EdwardDempseyMD

Pulmonology • Aurora, CO

Critical Care Medicine, Pleural Disease, Pulmonary Vascular Medicine

Professor, Medicine, University of Colorado School of Medicine

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Office
12700 E 19th St; RC2; Box B133
Aurora, CO 80045
Phone+1 720-724-3679

Fax+1 303-724-3693
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Education & Training

University of ColoradoFellowship, Pulmonary Disease and Critical Care Medicine, 1986 - 1989
Yale-New Haven Medical CenterResidency, Internal Medicine, 1982 - 1986
Harvard Medical SchoolClass of 1982

Certifications & Licensure

CO State Medical License 1987 - 2025
PA State Medical License 1995 - 2016
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Publications & Presentations

PubMed

2 citations
Tadalafil for veterans with chronic obstructive pulmonary disease-pulmonary hypertension: A multicenter, placebo-controlled randomized trial.
Bradley A Maron, Gaurav Choudhary, Rebekah L Goldstein, Eric Garshick, Matthew Jankowich, Troo J S Tucker, Kathleen A LaCerda, Brack Hattler, Edward C Dempsey, Ruxana ...> ;Pulmonary Circulation. 2022 Jan 1
4 citations
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
Derek Strassheim, Timothy M. Sullivan, David Irwin, Evgenia V. Gerasimovskaya, Tim Lahm, Dwight J. Klemm, Edward C. Dempsey, Kurt R. Stenmark, Vijaya Karoor> ;Cells. 2021 Nov 29
2 citations
Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia.
Vijaya Karoor, Delaney C. Swindle, David I. Pak, Derek Strassheim, Mehdi A. Fini, Edward C. Dempsey, Kurt R. Stenmark, Kathryn L. Hassell, Rachelle Nuss, Paul W. Buehl...> ;Pulmonary Circulation. 2021 Oct 1
22 citations
The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension.
Vijaya Karoor, Derek Strassheim, T. Sullivan, Alexander D. Verin, Nagavedi S. Umapathy, Edward C. Dempsey, Daniel N. Frank, Kurt R. Stenmark, Evgenia V. Gerasimovskaya> ;International Journal of Molecular Sciences. 2021 Sep 14
11 citations
The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence.
Martina King, Hermione Hurley, Kevin R. Davidson, Edward C. Dempsey, Michelle A. Barron, Edward D. Chan, Amy Frey> ;Immune Network. 2020 Jul 22
9 citations
c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells.
Derek Strassheim, Vijaya Karoor, Hala Nijmeh, Philip Weston, Martin Lapel, Jerome Schaack, T. Sullivan, Edward C. Dempsey, Kurt R. Stenmark, Evgenia V. Gerasimovskaya> ;Cells. 2020 Feb 11
2 citations
Impaired vascular function with age and RhoGTPase.
Edward C. Dempsey, Derek Strassheim, Vijaya Karoor> ;Aging. 2020 Jan 6
66 citations
Role of Inflammatory Cell Subtypes in Heart Failure.
Derek Strassheim, Edward C. Dempsey, Evgenia V. Gerasimovskaya, Kurt R. Stenmark, Vijaya Karoor> ;Journal of Immunology Research. 2019 Sep 2
44 citations
RhoGTPase in Vascular Disease.
Derek Strassheim, Evgenia V. Gerasimovskaya, David Irwin, Edward C. Dempsey, Kurt R. Stenmark, Vijaya Karoor> ;Cells. 2019 Jun 6
37 citations
An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse.
Marilee J. Wick, Julie W. Harral, Zoe Loomis, Edward C. Dempsey> ;Journal of Visualized Experiments. 2018 Sep 12
11 citations
Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice
Vijaya Karoor, Mehdi A. Fini, Zoe Loomis, Timothy M. Sullivan, Louis B. Hersh, Evgenia V. Gerasimovskaya, David Irwin, Edward C. Dempsey> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 Jan 1
1 citations
Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern.
Marilee J. Wick, Zoe Loomis, Julie W. Harral, Mysan Le, Carol A. Wehling, York E. Miller, Edward C. Dempsey> ;Transgenic Research. 2016 Jul 1
17 citations
Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism
Vijaya Karoor, Masahiko Oka, Sandra J. Walchak, Louis B. Hersh, York E. Miller, Edward C. Dempsey> ;Hypertension. 2013 Apr 1
5 citations
Sleep-disordered breathing, hypoxemia, and cancer mortality.
York E. Miller, Vijaya Karoor, Edward C. Dempsey, Karen A. Fagan> ;American Journal of Respiratory and Critical Care Medicine. 2013 Mar 5
23 citations
Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism.
Vijaya Karoor, Mysan Le, Daniel T. Merrick, Karen A. Fagan, Edward C. Dempsey, York E. Miller> ;Cancer Prevention Research. 2012 Aug 1
33 citations
Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease
Marilee J. Wick, Erica J. Buesing, Carol A. Wehling, Zoe Loomis, Carlyne D. Cool, Martin R. Zamora, York E. Miller, Sean P. Colgan, Louis B. Hersh, Norbert F. Voelkel,...> ;American Journal of Respiratory and Critical Care Medicine. 2011 Feb 1
8 citations
Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors.
Vijaya Karoor, Mysan Le, Daniel T. Merrick, Edward C. Dempsey, York E. Miller> ;Cancer Prevention Research. 2010 Sep 1
22 citations
A Randomized Phase II Chemoprevention Trial of 13-CIS Retinoic Acid with Or without α Tocopherol or Observation in Subjects at High Risk for Lung Cancer
Karen Kelly, John Kittelson, Wilbur A. Franklin, Timothy C. Kennedy, Catherine E. Klein, Robert L. Keith, Edward C. Dempsey, Marina T. Lewis, Mary Jackson, Fred R. Hir...> ;Cancer Prevention Research. 2009 May 1
45 citations
Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia
Edward C. Dempsey, Marilee J. Wick, Vijaya Karoor, Erica J. Barr, Dustin W. Tallman, Carol A. Wehling, Sandra J. Walchak, Sven Laudi, Mysan Le, Masahiko Oka, Susan M. ...> ;The American Journal of Pathology. 2009 Mar 1
64 citations
Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification.
David Irwin, Karen M. Helm, Nzali Campbell, Masa Imamura, Karen A. Fagan, Julie W. Harral, Michelle Carr, Katharine A Young, Dwight J. Klemm, Sarah A. Gebb, Edward C. ...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007 Aug 10
67 citations
Lung disease and PKCs
Edward C. Dempsey, Carlyne D. Cool, Cassana M. Littler> ;Pharmacological Research. 2007 Jun 1
148 citations
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
Joseph T. Crossno, Chrystelle Garat, Jane E.B. Reusch, Kenneth G. Morris, Edward C. Dempsey, Ivan F. McMurtry, Kurt R. Stenmark, Dwight J. Klemm> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007 Apr 1
34 citations
Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension.
David Case, David Irwin, Charles Ivester, Julie W. Harral, Kenneth G. Morris, Masatoshi Imamura, Mark Roedersheimer, Abby Patterson, Michelle Carr, Moira Hagen, Milene...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007 Jan 1
11 citations
Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro.
L. Christie Rockwell, Edward C. Dempsey, Lorna G. Moore> ;High Altitude Medicine & Biology. 2006 Sep 15
14 citations
Impact of customized videotape education on quality of life in patients with chronic obstructive pulmonary disease.
Thomas L. Petty, Edward C. Dempsey, Timothy Collins, William Pluss, Isaac M. Lipkus, Gary Cutter, Robin L. Chalmers, Amy Mitchell, Kenneth C Weil> ;Journal of Cardiopulmonary Rehabilitation. 2006 Mar 1
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Grant Support

Neprilysin And Pulmonary Vascular Remodeling: Cellular And Molecular MechanismsVeterans Affairs2011–2012
TissueNational Heart, Lung, And Blood Institute2009–2011
Selected Peptidases And Pulmonary Vascular Remodeling In Chronic Obstructive PulmNational Heart, Lung, And Blood Institute2008–2009
Neprilysin Apoptosis And Hypoxic Pulmonary HypertensionNational Heart, Lung, And Blood Institute2005–2008
NEP And Susceptibility To Hypoxic Pulmonary HypertensionNational Heart, Lung, And Blood Institute2003–2007
Core--Tissue CultureNational Heart, Lung, And Blood Institute1998–2007
Regulation Of PA SMC Proliferative Response To HypoxiaNational Heart, Lung, And Blood Institute1998–2002

Hospital Affiliations

University of Colorado HospitalAurora, Colorado
Rocky Mountain Regional VA Medical CenterAurora, Colorado
UCHealth Memorial HospitalColorado Springs, Colorado
UCHealth Poudre Valley HospitalFort Collins, Colorado