershock, Wolfgang H. Vogel> ;Life Sciences. 1989 Jan 1
• 5 citations
  Fibrinogen interaction with platelets of diabetic subjects
  Stefan Niewiarowski, Razia Rawala, Hanna Lukasiewicz, Diane Hershock, Anna M. Capitanio, Elizabeth Kornecki, Gunther Roden> ;Thrombosis Research. 1987 May 1
• 10 citations
  Quantitation and characterization of human platelet glycoprotein IIIa by radioimmunoassay
  Czeslaw S. Cierniewski, Stefan Niewiarowski, Diane Hershock, Boguslaw Rucinski, Alvin H. Schmaier> ;Biochimica Et Biophysica Acta. 1987 Apr 16
• 65 citations
  Interaction of platelet factor 4 with human platelets.
  Anna M. Capitanio, Stefan Niewiarowski, Boguslaw Rucinski, George P. Tuszynski, Czeslaw S. Cierniewski, Diane Hershock, Elizabeth Kornecki> ;Biochimica Et Biophysica Acta. 1985 Apr 17
• 89 citations
  Loss of fibrinogen receptors from the platelet surface during simulated extracorporeal circulation
  J. Musial, Stefan Niewiarowski, Diane Hershock, T. A. Morinelli, Robert W. Colman, L. H. Edmunds> ;The Journal of Laboratory and Clinical Medicine. 1985 Apr 1
• 12 citations
  Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa.
  S Niewiarowski, Kornecki E, Diane Hershock, Tuszynski Gp, Joel S. Bennett, Soria C, Soria J, Dunn F, Pidard D, Kieffer N> ;The Journal of Laboratory and Clinical Medicine. 1985 Dec 1
• 13 citations
  Comparison of platelet fibrinogen receptors on intact and proteolytically-treated platelets by use of an antiglycoprotein IIIa monoclonal antibody (MA 123)
  Elizabeth Kornecki, H. Lee, F. Merlin, Diane Hershock, George P. Tuszynski, Stefan Niewiarowski> ;Thrombosis Research. 1984 Apr 1
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Journal Articles

• Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: a randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03)  
  Machtay, M, Pajak, TF, Suntharalingam, M, Shenouda G, Hershock D, Stripp D, Cmelak AJ, Schulsinger, A, Fu KK, Int J Radiation Oncology, Biology, Physics, 1/1/2007
• Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer  
  Posner, MR, Hershock D, Blajman CR et al, NEJM, 1/1/2007
• Percutaneous placement of an implantable arm port through an internal mammary venous pathway: case report  
  Urbania T, Hershock D, Clark TWI, J. Vascular Access, 1/1/2003
• A Phase I study of SPI-77 (Stealth liposomal cisplatin) concurrent with radiation therapy for locally advanced head and neck Cancer  
  Rosenthal DI, yom SS, Liu L, Machtay M., Algazy K, Weber RS, Weinstaein GS, Chalian AA, Miller LK, Rockwell T, Schnipper E, Hershock D, Investigational New Drugs, 1/1/2002
• Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: A University of Pennsylvania Phase II trial  
  Machtay M, Rosenthal DI, Jones H, Hershock D, Williamson S, Greenberg M, Weinstein GS, Chalian AA, Weber RS, J. Clin. Onc., 1/1/2002
• Platelet growth factors: From the laboratory to the clinic  
  Hershock, D., and Schuchter, L., Infections in Medicine, 1/1/1998
• Angiogenesis Inhibitors: Is this the future of cancer therapy?  
  Hershock D and Schuchter L, Current Practice of Medicine, 1/1/1998
• Effects of adinazolam on plasma catecholamine, heart rate and blood pressure recognized in stressed and non-stressed rats  
  Krieman, MJ, Hershock, D, Greenberg, EJ, and Vogel, WH, Neuropharmacol, 1/1/1992
• The effects of immobilization stress on serum triglycerides, nonesterified fatty acids and total cholesterol in male rats after dietary modifications  
  Hershock, D. and Vogel, W.H., Life Science, 1/1/1989
• Quantitation and characterization of human platelet glycoprotein IIIa by radioimmunoassay  
  Cierniewski, C.S., Niewiarowski, S., Hershock, D., Rucinski, B., and Schmaier, A., Biochim. Biophy. Acta, 1/1/1987
• Fibrinogen interaction with platelets of diabetic subjects  
  Niewiarowski, S., Rawala, R., Lukasiewicz, H., Hershock, D., Capitanio, A., Kornecki, E.,and Boden G., Thrombosis Research, 1/1/1987
• Interaction of PF4 with human platelets  
  Capitanio, A., Niewiarowski, S., Cierniewski, C.S., Rucinski, B., Hershock, D., Tuszynski, G., Kornecki, E, Biochim. Biophy. Acta, 1/1/1985
• Loss of fibrinogen receptors from the platelet surface during simulated extracorporeal circulation  
  Musial, J., Niewiarowski, S., Hershock, D., Morinelli, T, Coleman, R., and Edmunds, L.H., J. Lab. Clin. Med., 1/1/1985
• Fibrinogen receptors exposed on thrombasthenic platelets by proteolytic enzymes are derived from residual glycoprotein IIb/IIIa complex  
  Niewiarowski, S., Kornecki, E. ,Hershock, D., Tuszynski, G., Bennet, J., Soria, C., Soria, J., Dunn, F., and Nurden, A., J. Lab. Clin. Med., 1/1/1985
• Comparison of platelet fibrinogen receptors on intact and proteolytically-treated platelets by use of an anti-glycoprotein IIIa monoclonal antibody (MA123)  
  Kornecki, E., Lee, H., Merlin, R., Hershock, D., Tuszynski, G.P., and Niewiarowski, S., Thromb. Research, 1/1/1984
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Books/Book Chapters

• Hematology/Oncology 
  Chapter: USMLE Step 1 Practice Tests. 
  Diane Hershock, MDEditors: Goldberg, J..Appleton and Lange/McGraw-Hill2005
• The Clinician's Guide to Gastrointestinal Oncology 
  Chapter: Approach to Chemotherapy and Radiation for Gastric and Esophageal Cancer. 
  Hershock DEditors: Kochman M.Slack Publishing2005
• Clinical Oncology 
  Chapter: Head and Neck Cancer. 
  Page 1497 - 1560Quon H, Hershock D, Feldman M, Sewell D, Weber RSEditors: Abeloff, Armitage, Niederhuber, Kastan and McKenna.Elsevier, PhiladelphiaEdition 3rd,2004
• Endocrine Surgery of the Head and Neck 
  Chapter: Anaplastic Thyroid Cancer. 
  Page 183 - 189Hershock, D. and Weber, R.Editors: Pellitteri , P and McCaffrey, T..Singular Publishing Group, Inc.2002
• Hematolgoy/Oncology 
  Chapter: USMLE Step 1 Practice Tests. 
  Diane Hershock, MDEditors: Goldberg, J..Appleton and Lange/McGraw-Hill2002
• Hematology/Oncology 
  Chapter: USMLE Step 3 Practice Tests. 
  Diane Hershock, MD2002
• Hemostasis and Thrombosis: Basic Principles and Clinical Practice 
  Chapter: Megakaryocytopoiesis. 
  Hershock, D. and Gewirtz, AEditors: Colman, R, Hirsh, J, Marder VJ, Salzman, EW.J.B. Lippincott Company, Philadelphia2000
• Geriatric Secrets 
  Chapter: Oral anticoagulation in the elderly. 
  Page 210 - 215Hershock, D. and Chavin, SIHanley and Belfus Inc.2000
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Abstracts/Posters

• Confirmation of the reliability and validity of Lung Cancer Symptom Scale (LCSS) forpPatients with malignant pleural mesothelioma: comparison of chemotherapy-pretreate...
  Arduino JM, Kindler HL, Hollen PJ, Sun X, Baas P, Bucci ME, Lubiniecki GM, Hershock DM, Krug LM, World Lung Conference, San Francisco, 7/1/2009
• A Phase III trial of docetaxel, cisplatin and 5-fluorouracil (TPF) versus cisplatin and 5-fluorouracil (PF) induction chemotherapy (IC) followed by chemoradiotherapy (...
  Posner, MR, Hershock D, Le-Lann L, Devlin, PM, Haddad RI, ASCO, 1/1/2006
• A phase I combination trial of fixed-dose rate gemcitabine and irinotecan in patients with advanced pancreatic and biliary cancer.
  Sun W, Theobald M, Hershock D, Haller DG, ASCO, 1/1/2004
• Weekly Carboplatin and paclitaxel concurrent with radiation therapy for locally advanced head and neck squamous cell carcinoma: preliminary results from the Hospital o...
  Hershock D, Santiago D, Smith RJ, Machtay M, Weber RS, Weinstein GS, Chalian AA, Rosenthal DI, ASCO, 1/1/2002
• A pilot study of postoperative chemosensitized re-irradiation plus amifostine after salvage surgery for recurrent head and neck cancer.
  Liu L, Rosenthal DI, Lustig RA, Hershock D, Miller L, Chalian A, Machtay M, ASCO, 1/1/2002
• Combined modality therapy for locally advanced oropharyngeal carcinoma: final results of a phase II study using induction and concurrent chemoradiation.
  Rosenthal DI, Hershock D, Jones H, Weber RS, Machtay M, ASCO, 1/1/2002
• Initial non-surgical treatment for T3/T4 head/neck squamous cell carcinoma (HNSCC) does not compromise ultimate local control: the role of planned pathologic restaging...
  Yom SS, Liu L, Machtay M, Biel MA, Hershock D, Chalian AA, Weinstein GS Weber RS, Sinard RJ, Rosenthal DI, ASCO, 1/1/2002
• Phase I/II trial of accelerated radiotherapy plus concurrent 96 hour infusional paclitaxel for locally advanced head and neck cancer.
  Bucci MK, Rosenthal DI, Hershock D, Metz J, Devine P, Kligerman MM, Machtay M, ASCO, 1/1/2002
• Self-reported symptom distress during treatement for head and neck squamous cell carcinoma (HNSCC): concurrent chemoradiation (CRT) versus radiation therapy (RT) alone.
  Jones HA, Hershock D, Machtay M, Chalian AA, Weber RS, Weinstein GS, Kligerman MM, Rosenthal DI, ASCO, 1/1/2002
• Multimodality therapy for locally advanced resectable head/neck cancers with early surgical salvage immproves local control and organ preservation.
  Yom SS, Liu L, Machtay M, Beal m, Hershock, D, Chalian AA, Weinstein GS, Weber, RS Sinard R, Rosenthal DI, ASTRO, 1/1/2001
• A Phase I study of SPI-77 (Stealth Liposomal Cisplatin0 concurrent with radiation therapy for locally advanced head and neck cancer.
  Liu, L, Hershock, D, Machtay, M, Algazy, K, Weber RS, Weinstein, GS, Chalian, AA, Miller LK, Rockwell, K, Tonda, M, Schnipper E, Rosenthal, D, ASCO, 1/1/2001
• A Phase I study of SPI-77 (Stealth Liposomal Cisplatin) concurrent with radiation therapy for locally advanced head and neck cancer.
  Liu, L, Hershock, D, Machtay, M, Algazy, K, Weber RS, Weinstein, GS, Chalian, AA, Miller LK, Rockwell, K, Tonda, M, Schnipper E, Rosenthal, D, ASCO, 1/1/2001
• Induction chemotherapy for T4 oropharynx carcinoma in a prospective multimodality Phase II trial: "partial" response is not enough.
  Hsiung-Stripp, D, Machtay M., Robnett T, Rosenthal D, Algazy K, Hershock D, Chalian A, `Weinstein G, Weber R., Proceedings of ASCO, 1/1/2000
• A Phase I/II trial of accelerated radiotherapy plus concurrent 96-hour paclitaxel infusion for unresectable suamous cell carcinoma of the head and neck (SCCHN).
  Doyle T, Devine P, Rosenthal D, Hershock D, Levin W, Metz J, Mirza N, Machtay M, Proceedings of ASCO, 1/1/2000
• Long term outcome of 33 patients with posttransplant lymphoproliferative disorder (PTLD) following achievement of complete remission (CR).
  Tsai D, Hardy C, Somer B, Porter D, Schuster S, Hershock D, Laport G, Luger S, Stadtmauer E, Proceedings of ASCO, 1/1/2000
• Differentiating normal human megakaryoblasts express APO-FAS (CD95), TNF-RII, secrete several megakaryopoietic inhibitors, downregulate myb and undergo apoptosis; an i...
  Majka, M, Hershock, D., Ratajczak, J., Gontarewicz, A, Gewirtz, A.M, and Ratajczak, M.Z., American Society of Hematology Meeting, 12/1/1999
• Repeated immobilization effects on serum free fatty acids, triglycerides, total and HDL cholesterol in adult male Sprague-Dawley rats.
  Hershock, D., Harris, N., and Vogel, W.H., FASEB J, 1/1/1989
• The effects of stress on serum triglycerides, nonesterified fatty acids and total cholesterol levels in male rats after ethanol administration.
  Hershock, D. and Vogel, W.H., The Pharmacologist, 1/1/1988
• Stress effects on serum triglyceride, NEFA, and total cholesterol levels in male rats.
  Hershock, D. and Vogel, W.H., FASEB J, 1/1/1988
• The effects of immobilization stress on selected serum lipids in male rats under varied dietary conditions.
  Hershock, D. and Vogel, W.H., FASEB J, 1/1/1988
• Quantitation of glycoprotein IIIa in human blood platelets by radioimmunoassay.
  Cierniewski, C., Niewiarowski, S., Hershock, D., and Schmaier, A., Thromb. Haem., 1/1/1985
• Inhibition of platelet aggregation by an antibody raised against a 66,000 Mr platelet membrane component derived from glycoprotein IIIa.
  Chung, S., Hershock, D., Rucinski, B., Tuszynski, G.P., and Niewiarowski, S., Thromb. Haem., 1/1/1985
• Exposure of additional antigenic sites of the GPIIb/IIIa complex following chymotrypsin treatment of human platelets.
  Hershock, D., Niewiarowski, S., Cierniewski, C., Tuszynski, G., and Perussia, B., Fed. Proc., 1/1/1984
• Association of alpha granule proteins with platelet membranes and cytoskeletons.
  Cierniewski, C.S., Switalska, H., Hershock, D., Capitanio, A., Tuszynski, G., and Niewiarowski, S., Fed. Proc., 1/1/1984
• Isolation and characterization of a 66,000 Mr platelet membrane component derived from glycoprotein IIIa.
  Chung, S., Hershock, D., Tuszynski, G., Cierniewski, C.S. and Holt, J., Am. Soc. Hem., 1/1/1984
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Lectures

• "CTEP/NCI-cMet Program-Preclinical/Clinical Data to the Drug Development Group for Approval to Develop" 
  Bethesda, MD - 12/1/2008
• "Chemical Carcinogenesis/Clinical Implications in Oncology" 
  Graduate School, Thomas Jefferson University Hospital - 7/1/2008
• Grand Rounds: "Update on Head/Neck Cancers in the Community" 
  Grandview Hospital - 12/1/2007
• "Taxotere Induction in the Head/Neck-the 324 US-based Study" 
  White Flint, MD - 5/1/2007
• "Taxotere Induction in the Head/Neck 323 Study" 
  White Flint, MD - 1/1/2007
• "Genetics of Melanoma" 
  Hospital of the University of Pennsylvania - 4/1/2006
• "Management of Laryngeal Cancers" 
  Rittenhouse Hotel, Philadelphia - 4/1/2005
• "Management patients after chemoradiation" (Panel Discussant) 
  Loews, Philadelphia - 9/1/2004
• "Medullary Thyroid Cancer" 
  Loews Hotel, Philadelphia - 4/1/2003
• "Chemotherapy in the Management of Head and Neck Cancers" 
  Marriott Hotel, Conshohocken - 4/1/2001
• "Management Issues in Upper Gastrointestinal Cancer" 
  Rittenhouse Hotel - 12/1/2000
• "The Role of Chemotherapy and Chemoradiation in the Management of Laryngeal Cancers" 
  Pennsylvania Convention Center - 3/1/2000
• "Anaplastic Thyroid Cancer" 
  Rittenhouse Hotel - 10/1/1999
• "The Pathology of Cancer" 
  8/1/1998
• "Chemical Carcinogenesis/Mutagenesis" 
  Thomas Jefferson University, College of Graduate Studies - 6/1/1997
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