DushyantPurushottamPurohitMD

PubMed

• 14 citations
  Genome-wide association study and functional validation implicates JADE1 in tauopathy.
  Kurt Farrell, SoongHo Kim, Natalia Han, Megan A. Iida, Elias M. Gonzalez, Marcos Otero-Garcia, Jamie M. Walker, Timothy E. Richardson, Alan E. Renton, Shea J. Andrews,...> ;Acta Neuropathologica. 2021 Nov 1
• 30 citations
  Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
  Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson, Gabriel A. Marx, Clare Bryce, Dushyant P. Purohit, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, E...> ;Acta Neuropathologica Communications. 2021 Aug 5
• 63 citations
  Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19.
  John F. Fullard, Hao-Chih Lee, Georgios Voloudakis, Shengbao Suo, Behnam Javidfar, Zhiping Shao, Cyril J. Peter, Wen Zhang, Shan Jiang, André Corvelo, Heather Wargnier...> ;Genome Medicine. 2021 Jul 19
• 30 citations
  Progressive Multifocal Leukoencephalopathy in a Patient With Progressive Multiple Sclerosis Treated With Ocrelizumab Monotherapy.
  Arpan Patel, James Sul, Marc L. Gordon, Jared Steinklein, Shayna Sanguinetti, Bidyut Pramanik, Dushyant P. Purohit, Vahram Haroutunian, Alex K. Williamson, Igor J. Kor...> ;JAMA Neurology. 2021 Jun 1
• 31 citations
  Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.
  Jamie M. Walker, Timothy E. Richardson, Kurt Farrell, Megan A. Iida, Chan Foong, Ping Shang, Johannes Attems, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, Andrew E. B...> ;Journal of Neuropathology and Experimental Neurology. 2021 Jan 20
• 13 citations
  Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients
  Andrew Pearson, Rosa Ajoy, Gogce Crynen, Jon Reed, Moustafa Algamal, Michael Mullan, Dushyant P. Purohit, Fiona Crawford, Joseph O. Ojo> ;BMC Neurology. 2020 Aug 27
• 58 citations
  Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.
  Maxim Signaevsky, Marcel Prastawa, Kurt Farrell, Nabil Tabish, Elena Baldwin, Natalia Han, Megan A. Iida, John Koll, Clare Bryce, Dushyant P. Purohit, Vahram Haroutuni...> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2019 Feb 15
• 38 citations
  Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain
  Sharon B. Shively, Sarah L. Edgerton, Diego Iacono, Dushyant P. Purohit, Bao-Xi Qu, Vahram Haroutunian, Kenneth L. Davis, Ramon Diaz-Arrastia> ;Acta Neuropathologica. 2017 Mar 1
• 66 citations
  The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dem...
  Panos Roussos, Pavel Katsel, Peter Fam, Weilun Tan, Dushyant P. Purohit, Vahram Haroutunian> ;Alzheimer's & Dementia. 2015 Oct 1
• 44 citations
  Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease
  Pavel Katsel, Weilun Tan, Peter Fam, Dushyant P. Purohit, Vahram Haroutunian> ;Plos One. 2013 Jul 5
• 6 citations
  Characterizing Cognitive Deficits and Dementia in an Aging Urban Population in India
  G. Nair, K. Van Dyk, U. Shah, Dushyant P. Purohit, C. Pinto, A. B. Shah, Hillel Z. Grossman, Shanti Shanker, Mary Sano, Daniel P. Perl> ;International Journal of Alzheimer's Disease. 2012 Jun 27
• 28 citations
  Cholesterol and LDL Relate to Neuritic Plaques and to APOE4 Presence but Not to Neurofibrillary Tangles
  Gerson T. Lesser, Michal Schnaider Beeri, James Schmeidler, Dushyant P. Purohit, Vahram Haroutunian> ;Current Alzheimer Research. 2011 May 1
• 24 citations
  Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology.
  Michal Schnaider Beeri, James Schmeidler, Gerson T. Lesser, Maria Maroukian, Rebecca K. West, Stephanie Leung, Michael Wysocki, Dushyant P. Purohit, Vahram Haroutunian> ;Neurobiology of Aging. 2012 Jul 1
• 12 citations
  Profiles of Alzheimer's Disease-Related Pathology in an Aging Urban Population Sample in India
  Dushyant P. Purohit, Nirmala Batheja, Mary Sano, Kusum D. Jashnani, Rajesh N. Kalaria, Arivarasan Karunamurthy, Shalinder Kaur, Asha S. Shenoy, Kathleen Van Dyk, James...> ;Journal of Alzheimer's Disease. 2011 Jan 1
• 22 citations
  Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients.
  Michael A. Rapp, Michal Schnaider-Beeri, Dushyant P. Purohit, Abraham Reichenberg, Susan R. McGurk, Vahram Haroutunian, Philip D. Harvey> ;Schizophrenia Research. 2010 Jan 1
• 16 citations
  Parkinson's disease dementia – A diminished role for the Lewy body
  Leslie S. Libow, Pasquale G. Frisina, Vahram Haroutunian, Dushyant P. Purohit> ;Parkinsonism & Related Disorders. 2009 Sep 1
• 56 citations
  Number of children is associated with neuropathology of Alzheimer's disease in women
  Michal Schnaider Beeri, Michael A. Rapp, James Schmeidler, Abraham Reichenberg, Dushyant P. Purohit, Hillel Grossman, Isak Prohovnik, Vahram Haroutunian, Jeremy M. Sil...> ;Neurobiology of Aging. 2009 Aug 1
• 112 citations
  Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons.
  Lisa B Kleiner Hoffman, James Schmeidler, Gerson T. Lesser, Michal Schnaider Beeri, Dushyant P. Purohit, Hillel Grossman, Vahram Haroutunian> ;Neurology. 2009 May 19
• 31 citations
  Serum Lipids Are Related to Alzheimer’s Pathology in Nursing Home Residents
  Gerson T. Lesser, Vahram Haroutunian, Dushyant P. Purohit, Michal Schnaider Beeri, James Schmeidler, Linda Honkanen, Richard R. Neufeld, Leslie S. Libow> ;Dementia and Geriatric Cognitive Disorders. 2009 Jan 8
• 122 citations
  Role of the neuropathology of Alzheimer disease in dementia in the oldest-old.
  Vahram Haroutunian, Michal Schnaider-Beeri, James Schmeidler, Michael Wysocki, Dushyant P. Purohit, Leslie S. Libow, Gerson T. Lesser, Maria Maroukian, Hillel Grossman> ;Archives of Neurology. 2008 Sep 8
• 116 citations
  Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology.
  Michal Schnaider Beeri, James Schmeidler, Jeremy M. Silverman, Sam Gandy, Michael Wysocki, Christine Hannigan, Dushyant P. Purohit, Gerson T. Lesser, Hillel Grossman, ...> ;Neurology. 2008 Sep 2
• 49 citations
  Galanin-like immunoreactivity is increased in the postmortem cerebral cortex from patients with Alzheimer's disease.
  Steven M. Gabriel, Linda M. Bierer, Michael H. Davidson, Dushyant P. Purohit, Vahram Harotunian> ;Journal of Neurochemistry. 2008 Jun 28
• 8 citations
  Clinical Dementia Rating Performed Several Years prior to Death Predicts Regional Alzheimer's Neuropathology
  Michal Schnaider Beeri, Jeremy M. Silverman, James Schmeidler, Michael Wysocki, Hillel Z. Grossman, Dushyant P. Purohit, Vahram Haroutunian> ;Dementia and Geriatric Cognitive Disorders. 2008 Mar 27
• 130 citations
  Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression.
  Michael A. Rapp, Michal Schnaider-Beeri, Dushyant P. Purohit, Vahram Haroutunian, Mary Sano> ;The American Journal of Geriatric Psychiatry. 2008 Feb 1
• 65 citations
  Tau protein abnormalities associated with the progression of alzheimer disease type dementia.
  Vahram Haroutunian, Peter Davies, C. Vianna, Joseph D. Buxbaum, Dushyant P. Purohit> ;Neurobiology of Aging. 2007 Jan 1
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Journal Articles

• Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease [corrected]  
  Katsel P, Tan W, Fam P, Purohit DP, Haroutunian V, PLoS One, 1/1/2013
• Characterizing Cognitive Deficits and Dementia in an Aging Urban Population in India  
  Nair G, Van Dyk, U. Shah, D. P. Purohit, C. Pinto, A. B. Shah, H. Grossman, D. Perl, V. Ganwir, S. Shanker, and M. Sano, Int J Alzheimer's Dis, 1/1/2012
• Less Alzheimer’s disease neuropathology in medicated hypertensive than normotensive persons  
  Hoffman LB, Schmeidler J, Lesser GT, Beeri MS, Purohit DP, Grossman HT, Haroutunian V, Neurology, 1/1/2009
• Parkinson’s disease dementia: a diminished role for the Lewy body  
  Libow LS, Frisina PG, Haroutunian V, Perl DP, Purohit DP, Parkinsonism Relat Disord, 1/1/2009
• Serum lipids are related to Alzheimer’s pathology in nursing home patients  
  Lesser GT, Haroutunian V, Purohit DP, Schnaider Beeri M, Schmeidler J, Honkanen L, Neufeld R, Libow LS, Dement Geriatr Cogn Disord, 1/1/2009
• Role of neuropathology of Alzheimer’s disease in dementia in the oldest old  
  Haroutunian V, Schnaider-Beeri M, Schmeidler J, Wysocki M, Purohit DP, Perl DP, Libow LS, Lesser GT, Maroukian M, Grossman HT, Arch Neurol, 1/1/2008
• Clinical dementia rating performed several years prior to death predicts regional Allzheimer's neuropathology  
  Schnaider Beeri M, Silverman JM, Schmeidler J, Wysocki M, Grossman HZ, Purohit DP, Perl DP, Haroutunian V, Dement Geriatr Cogn Disord, 1/1/2008
• Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia  
  Xiang Z, Haroutunian V, Ho L, Purohit D, Pasinetti GM, Dis Markers, 1/1/2006
• Coronary artery disease is associated with Alzheimer’s disease neuropathology in APOE 4 carriers  
  Beeri MS, Rap M, Silvrman J, Schmeidler J, Grossman HT, Fallon JT, Purohit DP, Perl, DP. Siddiqui A, Lesser G, Rssendorff, C, Haroutunian, V, Neurology, 1/1/2006
• Pituicytoma presenting with spontaneous hemorrhage: Case report  
  Benveniste RJ, Purohit D, Byun H, Pituitary, 1/1/2006
• Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology  
  Beeri MS, Silverman JM, Davis KL, Marin D, Grossman HZ, Schmeidler J, Purohit DP, Perl DP, Davidson M, Mohs RC, Haroutunian V, J Gerontol A Biol Sci Med Sci, 1/1/2005
• Depression in AutopsyConfirmed Dementia with Lewy Bodies and Alzheimer's Disease  
  Samuels SC, Brickman AM, Burd JA, Purohit DP, Qureshi PQ, Serby M, Mt Sinai J Medicine, 1/1/2004
• Isolated autonomic failure as an initial presentation of Parkinson’s disease and dementia with Lewy bodies  
  Kaufmann H, Nahm K, Purohit D and Wolfe D, Neurology, 1/1/2004
• Cognitive burden and excess Lewy body formation in the Lewy body variant of Alzheimer Disease  
  Serby M, Brickman AM, Haroutunian V, Purohit DP, Marin, D, Lantz M, Mohs RC, Davis, KL, Am J Geriatric Psychiatry, 1/1/2003
• Co-occurrence of essential tremor and Parkinson’s disease: Clinical study of a large kindred with autopsy findings  
  Yahr MD, Orosz D, Purohit DP, Parkinsonism and Related Disorders, 1/1/2003
• Severe generalized dystonia due to primary putaminal degeneration: Case report and review of the literature  
  Walker RH, Purohit DP, Good P, Perl DP, Brin, MF, Movement Disorders, 1/1/2002
• Neuronal cyclooxygenase-2 in the hippocampal formation as a function of the clinical progression of Alzheimer's disease  
  Ho L, Purohit DP, Haroutunian V, Luterman JD, Willis, F, Naslund J, Buxbaum, JD, Mohs RC, Aisen PS, Pasinetti, GM, Arch Neurol, 1/1/2001
• Plaques and Cognitive Decline  
  S Parvathy, Davies P, Haroutunian V, Purohit DP, Davis KL, Mohs RC, Park H, Moran TM, Chan JY, Buxbaum JD, Arch Neurol, 1/1/2001
• Intramedullary spinal enterogenous cysts: Case report and review of the literature  
  Lippman CR, Argineteau M, Purohit DP, Naidich TP, Camins MB, J Neurosurgery, 1/1/2001
• Altered synapsin a-type but not b-type isoform in brain of patients at high risk for Alzheimer's disease assessed by DNA-microarray technique  
  Ho, L, Guo, Y, Spielman, L, Haroutunian, V, Purohit DP, Czernik, A, Yemul, S, Aisen, PS, Mohs, R, Pasinetti, GM, Neurosci Lett, 1/1/2001
• Contribution of Lewy body inclusions to dementia in patents with and without Alzheimer’s disease  
  Haroutunian V, Serby M, Purohit DP, Perl DP, Marin D,, Lantz, M, Mohs RC, Davis KL, Arch Neurol, 1/1/2000
• Cytokine gene expression as a function of the clinical progression of Alzheimer's disease dementia  
  Luterman JD, Haroutunian V,Yemul S, Ho L, Purohit DP, Aisen PS, Mohs R, Pasinetti GM, Arch Neurol, 1/1/2000
• Neuropeptide abnormalities in the patients with early Alzheimer Disease  
  Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz, M, Austin G, Haroutunian V, Arch Gen Psychiatry, 1/1/1999
• Regional distribution of neurofibrillary tangles in non-demented elderly and cases od very mild Alzheimer’s disease  
  Haroutunian V, Purohit DP, Perl DP, Marin D, Khan K, Lantz, M, Davis KL, Mohs RC, Arch Neurol, 1/1/1999
• Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer’s disease  
  Ho L, Pieroni C, Winger D, Purohit DP, Aisen P, Pasinetti, G, J Neurosci Res, 1/1/1999
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Books/Book Chapters

• Neuroimaging:The Essential 
  Chapter: Normal Anatomy of the Brain: What You Need to Know. 
  Page 16 - 39De Leary R, Fowkes ME, Yourtry TA, Habil M, Purohit D, Carpenter DM and Naidich TPEditors: Pina C. Sanelli, Pamela W. Schaefer and Laurie A. Loevner.Wolters Kluwer2015
• Cingulate Neurobiology and Disease 
  Chapter: Cingulate Subregional Neuropathology in Dementia with Lewy Bodies and Parkinson’s disease with Dementia. 
  Page 708 - 728Brent A. Vogt, Leslie Vogt, Purohit Dushyant P and Patrick R. HofEditors: Brent A Vogt.Oxford U. Press2009
• New Advances in Toxicology and Epidemiology. 
  Chapter: Amyotrophic lateral sclerosis in Caucasian Mainland U.S. born long-term resident on Guam - A case report including neuropathological examination in ALS. 
  Page 99 - 102Perl DP, Steele JC, Purohit DPEditors: F. Clifford Rose and Forbes H. Norris.Smith-Gordon, London1990

Abstracts/Posters

• Age-Related Cognitive Loss in Mumbai, India, A Research Partnership 2004-2012.
  Purohit DP, Sano M, Batheja P, Pinto, Deshpande J, Shah AB and Jashnani J, 10th Anniversary Brain Disorders in Developing Countries Symposium, NIH Campus, Bethesda, MD, 1/11/2014
• A Clinicopathological Correlation Study of Cognitive Status and Senile Plaques and Neurofibrillary Tangles in Clinically Well- Characterized Individuals of Extreme old...
  Purohit DP, FASEB Journal; Eighty-Fourth Annual Meeting of American Association of Neuropathologists, San Diego, CA, 1/1/2008
• Clinical and neuropathologic studies of age-related cognitive loss in Mumbai, India.
  Purohit DP, Alzheimer’s and Dementia; 10th International Conference on Alzheimer's Disease and related Disorders, Madrid, Spain, 1/15/2006

Lectures

• Type-2 Diabetes, Cognitive Impairment and Dementia 
  Sir HN Reliance Foundation Hospital and Research Center, Mumbai, India - 1/13/2015
• Single Episode of Severe Axonal Injury in Humans Can Lead to Tau Pathology Resembling Chronic Traumatic Encephalopathy. 
  Portland, OR - 1/12/2014
• Direct and Indirect Impacts of Research Collaborations in Developing Countries 
  NIH Campus, Bethesda, MD - 1/11/2014
• Review and Diagnostic Application of the NIA-AA Guidelines for Neuropathological Assessment of Alzheimer’s disease 
  Chicago, IL - 1/22/2012
• Advancement of Clinical Services and Research on Dementia in an Urban Setting in India through International Collaboration 
  Nairobi, Kenya - 1/4/2012
• Progress in Research Development on Dementia in NIH funded Project in Mumbai, India. 
  Nairobi, Kenya - 1/28/2007
• Neuropathology of Dementia in India. 
  Nairobi, Kenya - 1/22/2001
• Pathobiologic correlates of dementia. 
  Jewish Home & Hospital, Bronx, NY - 1/20/1999
• Alzheimer’s disease and allied dementing disorders. 
  Jewish Home and Hospital, New York, NY - 1/16/1999
• Diffuse plaque formation in the cerebral cortex of non-demented elderly and individuals with mild to moderate dementia. 
  Amsterdam, Netherlands - 1/1/1998
• Neuropathologic evidence for the existence of Alzheimer’s disease in an urban population of Bombay, India. 
  Vancouver, British Columbia, Canada - 1/1/1996
• Alzheimer’s disease and allied neurodegenerative Diseases: Neuropathological diagnosis. 
  New Delhi, India - 1/1/1995
• Alzheimer's disease and related neurodegenerative diseases in elderly schizophrenic patients. 
  San Antonio, TX - 1/1/1995
• Pathology of Alzheimer’s disease: The significance of neuropathologic study of non-demented elderly. 
  Grant Medical College, Bombay, India - 1/1/1995
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  Toronto, Ontario, Canada - 1/1/1994
• ALS/Parkinsonism complex of Guam among Filipino migrants to Guam. 
  St. Louis, MO - 1/1/1992
• Dementia in elderly schizophrenics: is it related to the superimposed Alzheimer's disease? 
  Baltimore, MD - 1/1/1991
• Primary cerebellar degeneration presenting as progressive familial dementia. 
  Toronto, Canada - 1/1/1990
• Alzheimer-type Pathology in Dentate Gyrus of the Hippocampus. 
  Dallas, TX - 1/1/1989
• Identification of an Atypical Senile Dementia Syndrome. 
  Newcastle upon Tyne, England - 1/5/1988
• Intracranial Hemorrhage in a Case of Neuro-syphilis. 
  London, England - 1/1/1986
• Neuropathology of Alzheimer’s disease. 
  Newcastle upon Tyne, England - 1/5/1985
• Pathological significance of neurofibrillary tangle formation in mid brain and brain stem nuclei in Alzheimer's disease. 
  Bristol, England - 1/1/1985
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