DouglasJohnConradMD

PubMed

• 1 citations
  Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations.
  Regan, E., Lowe, M., Make, B., Curtis, J., Chen, Q., Crooks, J., Wilson, C., Oates, G., Gregg, R., Baldomero, A., Bhatt, S., Diaz, A., Benos, P., O'Brien, J., Young, K...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Jan 1
• 1 citations
  CompoundingPhages for Therapeutic Applications.
  Ana Georgina Cobián Güemes, Tram Le, Maria Isabel Rojas, Nicole E Jacobson, Helena Villela, Katelyn McNair, Shr-Hau Hung, Lili Han, Lance Boling, Jessica Claire Octavi...> ;Viruses. 2023 Jul 30
• 3 citations
  Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity againstpneumonia.
  Fatemeh Askarian, Chih-Ming Tsai, Gabriele Cordara, Raymond H Zurich, Elisabet Bjånes, Ole Golten, Henrik Vinther Sørensen, Armin Kousha, Angela Meier, Elvis Chikwati,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jul 25
• 5 citations
  Cystic Fibrosis Screen Positive, Inconclusive Diagnosis Genotypes in People with Cystic Fibrosis from the U.S. Patient Registry.
  Danieli B Salinas, Choo Phei Wee, Barbara Bailey, Karen Raraigh, Douglas Conrad> ;Annals of the American Thoracic Society. 2023 Apr 1
• 2 citations
  Integrating specialist palliative care to improve care and reduce suffering: cystic fibrosis (InSPIRe:CF) - study protocol for a multicentre randomised clinical trial.
  Jane Lowers, Elisabeth P Dellon, Anne Stephenson, Robert Arnold, Andrew Althouse, Kwonho Jeong, Ethan Dubin, Jesse Soodalter, Cade Hovater, Marie Bakitas, Jessica Gogg...> ;BMJ Open Respiratory Research. 2022 Sep 1
• Unsupervised Learning Identifies Computed Tomographic Measurements as Primary Drivers of Progression, Exacerbation, and Mortality in Chronic Obstructive Pulmonary Dise...
  Nancy F Yuan, Kyle Hasenstab, Tara Retson, Douglas J Conrad, David A Lynch, Albert Hsiao> ;Annals of the American Thoracic Society. 2022 Dec 1
• 4 citations
  Stenotrophomonas maltophilia in patients with bronchiectasis: An analysis of the US bronchiectasis and NTM Research Registry.
  Mark L Metersky, Radmila Choate, Timothy R Aksamit, Douglas Conrad, Nicole C Lapinel, Diego J Maselli, Pamela J McShane> ;Respiratory Medicine. 2022 Mar 1
• 1 citations
  Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice.
  Zhichao Fan, Elise Pitmon, Lai Wen, Jacqueline Miller, Erik Ehinger, Rana Herro, Wei Liu, Ju Chen, Zbigniew Mikulski, Douglas J Conrad, Alex Marki, Marco Orecchioni, P...> ;Journal of Immunology. 2022 Feb 1
• 11 citations
  Multi-Omics Study of Keystone Species in a Cystic Fibrosis Microbiome
  Cynthia B. Silveira, Ana G Cobián-Güemes, Carla C. Uranga, Jonathon L. Baker, Anna Edlund, Forest Rohwer, Douglas Conrad> ;International Journal of Molecular Sciences. 2021 Nov 7
• 7 citations
  Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort.
  Vickram Tejwani, Ashraf Fawzy, Nirupama Putcha, Peter J. Castaldi, Michael H. Cho, Katherine A. Pratte, Surya P. Bhatt, David A. Lynch, Stephen M. Humphries, Gregory L...> ;Chest. 2021 Oct 1
• Draft Genome Sequence of the Multidrug-Resistant Strain Pseudomonas aeruginosa PA291, Isolated from Cystic Fibrosis Sputum.
  Tiffany Luong, Ashley Schumann, Douglas Conrad, Dwayne R. Roach> ;Microbiology Resource Announcements. 2021 Sep 9
• Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
  Nathan I. Walton, Xijun Zhang, Anthony R. Soltis, Joshua Starr, Clifton L. Dalgard, Matthew D. Wilkerson, Douglas Conrad, Harvey B. Pollard> ;Physiological Reports. 2021 Jun 1
• 2 citations
  Plasmonic Sensing Studies of a Gas-Phase Cystic Fibrosis Marker in Moisture Laden Air.
  Libin Sun, Douglas Conrad, Drew A. Hall, Kurt D. Benkstein, Steve Semancik, Mona Zaghloul> ;Sensors. 2021 May 29
• 16 citations
  Automated CT Staging of Chronic Obstructive Pulmonary Disease Severity for Predicting Disease Progression and Mortality with a Deep Learning Convolutional Neural Network.
  Kyle Hasenstab, Nancy Yuan, Tara Retson, Douglas Conrad, Seth Kligerman, David A. Lynch, Albert Hsiao> ;Radiology. Cardiothoracic Imaging. 2021 Apr 8
• 5 citations
  Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients
  Douglas Conrad, Joanne Billings, Charlotte C. Teneback, Jonathan L. Koff, Daniel B. Rosenbluth, Barbara A. Bailey, Raksha Jain> ;Journal of Cystic Fibrosis. 2021 Jan 1
• 36 citations
  High-Resolution Longitudinal Dynamics of the Cystic Fibrosis Sputum Microbiome and Metabolome through Antibiotic Therapy.
  Ruma Raghuvanshi, Karla Vasco, Yoshiki Vázquez-Baeza, Lingjing Jiang, James T. Morton, Danxun Li, Antonio Gonzalez, Lindsay DeRight Goldasich, Gregory Humphrey, Gail A...> ;Msystems. 2020 Jun 23
• 15 citations
  Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis
  Carla Cristina Souza Gomez, Paloma Lopes Francisco Parazzi, Karl Jan Clinckspoor, Renan Marrichi Mauch, Francisco B. T. Pessine, Carlos Emílio Levy, Andressa Oliveira ...> ;Clinical Drug Investigation. 2020 Feb 1
• 89 citations
  COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.
  Bhatt, S. P., Katherine E Lowe, Elizabeth A. Regan, Antonio Anzueto, Erin Austin, John H. M. Austin, Terri H. Beaty, Panayiotis V. Benos, Christopher J. Benway, Surya ...> ;Chronic Obstructive Pulmonary Diseases. 2019 Nov 1
• 34 citations
  Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads.
  Jon G. Sanders, Sergey Nurk, Rodolfo A. Salido, Jeremiah J. Minich, Zhenjiang Zech Xu, Qiyun Zhu, Cameron Martino, Marcus W. Fedarko, Timothy D. Arthur, Feng Chen, Bri...> ;Genome Biology. 2019 Oct 31
• 15 citations
  Molecular and Microbial Microenvironments in Chronically Diseased Lungs Associated with Cystic Fibrosis.
  Alexey V. Melnik, Yoshiki Vázquez-Baeza, Alexander A. Aksenov, Embriette R. Hyde, Andrew C. McAvoy, Mingxun Wang, Ricardo Silva, Ivan Protsyuk, Jason V. Wu, Amina Bous...> ;Msystems. 2019 Sep 24
• 20 citations
  Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information.
  Ana Georgina Cobián Güemes, Yan Wei Lim, Robert A. Quinn, Douglas Conrad, Sean Benler, Heather Maughan, Robert Edwards, Thomas Brettin, Vito Adrian Cantu, Daniel A. Cu...> ;Mbio. 2019 Apr 16
• 32 citations
  Niche partitioning of a pathogenic microbiome driven by chemical gradients
  Robert A. Quinn, William Comstock, Tianyu Zhang, James T. Morton, Ricardo Silva, Alda Tran, Alexander A. Aksenov, Louis-Félix Nothias, Daniel Wangpraseurt, Alexey V. M...> ;Science Advances. 2018 Sep 1
• 6 citations
  Median regression spline modeling of longitudinal FEV1 measurements in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients.
  Douglas Conrad, Barbara A. Bailey, Jon A. Hardie, Per Bakke, Tomas Mikal Eagan, Bernt B. Aarli> ;Plos One. 2017 Dec 20
• 76 citations
  Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung
  Neha Garg, Mingxun Wang, Embriette R. Hyde, Ricardo Silva, Alexey V. Melnik, Ivan Protsyuk, Amina Bouslimani, Yan Wei Lim, Richard J. Wong, Greg Humphrey, Gail Ackerma...> ;Cell Host & Microbe. 2017 Nov 8
• 6 citations
  Smartphone-Based pH Sensor for Home Monitoring of Pulmonary Exacerbations in Cystic Fibrosis
  Alexander Sun, Tom Phelps, Chengyang Yao, A. G. Venkatesh, Douglas Conrad, Drew A. Hall> ;Sensors. 2017 May 30
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Journal Articles

• A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT...  
  Flume PA, VanDevanter DR, Morgan EE, Dudley MN, Loutit JS, Bell SC, Kerem E, Fischer R, Smyth AR, Aaron SD, Conrad D, Geller DE, Elborn JS, Cyst Fibros, 1/1/2016
• A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in sta...  
  Stuart Elborn J, Geller DE, Conrad D, Aaron SD, Smyth AR, Fischer R, Kerem E, Bell SC, Loutit JS, Dudley MN, Morgan EE, VanDevanter DR, Flume PA, J Cyst Fibros, 1/1/2015
• Mass spectral similarity for untargeted metabolomics data analysis of complex mixtures  
  Garg N, Kapono C, Lim YW, Koyama N, Vermeij MJ, Conrad D, Rohwer F, Dorrestein PC, Int J Mass Spectrom, 1/1/2015
• A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation  
  Quinn RA, Whiteson K, Lim YW, Salamon P, Bailey B, Mienardi S, Sanchez SE, Blake D, Conrad D, Rohwer F, ISME J, 1/17/2014
• Mechanistic model of Rothia mucilaginosa adaptation toward persistence in the CF lung, based on a genome reconstructed from metagenomic data  
  Lim YW, Schmieder R, Haynes M, Furlan M, Matthews TD, Whiteson K, Poole SJ, Hayes CS, Low DA, Maughan H, Edwards R, Conrad D, Rohwer F, PloS One, 1/30/2013
• Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states  
  Struss AK, Nunes A, Waalen J, Lowery CA, Pullanikat P, Denery JR, Conrad DJ, Kaufmann GF, Janda KD, Anal Chem, 1/19/2013
• Metagenomics and metatranscriptomics: Windows on CF-associated viral and microbial communities  
  Lim YW, Schmieder R, Haynes M, Willner D, Furlan M, Youle M, Abbott K, Edwards R, Evangelista J, Conrad D, Rohwer F, J Cyst Fibros, 1/28/2012
• Spatial distribution of microbial communities in the cystic fibrosis lung  
  Willner D, Haynes MR, Furlan M, Schmieder R, Lim YW, Rainey PB, Rohwer F, Conrad D, ISME J, 1/1/2012
• Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung  
  Willner D, Haynes MR, Furlan M, Hanson N, Kirby B, Lim YW, Rainey PB, Schmieder R, Youle M, Conrad D, Rohwer F, Am J Respir Cell Mol Biol, 1/1/2012
• Long term effects of denufosol tetrasodium in patients with cystic fibrosis  
  Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, Barnes M, Moss RB; TIGER-2 Study Investigator Group, J Cyst Fibros, 1/1/2012
• Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals  
  Willner D, Furlan M, Haynes M, Schmieder R, Angly FE, Silva J, Tammadoni S, Nosrat B, Conrad D, Rohwer F, PLoS One, 1/9/2009
• 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs  
  Nicoletti F, Conrad D, Wang A, Pieters R, Mangano K, van Heeckeren A, White SK, Frincke J, Reading CL, Auci DL, Stickney D, Clin Exp Immunol, 1/1/2009
• Sleep disruption in cystic fibrosis  
  Yue HJ, Conrad D, Dimsdale JE, Med Hypotheses, 1/5/2008
• The Clinical Use of Aerosolized Antibiotics  
  Conrad, DJ, Clinical Pulmonary Medicine, 1/1/2003
• Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition  
  Chu HW, Balzar S, Westcott JY, Trudeau JB, Sun Y, Conrad DJ, Wenzel SE, Clin Exp Allergy, 1/1/2002
• Peroxisome Proliferator-Activiated Receptor Regulates Airway Epithelial Cell Activation  
  Wang, C. C. A., Dai X., Luu B.Q., Conrad DJ, Amer J Resp Cell and Mol Biol, 1/1/2001
• Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Regulation  
  Conrad, DJ and Lu Min, Amer J Resp Cell and Mol Biol, 1/1/2000
• Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase  
  Huang JT, Welsh JS, Ricote M, Kelly C, Binder C, Willson TM, Kelly C, Witztum JL, Funk C, Conrad DJ, Glass C, Nature, 1/1/1999
• The Arachidonate 12/15 Lipoxygenases: A Review of Tissue Expression and Biologic Function  
  Conrad, DJ, Clin Rev Allery Immunol, 1/1/1999
• Recent advances in the understanding and treatment of cystic fibrosis  
  Resnikoff JR; Conrad DJ, Current Opinion in Pulmonary Medicine, 1/1/1998
• Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene  
  Kritzik MR; Ziober AF; Dicharry S; Conrad DJ; Sigal E, Biochim Biophys Acta, 1/26/1997
• Intraluminal water increases expression of plasmid DNA in rat lung  
  Sawa T; Miyazaki H; Pittet JF; Widdicombe JH; Gropper MA; Hashimoto S, Conrad DJ; Folkesson HG; Debs R; Forsayeth JR; et al, Human Gene Therapy, 1/20/1996
• 15-Lipoxygenase immunoreactivity in normal and asthmatic airways  
  Bradding P, Redington AE, Djukanovic R, Conrad DJ and Holgate ST, Am J Respir Crit Care Med, 1/1/1995
• Human 15-Lipoxygenase: Induction by Interleukin-4 and Insights into Positional Specificity  
  Sigal E, Sloan DL and Conrad DJ, J Lipid Med, 1/1/1993
• Specific Inflammatory Cytokines Regulate the Expression of Human Monocyte 15-Lipoxygenase  
  Conrad DJ, Kuhn H, Mulkins M, Highland E and Sigal E, Proc Natl Acad Sci, USA, 1/1/1992
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Books/Book Chapters

• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Cystic Fibrosis 
  Page 378 - 382Conrad, DJEditors: Bordow RA, Ries AL, Morris TA.Lippincott, Williams and Wilkins2005
• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Cystic Fibrosis. 
  Page 378 - 383Conrad, DJEditors: Bordow RA, Ries AL, Morris TA.Lippincott, Williams and Wilkins2001
• Advances in Prostaglandins, Thromboxane and Leukotriene Research 
  Chapter: Human 15-Lipoxygenase: A potential effector molecule for Interleukin-4. 
  Page 309 - 316Sigal E, Conrad DJRaven Press1994

Lectures

• "The Airway Microbiome: Lessons from Cystic Fibrosis Studies" 
  Carmel, CA - 1/1/2016
• "Clinical Implications of the CF Airway Metagenome" 
  Basel, Swizterland - 1/1/2016
• "Adult Cystic Fibrosis Clinical Phenotyping: The Application of the Statistical Learning Algorithm, Random Forest, to the Generation and Description of Adult Clinical ... 
  1/1/2015
• "Clinical Cystic Fibrosis" 
  1/1/2015
• "Practical approach to Clinical Cystic Fibrosis" 
  1/1/2015
• "Lung function modeling and smoothing splines" 
  1/1/2015
• "Viral Interactions in the Microbiome" 
  1/1/2014
• Topics and Advances in Pulmonary and Critical Care Medicine 
  University of California, San Diego, San Diego, California - 2/9/2013
• "Bronchiectasis" 
  1/1/2013
• "Clinical Applications of Genetics and Genomics to CF" 
  1/1/2013
• "Ethical Issues in Transition from Pediatric to Adult Care Settings" 
  1/1/2013
• "CF Pulmonary Exacerbations" 
  1/1/2013
• "Complex Clinical CF Phenotyping" 
  1/1/2013
• "Cystic Fibrosis: Evolutionary Perspectives of Mucoviscidosis" 
  1/1/2012
• "CF Airway Biofilm Quantification: A Clinical Perspective" 
  1/1/2011
• "Bronchiectatic Syndromes: Diagnosis and Management" 
  1/1/2010
• "Cystic Fibrosis in Adults and Bronchiectactic Disorders" 
  1/1/2010
• "Characterization and Implications of Bacteriophage Communities in the Airway Secretions from Normal Healthy Volunteers and Clinically Stable CF Patients" 
  1/25/2009
• "The CF Airway Metagenome: Clinical and Therapeutic Implications" 
  1/6/2009
• "Culture-Independent Microbiologic Analysis of CF Airway Secretions" 
  1/5/2009
• "CF 101" 
  1/1/2009
• "Lung Phenotypes using Longitudinal Pulmonary Function" 
  1/1/2009
• "The CF Microbiome" 
  1/1/2009
• "The Importance of Longitudinal Lung Function in Assess CF Disease Severity." 
  1/1/2009
• "Adult Cystic Fibrosis" 
  1/1/2007
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Other

• Arachidonate 15-Lipoxygenase: Immunocytochemical Localization in Blood and Airway Cells. 
  Nadel JA, Ueki IF, Schuster A, Conrad DJ and E Sigal, 1990 Transactions of the Association of American Physicians
  1/1/1990