DouglasCecilWallaceMD

Medical Genetics • Irvine, CA

Clinical Molecular Genetics, Ph.D. Medical Genetics

Physician

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Office
2014 Hewitt Hall
University Of California Irvine
Irvine, CA 92697
Phone+1 949-824-3490
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Summary

Dr. Douglas Wallace, MD is a board certified medical geneticist in Irvine, California.

Certifications & Licensure

American Board of Medical Genetics and Genomics Ph.D. Medical Genetics

Publications & Presentations

PubMed

USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis.
Barca, E.,Ganetzky, R. D.,Potluri, P.,Juanola-Falgarona, M.,Gai, X.,Li, D.,Jalas, C.,Hirsch, Y.,Emmanuele, V.,Tadesse, S.,Ziosi, M.,Akman, H. O.,Chung, W. K.,Tanji, K....> ;Hum. Mol. Genet.. 2018 Jun 20
Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma.
Singh, L. N.,Crowston, J. G.,Lopez Sanchez, MIG.,Van Bergen, N. J.,Kearns, L. S.,Hewitt, A. W.,Yazar, S.,Mackey, D. A.,Wallace, D. C.,Trounce, I. A.> ;Invest. Ophthalmol. Vis. Sci.. 2018 Sep 23
Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy.
McManus, M. J.,Picard, M.,Chen, H. W.,De Haas, H. J.,Potluri, P.,Leipzig, J.,Towheed, A.,Angelin, A.,Sengupta, P.,Morrow, R. M.,Kauffman, B. A.,Vermulst, M.,Narula, J....> ;Cell Metab.. 2018 Sep 04
Mitochondrial DNA associations with East Asian metabolic syndrome.
Chalkia, D.,Chang, Y. C.,Derbeneva, O.,Lvova, M.,Wang, P.,Mishmar, D.,Liu, X.,Singh, L. N.,Chuang, L. M.,Wallace, D. C.> ;Biochim. Biophys. Acta. 2018 Jul 13
Scanning Microwave Microscopy of Vital Mitochondria in Respiration Buffer.
Li, J.,Nemati, Z.,Haddadi, K.,Wallace, D. C.,Burke, P. J.> ;IEEE MTTS Int Microw Symp. 2019 Apr 23
Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP.
Sonney, S.,Leipzig, J.,Lott, M. T.,Zhang, S.,Procaccio, V.,Wallace, D. C.,Sondheimer, N.> ;PLoS Comput. Biol.. 2017 Dec 12
Mitochondrial functions modulate the stress response in mice.
Picard, M.,McManus, M.,Gray, J.,Nasca, C.,Moffat, C.,Kopinsky, P.,Seifert, E.,McEwen, B.,Wallace, D.> ;Psychoneuroendocrinology. 2015 Sep 19
Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia.
Surampalli, A.,Khare, M.,Kubrussi, G.,Wencel, M.,Tanaja, J.,Donkervoort, S.,Osann, K.,Simon, M.,Wallace, D.,Smith, C.,M McInerney-Leo, A.,Kimonis, V.> ;J Genet Couns. 2015 Feb 27
Mutations of Human NARS2, Encoding the Mitochondrial Asparaginyl-tRNA Synthetase, Cause Nonsyndromic Deafness and Leigh Syndrome.
Simon, M.,Richard, E. M.,Wang, X.,Shahzad, M.,Huang, V. H.,Qaiser, T. A.,Potluri, P.,Mahl, S. E.,Davila, A.,Nazli, S.,Hancock, S.,Yu, M.,Gargus, J.,Chang, R.,Al-Sheqai...> ;PLoS Genet.. 2015 Mar 26
Phy-Mer: a novel alignment-free and reference-independent mitochondrial haplogroup classifier.
Navarro-Gomez, D.,Leipzig, J.,Shen, L.,Lott, M.,Stassen, A. P.,Wallace, D. C.,Wiggs, J. L.,Falk, M. J.,van Oven, M.,Gai, X.> ;Bioinformatics. 2014 Dec 17
Mitochondrial Disease Sequence Data Resource (MSeqDR): A global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genom...
Falk, M. J.,Shen, L.,Gonzalez, M.,Leipzig, J.,Lott, M. T.,Stassen, A. P.,Diroma, M. A.,Navarro-Gomez, D.,Yeske, P.,Bai, R.,Boles, R. G.,Brilhante, V.,Ralph, D.,DaRe, J...> ;Mol. Genet. Metab.. 2014 Dec 30
Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming.
Picard, M.,Zhang, J.,Hancock, S.,Derbeneva, O.,Golhar, R.,Golik, P.,O'Hearn, S.,Levy, S.,Potluri, P.,Lvova, M.,Davila, A.,Lin, C. S.,Perin, J. C.,Rappaport, E. F.,Hako...> ;Proc. Natl. Acad. Sci. U.S.A.. 2014 Sep 07
Inherited Mitochondrial DNA Variants Can Affect Complement, Inflammation, and Apoptosis Pathways: Insights into Mitochondrial-Nuclear Interactions.
Kenney, M. C.,Chwa, M.,Atilano, S. R.,Falatoonzadeh, P.,Ramirez, C.,Malik, D.,Tarek, M.,Cáceres Del Carpio, J.,Nesburn, A. B.,Boyer, D. S.,Kuppermann, B. D.,Vawter, M....> ;Hum. Mol. Genet.. 2014 Mar 04
mtDNA Variation and Analysis Using MITOMAP and MITOMASTER.
Lott, M. T.,Leipzig, J. N.,Derbeneva, O.,Xie, H. M.,Chalkia, D.,Sarmady, M.,Procaccio, V.,Wallace, D. C.> ;Curr Protoc Bioinformatics. 2014 Dec 10
Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility t...
Kenney, M. C.,Chwa, M.,Atilano, S. R.,Falatoonzadeh, P.,Ramirez, C.,Malik, D.,Tarek, M.,Del Carpio, J. C.,Nesburn, A. B.,Boyer, D. S.,Kuppermann, B. D.,Vawter, M. P.,J...> ;Biochim. Biophys. Acta. 2013 Nov 10
Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome.
Yazdi, P. G.,Su, H.,Ghimbovschi, S.,Fan, W.,Coskun, P. E.,Nalbandian, A.,Knoblach, S.,Resnick, J. L.,Hoffman, E.,Wallace, D. C.,Kimonis, V. E.> ;Clin Transl Sci. 2013 Oct 17
Assessing Bioenergetic Compromise in Autism Spectrum Disorder With 31P Magnetic Resonance Spectroscopy: Preliminary Report.
Golomb, B. A.,Erickson, L. C.,Scott-Van Zeeland, A. A.,Koperski, S.,Haas, R. H.,Wallace, D. C.,Naviaux, R. K.,Lincoln, A. J.,Reiner, G. E.,Hamilton, G.> ;J. Child Neurol.. 2013 Oct 22
Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle.
Picard, M.,Gentil, B. J.,McManus, M. J.,White, K.,St Louis, K.,Gartside, S. E.,Wallace, D. C.,Turnbull, D. M.> ;J. Appl. Physiol.. 2013 Aug 22
Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.
Wallace, D. C.> ;Philos. Trans. R. Soc. Lond., B, Biol. Sci.. 2013 Jun 12
Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium.
Yang, J. Y.,Deng, W.,Chen, Y.,Fan, W.,Baldwin, K. M.,Jope, R. S.,Wallace, D. C.,Wang, P. H.> ;J. Mol. Cell. Cardiol.. 2013 Jun
Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.
Chen, P. L.,Chen, C. F.,Chen, Y.,Guo, X. E.,Huang, C. K.,Shew, J. Y.,Reddick, R. L.,Wallace, D. C.,Lee, W. H.> ;Oncogene. 2013 Feb 28
Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup.
Strauss, K. A.,Dubiner, L.,Simon, M.,Zaragoza, M.,Sengupta, P. P.,Li, P.,Narula, N.,Dreike, S.,Platt, J.,Procaccio, V.,Ortiz-González, X. R.,Puffenberger, E. G.,Kelley...> ;Proc Natl Acad Sci USA. 2013 Feb 26
Mitochondrial DNA Variants Mediate Energy Production and Expression Levels for CFH, C3 and EFEMP1 Genes: Implications for Age-Related Macular Degeneration.
Kenney, M. C.,Chwa, M.,Atilano, S. R.,Pavlis, J. M.,Falatoonzadeh, P.,Ramirez, C.,Malik, D.,Hsu, T.,Woo, G.,Soe, K.,Nesburn, A. B.,Boyer, D. S.,Kuppermann, B. D.,Jazwi...> ;PLoS ONE. 2013
Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions.
Zhang, C., Huang, V. H., Simon, M., Sharma, L. K., Fan, W., Haas, R., Wallace, D. C., Bai, Y., Huang, T.> ;FASEB J. 2012 Dec
Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts.
Fielder, T. J., Yi, C. S., Masumi, J., Waymire, K. G., Chen, H. W., Wang, S., Shi, K. X., Wallace, D. C., Macgregor, G. R.> ;Transgenic Res. 2012 Dec
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Press Mentions

321: Detoxification, Mitochondrial Health, Biophysics, and Figuring Out Your Optimal with Caleb JenningsMarch 12th, 2020