Diego H Castrillon MD PhD

Obstetrics & Perinatal Pathology, Anatomic Pathology

Professor of Pathology, Director of Investigative Pathology, and Vernie A. Stembridge, M.D., Distinguished Chair in Pathology, UT Southwestern

Summary

My research laboratory studies women's cancers with an emphasis on endometrial cancer. We focus on the genetic and genomic basis of cancer, and how DNA errors promote the formation of cancer. Our goal is to apply insights from our research towards the development of new therapies, predictive biomarkers, and diagnostic methods for these extremely common yet understudied cancers and their early precursors. I also serve as a pathologist in the Obstetric and Gynecologic Pathology Division at UT Southwestern.

Brigham and Womens HospitalFellowship, Selective Pathology, 1998 - 1999
Mass General Brigham/Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1996 - 1998
University of Texas Southwestern Medical SchoolClass of 1996

Elected Fellow, Section on Medical Sciences American Association for the Advancement of Science (AAAS), 2022
Vernie A. Stembridge, M.D., Distinguished Chair in Pathology UT Southwestern Medical School, 2014
Elected Member The American Society for Clinical Investigation, 2009

PubMed

Caveolin-1 regulates context-dependent signaling and survival in Ewing sarcoma.
Dagan Segal, Xiaoyu Wang, Hanieh Mazloom-Farisbaf, Divya Rajendran, Erin Butler
Biorxiv. 2025-01-28
1 citations
β-catenin, PAX2, and PTEN Aberrancy Across the Spectrum of Endometrioid Ovarian Lesions.
Maria M Del Mundo, Mitzi Aguilar, Hao Chen, Shuang Niu, Subhransu S Sahoo
International Journal of Gynecological Pathology. 2025-01-01
Expression and Prognostic Significance of LAG-3, TIGIT, VISTA, and IDO1 in Endometrial Serous Carcinoma.
Hao Chen, Kyle Molberg, Kelley Carrick, Shuang Niu, Glorimar Rivera Colon
Modern Pathology. 2024-08-01

Journal Articles

β-Catenin, PAX2 and PTEN panel in the diagnosis of endometrial precancers: a case-based review
Elena Lucas Hao Chen Subhransu S. Sahoo Kelley Carrick Jessica Grubman Wenxin Zheng Jonathan Hecht Diego H. Castrillon, Diagnostic Histpathology, 7/22/2023
Foxo3 Promotes Apoptosis of B Cell Receptor–Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing
Brian Skaug, Evan Barrios, Diego H Castrillon, The Journal of Immunology

Lkb1 Deficiency Confers Glutamine Dependency in Polycystic Kidney DiseaseFebruary 26th, 2020
Researchers Uncover Mutated Genes Involved in Lung Cancer; One Affects NonsmokersOctober 24th, 2017
Gene Inactivation Drives Spread of MelanomaJune 11th, 2012

Mechanisms and Consequences of PAX2 Inactivation in the Initiation of Endometrial CarcinogenesisUT SOUTHWESTERN MEDICAL CENTER2024–2029
Mechanisms and Consequences of PAX2 Inactivation in the Initiation of Endometrial CarcinogenesisUT SOUTHWESTERN MEDICAL CENTER2024–2029
Polymerase epsilon-based mouse and derived organoid models of intestinal cancerUT SOUTHWESTERN MEDICAL CENTER2022–2027
Polymerase epsilon-based mouse and derived organoid models of intestinal cancerUT SOUTHWESTERN MEDICAL CENTER2022–2027
Polymerase-mediated ultramutagenesis and carcinogenesis in miceUT SOUTHWESTERN MEDICAL CENTER2019–2025
Mouse Models And Translational Studies Of Endometrial CancerNational Cancer Institute2010–2012
LKB1 Tumor Suppressor And Human CancerNational Cancer Institute2009–2011
Mentoring And Research In Mouse Models Of Cancer And InfertilityNational Center For Research Resources2007–2011
Regulation Of Ovarian Follicle ActivationEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009
Feedback Regulation Of WNT SignalingNational Institute Of General Medical Sciences2007
Use Of The Mouse For Prostate Cancer Gene DiscoveryNational Cancer Institute2003–2004
Use Of The Mouse For Prostate Cancer Gene DiscoveryNational Cancer Institute2000–2003