DouglasSHawkinsMD

Pediatric Hematology & Oncology • Seattle, WA

Pediatric Sarcoma Oncology, Pediatric Solid Tumor Oncology

Professor of Pediatrics, University Wash

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Office
4800 Sand Point Way Ne
Seattle, WA 98105
Phone+1 206-987-2000
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Education & Training

University of WashingtonFellowship, Pediatric Hematology/Oncology, 1993 - 1996
University of WashingtonResidency, Pediatrics, 1990 - 1993
Harvard Medical SchoolClass of 1990

Certifications & Licensure

WA State Medical License 1992 - 2026
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top MD Consumers Checkbook
Super Doctor SuperDoctors.com
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Clinical Trials

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Solid Tumors Start of enrollment: 1997 Jul 01
Terminated
Phase 1
Chemotherapy in Treating Children With Recurrent or Refractory Sarcomas Start of enrollment: 1999 May 01
Completed
Phase 2
Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone Start of enrollment: 2001 Nov 01
Completed
Phase 1, Phase 2
Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Start of enrollment: 2001 Feb 01
Unknown status
Phase 3
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Start of enrollment: 2006 Dec 26
Completed
Phase 3
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Start of enrollment: 2010 Oct 04
Active, not recruiting
Phase 1
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Brentuximab Vedotin and Gemcitabine Hydrochloride in Treating Younger Patients With Relapsed or Refractory Hodgkin Lymphoma Start of enrollment: 2013 Jan 31
Completed
Phase 1, Phase 2
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas Start of enrollment: 2013 Jun 17
Active, not recruiting
Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia Start of enrollment: 2013 Jun 24
Completed
Phase 2
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Selecting Patient-Specific Biologically Targeted Therapy for Pediatric Patients With Refractory Or Recurrent Brain Tumors Start of enrollment: 2013 Dec 01
Unknown status
Not Applicable
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
To Evaluate Maximally Tolerated Dose (MTD), Safety and Efficacy of CPI-613® (Devimistat) Plus Hydroxychloroquine in Patients With Relapsed or Refractory Clear Cell Sarcoma of Soft Tissue Start of enrollment: 2021 Sep 01
Completed
Phase 1, Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Bailey A Martin-Giacalone, He Li, Michael E Scheurer, Dana L Casey, Shannon Dugan-Perez, Deborah A Marquez-Do, Donna Muzny, Richard A Gibbs, Donald A Barkauskas, David...> ;JAMA Network Open. 2024 Mar 4
1 citations
Rare Tumors: Opportunities and challenges from the Children's Oncology Group perspective.
Kris Ann P Schultz, Murali Chintagumpala, Jin Piao, Kenneth S Chen, Rachana Shah, Robyn D Gartrell, Emily Christison-Lagay, Farzana Pashnakar, Jesse L Berry, Allison F...> ;EJC Paediatric Oncology. 2023 Dec 1
Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaborat...
Andrew D J Pearson, Sara Federico, Susanne A Gatz, Michael Ortiz, Giovanni Lesa, Nicole Scobie, Ioannis Gounaris, Susan L Weiner, Brenda Weigel, T J Unger, Elizabeth S...> ;European Journal of Cancer. 2023 Sep 1
A pilot study evaluating the use of sirolimus in children and young adults with desmoid-type fibromatosis.
Aaron R Weiss, Sarah Dry, Clara Maygar, Anya Cutler, Christine W Lary, Carmen Khoo, Jillian E Fergione, Melanie M Hounchell, Kathleen Glick, Meghen Browning, Sun Ha Ch...> ;Pediatric Blood & Cancer. 2023 Jun 7
8 citations
Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C.
Susan N Chi, Joanna S Yi, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Be...> ;Journal of the National Cancer Institute. 2023 Nov 8
2 citations
Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group.
Bailey A Martin-Giacalone, Melissa A Richard, Michael E Scheurer, Javed Khan, Pagna Sok, Priya B Shetty, Stephen J Chanock, Shengchao Alfred Li, Meredith Yeager, Debor...> ;Journal of the National Cancer Institute. 2023 Jun 8
1 citations
Genome-Wide Association Study Identifiesas a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors.
Xuexia Wang, Purnima Singh, Liting Zhou, Noha Sharafeldin, Wendy Landier, Lindsey Hageman, Paul Burridge, Yutaka Yasui, Yadav Sapkota, Javier G Blanco, Kevin C Oeffing...> ;Journal of Clinical Oncology. 2023 Mar 20
3 citations
Neoadjuvant pazopanib in nonrhabdomyosarcoma soft tissue sarcomas (ARST1321): A report of major wound complications from the Children's Oncology Group and NRG Oncology.
Mark L Kayton, Aaron R Weiss, Wei Xue, Odion Binitie, Andrea Hayes Dixon, R Lor Randall, Joel I Sorger, Douglas S Hawkins, Sheri L Spunt, Dian Wang, Lynn Million, Step...> ;Journal of Surgical Oncology. 2023 Apr 1
7 citations
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Samuel Abbou, Kelly Klega, Junko Tsuji, Mohammad Tanhaemami, David Hall, Donald A Barkauskas, Mark D Krailo, Carrie Cibulskis, Anwesha Nag, Aaron R Thorner, Samuel Pol...> ;Journal of Clinical Oncology. 2023 May 1
11 citations
National Cancer Institute Combination Therapy Platform Trial with Molecular Analysis for Therapy Choice (ComboMATCH).
Funda Meric-Bernstam, James M Ford, Peter J O'Dwyer, Geoffrey I Shapiro, Lisa M McShane, Boris Freidlin, Roisin E O'Cearbhaill, Suzanne George, Julia Glade-Bender, Gar...> ;Clinical Cancer Research. 2023 Apr 14
4 citations
Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medic...
Andrew Dj Pearson, Carl Allen, Jason Fangusaro, Caroline Hutter, Olaf Witt, Susan Weiner, Gregory Reaman, Mark Russo, Pratiti Bandopadhayay, Sama Ahsan, Amy Barone, El...> ;European Journal of Cancer. 2022 Dec 1
2 citations
Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group.
David Milewski, Hyun Jung, G Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, Erin R Rudzinski, Hyoyoung Choo-Wosoba, Donald A Barkauskas, Tammy ...> ;Clinical Cancer Research. 2023 Jan 17
3 citations
Patients with completely resected nongenitourinary low-risk embryonal rhabdomyosarcoma are candidates for reduced duration low-intensity chemotherapy.
Gianni Bisogno, Joerg Fuchs, Roshni Dasgupta, Andrea Ferrari, Josephine H Haduong, Timothy Rogers, David O Walterhouse, Beatrice Coppadoro, Wei Xue, Christian Vokuhl, ...> ;Cancer. 2022 Dec 1
2 citations
Automated Ascertainment of Typhlitis From the Electronic Health Record.
Tamara P Miller, Yimei Li, Aaron J Masino, Emma Vallee, Evanette Burrows, Mark Ramos, Todd A Alonzo, Robert Gerbing, Sharon M Castellino, Douglas S Hawkins, Timothy L ...> ;JCO Clinical Cancer Informatics. 2022 Sep 1
15 citations
Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Stud...
Simone Hettmer, Corinne M Linardic, Anna Kelsey, Erin R Rudzinski, Christian Vokuhl, Joanna Selfe, Olivia Ruhen, Jack F Shern, Javed Khan, Alexander R Kovach, Philip J...> ;European Journal of Cancer. 2022 Sep 1
5 citations
Creating a data commons: The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).
Kirk D Wyatt, Suzi Birz, Douglas S Hawkins, Veronique Minard-Colin, David A Rodeberg, Monika Sparber-Sauer, Gianni Bisogno, Ewa Koscielniak, Gian Luca De Salvo, Martin...> ;Pediatric Blood & Cancer. 2022 Nov 1
6 citations
Is Detection of Relapse by Surveillance Imaging Associated With Longer Survival in Patients With Rhabdomyosarcoma?
Stephanie Fetzko, Adriana Fonseca, Mary Frances Wedekind, Abha A Gupta, Bhuvana A Setty, Jeremy Schraw, Philip J Lupo, Robert P Guillerman, Anish A Butala, Heidi Russe...> ;Journal of Pediatric Hematology/oncology. 2022 Aug 1
13 citations
Rates of laboratory adverse events by course in paediatric leukaemia ascertained with automated electronic health record extraction: a retrospective cohort study from ...
Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T F...> ;The Lancet. Haematology. 2022 Sep 1
6 citations
Paediatric Strategy Forum for medicinal product development of multi-targeted kinase inhibitors in bone sarcomas: ACCELERATE in collaboration with the European Medicin...
Andrew Dj Pearson, Nathalie Gaspar, Katherine Janeway, Quentin Campbell-Hewson, Elizabeth R Lawlor, Chris Copland, Dominik Karres, Koen Norga, Fawzi Benzaghou, Susan W...> ;European Journal of Cancer. 2022 Sep 1
21 citations
An updated assessment of 43,110 patients enrolled in the Childhood Cancer Research Network: A Children's Oncology Group report.
Austin L Brown, Pagna Sok, Michael E Scheurer, Karen R Rabin, Erin L Marcotte, Douglas S Hawkins, Logan G Spector, Philip J Lupo> ;Cancer. 2022 Jul 15
16 citations
Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group.
Jacquelyn N Crane, Wei Xue, Amira Qumseya, Zhengya Gao, Carola A S Arndt, Sarah S Donaldson, Douglas J Harrison, Douglas S Hawkins, Corinne M Linardic, Leo Mascarenhas...> ;Pediatric Blood & Cancer. 2022 Jun 1
7 citations
Congenital spindle cell rhabdomyosarcoma: An international cooperative analysis.
Sarah Whittle, Rajkumar Venkatramani, Anton Schönstein, Svetlana D Pack, Rita Alaggio, Christian Vokuhl, Erin R Rudzinski, Anna-Lena Wulf, Angelica Zin, Juliana R Gruv...> ;European Journal of Cancer. 2022 Jun 1
32 citations
An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials.
Josephine H Haduong, Christine M Heske, Wendy Allen-Rhoades, Wei Xue, Lisa A Teot, David A Rodeberg, Sarah S Donaldson, Aaron Weiss, Douglas S Hawkins, Rajkumar Venkat...> ;Pediatric Blood & Cancer. 2022 Apr 1
1 citations
The effects of pazopanib on doxorubicin pharmacokinetics in children and adults with non-rhabdomyosarcoma soft tissue sarcoma: a report from Children's Oncology Group ...
J Gartrell, J C Panetta, S D Baker, Y L Chen, D S Hawkins, A Ostrenga, T J Scharschmidt, S L Spunt, D Wang, A R Weiss> ;Cancer Chemotherapy and Pharmacology. 2022 Apr 1
17 citations
Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the ...
Olive S Eckstein, Carl E Allen, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey ...> ;Journal of Clinical Oncology. 2022 Jul 10
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Press Mentions

Drug Combination Shows Promise for Rhabdomyosarcoma, but Can It Get to Clinical Trials?December 9th, 2022
To Save Children with Cancer, Doctors Turn to New WeaponsAugust 5th, 2022
Initiative Seeks to Improve Solid Tumor Treatment and Diagnosis in ChildrenApril 27th, 2022
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Grant Support

Chmc B008: Pharmacokinetic And Pharmocogenetics Of CyclophosphamideNational Center For Research Resources2007
Filgrastim-Sd/01 VS Filgrastim In Newly Diagnosed Children With SarcomaNational Center For Research Resources2005–2006
Targeted Radiotherapy For Ewing'S SarcomaNational Cancer Institute2000–2005
Filgrastim-Sd/01 Vs. Filgrastim In Newly Diagnosed Children With SarcomaNational Center For Research Resources2004
Phase I Study Of SMS 201 995 PA LAR (Nsc 685403)+ &Tamoxifen In PANational Center For Research Resources1999–2000