DouglasAlexanderMataMDMPH

Pathology • Cambridge, MA

Molecular Genetics, Anatomic Pathology, Clinical Pathology

Pathologist and Associate Medical Director, Foundation Medicine, Inc.

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Office
Foundation Medicine, Inc.
150 Second Street
Cambridge, MA 02141
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Education & Training

Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 2015 - 2019
Baylor College of MedicineClass of 2014
University of CambridgeMPH, Epidemiology, 2007 - 2009
Rice UniversityBA, Biochemistry and Cell Biology, Phi Beta Kappa, 2003 - 2007

Certifications & Licensure

NY State Medical License 2018 - 2026
MA State Medical License 2014 - 2025
NC State Medical License 2021 - 2025
American Board of Pathology Pathology - Anatomic/Pathology - Clinical
American Board of Pathology Pathology - Molecular Genetic

Awards, Honors, & Recognition

Fulbright Scholar U.S. Department of State, 2011

Clinical Trials

4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer Start of enrollment: 1997 Aug 01
Terminated
Phase 3

Publications & Presentations

PubMed

Liquid biopsy-based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results.
Douglas A Mata, Jessica K Lee, Vignesh Shanmugam, Chelsea B Marcus, Alexa B Schrock, Erik A Williams, Lauren L Ritterhouse, Richard A Hickman, Tyler Janovitz, Nimesh R...> ;Histopathology. 2024 Jun 1
Precision needle-punch tumor enrichment from paraffin blocks improves the detection of clinically actionable genomic alterations and biomarkers.
Ladas, I., Keller, R., Patel, N., Lakis, S., Mack, P., Killian, J., Lin, D., Huang, R., Decker, B., Janovitz, T., Mata, D., Ross, J., Vergilio, J., Elvin, J., Herbst, R.> ;Frontiers in Oncology. 2024 Jan 1
GLI1-Altered Mesenchymal Tumors With ACTB or PTCH1 Fusion: A Molecular and Clinicopathologic Analysis.
Darcy A Kerr, Jeffrey M Cloutier, Matthew Margolis, Douglas A Mata, Nathalie J Rodrigues Simoes, William C Faquin, Dora Dias-Santagata, Shefali Chopra, Gregory W Charv...> ;Modern Pathology. 2024 Feb 1
1 citations
Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and...
Soo-Ryum Yang, Erika Gedvilaite, Ryan Ptashkin, Jason Chang, John Ziegler, Douglas A Mata, Liliana B Villafania, Khedoudja Nafa, Jaclyn F Hechtman, Ryma Benayed, Ahmet...> ;Journal of Thoracic Oncology. 2024 Mar 1
Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With a Novel CLTC::SYK Fusion.
Helena M Crowley, Natalia Georgantzoglou, Julie Y Tse, Erik A Williams, Douglas A Mata, Stuart S Martin, Joan Guitart, Julia A Bridge, Konstantinos Linos> ;The American Journal of Surgical Pathology. 2023 Oct 1
3 citations
Sinonasal Myxoma: A Distinct Entity or a Myxoid Variant of Desmoid Fibromatosis?
Jaylou M Velez Torres, Douglas A Mata, Laurence M Briski, Donald C Green, Jeffrey M Cloutier, Darcy A Kerr, Elizabeth A Montgomery, Andrew E Rosenberg> ;Modern Pathology. 2023 Jul 1
Determining the Association Between Melanomas and Fields of Melanocytic Dysplasia.
Douglas A Mata, Christine G Lian, Farhaan Hafeez> ;The American Journal of Dermatopathology. 2023 Feb 1
1 citations
Clear cell mesotheliomas with inactivating VHL mutations and near-haploid genomic features.
Michael Michal, Oleksandr Kravtsov, Jeffrey S Ross, Daniela Skanderová, Petr Martínek, Elaheh Mosaieby, Douglas A Mata, Erik A Williams, Yin P Hung> ;Genes, Chromosomes & Cancer. 2023 May 1
1 citations
Activating IGF1R hotspot non-frameshift insertions define a novel, potentially targetable molecular subtype of adenoid cystic carcinoma.
Matthew Margolis, Tyler Janovitz, Jason Laird, Douglas A Mata, Meagan Montesion, Jessica K Lee, Russell W Madison, Alexa B Schrock, Hanna Tukachinsky, Justin M Allen, ...> ;Modern Pathology. 2022 Nov 1
Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas.
Jamal K Benhamida, Monika Vyas, Atsushi Tanaka, Lu Wang, Armita Bahrami, Olca Basturk, Liliana Villafania, Douglas A Mata, Tony El Jabbour, Pier Selenica, Michael H A ...> ;Modern Pathology. 2022 Jul 1
3 citations
Method of Tissue Acquisition Affects Success of Comprehensive Genomic Profiling in Lung Cancer.
Douglas A Mata, Lukas Harries, Erik A Williams, Matthew C Hiemenz, Brennan Decker, Julie Y Tse, Tyler Janovitz, Donna C Ferguson, Iain A Speece, Matthew L Margolis, Be...> ;Archives of Pathology & Laboratory Medicine. 2023 Mar 1
2 citations
Triggering with 1,500 IU of human chorionic gonadotropin plus follicle-stimulating hormone compared to a standard human chorionic gonadotropin trigger dose for oocyte ...
Yanett Anaya, Hakan Cakmak, Douglas A Mata, Joseph Letourneau, Li Zhang, Nikolaus Lenhart, Flor Juarez-Hernandez, Liza Jalalian, Marcelle I Cedars, Mitchell Rosen> ;Fertility and Sterility. 2022 Aug 1
1 citations
HPV51-associated Leiomyosarcoma: A Novel Class of TP53/RB1-Wildtype Tumor With Predilection for the Female Lower Reproductive Tract.
Erik A Williams, Meagan Montesion, Vadim Lincoln, Julie Y Tse, Matthew C Hiemenz, Douglas A Mata, Bhamini B Shah, Adebowale Shoroye, Brian M Alexander, Adrienne J Wert...> ;The American Journal of Surgical Pathology. 2022 Jun 1
11 citations
DNA methylation analysis of glioblastomas harboring FGFR3-TACC3 fusions identifies a methylation subclass with better patient survival.
Zhichao Wu, Osorio Lopes Abath Neto, Tejus A Bale, Jamal Benhamida, Douglas Mata, Rust Turakulov, Zied Abdullaev, Daniel Marker, Courtney Ketchum, Hye-Jung Chung, Cate...> ;Acta Neuropathologica. 2022 Jul 1
A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost.
Douglas A Mata, Matthew B Greenblatt, Janet Means, Petr Jarolim, Lucas, F.> ;American Journal of Clinical Pathology. 2022 May 4
9 citations
Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors.
Douglas A Mata, Erik A Williams, Ethan Sokol, Geoffrey R Oxnard, Zoe Fleischmann, Julie Y Tse, Brennan Decker> ;JAMA Network Open. 2022 Mar 1
8 citations
Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
Douglas I Lin, Alexander Fine, Natalie A Danziger, Richard S P Huang, Douglas A Mata, Brennan Decker, Jonathan K Killian, Shakti H Ramkissoon, Mirna Lechpammer, Tyler ...> ;Gynecologic Oncology. 2022 Mar 1
14 citations
Predictive Genomic Biomarkers of Hormonal Therapy Versus Chemotherapy Benefit in Metastatic Castration-resistant Prostate Cancer.
Ryon Graf, Virginia Fisher, Joaquin Mateo, Ole Gjoerup, Russell Madison, Kira Raskina, Hanna Tukachinsky, James Creeden, Rachel Cunningham, Richard S.P. Huang, Douglas...> ;European Urology. 2021 Oct 26
8 citations
Androgen receptor splice variant-7 in breast cancer: clinical and pathologic correlations
Donna C. Ferguson, Douglas A. Mata, Timothy Ky. Tay, Tiffany A. Traina, Ayca Gucalp, Sarat Chandarlapaty, Timothy M. D'Alfonso, Edi Brogi, Kerry Mullaney, Marc Ladanyi...> ;Modern Pathology. 2021 Sep 30
18 citations
Clinicopathological and genomic characterization of BCORL1-driven high-grade endometrial stromal sarcomas.
Douglas I. Lin, Richard S.P. Huang, Douglas A. Mata, Brennan Decker, Natalie Danziger, Mirna Lechpammer, Matthew Hiemenz, Shakti H. Ramkissoon, Jeffrey S. Ross, Julia ...> ;Modern Pathology. 2021 Jul 23
14 citations
Clinicopathologic and Genomic Landscape of Breast Carcinoma Brain Metastases.
Richard S.P. Huang, James Haberberger, Kimberly McGregor, Douglas A. Mata, Brennan Decker, Matthew Hiemenz, Mirna Lechpammer, Natalie Danziger, Kelsie Schiavone, James...> ;The Oncologist. 2021 Jun 23
52 citations
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS.
A. Rose Brannon, Gowtham Jayakumaran, Monica Diosdado, Juber Patel, Anna Razumova, Yu Hu, Fanli Meng, Mohammad Haque, Justyna Sadowska, Brian J. Murphy, Tessara Baldi,...> ;Nature Communications. 2021 Jun 18
6 citations
Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression.
Richard S.P. Huang, Brennan Decker, Karthikeyan Murugesan, Matthew Hiemenz, Douglas A. Mata, Gerald Li, James Creeden, Shakti Ramkissoon, Jeffrey S. Ross> ;Journal for Immunotherapy of Cancer. 2021 Jun 1
1 citations
Differences in Gender Representation in the Altmetric Top 100
Lisa S. Rotenstein, Matthew Torre, Jennifer L Cleary, Srijan Sen, Constance Guille, Douglas A. Mata> ;Journal of General Internal Medicine. 2021 May 4
14 citations
Pan-cancer landscape of CD274 (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression
Richard S.P. Huang, Karthikeyan Murugesan, Meagan Montesion, Dean Pavlick, Douglas A. Mata, Matthew Hiemenz, Brennan Decker, Garrett M. Frampton, Lee A. Albacker, Jeff...> ;Journal for Immunotherapy of Cancer. 2021 May 1
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