EdwardJosephLesnefskyJr.MD

PubMed

• 1 citations
  Acute endoplasmic reticulum stress-induced mitochondria respiratory chain damage: The role of activated calpains.
  Qun Chen, Ling Li, Arun Samidurai, Jeremy Thompson, Ying Hu, Belinda Willard, Edward J Lesnefsky> ;FASEB Journal. 2024 Jan 31
• Aging-induced mitochondrial dysfunction: two distinct populations of mitochondria versus a combined population.
  Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky> ;American Journal of Physiology. Heart and Circulatory Physiology. 2024 Feb 1
• 1 citations
  Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts.
  Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky> ;Mechanisms of Ageing and Development. 2023 Oct 1
• 1 citations
  Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids.
  Qun Chen, Anna Kovilakath, Jeremy Allegood, Jeremy Thompson, Ying Hu, L Ashley Cowart, Edward J Lesnefsky> ;Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 2023 Oct 1
• Infarct Size With Incremental Global Myocardial Ischemia Times: Cyclosporine A in Donation After Circulatory Death Rat Hearts.
  Mohammed Quader, Oluwatoyin Akande, Renee Cholyway, Edward J Lesnefsky, Stefano Toldo, Qun Chen> ;Transplantation Proceedings. 2023 Sep 1
• New Insight Into Cardioprotection From Anthracyclines: Still Converging on the Mitochondria.
  Qun Chen, Giselle C Meléndez, Edward J Lesnefsky> ;JACC. Cardiooncology. 2023 Jun 1
• 3 citations
  Administration of metformin rescues age-related vulnerability to ischemic insults through mitochondrial energy metabolism.
  Zehui Li, Hao Wang, Linda Ines Zoungrana, Adewale James, Lily Slotabec, Steven Didik, Mohammad Kasim Fatmi, Meredith Krause-Hauch, Edward J Lesnefsky, Ji Li> ;Biochemical and Biophysical Research Communications. 2023 Jun 4
• Electron Transport Chain Inhibition to Decrease Injury in Transplanted Donation After Circulatory Death Rat Hearts.
  Mohammed Quader, Qun Chen, Oluwatoyin Akande, Renee Cholyway, Eleonora Mezzaroma, Edward J Lesnefsky, Stefano Toldo> ;Journal of Cardiovascular Pharmacology. 2023 Jun 1
• 3 citations
  Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease.
  Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J Lesnefsky, Kuniko Mitamura,...> ;Journal of Lipid Research. 2023 May 1
• 2 citations
  Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3.
  Migdalia Iglesias, Hao Wang, Meredith Krause-Hauch, Di Ren, Linda Ines Zoungrana, Zehui Li, Jie Zhang, Jin Wei, Nikita Yadav, Kshama Patel, Mohammad Kasim Fatmi, Ruish...> ;Cells. 2023 Mar 8
• 2 citations
  Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart.
  Lauryn Bates, Meredith Krause-Hauch, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Qun Chen, Di Ren, Ji Li, Edward J Lesnefsky> ;Aging and Disease. 2023 Oct 1
• 7 citations
  Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging.
  Mohammad Kasim Fatmi, Di Ren, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Kayla Davitt, Zehui Li, Migdalia Iglesias, Edward J Lesnefsky, Meredith Krause-Hauch, Ji Li> ;Aging Cell. 2023 Apr 1
• 7 citations
  NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful.
  Adolfo G Mauro, Eleonora Mezzaroma, Stefano Toldo, Giselle C Melendez, R Lee Franco, Edward J Lesnefsky, Antonio Abbate, W Gregory Hundley, Fadi N Salloum> ;Translational Research. 2023 Feb 1
• Influence of sex on global myocardial ischemia tolerance and mitochondrial function in circulatory death donor hearts.
  Qun Chen, Oluwatoyin Akande, Edward J Lesnefsky, Mohammed Quader> ;American Journal of Physiology. Heart and Circulatory Physiology. 2023 Jan 1
• 3 citations
  Testosterone and long pulse width stimulation (TLPS) for denervated muscles after spinal cord injury: a study protocol of randomised clinical trial.
  Ashraf S Gorgey, Refka E Khalil, Malak Alrubaye, Ranjodh Gill, Jeannie Rivers, Lance L Goetz, David X Cifu, Teodoro Castillo, Deborah Caruso, Timothy D Lavis, Edward J...> ;BMJ Open. 2022 Oct 5
• 2 citations
  Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria.
  Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky> ;Life. 2022 Aug 9
• 8 citations
  The mitochondrial electron transport chain contributes to calpain 1 activation during ischemia-reperfusion.
  Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky> ;Biochemical and Biophysical Research Communications. 2022 Jul 12
• 3 citations
  Modulation of Mitochondrial Respiration During Early Reperfusion Reduces Cardiac Injury in Donation After Circulatory Death Hearts.
  Oluwatoyin Akande, Qun Chen, Renee Cholyway, Stefano Toldo, Edward J Lesnefsky, Mohammed Quader> ;Journal of Cardiovascular Pharmacology. 2022 Jul 1
• 9 citations
  Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation.
  Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky> ;American Journal of Physiology. Cell Physiology. 2022 Feb 1
• 8 citations
  Calpain-mediated protein targets in cardiac mitochondria following ischemia-reperfusion.
  Ling Li, Jeremy Thompson, Ying Hu, Edward J Lesnefsky, Belinda Willard, Qun Chen> ;Scientific Reports. 2022 Jan 7
• 2 citations
  Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury.
  Raymond E Lai, Matthew E Holman, Qun Chen, Jeannie Rivers, Edward J Lesnefsky, Ashraf S Gorgey> ;Plos One. 2022 Jan 1
• 9 citations
  The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease.
  Jiayuan Murphy, Tran Ngoc Van Le, Julia Fedorova, Yi Yang, Meredith Krause-Hauch, Kayla Davitt, Linda Ines Zoungrana, Mohammad Kasim Fatmi, Edward J Lesnefsky, Ji Li, ...> ;Frontiers in Cardiovascular Medicine. 2022 Jan 1
• 3 citations
  Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury.
  Jacob A Goldsmith, Raymond E Lai, Ryan S Garten, Qun Chen, Edward J Lesnefsky, Robert A Perera, Ashraf S Gorgey> ;Frontiers in Physiology. 2022 Jan 1
• Time to Target Mitochondrial Reactive Oxygen Species Generation from Complex I.
  Qun Chen, Edward J Lesnefsky> ;Function. 2022 Jan 1
• 4 citations
  25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models.
  Yaping Wang, William M. Pandak, Edward J. Lesnefsky, Phillip B. Hylemon, Shunlin Ren> ;Cells. 2021 Nov 5
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Journal Articles

• Intracoronary Plaque Composition in Non-Lesional Segments Differs in Unstable Angina and Stable Angina Patients: Evidence from Intracoronary Ultrasound.  
  Hodgson J.McB., Reddy K.G., Suneja R., Sheehan H.M., Lesnefsky E.J., Nair R.N, Journal American College of Cardiology
• In Vivo Evidence for Plaque Fracture Following PTCA: Intracoronary Ultrasound Imaging of Arterial Distensibility.  
  Reddy K.G., Suneja R., Nair R.N., Sheehan H.M., Lesnefsky E.J., Hodgson J.McB, Journal American College of Cardiology
• Near Fatal Bronchospasm Induced by Zomepirac Sodium.  
  Ross S.R., Friedman C.J., Lesnefsky E.J, Annals of Allergy
• Effects of Acute Left Anterior Descending Occlusion on Regional Myocardial Blood Flow and Wall Thickening in the Presence of Circumflex Stenosis in Dogs.  
  Gascho J.A., Lesnefsky E.J., Mahanes M.S., Beller G.A, American Journal of Cardiology
• Early Thrombosis of a Porcine Bioprosthesis in the Aortic Valve Position.  
  Lesnefsky E.J., Groves B.M., Woelfel G.F., Dauber I.M.,Campbell D.N, American Journal of Cardiology
• Thallium Scintigraphic Evidence of Reversible Myocardial Ischemia Due to Anomalous Origin of the Left Main Coronary Artery From the Anterior Sinus Valsalva.  
  Lesnefsky E.J., Pacheco J., Adcock K.A., Buckner J.K., VanBenthuysen K.M, American Heart Journal
• Superoxide Dismutase Decreases Early Reperfusion Release of Conjugated Dienes Following Regional Canine Ischemia.  
  Lesnefsky E.J., Fennessey P.M., VanBenthuysen K.M., McMurtry I.F., Travis, V.L., Horwitz, L.D, Basic Research in Cardiology
• Lidocaine Reduces Canine Infarct Size and Decreases Release of a Lipid Peroxidation Product.  
  Lesnefsky E.J., VanBenthuysen K.M., McMurtry I.F., Shikes R.H., Johnston R.B., Horwitz L.D, Journal of Cardiovascular Pharmacology
• Oxidation and Release of Glutathione from Myocardium During Early Reperfusion.  
  Lesnefsky E.J., Repine J.E., Horwitz L.D, Free Radicals Biology and Medicine
• Dimethylthiourea, But Not Dimethylsulfoxide, Reduces Canine Myocardial Infarct Size.  
  Portz S.J., Lesnefsky E.J., VanBenthuysen K.M., Repine J.E., Parker N.B., McMurtry I.F., Horwitz L.D, Free Radicals Biology and Medicine
• Right Ventricular Ischemia and Proximal Right Coronary Artery Disease Indicated by Transient ST Elevation in Lead V1.  
  Krueger, D.W., Lesnefsky, E.J., Groves, B.M., Lindenfeld, J, American Journal of Cardiology
• Cough-Cardiopulmonary Resuscitation in the Cardiac Catheterization Laboratory.  
  Miller B., Lesnefsky E., Heyborne T., Schmidt B., Kelly K., Mann D., Reiter M, Catheterization and Cardiovascular Diagnosis
• Coronary Endothelial Dysfunction From Ischemia and Reperfusion: Effect of Reactive Oxygen Metabolite Scavengers.  
  Horwitz L.D., VanBenthuysen K.M., Sheridan F.M., Lesnefsky E.J., Dauber I.M., McMurtry I.F, Free Radicals Biology and Medicine
• Functional Coronary Microvascular Injury Evident As Increased Permeability due to Brief Ischemia and Reperfusion.  
  Dauber I.M., VanBenthuysen K.M., McMurtry I.F., Wheeler G.S., Lesnefsky E.J., Horwitz L.D., Weil J.V, Circulation Research
• Deferoxamine Pretreatment Reduces Canine Infarct Size and Oxidative Injury.  
  Lesnefsky E.J., Repine J.E., Horwitz L.D, Journal of Pharmacology and Experimental Therapeutics
• High-dose Iron Chelator Therapy During Reperfusion with Deferoxamine-Hydroxyethyl Starch Conjugate Fails to Reduce Canine Infarct Size.  
  Lesnefsky E.J., Hedlund B.E., Hallaway P.E., Horwitz L.D, Journal of Cardiovascular Pharmacolog
• Reactive Oxygen Metabolite Scavengers Decrease Functional Coronary Microvascular Injury Due to Ischemia- Reperfusion.  
  Dauber I.M., Lesnefsky E.J., VanBenthuysen K.M., Weil J.V., Horwitz L.D, American Journal of Physiology
• Myocardial Sulfhydryl Pool Alterations Occur During Reperfusion Following Brief and Prolonged Myocardial Ischemia In Vivo.  
  Lesnefsky E.J., Dauber I.M., Horwitz L.D, Circulation Research
• Existence and Participation of Xanthine Oxidase in Reperfusion Injury of Ischemic Rabbit Myocardium.  
  Terada L.S., Rubinstein J.D., Lesnefsky E.J., Horwitz L.D., Leff J.A., Repine J.E, American Journal of Physiology
• Reduction of Canine Myocardial Infarct Size by a Diffusible Reactive Oxygen Metabolite Scavenger: Efficacy of Dimethylthiourea Given at the Onset of Reperfusion.  
  Carrea F.P., Lesnefsky E.J., Repine J.E., Shikes R.H., Horwitz L.D., Lesnefsky E.J., Horwitz L.D., Leff J.A., Repine J.E, Circulation Research
• Role of Leukocytes in Coronary Vascular Endothelial Injury Due to Ischemia and Reperfusion.  
  Sheridan F.M., Dauber I.M., McMurtry I.F., Lesnefsky E.J., Horwitz L.D, Circulation Research
• Electrophysiologic Effects of Hydrogen Peroxide in the Isolated Rabbit Heart: Evidence for a Direct Effect of a Reactive Oxygen Metabolite on Myocardial Refractoriness.  
  Lesnefsky E.J., Williams G.R., Rubinstein J.D., Hogue T.S., Horwitz L.D., Reiter M.J, Free Radicals Biology and Medicine
• Racial Variation in Treatment Recommendations for Coronary Artery Disease in a VA Population.  
  Okelo S.O., Mohan G., Rosenthal G., Lesnefsky E.J., Wright, Jr. J.T., Taylor A.L, Circulation
• Coronary Vascular Injury Due to Ischemia-Reperfusion is Reduced by Pentoxifylline.  
  Dauber, I.M., Lesnefsky, E., Martel D.M., Sheridan F.M., Weil J.V., Horwitz L.D, Journal of Pharmacology and Experimental Therapeutics
• Lazaroid U74006F, A 21- Aminosteroid Inhibitor of Lipid Peroxidation, Attenuates Myocardial Injury From Ischemia and Reperfusion.  
  Carrea F.P., Lesnefsky E.J., Kaiser D.G., Horwitz L.D, Journal of Cardiovascular Pharmacology
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Books/Book Chapters

• Free Radicals in Diagnostic Medicine. 
  Chapter: Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury 
  Lesnefsky E.JEditors: Donald Armstrong, Ph.D.Plenum Press, New York, NY
• Mechanisms of Cardiovascular Aging. 
  Chapter: Mitochondrial Electron Transport And Aging In The Heart 
  Lesnefsky E.J., Tandler B., Moghaddas S., Hassan M.O., Hoppel C.LEditors: Tory Hagan, Ph.D.Elsevier, Amsterdam, The Netherlands
• Muscle Plasticity-Advances in Biochemical and Physiological Research. 
  Chapter: Mitochondria and Cardiac Injury: A Journey From Reperfusion to Ischemia and Back Again 
  Chen Q., Lesnefsky E.JEditors: Jose Magalhaes, Ph.D. and Antonio Ascensal, Ph.D.Research Signpost, Kerala, India

Abstracts/Posters

• In Vivo Ischemia-Decreases All Myocardial Sulfhydryl Groups.
  Lesnefsky E.J., Hogue T.S., Horwitz L.D, Clinical Research
• Reperfusion Therapy With Dimethylthiourea Reduces Canine Infarct Size Measured 48 Hours Later.
  Carrea F.P., Lesnefsky E.J., Horwitz L.D, Clinical Research
• Oxygen Radical-Induced Lipid Peroxidation: Adaptation of a Novel Lipid Peroxide Assay to Myocardial Tissue.
  Lesnefsky E.J., Allen K.G.D., Horwitz L.D, Clinical Research
• Differential Myocardial Sulfhydryl Depletion Occurs During Reperfusion Following Brief Vs. Prolonged Ischemia In Vivo.
  Lesnefsky E.J., Dauber I.M., Horwitz L.D, Circulation
• Leukocytes Cause Microvascular, But Little Epicardial Coronary Endothelial Injury Due to Ischemia and Reperfusion.
  Sheridan F.M., Dauber I.M., Lesnefsky E.J., Coller H.S., Peach J.L., Hogue T.S., Horwitz L.D, Circulation
• U74006F Decreases Necrosis and Enhances Functional Recovery After Ischemia/Reperfusion in Isolated Rabbit Hearts.
  Carrea F.P., Lesnefsky, E.J., Horwitz L.D, Journal American College of Cardiology
• Streptokinase and T-PA Treatment Reduces Superoxide Anion (O2-.) Generation by Human Neutrophils In Vitro.
  Lindenfeld J., Stringer K.A., Lesnefsky E.J., Repine J.E, linical Research
• Initial Clinical Use of Combined Angioplasty Balloon Ultrasound Catheter.
  Cacchione J.G., Sheehan H, Reddy K.G., Nair R.N., Lesnefsky E.J., Richards F.M., Hodgson JMcB, Catheterization and Cardiovascular Diagnosis
• Excess Intracellular, But Not Extracellular Iron Augments Myocardial Lipid Peroxidation and Injury During Reperfusion.
  Lesnefsky E.J., Ye J, Clinical Research
• Effects of Hyperbaric Oxygen, Coenzyme Q10 and Duration of Controlled Reperfusion on Reperfusion Injury.
  Ye J., Le W.R., Xie W.Q. (intr. by Lesnefsky E.J), Clinical Research
• Streptokinase and t-PA Reduce Neutrophil Oxygen Radical Generation In Vitro.
  Lindenfeld J.A., Stringer K.A., Lesnefsky E.J., Repine J.E, Circulation
• Plaque Typing by Intracoronary Ultrasound: Correlates with Unstable Angina and Comparison with Angiography.
  Reddy K.G., Cacchione J.G., Richards F.M., Nair R.N., Lesnefsky, E.J., Sheehan H.M., Hodgson J.McB, Circulation
• Initial Use of Combined Angioplasty Balloon Ultrasound Catheter.
  Cacchione J.G., Sheehan H., Reddy K.G., Nair R.N., Lesnefsky E.J., Richards F.M., Hodgson J.McB, Catheterization and Cardiovascular Diagnosis
• Phosphodiesterase-5 (PDE-5) inhibitor, tadalafil, activates NO/Sirt1/PGC-1α signaling and attenuates mitochondrial dysfunction in type 2 diabetic hearts.
  Koka S.S., Aluri H.S., Lesnefsky E.J., Kukreja, R.C, Circulation
• Apoptosis signaling kinase-1 inhibitor decreases mitochondrial damage during ischemia-reperfusion.
  Aluri H.S., Chen Q., Hu Y., Toldo S., Abbate A., Budas G.R., Lesnefsky E.J, Circulation
• Chronic treatment with the long acting phosphodiesterase-5 inhibitor, tadalafil, decreases mitochondrial damage in diabetic mice.
  Aluri H.S., Koka S.S., Lesnefsky E.J., Kukreja, R.C, Mitochondrion
• Safety of Cardiac Catheterization via Aorto-Femoral Grafts.
  Lesnefsky E.J., Carrea F.P., Groves B.M, Journal American College of Cardiology
• Blockade of electron transport before ischemia provides an additive protection in bcl-2 overexpressor mice following prolonged ischemia-reperfusion.
  Xu A., Szczepanek K., Hu Y., Chen Q., Lesnefsky E.J, Mitochondrion
• Intracellular, But Not Extracellular, Iron Facilitates Myocardial Reperfusion Injury.
  Lesnefsky E.J., Ye J, The FASEB Journal
• Chronic dietary supplementation of nitrate decreases doxorubicin-induced oxidative stress in cardiac mitochondria and tissues.
  Chen Q., Zhu S.G., Lesnefsky E.J., Kukreja R.C., Xi L, Circulation
• Mitochondrial ROS elicit volume-sensitive chloride current in simulated cardiac ischemia/reperfusion injury.
  Deng W., Yin J., Lesnefsky E.J., Baumgarten CM, Biophysical Journal
• Reversible, brief blockade of mitochondrial respiration at the onset of reperfusion decreases myocardial injury in aging hearts.
  Chen Q., Ross T., Hu Y., Lesnefsky E.J, FASEB Journal
• Differential Sensitivity of Protein Repair Enzymes to Oxidative Injury.
  Bapna C.P., Lesnefsky E.J., Mieyal J.J, Clinical Research
• Postconditioning protects reperfused myocardium from ischemia-damaged mitochondria.
  Chen Q., Ross T., Hu Y., Lesnefsky E.J, FASEB Journal
• Iron-Catalyzed Lipid Peroxidation During Reperfusion Is Mediated By Intracellular Hydroxyl Radical.
  Lesnefsky E.J., Ye J, Clinical Research
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Other

• Activation of mitochondrial calpain during cardiac ischemia-reperfusion. 
  Chen Q., Paillard M., Gomez L., Ross T., Hu Y., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
  Palm Springs, CA
• Failure to Precondition SK2-KO Mice: Not Without RISK. 
  Gomez L, Paillard M, Allegood JC, Hait NC, Price M, Chen Q, Milstien S, Spiegel S, and Lesnefsky EJ, Basic Cardiovascular Sciences Meeting
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
  Palm Springs, CA
• Oxidative Phospylation Provides A Valuable Tool For Identifying The Aging Mitochondrial Phenotype. 
  Kypriotakis G., Vazquez E., Lesnefsky E., Hoppel C, 12th Congress of the International Association of Biomedical Gerontology
  http://www.eie.gr/nhrf/institutes/ibrb/spetses-2007/poster_abstracts.pdf
• Protection of mitochondrial respiration prevents permeability transition pore opening during reperfusion. 
  Chen Q., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting, Palm Springs, CA
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
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