DouglasScottJohnsonMD

PubMed

• Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474.
  Huang, Z.,Ogasawara, D.,Seneviratne, U. I.,Cognetta, A. B.,Am Ende, C. W.,Nason, D. M.,Lapham, K.,Litchfield, J.,Johnson, D. S.,Cravatt, B. F.> ;ACS Chem. Biol.. 2019 Feb 01
• Integrated Care for People with Kidney Disease: The Perspective of a Nonprofit Dialysis Provider.
  Johnson, D. S.,Meyer, K. B.> ;Clin J Am Soc Nephrol. 2019 Jan 31
• Leading Integrated Kidney Care Entities of the Future.
  Johnson, D. S.,Meyer, K. B.> ;Adv Chronic Kidney Dis. 2018 Dec 12
• Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
  Pettersson, M.,Johnson, D. S.,Rankic, D. A.,Kauffman, G. W.,Am Ende, C. W.,Butler, T. W.,Boscoe, B.,Evrard, E.,Helal, C. J.,Humphrey, J. M.,Stepan, A. F.,Stiff, C. M.,...> ;Medchemcomm. 2016 Nov 02
• Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
  Pettersson, M.,Johnson, D. S.,Humphrey, J. M.,Am Ende, C. W.,Evrard, E.,Efremov, I.,Kauffman, G. W.,Stepan, A. F.,Stiff, C. M.,Xie, L.,Bales, K. R.,Hajos-Korcsok, E.,M...> ;Bioorg. Med. Chem. Lett.. 2015 Jan 15
• Molecular medicine and neurodegenerative diseases.
  Chang, C. J.,Cravatt, B. F.,Johnson, D. S.,Lim, M. H.> ;Chem Soc Rev. 2014 Aug 12
• Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment.
  Schülke, J. P.,McAllister, L. A.,Geoghegan, K. F.,Parikh, V.,Chappie, T. A.,Verhoest, P. R.,Schmidt, C. J.,Johnson, D. S.,Brandon, N. J.> ;ACS Chem. Biol.. 2014 Oct 09
• Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.
  Gertsik, N.,Ballard, T. E.,Am Ende, C. W.,Johnson, D. S.,Li, Y. M.> ;Medchemcomm. 2014 Jun 11
• Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators.
  Pettersson, M.,Johnson, D. S.,Subramanyam, C.,Bales, K. R.,Am Ende, C. W.,Fish, B. A.,Green, M. E.,Kauffman, G. W.,Mullins, P. B.,Navaratnam, T.,Sakya, S. M.,Stiff, C....> ;J. Med. Chem.. 2014 Jan 17
• An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics.
  Qian, Y.,Martell, J.,Pace, N. J.,Ballard, T. E.,Johnson, D. S.,Weerapana, E.> ;Chembiochem. 2013 Aug 19
• Piperidine acetic acid based ?-secretase modulators directly bind to Presenilin-1.
  Crump, C.J., Fish, B.A., Castro, S.V., Chau, D., Gertsik, N., Ahn, K., Stiff, C., Pozdnyakov, N., Bales, K.R., Johnson, D.S., Li, Y.> ;ACS Chem Neurosci. 2011 Dec 21
• Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain.
  Ahn, K., Smith, S.E., Liimatta, M.B., Beidler, D., Sadagopan, N., Dudley, D.T., Young, T., Wren, P., Zhang, Y., Swaney, S., Van Becelaere, K., Blankman, J.L., Nomura, ...> ;J Pharmacol Exp Ther. 2011 Jul
• The 2011 ESRD prospective payment system and the survival of an endangered species: the perspective of a not-for-profit medium-sized dialysis organization.
  Johnson, D.S., Meyer, K.B., Johnson, H.K.> ;Am J Kidney Dis. 2011 Apr
• Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
  Johnson, D.S., Stiff, C., Lazerwith, S.E., Kesten, S.R., Fay, L.K., Morris, M., Beidler, D., Liimatta, M.B., Smith, S.E., Dudley, D.T., Sadagopan, N., Bhattachar, S.N....> ;ACS Med Chem Lett. 2011 Feb 10
• Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders.
  Ahn, K., Johnson, D.S., Cravatt, B.F.> ;Expert Opin Drug Discov. 2009 Jul
• Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
  Ahn, K., Johnson, D.S., Mileni, M., Beidler, D., Long, J.Z., McKinney, M.K., Weerapana, E., Sadagopan, N., Liimatta, M., Smith, S.E., Lazerwith, S., Stiff, C., Kamteka...> ;Chem Biol. 2009-04-24
• Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
  Mileni, M., Johnson, D.S., Wang, Z., Everdeen, D.S., Liimatta, M., Pabst, B., Bhattacharya, K., Nugent, R.A., Kamtekar, S., Cravatt, B.F., Ahn, K., Stevens, R.C.> ;Proc Natl Acad Sci U S A. 2008 Sep 2
• Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
  Ahn, K., Johnson, D.S., Fitzgerald, L.R., Liimatta, M., Arendse, A., Stevenson, T., Lund, E.T., Nugent, R.A., Nomanbhoy, T.K., Alexander, J.P., Cravatt, B.F.> ;Biochemistry. 2007 Nov 13
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