EddyAngladeMD

Ophthalmology • Jersey City, NJ

Uveitis

Executive Vice President of Clinical Development

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Office
Harborside Financial Center, Plaza 10
14th floor
Jersey City, NJ 07302
Phone+1 201-946-0223

Fax+1 866-331-2790
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Education & Training

Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolResidency, Ophthalmology, 1990 - 1993
Yale School of MedicineClass of 1989
Columbia UniversityAB, 1989

Awards, Honors, & Recognition

Best R&D Project Proposal or Idea Enzon Pharmaceuticals Inc, 2002, 2004
Best R&D Team Effort Enzon Pharmaceuticals Inc, 2003

Clinical Trials

A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Start of enrollment: 2007 Jan 01
Completed
Phase 3
A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Start of enrollment: 2007 Jan 01
Completed
Phase 3
A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Start of enrollment: 2007 Jan 01
Completed
Phase 3
Study to Assess LX201 for Prevention of Corneal Allograft Rejection or Graft Failure in Subjects Who Have Experienced One or More Rejection Episodes Following Penetrating Keratoplasty Start of enrollment: 2007 Apr 01
Terminated
Phase 3
Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Start of enrollment: 2011 Feb 01
Completed
Phase 3
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Publications & Presentations

PubMed

141 citations
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration
Manjit S Mehat, Venki Sundaram, Caterina Ripamonti, Anthony G. Robson, Alexander J. Smith, Shyamanga Borooah, Martha Robinson, Adam N. Rosenthal, William Innes, Richar...> ;Ophthalmology. 2018 Jun 5
7 citations
Stem cells in age-related macular degeneration and Stargardt's macular dystrophy - Authors' reply.
Steven D. Schwartz, Eddy Anglade, Robert Lanza> ;Lancet. 2015 Jul 4
799 citations
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open...
Steven D. Schwartz, Carl D. Regillo, Byron L. Lam, Dean Eliott, Philip J. Rosenfeld, Ninel Z. Gregori, Jean-Pierre Hubschman, Janet L. Davis, Gad Heilwell, Marc J. Spi...> ;Lancet. 2015 Feb 7
20 citations
LX211 (Voclosporin) Suppresses Experimental Uveitis and Inhibits Human T Cells
Matthew A. Cunningham, Bobbie Ann Austin, Zhuqing Li, Baoying Liu, Steven Yeh, Chi-Chao Chan, Eddy Anglade, Poonam Velagaleti, Robert B. Nussenblatt> ;Investigative Ophthalmology & Visual Science. 2009 Jan 1
19 citations
A new agent for the treatment of noninfectious uveitis: rationale and design of three LUMINATE (Lux Uveitis Multicenter Investigation of a New Approach to Treatment) t...
Eddy Anglade, Launa J Aspeslet, Sidney L Weiss> ;Clinical Ophthalmology. 2008 Dec 5
26 citations
Next-generation calcineurin inhibitors for ophthalmic indications.
Eddy Anglade, Randall W. Yatscoff, Robert T. Foster, Ulrich Grau> ;Expert Opinion on Investigational Drugs. 2007 Oct 9
12 citations
Argatroban therapy in women with heparin-induced thrombocytopenia.
Ik-Kyung Jang, Suzanne J. Baron, Marcie J. Hursting, Eddy Anglade> ;Journal of Women's Health. 2007 Jul 1
27 citations
Recombinant adenovirus-mediated gene transfer into the adult rat retina
Eddy Anglade, Karl G. Csaky> ;Current Eye Research. 1998 Jan 1
38 citations
Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells
Daniel M. Sullivan, Lauri Erb, Eddy Anglade, Gary A. Weisman, John T. Turner, Karl G. Csaky> ;Journal of Neuroscience Research. 1997 Jul 1
2 citations
Interleukin-10 immunoadhesin production by a replication-defective adenovirus
Eddy Anglade, Daniel M. Sullivan, Karl G. Csaky> ;Journal of Immunological Methods. 1997 Mar 10
18 citations
Adenovirus-mediated gene transfer of ornithine aminotransferase in cultured human retinal pigment epithelium.
Daniel M. Sullivan, Daniel C. Chung, Eddy Anglade, Robert B. Nussenblatt, Karl G. Csaky> ;Investigative Ophthalmology & Visual Science. 1996 Apr 1
20 citations
The diagnosis and management of uveitis.
Eddy Anglade, Scott M. Whitcup> ;Drugs. 1995 Feb 1
63 citations
Recoverin is highly uveitogenic in Lewis rats.
Igal Gery, Norman P. Chanaud, Eddy Anglade> ;Investigative Ophthalmology & Visual Science. 1994 Jul 1
5 citations
Brown's syndrome.
Eddy Anglade, Craig A. McKeown, Richard M. Robb> ;International Ophthalmology Clinics. 1992 Jan 1
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Journal Articles

A comparison of human and murine cytomegalovirus promoters on gene expression in adult rat ocular tissues.
Anglade E, Chung DC, Sullivan DM, Nussenblatt RB, Graham F, Csaky KG, Invest Ophthalmol Vis Sci 1996; 37:S771
Comparison of lipofection, calcium phosphate co-precipitation and adenovirus facilitated lipofection mediated ex vivo gene transfer into cultured human retinal pigment...
Chung DC, Anglade E, Sullivan DM, Nussenblatt RB, Csaky KG, Invest Ophthalmol Vis Sci 1996; 37:S9
The use of green fluorescent protein to monitor gene transfer in human retinal pigment epithelial cells.
Csaky KG, Sullivan DM, Lee YJ, Chung DC, Nussenblatt RB, Anglade E, Invest Ophthalmol Vis Sci 1996; 37:S640
Overexpression of ornithine-?-aminotransferase in keratinocytes cultured from gyrate atrophy patients.
Sullivan DM, Chung DC, Taichman LB, Nussenblatt RB, Anglade E, Csaky KG, Invest Ophthalmol Vis Sci 1996; 37:S1047
Production of an immunoadhesin with antagonist activity towards the murine interleukin-2 receptor.
Anglade E, Sullivan DM, Nussenblatt RB, Csaky KG, Invest Ophthalmol Vis Sci 1995; 36:S542
Adenovirus mediated gene transfer of transforming growth factor beta-1 in cultured human RPE.
Sullivan DM, Anglade E, Salamon C, Hooks JJ, Nussenblatt RB, Csaky KG, FASEB J 1995; 9:A512
Recoverin is a potent uveitogen in Lewis rats.
Anglade E, Chanaud III NP, Gery I, Invest Ophthalmol Vis Sci 1994; 35:S2244
Uveitogenicity, immunogenicity and antigenicity of neurocalcin and chimeric molecules of neurocalcin and recoverin.
Vistica BP, Anglade E, Gery I, Invest Ophthalmol Vis Sci 1994; 35:S2245
The effect of mitomycin-C and 5-fluorouracil on corneal endothelium in trabeculectomy surgery.
Anglade E, Dreyer EB, Invest Ophthalmol Vis Sci 1993; 34:S130
Brown’s Syndrome.
Anglade E, McKeown CA, Robb RM, Int Ophthalmol Clin 1992; 63-70
Lymphokine requirements for receptor- mediated T-cell activation.
Anglade E, Bluestone JA, Irving SG, Kelly K, Hodes RJ, Immunobiology 1987; supplement 3:1
Gene Expression during receptor-mediated T-cell activation.
Anglade E, Irving SG, Kelly K, Hodes RJ, Fed Proc 1987; 46:853
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Abstracts/Posters

Subcutaneous injections of LX211 prevent and reverse experimental autoimmune uveoretinitis in rats.
Cunningham MA, Li Z, Liu et al, Invest Ophthal Vis Sci 2007; Abstract No. 2640, The Association for Research in Vision and Ophthalmology Annual Meeting
Subretinal adenovirus-mediated gene transfer of vascular endothelial growth factor-165 in adult rats results in the development of fibrovascular proliferation.
Csaky KG, Nussenblatt RB, Anglade E, Keystone Molecular Biology Symposium 1997; abstract

Lectures

T-cell activation in the mouse. Doctor of Medicine Thesis.
Yale University School of Medicine

Other

Immunoadhesins, Methods of production and use thereof.
Eddy Anglade, Karl G. Csaky, Daniel M. Sullivan, William LaRochelle, Patient. No. 5,998,598

Press Mentions

Glaucoma 360 Reaches Milestones in Search of Glaucoma CureJanuary 29th, 2016