DouglasBrennemanDO

PubMed

• 13 citations
  Knockdown siRNA Targeting the Mitochondrial Sodium-Calcium Exchanger-1 Inhibits the Protective Effects of Two Cannabinoids Against Acute Paclitaxel Toxicity.
  Douglas E. Brenneman, William A. Kinney, Sara Jane Ward> ;Journal of Molecular Neuroscience. 2019 May 10
• 11 citations
  Pharmacological Comparisons Between Cannabidiol and KLS-13019
  Douglas E. Brenneman, Dean Petkanas, William A. Kinney> ;Journal of Molecular Neuroscience. 2018 Aug 14
• 3 citations
  Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties.
  Garry R. Smith, Douglas E. Brenneman, Yan Zhang, Yanming Du, Allen B. Reitz> ;Journal of Molecular Neuroscience. 2014 Mar 1
• 11 citations
  Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (J...
  Mccomsey David F, Smith-Swintosky Virginia L, Parker Michael H, Douglas E. Brenneman, Ewa Malatynska, H. Steve White, Brian D. Klein, Karen S. Wilcox, Michael E. Milew...> ;Journal of Medicinal Chemistry. 2013 Nov 11
• 6 citations
  Small Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection
  Douglas E. Brenneman, Garry R. Smith, Yan Zhang, Yanming Du, Sandeep K. Kondaveeti, Michael J. Zdilla, Allen B. Reitz> ;Journal of Molecular Neuroscience. 2012 Apr 26
• 21 citations
  Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads
  Yifang Huang, Eric D. Strobel, Chih Y. Ho, Charles H. Reynolds, Kelly A. Conway, Jennifer Piesvaux, Douglas E. Brenneman, George J. Yohrling, H. Moore Arnold, Daniel I...> ;Bioorganic & Medicinal Chemistry Letters. 2010 May 15
• 20 citations
  Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
  Michael H. Parker, Smith-Swintosky Virginia L, David F. McComsey, Yifang Huang, Douglas E. Brenneman, Brian D. Klein, Ewa Malatynska, H. Steve White, Michael E. Milews...> ;Journal of Medicinal Chemistry. 2009 Dec 10
• 31 citations
  Cathepsins B and L Differentially Regulate Amyloid Precursor Protein Processing
  Donna M. Klein, Kevin M. Felsenstein, Douglas E. Brenneman> ;The Journal of Pharmacology and Experimental Therapeutics. 2009 Mar 1
• 32 citations
  Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons.
  Yi Liu, George J. Yohrling, Yan Wang, Tasha Hutchinson, Douglas E. Brenneman, Christopher M. Flores, Boyu Zhao> ;Epilepsy Research. 2009 Jan 1
• 298 citations
  Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide.
  Merav Bassan, Rachel Zamostiano, Ariane Davidson, Albert Pinhasov, Eliezer Giladi, Orly Perl, Haim Bassan, Cila Blat, Gretchen Gibney, Gordon W. Glazner, Douglas E. Br...> ;Journal of Neurochemistry. 2008 Jul 7
• 30 citations
  Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations
  Ewa Malatynska, Albert Pinhasov, Jeffrey Crooke, Smith-Swintosky Virginia L, Douglas E. Brenneman> ;Journal of Neuroscience Methods. 2007 Sep 30
• 86 citations
  Neuroprotection : A comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
  Douglas E. Brenneman> ;Peptides. 2007 Sep 1
• 101 citations
  2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
  Ellen W. Baxter, Kelly A. Conway, Ludo Edmond Josephine Kennis, François Paul Bischoff, Marc Mercken, Hans De Winter, Charles H. Reynolds, Brett A. Tounge, Chi Luo, Ma...> ;Journal of Medicinal Chemistry. 2007 Aug 8
• 41 citations
  NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.
  Jorge Busciglio, Alejandra Pelsman, Pablo Helguera, Osnat Ashur-Fabian, Albert Pinhasov, Douglas E. Brenneman, Illana Gozes> ;Current Pharmaceutical Design. 2007 Mar 31
• 10 citations
  Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant-submissive relationships.
  Ewa Malatynska, Albert Pinhasov, Christopher J. Creighton, Jeffrey Crooke, Allen B. Reitz, Douglas E. Brenneman, Mariusz Lubomirski> ;Neuroscience and Biobehavioral Reviews. 2007 Jan 1
• 6 citations
  Vasoactive Intestinal Peptide Releases Interleukin-1 from Astrocytes
  Douglas E. Brenneman, Joanna M. Hill, Illana Gozes, Terry M. Phillips> ;Annals of the New York Academy of Sciences. 2006 Dec 17
• 2 citations
  VIP regulation of embryonic growth.
  Joanna M. Hill, Susan K McCune, Ruben Alvero, Gordon W. Glazner, Douglas E. Brenneman> ;Annals of the New York Academy of Sciences. 2006 Dec 17
• 4 citations
  Development of VIP Agonists and Antagonists with Tissue and Receptor Specificity: Effects on Behavioral Maturation, Sexual Function, and the Biologic Clocka
  Illana Gozes, G. Lilling, Ariane Davidson, Amos Bardea, A. Reshef, R. Glazer, Rachel Zamostiano, Osnat Ashur-Fabian, A. Ticher, I. E. Ashkenazi, Terry W. Moody, S. Rub...> ;Annals of the New York Academy of Sciences. 2006 Dec 17
• 14 citations
  Learning enhancement with neuropeptides
  Laura Toso, Melanie Endres, Joy Vink, Daniel Abebe, Douglas E. Brenneman, Catherine Y. Spong> ;American Journal of Obstetrics and Gynecology. 2006 Apr 1
• 30 citations
  A Novel VIP Responsive Gene: Activity Dependent Neuroprotective Protein
  Illana Gozes, Rachel Zamostiano, Albert Pinhasov, Merav Bassan, Eliezer Giladi, Ruth A. Steingart, Douglas E. Brenneman> ;Annals of the New York Academy of Sciences. 2006 Jan 25
• 21 citations
  Chemokines Released from Astroglia by Vasoactive Intestinal Peptide: Mechanism of Neuroprotection from HIV Envelope Protein Toxicity
  Douglas E. Brenneman, Janet Hauser, Catherine Y. Spong, Terry M. Phillips> ;Annals of the New York Academy of Sciences. 2006 Jan 25
• 13 citations
  Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation.
  Nadia Sahir, Douglas E. Brenneman, Joanna M. Hill> ;Journal of Molecular Neuroscience. 2006 Jan 1
• 11 citations
  Levels of mRNA coding for α-, β- and γ-synuclein in the brains of newborn, juvenile, and adult rats
  Ewa Malatynska, Albert Pinhasov, Jeffrey Crooke, Daniel Horowitz, Douglas E. Brenneman, Sergey E. Ilyin> ;Journal of Molecular Neuroscience. 2006 Jan 1
• 29 citations
  Reduction of Submissive Behavior Model for antidepressant drug activity testing: study using a video-tracking system
  Albert Pinhasov, Jeffrey Crooke, Daniel I. Rosenthal, Douglas E. Brenneman, Ewa Malatynska> ;Behavioural Pharmacology. 2005 Dec 1
• 3 citations
  8-(Heteroaryl)phenalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as opioid receptor modulators.
  Alfonzo D. Jordan, Michael J. Orsini, Steven A. Middleton, Peter J. Connolly, Douglas E. Brenneman, Kevin Pan, Allen B. Reitz> ;Medicinal Chemistry. 2005 Oct 31
• Join now to see all