DonaldRayJohnsMD

Neurology • Woburn, MA

Physician

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Office
Axon Guidance LLC
105 Harrison Avenue
Woburn, MA 01801
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Education & Training

Yale School of MedicineClass of 1983

Certifications & Licensure

American Board of Psychiatry and Neurology Neurology

Publications & Presentations

PubMed

19 citations
Serum urate at trial entry and ALS progression in EMPOWER.
Éilis J. O’Reilly, Dawei Liu, Donald R. Johns, Merit Cudkowicz, Sabrina Paganoni, Michael A. Schwarzschild, Melanie Leitner, Alberto Ascherio> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2017 Jan 2
31 citations
Quantitative strength testing in ALS clinical trials
Jeremy M. Shefner, Dawei Liu, Melanie Leitner, David A. Schoenfeld, Donald R. Johns, Toby A. Ferguson, Merit Cudkowicz> ;Neurology. 2016 Aug 9
27 citations
A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.
Claudia Trenkwalder, Daniela Berg, Olivier Rascol, Karla Eggert, Andres O. Ceballos-Baumann, Jean-Christophe Corvol, Alexander Storch, Lin Zhang, Jean-Philippe Azulay,...> ;Movement Disorders. 2016 Jul 1
134 citations
Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study.
Eva Havrdova, Anna Belova, Alla Goloborodko, Anne Tisserant, Andrew M Wright, Erik Wallstroem, Hideki Garren, Ralph Paul Maguire, Donald Johns> ;Journal of Neurology. 2016 May 3
21 citations
Dose‐dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492: Clear PK/PD relationship
Dorothée G.A. Kasteleijn-Nolst Trenité, Christian Brandt, Thomas Mayer, Felix Rosenow, Bernd Schmidt, Bernhard J. Steinhoff, Anne Gardin, Georges Imbert, Donald R. Joh...> ;Epilepsia. 2015 Jun 1
59 citations
A randomized, placebo‐controlled trial of AFQ056 for the treatment of chorea in Huntington's disease
Ralf Reilmann, Marie-Laure Rouzade-Dominguez, Carsten Saft, Sigurd D. Süssmuth, Josef Priller, Anne Elizabeth Rosser, Hugh Rickards, Ludger Schöls, Nicole Pezous, Fabr...> ;Movement Disorders. 2015 Mar 1
79 citations
Metabotropic glutamate receptor type 5 in levodopa-induced motor complications.
Bazoumana Ouattara, Laurent Grégoire, Marc Morissette, Fabrizio Gasparini, Ivo Vranesic, Graeme Bilbe, Donald Johns, Alex Rajput, Oleh Hornykiewicz, Ali H. Rajput, Bal...> ;Neurobiology of Aging. 2011 Jul 1
138 citations
AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials
Daniela Berg, Jana Godau, Claudia Trenkwalder, Karla Eggert, IIona Csoti, Alexander Storch, Heiko Huber, Monica Morelli-Canelo, Maria Stamelou, Vincent Ries, Martin Wo...> ;Movement Disorders. 2011 Jun 1
70 citations
Somatic mitochondrial DNA mutations in single neurons and glia.
Ippolita Cantuti-Castelvetri, Michael T. Lin, Kangni Zheng, Christine E. Keller-McGandy, Rebecca A. Betensky, Donald R. Johns, M. Flint Beal, David G. Standaert, David...> ;Neurobiology of Aging. 2005 Nov 1
36 citations
Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation.
Mark A. Tarnopolsky, David Simon, Brian D. Roy, Katherine Chorneyko, Stuart A. Lowther, Donald R. Johns, Jagdeep K. Sandhu, Yan Li, Marianna Sikorska> ;Muscle & Nerve. 2004 Apr 1
90 citations
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
David Simon, Michael T. Lin, Leiya Zheng, Guang-Jun Liu, Colette H. Ahn, Lauren M. Kim, William M. Mauck, Florence Twu, M. Flint Beal, Donald R. Johns> ;Neurobiology of Aging. 2004 Jan 1
13 citations
Paternal transmission of mitochondrial DNA is (fortunately) rare.
Donald R. Johns> ;Annals of Neurology. 2003 Oct 1
30 citations
A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia
David Simon, Jennifer Friedman, Xandra O. Breakefield, Joseph Jankovic, Mitchell F. Brin, John Provias, Susan B. Bressman, Michael E. Charness, Daniel Tarsy, Donald R....> ;Neurogenetics. 2003 May 17
3 citations
Treatment of Leber's hereditary optic neuropathy: theory to practice.
Donald R. Johns, Kathryn Colby> ;Seminars in Ophthalmology. 2002 Mar 1
26 citations
Low mutational burden of individual acquired mitochondrial DNA mutations in brain.
David Simon, Michael T. Lin, Chong H. Ahn, G.-J. Liu, Gary E. Gibson, M. F. Beal, Donald R. Johns> ;Genomics. 2001 Apr 1
62 citations
Mitochondrial dysfunction and neuromuscular disease
Rachel Nardin, Donald R. Johns> ;Muscle & Nerve. 2001 Feb 1
9 citations
A frameshift mitochondrial complex I gene mutation in a patient with dystonia and cataracts: is the mutation pathogenic?
David Simon, Mark A. Tarnopolsky, J T Greenamyre, Donald R. Johns> ;Journal of Medical Genetics. 2001 Jan 1
84 citations
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease.
David Simon, Richard Mayeux, Karen Marder, Neil W. Kowall, M F Beal, Donald R. Johns> ;Neurology. 2000 Feb 8
101 citations
Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation.
David Simon, Stefan M. Pulst, James P. Sutton, S. E. Browne, M. F. Beal, Donald R. Johns> ;Neurology. 1999 Nov 1
79 citations
Smoking as an aetiological factor in a pedigree with Leber's hereditary optic neuropathy.
Kailenn Tsao, Phil A Aitken, Donald R Johns> ;The British Journal of Ophthalmology. 1999 May 1
29 citations
Dystonia as a presenting feature of the 3243 mitochondrial DNA mutation.
Lewis Sudarsky, George M. Plotkin, Eric L. Logigian, Donald R. Johns> ;Movement Disorders. 1999 May 1
101 citations
Mitochondrial disorders: clinical and genetic features.
David Simon, Donald R. Johns> ;Annual Review of Medicine. 1999 Jan 1
43 citations
Expanding the phenotype of the 8344 transfer RNAlysine mitochondrial DNA mutation
Sara Austin, Francine J. Vriesendorp, F. T. Thandroyen, Jacqueline T. Hecht, O. T. Jones, Donald R. Johns> ;Neurology. 1998 Nov 1
47 citations
Mitochondrial neurogastrointestinal encephalomyopathy : Diagnosis by rectal biopsy
Antonio R. Perez-Atayde, Victor L. Fox, Jonathan E. Teitelbaum, Douglas A. Anthony, Ricardo Fadic, Louisa Kalsner, Michael J. Rivkin, Donald R. Johns, Gerald F. Cox> ;The American Journal of Surgical Pathology. 1998 Sep 1
19 citations
Mutational Scanning of Mitochondrial DNA by Two-Dimensional Electrophoresis ☆
N. J. Van Orsouw, Xiaomin Zhang, Jeanne Y. Wei, Donald R. Johns, Jan Vijg> ;Genomics. 1998 Aug 15
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Grant Support

Clinical Studies Of Mitochondrial DiseaseNational Institute Of Neurological Disorders And Stroke2000–2004
Mitochondrial DNA Analysis In Optic NeuropathyNational Eye Institute1995–1998
Molecular Biologic Analysis Of Mitochrondial MyopathiesNational Institute Of Neurological Disorders And Stroke1993
Molecular Biologic Analysis Of Mitochondrial MyopathiesNational Institute Of Neurological Disorders And Stroke1989–1993

DonaldRayJohnsMD

Dr. Johns is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Grant Support

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