DilipDevjeebhaiPatelMD

PubMed

• Premature Senescence in Cells From Patients With Autosomal Recessive Hypercholesterolemia (ARH): Evidence for a Role for ARH in Mitosis.
  Sun, X., Patel, D.D., Acosta, J., Gil, J., Soutar, A.K.> ;Arterioscler Thromb Vasc Biol. 2011 Oct
• Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by ac...
  Hebbachi, A.M., Knight, B.L., Wiggins, D., Patel, D.D., Gibbons, G.F.> ;J Biol Chem. 2008 Feb 22
• Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.
  Knight, B.L., Patel, D.D., Humphreys, S.M., Wiggins, D., Gibbons, G.F.> ;J Lipid Res. 2003 Nov
• Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
  Trickett JI, Patel DD, Knight BL, Saggerson ED, Gibbons GF, Pease RJ> ;J. Biol. Chem.. 2001-10-26
• Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion.
  Harrison JK, Fong AM, Swain PA, Chen S, Yu YR, Salafranca MN, Greenleaf WB, Imai T, Patel DD> ;J. Biol. Chem.. 2001-06-15
• Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia.
  O'Neill FH, Patel DD, Knight BL, Neuwirth CK, Bourbon M, Soutar AK, Taylor GW, Thompson GR, Naoumova RP> ;Arterioscler. Thromb. Vasc. Biol.. 2001-05-01
• Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.
  Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF> ;J. Lipid Res.. 2001-03-01
• Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation.
  Fong AM, Erickson HP, Zachariah JP, Poon S, Schamberg NJ, Imai T, Patel DD> ;J. Biol. Chem.. 2000-02-11
• Analysis of two duplications of the LDL receptor gene affecting intracellular transport, catabolism, and surface binding of the LDL receptor.
  Patel DD, Lelli N, Garuti R, Li Volti S, Bertolini S, Knight BL, Calandra S> ;J. Lipid Res.. 1998-07-01
• Influence of genotype at the low density lipoprotein (LDL) receptor gene locus on the clinical phenotype and response to lipid-lowering drug therapy in heterozygous fa...
  Sun XM, Patel DD, Knight BL, Soutar AK> ;Atherosclerosis. 1998-01-01
• Comparison of the genetic defect with LDL-receptor activity in cultured cells from patients with a clinical diagnosis of heterozygous familial hypercholesterolemia. Th...
  Sun XM, Patel DD, Knight BL, Soutar AK> ;Arterioscler. Thromb. Vasc. Biol.. 1997-11-01
• The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
  Berkhout TA, Simon HM, Patel DD, Bentzen C, Niesor E, Jackson B, Suckling KE> ;J. Biol. Chem.. 1996-06-14
• Cholesterol-lowering drug therapy in a patient with receptor-negative homozygous familial hypercholesterolaemia.
  Feher MD, Webb JC, Patel DD, Lant AF, Mayne PD, Knight BL, Soutar AK> ;Atherosclerosis. 1993-11-01
• Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia.
  Webb JC, Sun XM, Patel DD, McCarthy SN, Knight BL, Soutar AK> ;J. Lipid Res.. 1992-05-01
• Non-saturable degradation of LDL by monocyte-derived macrophages leads to a reduction in HMG-CoA reductase activity with little synthesis of cholesteryl esters.
  Knight BL, Soutar AK, Patel DD> ;Atherosclerosis. 1987-04-01
• Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia.
  Pisciotta, L., Priore Oliva, C., Cefalù, A. B., Noto, D., Bellocchio, A., Fresa, R., Cantafora, A., Patel, D., Averna, M., Tarugi, P., Calandra, S., Bertolini, S.> ;Atherosclerosis. 2006 Jun
• Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men.
  Gouni-Berthold, I., Berthold, H. K., Gylling, H., Hallikainen, M., Giannakidou, E., Stier, S., Ko, Y., Patel, D., Soutar, A. K., Seedorf, U., Mantzoros, C. S., Plat, J...> ;Atherosclerosis. 2008 May
• Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.
  Herbert, B., Patel, D., Waddington, S. N., Eden, E. R., McAleenan, A., Sun, X. M., Soutar, A. K.> ;Arterioscler Thromb Vasc Biol. 2010 Jul
• Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response.
  Naoumova, R. P., Tosi, I., Patel, D., Neuwirth, C., Horswell, S. D., Marais, A. D., van Heyningen, C., Soutar, A. K.> ;Arterioscler Thromb Vasc Biol. 2005 Dec
• The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PP...
  Gibbons, G. F., Patel, D., Wiggins, D., Knight, B. L.> ;Adv Enzyme Regul. 2002
• A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
  Knight, B. L., Hebbachi, A., Hauton, D., Brown, A. M., Wiggins, D., Patel, D. D., Gibbons, G. F.> ;Biochem J. 2005 Jul 15
• Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1.
  Eden, E. R., Patel, D. D., Sun, X. M., Burden, J. J., Themis, M., Edwards, M., Lee, P., Neuwirth, C., Naoumova, R. P., Soutar, A. K.> ;J Clin Invest. 2002 Dec
• Adaptor protein disabled-2 modulates low density lipoprotein receptor synthesis in fibroblasts from patients with autosomal recessive hypercholesterolaemia.
  Eden, E. R., Sun, X. M., Patel, D. D., Soutar, A. K.> ;Hum Mol Genet. 2007 Nov 15
• Degradation of LDLR protein mediated by ''gain of function'' PCSK9 mutants in normal and ARH cells.
  Fasano, T., Sun, X. M., Patel, D. D., Soutar, A. K.> ;Atherosclerosis. 2009 Mar 01
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