EdwardNHanleyMD

PubMed

• 1 citations
  The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs.
  Yubo Sun, Alex J. Kiraly, Michael Cox, David R. Mauerhan, Edward N. Hanley> ;Experimental and Therapeutic Medicine. 2018 Apr 1
• 5 citations
  Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs.
  Yubo Sun, Alex J. Kiraly, A. R. Sun, Michael Cox, David R. Mauerhan, Edward N. Hanley> ;Bone & Joint Research. 2018 Feb 24
• 7 citations
  Expression of serglycin in human disc is increased in degenerated discs and up-regulated in vitro by exposure to IL-1ß or TNF-α.
  Helen E. Gruber, Edward N. Hanley> ;Biotechnic & Histochemistry. 2018 Jan 10
• 6 citations
  Proinflammatory Cytokines IL-1β and TNF-α Influence Human Annulus Cell Signaling Cues for Neurite Growth: In Vitro Coculture Studies.
  Helen E. Gruber, Brittany Jones, Emilio Marrero, Edward N. Hanley> ;Spine. 2017 Oct 15
• 5 citations
  Morphologic features of spontaneous annular tears and disc degeneration in the aging sand rat (Psammomys obesus obesus)
  Helen E. Gruber, Edward N. Hanley> ;Biotechnic & Histochemistry. 2017 Aug 11
• 4 citations
  Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01.
  Yubo Sun, Andrea Roberts, David R. Mauerhan, Edward N. Hanley> ;Journal of Orthopaedic Research. 2017 Jun 13
• 8 citations
  Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes.
  Yubo Sun, Atiya M. Franklin, David R. Mauerhan, Edward N. Hanley> ;The Open Rheumatology Journal. 2017 May 31
• 8 citations
  Comparison of Meniscal Cell-Mediated and Chondrocyte-Mediated Calcification.
  Alex J. Kiraly, Andrea Roberts, Michael Cox, David Mauerhan, Edward Hanley, Yubo Sun> ;The Open Orthopaedics Journal. 2017 Mar 31
• 2 citations
  Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α
  Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero, Edward N. Hanley> ;BMC Musculoskeletal Disorders. 2017 May 8
• 3 citations
  Constitutive expression of IL-22 in the human intervertebral disc and its reduction by exposure to pro-inflammatory cytokines in vitro.
  Helen E. Gruber, Emilio Marrero, Jane A. Ingram, Gretchen L. Hoelscher, Edward N. Hanley> ;Biotechnic & Histochemistry. 2017 Apr 14
• 11 citations
  The chemokine, CXCL16, and its receptor, CXCR6, are constitutively expressed in human annulus fibrosus and expression of CXCL16 is up-regulated by exposure to IL-1ß in...
  Helen E. Gruber, Emilio Marrero, Jane A. Ingram, Gretchen L. Hoelscher, Edward N. Hanley> ;Biotechnic & Histochemistry. 2017 Jan 1
• 21 citations
  Human annulus progenitor cells: Analyses of this viable endogenous cell population.
  Helen E. Gruber, Frank E. Riley, Gretchen L. Hoelscher, Jane A. Ingram, Letitia Bullock, Edward N. Hanley> ;Journal of Orthopaedic Research. 2016 Aug 1
• 5 citations
  Human annulus signaling cues for nerve outgrowth: In vitro studies.
  Helen E. Gruber, Gretchen L. Hoelscher, Letitia Bullock, Jane A. Ingram, H. James Norton, Edward N. Hanley> ;Journal of Orthopaedic Research. 2016 Aug 1
• 27 citations
  Coccygectomy for patients with chronic coccydynia: a prospective, observational study of 98 patients.
  E. N. Hanley, G. Ode, J. B. Jackson, Rachel B. Seymour> ;The Bone & Joint Journal. 2016 Apr 1
• Alkaptonuria-Associated Changes in Disc Degeneration: A Case Report.
  Helen E. Gruber, Edward N. Hanley> ;JBJS Case Connector. 2015 Nov 11
• 10 citations
  Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis
  Yubo Sun, Nikkole Haines, Andrea Roberts, M. Ruffolo, David R. Mauerhan, Kim L. Mihalko, Jane A. Ingram, Michael Cox, Edward N. Hanley> ;BMC Musculoskeletal Disorders. 2015 Sep 30
• 8 citations
  Cartilage Degeneration, Subchondral Mineral and Meniscal Mineral Densities in Hartley and Strain 13 Guinea Pigs
  Yubo Sun, Brian P. Scannell, Patrick R Honeycutt, David R. Mauerhan, James Norton H, Edward N. Hanley> ;The Open Rheumatology Journal. 2015 Sep 15
• 18 citations
  Mitochondrial Membrane Potential and Nuclear and Gene Expression Changes During Human Disc Cell Apoptosis: In Vitro and In Vivo Annulus Findings.
  Helen E. Gruber, Gretchen L. Hoelscher, Synthia Bethea, Edward N. Hanley> ;Spine. 2015 Jun 15
• 16 citations
  High-mobility group box-1 gene, a potent proinflammatory mediators, is upregulated in more degenerated human discs in vivo and its receptor upregulated by TNF-α exposu...
  Helen E. Gruber, Gretchen L. Hoelscher, Synthia Bethea, Jane A. Ingram, Michael Cox, Edward N. Hanley> ;Experimental and Molecular Pathology. 2015 Jun 1
• 69 citations
  Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to ...
  Helen E. Gruber, Gretchen L. Hoelscher, Jane A. Ingram, Synthia Bethea, Edward N. Hanley> ;Spine. 2015 Jun 1
• 35 citations
  Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production.
  Helen E. Gruber, Gretchen L. Hoelscher, Jane A. Ingram, Synthia Bethea, Michael Cox, Edward N. Hanley> ;Experimental and Molecular Pathology. 2015 Feb 1
• 9 citations
  Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression.
  Helen E. Gruber, Gretchen L. Hoelscher, Synthia Bethea, Evan A. Menscher, Jane A. Ingram, Megan Templin, Edward N. Hanley> ;The Spine Journal. 2014 Dec 1
• 7 citations
  Expression of phosphocitrate-targeted genes in osteoarthritis menisci.
  Yubo Sun, David R. Mauerhan, Nury Steuerwald, Jane A. Ingram, Jeffrey S. Kneisl, Edward N. Hanley> ;Biomed Research International. 2014 Nov 23
• 10 citations
  Matrix metalloproteinase-12 immunolocalization in the degenerating human intervertebral disc and sand rat spine: Biologic implications.
  Helen E. Gruber, Jane A. Ingram, Michael Cox, Edward N. Hanley> ;Experimental and Molecular Pathology. 2014 Aug 1
• 12 citations
  A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration
  Helen E. Gruber, Wei Sha, Cory Brouwer, Nury Steuerwald, Gretchen L. Hoelscher, Edward N. Hanley> ;International Journal of Medical Sciences. 2014 May 15
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