DominicNReedsMD

Endocrinology • Saint Louis, MO

Diabetes, HIV/AIDS Related Metabolism, Lipid Metabolism, Obesity

Professor, Internal Medicine, Washington University School of Medicine

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Office
1 Barnes Jewish Hospital Plz
Saint Louis, MO 63110
Phone+1 314-362-7578
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Endocrinology, Diabetes, and Metabolism, 2000 - 2003
University of RochesterResidency, Internal Medicine, 1996 - 2000
Texas Tech University Health Sciences Center School of MedicineClass of 1996

Certifications & Licensure

MO State Medical License 2003 - 2025
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Clinical Trials

Study of the Effects of Xenin-25 in Humans With and Without Type 2 Diabetes Mellitus Start of enrollment: 2008 Dec 01
Completed
Phase 1
Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome Start of enrollment: 2009 Feb 01
Completed
Not Applicable
Xenin-25: Novel Regulator of Insulin Secretion and Beta-cell Function Start of enrollment: 2009 Oct 01
Completed
Phase 1
The Effects of Bethanechol on Glucose Homeostasis Start of enrollment: 2011 Aug 15
Completed
Phase 1
Effectiveness of Sitagliptin for HIV Insulin Resistance and Inflammation Start of enrollment: 2012 Oct 01
Completed
Phase 3
Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese Start of enrollment: 2012 Dec 01
Terminated
Not Applicable
Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance Start of enrollment: 2013 Sep 01
Completed
Not Applicable
Effects of Xenin-25 on Insulin Secretion and Gastric Emptying in Humans With and Without a Complete Truncal Vagotomy Start of enrollment: 2013 Jan 01
Withdrawn
Phase 1
The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion Start of enrollment: 2013 Mar 13
Completed
Phase 1
To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery Start of enrollment: 2014 Jul 01
Completed
Phase 1
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Publications & Presentations

PubMed

Critical Evaluation of Indices Used to Assess β-Cell Function.
Chao Cao, Han-Chow E Koh, Dominic N Reeds, Bruce W Patterson, Samuel Klein, Bettina Mittendorfer> ;Diabetes. 2024 Mar 1
6 citations
Increased plasma fatty acid clearance, not fatty acid concentration, is associated with muscle insulin resistance in people with obesity.
Chao Cao, Han-Chow E Koh, Stephan Van Vliet, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Bettina Mittendorfer> ;Metabolism. 2022 Jul 1
1 citations
Socioeconomic status largely explains integrase inhibitors-related body composition differences in chronically infected men living with HIV.
Julie K Wisch, Sarah A Cooley, Kevin E Yarasheski, W Todd Cade, Dominic N Reeds, Brittany Nelson, Ruth Alemu, Tricia H Burdo, Beau M Ances> ;Antiviral Therapy. 2022 Jun 1
2 citations
Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics.
Faidon Magkos, Dominic N Reeds, Bettina Mittendorfer> ;Physiological Reviews. 2023 Jan 1
1 citations
High rates of undiagnosed and uncontrolled hypertension upon a screening campaign in rural Rwanda: a cross-sectional study.
Evariste Ntaganda, Regine Mugeni, Emmanuel Harerimana, Gedeon Ngoga, Symaque Dusabeyezu, Francois Uwinkindi, Jean N Utumatwishima, Eugene Mutimura, Victor G Davila-Rom...> ;BMC Cardiovascular Disorders. 2022 Apr 26
3 citations
Cardiorespiratory Fitness Is Associated With Better White Matter Integrity in Persons Living With HIV.
Collin B Kilgore, Jeremy F Strain, Brittany Nelson, Sarah A Cooley, Alexander Rosenow, Michelle Glans, William Todd Cade, Dominic N Reeds, Robert H Paul, Beau M Ances> ;Journal of Acquired Immune Deficiency Syndromes. 2022 Apr 15
1 citations
Insulin sensitivity and kinetics in African American and White people with obesity: Insights from different study protocols.
Han-Chow E Koh, Bruce W Patterson, Dominic N Reeds, Bettina Mittendorfer> ;Obesity. 2022 Mar 1
2 citations
Effect of obstructive sleep apnea on glucose metabolism.
Han-Chow E Koh, Stephan van Vliet, Chao Cao, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Yo-El S Ju, Bettina Mittendorfer> ;European Journal of Endocrinology. 2022 Feb 23
1 citations
Exploring contextual factors influencing the implementation of evidence-based care for hypertension in Rwanda: a cross-sectional study using the COACH questionnaire.
Ana A. Baumann, Cole Hooley, Charles W. Goss, Vincent Mutabazi, Angela L. Brown, Kenneth B. Schechtman, Marc Twagirumukiza, Lisa de las Fuentes, Dominic N. Reeds, Make...> ;BMJ Open. 2021 Sep 21
1 citations
Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Bart...
Kathryn L. Bohnert, Grace Ditzenberger, Adam J. Bittel, Lisa de las Fuentes, Manuela Corti, Christina A. Pacak, Carolyn L. Taylor, Barry J. Byrne, Dominic N. Reeds, W....> ;JIMD Reports. 2021 Aug 9
25 citations
Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus.
Nathanial S Nolan, Samantha Adamson, Dominic N. Reeds, Jane A. O’Halloran> ;Open Forum Infectious Diseases. 2021 Apr 16
11 citations
No independent or combined effects of vitamin D and conjugated linoleic acids on muscle protein synthesis in older adults: a randomized, double-blind, placebo-controll...
Stephan van Vliet, Alan Fappi, Dominic N. Reeds, Bettina Mittendorfer> ;The American Journal of Clinical Nutrition. 2020 Nov 11
1 citations
Comparison of the Ekblom-Bak Submaximal Test to a Maximal Test in a Cohort of Healthy Younger and Older Adults in the United States.
Stephanie A. Schultz, Jennifer Byers, Tammie L.S. Benzinger, Dominic N. Reeds, Andrei G. Vlassenko, W. Todd Cade, Manu S. Goyal> ;Frontiers in Physiology. 2020 Nov 6
2 citations
Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome
W. Todd Cade, Kathryn L. Bohnert, Adam J. Bittel, Shaji J. Chacko, Bruce W. Patterson, Christina A. Pacak, Barry J. Byrne, Hilary J. Vernon, Dominic N. Reeds> ;Molecular Genetics and Metabolism Reports. 2020 Nov 4
7 citations
A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
Adam J. Bittel, Daniel C. Bittel, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Nada A. Abumrad, Dominic N. Reeds, William Todd Cade> ;Medicine and Science in Sports and Exercise. 2021 Apr 1
70 citations
Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes.
Mihoko Yoshino, Brandon D Kayser, Jun Yoshino, Richard I Stein, Dominic Reeds, J Christopher Eagon, Shaina R Eckhouse, Jeramie D Watrous, Mohit Jain, Rob Knight, Kenne...> ;The New England Journal of Medicine. 2020 Aug 20
12 citations
The TDR MOOC training in implementation research: evaluation of feasibility and lessons learned in Rwanda
Cole Hooley, Ana A. Baumann, Vincent Mutabazi, Angela L. Brown, Dominic N. Reeds, W. Todd Cade, Lisa de las Fuentes, Enola K. Proctor, Stephen Karengera, Kenneth B. Sc...> ;Pilot and Feasibility Studies. 2020 May 15
11 citations
A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes
Adam J. Bittel, Daniel C. Bittel, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Jun Yoshino, Lane C. Porter, Nada A. Abumrad, Dominic N. Reeds, W. Todd...> ;Diabetologia. 2020 Mar 1
19 citations
Myocardial glucose and fatty acid metabolism is altered and associated with lower cardiac function in young adults with Barth syndrome.
William Todd Cade, Richard Laforest, Kathryn L. Bohnert, Dominic N. Reeds, Adam J. Bittel, Lisa de las Fuentes, Adil Bashir, Pamela K. Woodard, Christina A. Pacak, Bar...> ;Journal of Nuclear Cardiology. 2021 Aug 1
8 citations
Dissemination and Implementation Program in Hypertension in Rwanda: Report on Initial Training and Evaluation.
Ana A. Baumann, Vincent Mutabazi, Angela L. Brown, Cole Hooley, Dominic N. Reeds, Cecile Ingabire, Vedaste Ndahindwa, Aurore Nishimwe, W. Todd Cade, Lisa de las Fuente...> ;Global Heart. 2019 Jun 1
21 citations
Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents, and young adults with Barth syndrome.
William Todd Cade, Kathryn L. Bohnert, Linda R. Peterson, Bruce W. Patterson, Adam J. Bittel, Adewole L. Okunade, Lisa de las Fuentes, Karen Steger-May, Adil Bashir, G...> ;Journal of Inherited Metabolic Disease. 2019 Apr 11
8 citations
The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone
Stephan van Vliet, Gordon I. Smith, Lane C. Porter, Raja S. Ramaswamy, Dominic N. Reeds, Adewole L. Okunade, Jun Yoshino, Samuel Klein, Bettina Mittendorfer> ;The Journal of Physiology. 2018 Oct 1
12 citations
Peak oxygen uptake (VO2peak) across childhood, adolescence and young adulthood in Barth syndrome: Data from cross-sectional and longitudinal studies
William Todd Cade, Kathryn L. Bohnert, Dominic N. Reeds, Linda R. Peterson, Adam J. Bittel, Adil Bashir, Barry J. Byrne, Carolyn L. Taylor> ;Plos One. 2018 May 24
16 citations
Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.
Gordon I. Smith, Paul K. Commean, Dominic N. Reeds, Samuel Klein, Bettina Mittendorfer> ;Obesity. 2018 May 1
41 citations
Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial.
Jeremy Pettus, Dominic N. Reeds, Tricia Santos Cavaiola, Schafer Boeder, Michelle Levin, Garry S. Tobin, Edda Cava, Dung Thai, Jim Shi, Hai Yan, Edgar D. Bautista, Joh...> ;Diabetes, Obesity & Metabolism. 2018 May 1
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Grant Support

Exercise Training Augments The Peripheral Insulin Sensitizing EffectsNational Center For Research Resources2011
Whole-Body Proteolysis Rate Is Elevated In Hiv-Associated Insulin ResistanceNational Center For Research Resources2007–2008
Alterations In Liver, Muscle, And Adipose Tissue Insulin SensitivityNational Center For Research Resources2006–2008
Metabolic Abnormalities In HIVNational Center For Research Resources2004–2008
Autonomic Nervous System Activity In HIVNational Center For Research Resources2006–2007
Acute And Chronic Calorie Restriction And The Metabolic SyndromeNational Center For Research Resources2006–2007
Caloric Restriction And Insulin ActionNational Center For Research Resources2005
Alterations In Lipid Kinetics In Men W/ HIV DyslipidemiaNational Center For Research Resources2004–2005
Effect Of Korean Ginseng And Ginsenocide RE On Insulin SensitivityNational Center For Research Resources2004

Hospital Affiliations

Barnes-Jewish HospitalSaint Louis, Missouri