DonaldGGuineyMD

Infectious Disease • La Jolla, CA

Microbiology

Professor of Medicine Attending Physician UCSD Medical Center

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Office
9500 Gilman Drive
Mail Code 0640
La Jolla, CA 92093
Phone(858) 534-6030
Fax(858) 564-6020
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Education & Training

University of California San DiegoFellowship, Infectious Disease, 1978 - 1980
University of Southern California - LAC+USC Medical CenterResidency, Internal Medicine, 1974 - 1977
University of California San Diego School of MedicineClass of 1974

Certifications & Licensure

CA State Medical License 1976 - 2020
American Board of Internal Medicine Internal Medicine

Publications & Presentations

PubMed

3 citations
Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation.
Marchelletta, R. R., Gareau, M. G., Okamoto, S., Guiney, D. G., Barrett, K. E., Fierer, J.> ;The Journal of infectious diseases. 2014 Dec 30
5 citations
Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.
Wu, C. C., Crain, B., Yao, S., Sabet, M., Lao, F. S., Tawatao, R. I., Chan, M., Smee, D. F., Julander, J. G., Cottam, H. B., Guiney, D. G., Corr, M., Carson, D. A., Ha...> ;Journal of innate immunity. 2013 Nov 7
1 citation
Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis.
Marchelletta, R. R., Gareau, M. G., McCole, D. F., Okamoto, S., Roel, E., Klinkenberg, R., Guiney, D. G., Fierer, J., Barrett, K. E.> ;Gastroenterology. 2013 Sep 5
Activated charcoal enhanced the antigen-expression and dendritic cell maturation of the vaccine using Listeria-platform.
Wanram, S., Guiney, D. G., Panomket, P., Jearanaikoon, P.> ;The Kobe journal of medical sciences. 2012 Nov 13
7 citations
Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California.
Preziosi, M. J., Kandel, S. M., Guiney, D. G., Browne, S. H.> ;Journal of clinical microbiology. 2012 Aug 31
5 citations
Diarrhea and colitis in mice require the Salmonella pathogenicity island 2-encoded secretion function but not SifA or Spv effectors.
Fierer, J., Okamoto, S., Banerjee, A., Guiney, D. G.> ;Infection and immunity. 2012 Jul 11
5 citations
Improving reverse vaccinology with a machine learning approach.
Bowman, B. N., McAdam, P. R., Vivona, S., Zhang, J. X., Luong, T., Belew, R. K., Sahota, H., Guiney, D. G., Valafar, F., Fierer, J., Woelk, C. H.> ;Vaccine. 2011 Sep 29
11 citations
Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.
Obonyo, M., Rickman, B. H., Guiney, D. G.> ;Helicobacter. 2011 Sep 20
35 citations
The Role of the spv Genes in Salmonella Pathogenesis.
Guiney, D. G., Fierer, J.> ;Frontiers in microbiology. 2011 Jul 1
49 citations
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.
Sandip K. Datta, Mojgan Sabet, Kim Phung Nguyen, Patricia A. Valdez, José M. González-Navajas, Shamima Islam, Ivan Mihajlov, Joshua Fierer, Paul A. Insel, Nicholas J. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2010 Jun 8
Small Molecule DnaK Modulators Targeting the β‐Domain
Jason Cellitti, Ziming Zhang, Si Wang, Bainan Wu, Hongbin Yuan, Patty Hasegawa, Donald G. Guiney, Maurizio Pellecchia> ;Chemical Biology & Drug Design. 2009 Oct 1
25 citations
The use of viral load as a surrogate marker in predicting disease progression for patients with early invasive cervical cancer with integrated human papillomavirus typ...
Wanram, S., Limpaiboon, T., Leelayuwat, C., Yuenyao, P., Guiney, D. G., Lulitanond, V., Jearanaikoon, P.> ;American journal of obstetrics and gynecology. 2009 May 19
20 citations
ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis.
McGillivray, S. M., Ebrahimi, C. M., Fisher, N., Sabet, M., Zhang, D. X., Chen, Y., Haste, N. M., Aroian, R. V., Gallo, R. L., Guiney, D. G., Friedlander, A. M., Koehl...> ;Journal of innate immunity. 2009 Jan 1
26 citations
Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.
Hernandez, M. L., Leichtle, A., Pak, K., Ebmeyer, J., Euteneuer, S., Obonyo, M., Guiney, D. G., Webster, N. J., Broide, D. H., Ryan, A. F., Wasserman, S. I.> ;The Journal of infectious diseases. 2008 Nov 7
25 citations
Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.
van Sorge, N. M., Ebrahimi, C. M., McGillivray, S. M., Quach, D., Sabet, M., Guiney, D. G., Doran, K. S.> ;PloS one. 2008 Aug 14
5 citations
Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds.
Takabayshi, K., Corr, M., Hayashi, T., Redecke, V., Beck, L., Guiney, D. G., Sheppard, D., Raz, E.> ;Immunity. 2008 May 28
1 citation
In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.
Wu, C. C., Sabet, M., Hayashi, T., Tawatao, R. I., Fierer, J., Carson, D. A., Guiney, D. G., Corr, M.> ;Cellular immunology. 2008 May 23
24 citations
Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice
Sara H. Browne, Patricia Hasegawa, Sharon Okamoto, Joshua Fierer, Donald G. Guiney> ;Fems Immunology and Medical Microbiology. 2008 Mar 1
17 citations
A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice.
Woo, H., Okamoto, S., Guiney, D. G., Gunn, J. S., Fierer, J.> ;PloS one. 2008 Feb 14
11 citations
Rhodanine derivatives as selective protease inhibitors against bacterial toxins.
Johnson, S. L., Chen, L., Harbach, R., Sabet, M., Savinov, A. Y., Cotton, N. J., Strongin, A. Y., Guiney, D. G., Pellecchia, M.> ;Chemical biology & drug design. 2008 Jan 29
38 citations
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Shiryaev, S. A., Remacle, A. G., Ratnikov, B. I., Nelson, N. A., Savinov, A. Y., Wei, G., Bottini, M., Rega, M. F., Parent, A., Desjardins, R., Fugere, M., Day, R. W.,...> ;The Journal of biological chemistry. 2007 Jun 1
32 citations
Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobact...
Obonyo, M., Sabet, M., Cole, S. P., Ebmeyer, J., Uematsu, S., Akira, S., Guiney, D. G.> ;Infection and immunity. 2007 Mar 14
4 citations
Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells defic...
Obonyo, M., Cole, S. P., Datta, S. K., Guiney, D. G.> ;FEMS immunology and medical microbiology. 2006 Jul 29
12 citations
Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages.
Sabet, M., Cottam, H. B., Guiney, D. G.> ;FEMS immunology and medical microbiology. 2006 Jul 29
4 citations
Vaccination with irradiated Listeria induces protective T cell immunity.
Datta, S. K., Okamoto, S., Hayashi, T., Shin, S. S., Mihajlov, I., Fermin, A., Guiney, D. G., Fierer, J., Raz, E.> ;Immunity. 2006 Jul 25
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Grant Support

Intestinal Physiology In The Host Response To Enteric Salmonella InfectionsNational Institute Of Allergy And Infectious Diseases2009–2012
Protection Against Inhalation Anthrax With Inactivated SporesNational Institute Of Allergy And Infectious Diseases2008–2012
Plasmid-Mediated Virulence In SalmonellaNational Institute Of Allergy And Infectious Diseases2010
Plasmid-Mediated Virulence In SalmonellaNational Institute Of Allergy And Infectious Diseases1993–2008
Salmonella-To-Eukaryotic Cell Multi-Task Gene DeliveryNational Institute Of Allergy And Infectious Diseases2005–2006
Plasmid Mediated Virulence In SalmonellaNational Institute Of Allergy And Infectious Diseases1999–2003
Salmonella Virulence Factors--Host Response To InfectionNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2002
Interactions Of Helicobacter With The Gastric MucosaNational Institute Of Diabetes And Digestive And Kidney Diseases1997–2001
Human Immune Response To M Tuberculosis Latency AntigensNational Institute Of Allergy And Infectious Diseases1994–1998
Core--Molecular Biology LaboratoryNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1997
Antibiotic Resistance Of BacteroidesNational Institute Of Allergy And Infectious Diseases1985–1994
Mechanism Of Plasmid DNA Transfer In BacteriaNational Institute Of General Medical Sciences1985–1993
Black-Pigmented Bacteroides--Drug Resistance &VirulenceNational Institute Of Dental &Craniofacial Research1985–1987