Dorothy K Grange MD

Clinical Genetics, Medical Biochemical Genetics

Professor, Pediatrics, Washington University School of Medicine

Division of Genetics and Genomic Medicine, Department of PediatricsWashington University School of Medicine, One Children’s PlaceSt. Louis, MO 63110
Phone+1 314-454-6093
Fax+1 314-454-2075

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Summary

Dr. Dorothy Grange is a seasoned medical genetics specialist based in St. Louis, MO in the Department of Pediatrics at Washington University School of Medicine. She has subspecialties in Clinical Genetics and Medical Biochemical Genetics. She is an alumnus of the University of Florida College of Medicine and completed her residencies in Pediatrics and Pathology-Anatomic and Clinical at University of Wisconsin Hospitals and Clinics. She specifically has experience in lysosomal storage diseases and inborn errors of metabolism. Dr. Grange has also made substantial contributions to medical literature, featuring in several publications that focus on molecular and genetic biosciences. Lastly, she has been part of multiple clinical trials, mostly addressing X-linked Hypohidrotic Ectodermal Dysplasia and PKU related ailments.

Education & Training

University of Wisconsin Hospitals and ClinicsResidency, Pathology-Anatomic and Clinical, 1985 - 1986
University of Wisconsin Hospitals and ClinicsResidency, Pediatrics, 1982 - 1985
University of Florida College of MedicineInternship, Transitional Year, 1981 - 1982
University of Florida College of MedicineClass of 1981

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Certifications & Licensure

IL State Medical License 1991 - 2029
MO State Medical License 1989 - 2027
MD State Medical License 1987 - 1990
WI State Medical License 1982 - 1987
American Board of Medical Genetics and Genomics Clinical Genetics
American Board of Pediatrics Pediatrics

Clinical Trials

Sapropterin in Individuals With Phenylketonuria
COMPLETED
Behavioral Effects of Kuvan in Children With Mild Phenylketonuria
TERMINATED
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia
COMPLETED

Publications & Presentations

PubMed

Characterization of the genotypic and phenotypic spectrum of TCF7L2-related neurodevelopmental disorder (TRND).
Sally Nijim, Mimi Kim, Melissa Denish, Michael V Gonzalez, Joseph Zinski
Genetics in Medicine. 2026-07-07
2 citations
Attitudes of female carriers of X-linked hypohidrotic ectodermal dysplasia towards prenatal treatment and their decisions during a pregnancy with a male fetus.
Holm Schneider, Michael Schneider, Massimiliano Lia, Dorothy K Grange, Smail Hadj-Rabia
Orphanet Journal of Rare Diseases. 2025-04-15
3 citations
Pathogenic de novo variants in PPP2R5C cause a neurodevelopmental disorder within the Houge-Janssens syndrome spectrum.
Iris Verbinnen, Sofia Douzgou Houge, Tzung-Chien Hsieh, Hellen Lesmann, Aron Kirchhoff
American Journal of Human Genetics. 2025-03-06

Journal Articles

Clinical Exome Sequencing Reveals Locus Heterogeneity and Phenotypic Variability of Cohesinopathies
Scott E Hickey, Leah Slattery, James R Lupski, Margaret P Adam, Olivia Wenger, Davut Pehlivan, Laura Martin, Farida Abid, Dorothy Grange, Jennifer E Posey, Alison A Be..., Nature