EdwardJGuntherMD

Oncology • Hershey, PA

Associate Professor, Medicine, Pennsylvania State University College of Medicine

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Office
500 University Dr
MC A410
Hershey, PA 17033
Phone+1 717-531-6585

Fax+1 717-531-5076
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Summary

Dr. Edward Gunther, MD is an oncologist in Hershey, Pennsylvania. He is currently licensed to practice medicine in Pennsylvania. He is affiliated with Penn State Milton S. Hershey Medical Center and is an Associate Professor at Pennsylvania State University College of Medicine.

Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1995 - 1999
University of Pennsylvania Health SystemResidency, Internal Medicine, 1993 - 1995
Yale School of MedicineClass of 1993

Certifications & Licensure

PA State Medical License 1994 - 2024
American Board of Internal Medicine Medical Oncology

Publications & Presentations

PubMed

Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models.
Maryknoll Linscott, Jerry Ruizhe Ren, Shelley Gestl, Edward J Gunther> ;The American Journal of Pathology. 2024 Mar 25
4 citations
A Multistage Murine Breast Cancer Model Reveals Long-Lived Premalignant Clones Refractory to Parity-Induced Protection.
Shuo Li, Shelley A. Gestl, Edward J. Gunther> ;Cancer Prevention Research. 2020 Feb 1
4 citations
Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer.
Ross R. Keller, Edward J. Gunther> ;Cell Reports. 2019 Jan 22
6 citations
Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias.
Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther> ;Carcinogenesis. 2016 Aug 1
315 citations
Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther> ;Nature. 2014 Apr 3
5 citations
Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth.
Kristin A. Plichta, Jessica L. Mathers, Shelley A. Gestl, Adam B. Glick, Edward J. Gunther> ;Cancer Research. 2012 Nov 15
23 citations
A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis
Wenwen Jia, Shuwen Wang, James W. Horner, Ning Wang, Huayan Wang, Edward J. Gunther, Ronald A. DePinho, Jiyue Zhu> ;FASEB Journal. 2011 Mar 1
28 citations
P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
Peter R McHenry, James C. Sears, Matthew P Herrick, Peggy Chang, Brandy M Heckman-Stoddard, Megan M. Rybarczyk, Lewis A. Chodosh, Edward J. Gunther, Susan G. Hilsenbec...> ;Breast Cancer Research. 2010 Sep 22
20 citations
Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors
Qiang Shen, Ivan P. Uray, Yuxin Li, Yun Zhang, Jamal Hill, Xiao Chun Xu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Lewis A. Chodosh, Powel H. Brown> ;Cancer Prevention Research. 2008 Jun 1
50 citations
Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16Ink4a loss
Michael T. Debies, Shelley A. Gestl, Jessica L. Mathers, Oliver R. Mikse, Travis L. Leonard, Susan E. Moody, Lewis A. Chodosh, Robert D. Cardiff, Edward J. Gunther> ;The Journal of Clinical Investigation. 2008 Jan 2
10 citations
Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands.
Shelley A. Gestl, Travis L. Leonard, Jessica L. Biddle, Michael T. Debies, Edward J. Gunther> ;Molecular and Cellular Biology. 2007 Jan 1
101 citations
Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation.
Robert A. Jones, Craig I. Campbell, Edward J. Gunther, Lewis A. Chodosh, Jim Petrik, Rama Khokha, Roger A. Moorehead> ;Oncogene. 2007 Mar 8
33 citations
The AP-1 transcription factor regulates postnatal mammary gland development.
Qiang Shen, Yun Zhang, Ivan P. Uray, Jamal Hill, Hee Tae Kim, Chunhua Lu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Lewis A. Chodosh, Powel H. Brown> ;Developmental Biology. 2006 Jul 15
37 citations
p190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland
Tracy Vargo-Gogola, Brandy M. Heckman, Edward J. Gunther, Lewis A. Chodosh, Jeffrey M. Rosen> ;Molecular Endocrinology. 2006 Jun 1
75 citations
Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma In situ
M. Silvina Frech, Ewa D. Halama, Maddalena T. Tilli, Baljit Singh, Edward J. Gunther, Lewis A. Chodosh, Jodi A. Flaws, Priscilla A. Furth> ;Cancer Research. 2005 Feb 1
160 citations
Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis.
Edward J. Gunther, Susan E. Moody, George K. Belka, Kristina T. Hahn, Nathalie Innocent, Katherine D. Dugan, Robert D. Cardiff, Lewis A. Chodosh> ;Genes & Development. 2003 Feb 15
264 citations
Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
Susan E. Moody, Christopher J. Sarkisian, Kristina T. Hahn, Edward J. Gunther, Steven Pickup, Katherine D. Dugan, Nathalie Innocent, Robert D. Cardiff, Mitchell D. Sch...> ;Cancer Cell. 2002 Dec 1
167 citations
A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology
Edward J. Gunther, George K. Belka, Gerald Wertheim, James Y. Wang, Jennifer L. Hartman, Robert Boxer, Lewis A. Chodosh> ;FASEB Journal. 2002 Mar 1
328 citations
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
Celina M. D'Cruz, Edward J. Gunther, Robert Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, ...> ;Nature Medicine. 2001 Feb 1
36 citations
Hormone-dependent Tumor Regression in Vivo by an Inducible Transcriptional Repressor Directed at the PAX3-FKHR Oncogene
Kasirajan Ayyanathan, William J. Fredericks, Carola Berking, Meenhard Herlyn, Christopher N. Balakrishnan, Edward J. Gunther, Frank J. Rauscher> ;Cancer Research. 2000 Oct 15
26 citations
Frequent spontaneous deletions at a shuttle vector locus in transgenic mice
Eric G. Leach, Edward J. Gunther, Toni M. Yeasky, Lisa H. Gibson, Teresa L. Yang-Feng, Peter M. Glazer> ;Mutagenesis. 1996 Jan 1
22 citations
Other transgenic mutation assays: Tissue specificity of spontaneous point mutations in λsupF transgenic mice
Eric G. Leach, Latha Narayanan, Pamela A. Havre, Edward J. Gunther, Toni M. Yeasky, Peter M. Glazer> ;Environmental and Molecular Mutagenesis. 1996 Jan 1
54 citations
Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: Mutations at cross-linkable sites induced by monoadducts as well as cross-links
Edward J. Gunther, Toni M. Yeasky, Francis P. Gasparro, Peter M. Glazer> ;Cancer Research. 1995 Mar 15
96 citations
Targeted mutagenesis of DNA using triple helix-forming oligonucleotides linked to psoralen
Pamela A. Havre, Edward J. Gunther, Francis P. Gasparro, Peter M. Glazer> ;Proceedings of the National Academy of Sciences of the United States of America. 1993 Aug 15
41 citations
High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen
Edward J. Gunther, Noreen E. Murray, Peter M. Glazer> ;Nucleic Acids Research. 1993 Aug 11
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Press Mentions

Breast Cancer Research Grant Awarded to Penn State Hershey DoctorFebruary 25th, 2016

Grant Support

Modeling Breast Cancer Relapse Prevention In MiceNational Cancer Institute2010–2012
Preclinical Modeling Of Latent Breast Cancer In MiceNational Cancer Institute2005–2009
BRCA 1 Function Using An Inducible TransgeneNational Cancer Institute2002–2003
BRCA 1 Function Using An Inducible TransgeneNational Cancer Institute1999–2002

Hospital Affiliations

Penn State Milton S. Hershey Medical CenterHershey, Pennsylvania