EdgarTurnerOvertonMD

Infectious Disease • Birmingham, AL

Assistant Professor, Medicine, University of Alabama School of Medicine

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Office
908 20th St S
Birmingham, AL 35294
Phone+1 205-934-5191

Fax+1 314-975-6027
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Infectious Disease, 2002 - 2004
University of Alabama Medical CenterResidency, Internal Medicine, 1999 - 2002
University of Tennessee Health Science Center College of MedicineClass of 1999

Certifications & Licensure

AL State Medical License 2001 - 2023
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Clinical Trials

Safety and Effectiveness of an Adjuvant in Improving Immune Response to Hepatitis B Virus Vaccine in HIV Infected Individuals
Completed
Phase 2
Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Start of enrollment: 2006 Jun 01
Completed
Phase 2
High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART Start of enrollment: 2011 Sep 01
Completed
Phase 2
Safety Study of FluMist With and Without Ampligen Start of enrollment: 2012 Apr 01
Terminated
Phase 1, Phase 2
FTC/RPV/TDF on T-Cell Activation, CD4+ T-Cell Count, Inflammatory Biomarkers and Viral Reservoir Start of enrollment: 2013 Apr 25
Completed
Phase 4
Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery Start of enrollment: 2014 Jul 02
Completed
Phase 2
Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Start of enrollment: 2014 Apr 28
Completed
Phase 2
Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers Start of enrollment: 2016 Apr 01
Completed
Phase 2
PREPARE (A5361s) Substudy of REPRIEVE (A5332) Start of enrollment: 2017 Feb 28
Active, not recruiting
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Publications & Presentations

PubMed

Association Between Metformin Use and Cognitive and Physical Function in Persons with HIV and Diabetes.
Mary Clare Masters, Janeway Granche, Jingyan Yang, Edgar T Overton, Scott Letendre, Susan L Koletar, Leah H Rubin, Todd T Brown, Katherine Tassiopoulos, Kristine M Erl...> ;AIDS Research and Human Retroviruses. 2023 Mar 17
Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection: 152-week results from ATLAS-2M, a randomized, open-label, Phase 3b, nonin...
Edgar T Overton, Gary Richmond, Giuliano Rizzardini, Anders Thalme, Pierre-Marie Girard, Alexander Wong, Norma Porteiro, Susan Swindells, Jacques Reynes, Sebastian Noe...> ;Clinical Infectious Diseases. 2023 Jan 20
A randomized phase 3 trial to assess the immunogenicity and safety of 3 consecutively produced lots of freeze-dried MVA-BN® vaccine in healthy adults.
Edgar Turner Overton, Darja Schmidt, Sanja Vidojkovic, Erika Menius, Katrin Nopora, Jane Maclennan, Heinz Weidenthaler> ;Digestive Diseases and Sciences. 2023 Jan 9
1 citations
Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV.
Pamela S Douglas, Sara McCallum, Michael T Lu, Triin Umbleja, Kathleen V Fitch, Borek Foldyna, Markella V Zanni, Evelynne S Fulda, Gerald S Bloomfield, Carl J Fichtenb...> ;AIDS. 2023 Mar 1
Parents' Acceptance of COVID-19 Compared to Human Papillomavirus Vaccines.
Alison Footman, Nita Kanney, Linda M Niccolai, Gregory D Zimet, Edgar Turner Overton, Susan L Davies, Barbara Van Der Pol> ;The Journal of Adolescent Health. 2022 Dec 1
Sex Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation Among People With Human Immunodeficiency Virus in the United States.
Markella V Zanni, Borek Foldyna, Sara McCallum, Tricia H Burdo, Sara E Looby, Kathleen V Fitch, Evelynne S Fulda, Patrick Autissier, Gerald S Bloomfield, Carlos D Malv...> ;Clinical Infectious Diseases. 2023 Jan 13
Brief Report: Intracellular Cystatin B Levels Are Altered in HIV-Infected Participants With Respect to Neurocognitive Status and Antiretroviral Therapy.
Skye Opsteen, David Moylan, Babafemi O Taiwo, Kevin R Robertson, E Turner Overton, Gary R Cutter, Steffanie Sabbaj, Sonya L Heath, John J Shacka> ;Journal of Acquired Immune Deficiency Syndromes. 2022 Dec 15
1 citations
Risk Factors for Incident Hypertension Within 1 Year of Initiating Antiretroviral Therapy Among People with HIV.
Mohammed Siddiqui, T J Moore, Dustin M Long, Greer A Burkholder, Amanda Willig, Christina Wyatt, Sonya Heath, Paul Muntner, Edgar Turner Overton> ;AIDS Research and Human Retroviruses. 2022 Sep 1
1 citations
Liver Inflammation Is Common and Linked to Metabolic Derangements in Persons With Treated Human Immunodeficiency Virus (HIV).
Kara W Chew, Kunling Wu, Katherine Tassiopoulos, Frank J Palella, Susanna Naggie, Netanya S Utay, Edgar T Overton, Mark Sulkowski> ;Clinical Infectious Diseases. 2023 Feb 8
Cytomegalovirus Immunoglobulin G (IgG) Titer and Coronary Artery Disease in People With Human Immunodeficiency Virus (HIV).
Samuel R Schnittman, Michael T Lu, Thomas Mayrhofer, Tricia H Burdo, Kathleen V Fitch, Sara McCallum, Evelynne S Fulda, Markella V Zanni, Borek Foldyna, Carlos Malvest...> ;Clinical Infectious Diseases. 2023 Feb 8
Chlamydia Vaccination: Parent Opinions and Implications for Future Promotion Programs.
Alison Footman, Nita Kanney, Linda M Niccolai, Gregory D Zimet, Edgar Turner Overton, Susan L Davies, Barbara Van Der Pol> ;Sexually Transmitted Diseases. 2022 Nov 1
Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk.
Kathleen V Fitch, Sara A McCallum, Kristine M Erlandson, Edgar Turner Overton, Markella V Zanni, Carl Fichtenbaum, Judith A Aberg, Evelynne S Fulda, Emma M Kileel, Lau...> ;AIDS. 2022 Nov 15
Perceived Need and Acceptance of a Future Chlamydia Vaccine Among Health Care Providers.
Alison Footman, Nita Kanney, Linda M Niccolai, Gregory D Zimet, Edgar Turner Overton, Susan L Davies, Barbara Van Der Pol> ;Sexually Transmitted Diseases. 2022 Nov 1
Safety and immunogenicity of monovalent H7N9 influenza vaccine with AS03 adjuvant given sequentially or simultaneously with a seasonal influenza vaccine: A randomized ...
Justin R Ortiz, Paul W Spearman, Paul A Goepfert, Kaitlyn Cross, C Buddy Creech, Wilbur H Chen, Susan Parker, Edgar T Overton, Michelle Dickey, Heather L Logan, Ashley...> ;Digestive Diseases and Sciences. 2022 May 20
2 citations
Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy.
Márton Kolossváry, Chris deFilippi, Michael T Lu, Markella V Zanni, Evelynne S Fulda, Borek Foldyna, Heather Ribaudo, Thomas Mayrhofer, Ann C Collier, Gerald S Bloomfi...> ;The Journal of Infectious Diseases. 2022 Nov 11
4 citations
Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV.
Edgar T Overton, Isabelle R Weir, Markella V Zanni, Stephanie Fischinger, Rodger D MacArthur, Judith A Aberg, Kathleen V Fitch, Michael Frank, Helmut Albrecht, Elliot ...> ;Journal of Acquired Immune Deficiency Syndromes. 2022 Aug 1
Bacterial Sexually Transmitted Infection Incidence Among Southern Men Who Have Sex With Men With Human Immunodeficiency Virus in the Treatment as Prevention Era, 2014-...
Ronnie M Gravett, John D Cleveland, Edgar T Overton, Jeanne Marrazzo> ;Clinical Infectious Diseases. 2022 Oct 12
Factors Associated With Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People With Human Immunodeficiency Virus on ...
Sara E Looby, Amy Kantor, Tricia H Burdo, Judith S Currier, Carl J Fichtenbaum, Edgar T Overton, Judith A Aberg, Carlos D Malvestutto, Gerald S Bloomfield, Kristine M ...> ;Clinical Infectious Diseases. 2022 Oct 12
Geographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk.
Kristine M Erlandson, Kathleen V Fitch, Sara A McCallum, Heather J Ribaudo, Edgar T Overton, Markella V Zanni, Gerald S Bloomfield, Todd T Brown, Carl J Fichtenbaum, S...> ;Clinical Infectious Diseases. 2022 Sep 30
6 citations
Assessment of Obesity and Cardiometabolic Status by Integrase Inhibitor Use in REPRIEVE: A Propensity-Weighted Analysis of a Multinational Primary Cardiovascular Preve...
Emma M Kileel, Janet Lo, Carlos Malvestutto, Kathleen V Fitch, Markella V Zanni, Carl J Fichtenbaum, Edgar T Overton, Nwora Lance Okeke, Princy Kumar, Esau Joao, Judit...> ;Open Forum Infectious Diseases. 2021 Dec 1
5 citations
A Randomized, Placebo-Controlled Trial Assessing the Effect of VISBIOME ES Probiotic in People With HIV on Antiretroviral Therapy.
Rachel M Presti, Eunice Yeh, Brett Williams, Alan Landay, Jeffrey M Jacobson, Cara Wilson, Carl J Fichtenbaum, Netanya S Utay, Michael P Dube, Karin L Klingman, Jacob ...> ;Open Forum Infectious Diseases. 2021 Dec 1
COVID-19 Vaccination Rates in a Global HIV Cohort.
Evelynne S Fulda, Kathleen V. Fitch, Edgar T. Overton, Markella V. Zanni, Judith A. Aberg, Judith S. Currier, Michael T. Lu, Carlos Malvestutto, Carl J. Fichtenbaum, E...> ;The Journal of Infectious Diseases. 2021 Nov 18
Evaluation of HIV-1 reservoir size and broadly neutralizing antibodies (bNAb) susceptibility in acute ART treated individuals.
Brian Moldt, Huldrych F. Günthard, Kimberly A. Workowski, Susan J. Little, Joseph J. Eron, Edgar T. Overton, Clara Lehmann, Casper Rokx, Michael J. Kozal, Rajesh T. Ga...> ;AIDS. 2021 Sep 29
6 citations
Suspected Immune-Related Adverse Events With an Anti-PD-1 Inhibitor in Otherwise Healthy People With HIV.
Ronald J. Bosch, Ashley McKahnn, Kendall F. Moseley, Chanelle L Wimbish, Steven Hendrickx, Michael Messer, Maureen Furlong, Danielle M Campbell, Cheryl Jennings, Const...> ;Journal of Acquired Immune Deficiency Syndromes. 2021 Aug 15
1 citations
Changes in lipidomic profile by anti-retroviral treatment regimen: An ACTG 5257 ancillary study.
Ninad S. Chaudhary, Tobias Kind, Amanda L. Willig, Michael S. Saag, Sadeep Shrestha, Nicholas T. Funderburg, Howard W. Wiener, E. Turner Overton, Marguerite R. Irvin> ;Medicine. 2021 Jul 30
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Journal Articles

Immunogenicity and Safety of Three Consecutive Production Lots of the Non Replicating Smallpox Vaccine MVA: A Randomised, Double Blind, Placebo Controlled Phase III Trial
Edgar Turner Overton, Steven J Lawrence, PLoS One
The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults with Human Immunodeficiency Virus...
C William Wester, Edgar Turner Overton, Susan L Koletar, Kristine M Erlandson, Constance A Benson, Robert C Kalayjian, Clinical Infectious Diseases

Lectures

Screening in Emergency Department Identifies a Large Cohort of Unrecognized Chronic Hepatitis C Virus Infection among Baby Boomers
University of Alabama at Birmingham, Birmingham, AL - 5/15/2014