EdwardLewisTobinickMD

PubMed

• Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.
  Ignatowski TA Spengler RN Dhandapani KM Folkersma H Butterworth RF Tobinick E> ;CNS Drugs. 2014 Aug
• Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic ...
  LaMacchia, Z. M., Spengler, R. N., Jaffari, M., Abidi, A. H., Ahmed, T., Singh, N., Tobinick, E. L., Ignatowski, T. A.> ;Brain, behavior, and immunity. 2019 Aug 4
• Perispinal etanercept advances as a neurotherapeutic.
  Tobinick, E.> ;Expert Rev Neurother. 2018 Apr 27
• Immediate neurological recovery following perispinal etanercept years after brain injury.
  Tobinick E Rodriguez-Romanacce H Levine A Ignatowski TA Spengler RN> ;Clin Drug Investig. 2014 May
• Selective TNF inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients treated with perispinal etanercept.
  Tobinick E Kim NM Reyzin G Rodriguez-Romanacce H DePuy V> ;CNS Drugs. 2012 Dec
• Rapid improvement of chronic stroke deficits after perispinal etanercept: three consecutive cases.
  Tobinick, E.> ;CNS Drugs. 2011 Feb
• 3 citations
  Perispinal Delivery of CNS Drugs.
  Tobinick, E. L.> ;CNS drugs. 2016 Apr 28
• Authors' reply to Whitlock: Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.
  Ignatowski TA, Spengler RN, Tobinick E> ;CNS Drugs. 2014-12-01
• Deciphering the physiology underlying the rapid clinical effects of perispinal etanercept in Alzheimer''s disease.
  Tobinick, E.> ;Curr Alzheimer Res. 2012 Jan
• Author's Reply to Page: "Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury: An Observational Study Involving 629 Consecutive Patients Treated with...
  Tobinick, E.> ;CNS Drugs. 2013 May
• 55 citations
  The value of drug repositioning in the current pharmaceutical market.
  Tobinick, E. L.> ;Drug news & perspectives. 2009 Mar 31
• 16 citations
  Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging.
  Tobinick, E. L., Chen, K., Chen, X.> ;BMC research notes. 2009 Mar 17
• 46 citations
  Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease.
  Tobinick, E. L., Gross, H.> ;BMC neurology. 2008 Jul 23
• 87 citations
  Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration.
  Tobinick, E. L., Gross, H.> ;Journal of neuroinflammation. 2008 Jan 11
• 24 citations
  Targeted etanercept for treatment-refractory pain due to bone metastasis: two case reports.
  Tobinick, E. L.> ;Clinical therapeutics. 2003 Sep 27
• Perispinal TNF-alpha inhibition for discogenic pain.
  Tobinick, E. L., Britschgi-Davoodifar, S.> ;Swiss medical weekly. 2003 Apr 26
• Basal cell carcinoma.
  Tobinick, E. L.> ;Am Fam Physician. 1987 Sep
• Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism.
  Tobinick, E.> ;Medscape J Med. 2008
• Perispinal etanercept for neuroinflammatory disorders.
  Tobinick, E.> ;Drug Discov Today. 2009 Feb 01
• TNF-alpha inhibition for potential therapeutic modulation of SARS coronavirus infection.
  Tobinick, E.> ;Curr Med Res Opin. 2004 Jan
• Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients.
  Tobinick, E., Davoodifar, S.> ;Curr Med Res Opin. 2004 Jul
• The cerebrospinal venous system: anatomy, physiology, and clinical implications.
  Tobinick, E., Vega, C. P.> ;MedGenMed. 2006
• TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study.
  Tobinick, E., Gross, H., Weinberger, A., Cohen, H.> ;MedGenMed. 2006
• Spinal delivery of p38: TNF-alpha inhibitors.
  Tobinick, E.> ;PLoS Med. 2006 Nov
• Resolution of chronic pain and fingertip ulceration due to hand-arm vibration syndrome following combination pharmacotherapy.
  Buell, C., Tobinick, E., Lamp, K.> ;Arch Dermatol. 2007 Oct
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Journal Articles

• Pathomechanisms of discogenic low back pain in humans and animal models  
  Ohtori, S., G. Inoue, M. Miyagi, and K. Takahashi, Spine J, 1/1/2015
• Transiently lowering tumor necrosis factor-alpha synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice  
  Baratz, R., D. Tweedie, J.Y. Wang, V. Rubovitch, et al., J Neuroinflammation, 1/1/2015
• Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial  
  Butchart, J., L. Brook, V. Hopkins, J. Teeling, et al., Neurology, 1/1/2015
• Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge  
  Camara, M.L., F. Corrigan, E.J. Jaehne, M.C. Jawahar, et al., Neuropsychopharmacology, 1/1/2015
• A neurologist’s guide to TNF biology, and to the principles behind the therapeutic removal of excess TNF in disease  
  Clark, I.A. and B. Vissel, Neural Plasticity, 1/1/2015
• The TNF-alpha/NF-kappaB signaling pathway has a key role in methamphetamine-induced blood-brain barrier dysfunction  
  Coelho-Santos, V., R.A. Leitao, F.L. Cardoso, I. Palmela, et al., J Cereb Blood Flow Metab, 1/1/2015
• The hippocampus and TNF: Common links between chronic pain and depression  
  Fasick, V., R.N. Spengler, S. Samankan, N.D. Nader, et al., Neurosci Biobehav Rev, 1/1/2015
• Immune attack: the role of inflammation in Alzheimer disease  
  Heppner, F.L., R.M. Ransohoff, and B. Becher, Nat Rev Neurosci, 1/1/2015
• CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model  
  Krauthausen, M., M.P. Kummer, J. Zimmermann, E. Reyes-Irisarri, et al., J Clin Invest, 1/1/2015
• Effects of systemic Thalidomide and intracerebroventricular Etanercept and Infliximab administration in a Streptozotocin induced dementia model in rats  
  Kubra Elcioglu, H., L. Kabasakal, F. Tufan, O.H. Elcioglu, et al., Acta Histochem, 1/1/2015
• Venous Drainage of the Spine and Spinal Cord: A Comprehensive Review of its History, Embryology, Anatomy, Physiology, and Pathology  
  Griessenauer, C.J., J. Raborn, P. Foreman, M.M. Shoja, M. Loukas and R. Shane Tubbs, Clinical Anatomy, 1/1/2015
• Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death  
  Rossi, D., Prog Neurobiol, 1/1/2015
• Action of anti-TNF-alpha drugs on the progression of Alzheimer’s disease A case report  
  C.H.F. Camargo, F.F. Justus, G. Retzlaff, M.R.Y. Blood, M.D. Schafranski, Dement Neuropsychol, 1/1/2015
• Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.  
  Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E., CNS Drugs, 8/1/2014
• Imaging neuroinflammation in Alzheimer’s and other dementias: Recent advances and future directions  
  Varley, J., D.J. Brooks, and P. Edison, Alzheimers Dement, 1/15/2014
• Tumor Necrosis Factor-alpha Modulates Cerebral Aneurysm Formation and Rupture  
  Starke, R.M., D. Raper, D. Ding, N. Chalouhi, et al., Translational Stroke Research, 1/1/2014
• The common inflammatory etiology of depression and cognitive impairment: a therapeutic target  
  Allison, D.J. and D.S. Ditor, J Neuroinflammation, 1/1/2014
• Drug repositioning: playing dirty to kill pain  
  Bastos, L.F. and M.M. Coelho, CNS Drugs, 1/1/2014
• Targeting TNF: a therapeutic strategy for Alzheimer’s disease  
  Cheng, X., Y. Shen, and R. Li, Drug Discov Today, 1/1/2014
• Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia  
  Clausen, B., M. Degn, N. Martin, Y. Couch, et al., J Neuroinflammation, 1/1/2014
• Combining select neuropsychological assessment with blood-based biomarkers to detect mild Alzheimer’s disease: a molecular neuropsychology approach  
  Edwards, M., V.H. Balldin, J. Hall, and S. O’Bryant, J Alzheimers Dis, 1/1/2014
• Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer’s disease  
  Ferreira, S.T., J.R. Clarke, T.R. Bomfim, and F.G. De Felice, Alzheimers Dement, 1/1/2014
• Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis  
  Gisondi, P., F. Sala, F. Alessandrini, V. Avesani, et al., Dermatology, 1/1/2014
• Inhibition of soluble tumor necrosis factor is therapeutic in Huntington’s disease  
  Hsiao, H.Y., F.L. Chiu, C.M. Chen, Y.R. Wu, et al., Hum Mol Genet, 1/1/2014
• Expression levels of tumor necrosis factor-alpha and the corresponding receptors are correlated with trauma severity  
  Liu, C. and J. Tang, Oncol Lett, 1/1/2014
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Books/Book Chapters

• The intervertebral disc: Molecular and structural studies of the disc in health and disease 
  Chapter: Enhancing disc repair by growth factors and other modalities 
  Bae, W.C. and K. MasudaEditors: I.M. Shapiro and M.V. Risbud.Springer-Verlag, Wein, Austria2014
• Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics 
  Chapter: Chapter 7: Network Control Mechanisms: Cellular Inputs, Neuroactive Substances, and Synaptic Changes 
  Faingold, C.L.Editors: C.L. Faingold and H. Blumenfeld.Elsevier2014
• Therapeutic Fc-Fusion Proteins 
  Chapter: Chapter 10: Etanercept 
  Grossman, J. and S.M. ChamowEditors: S.M. Chamow, Ryll, T., Lowman, H.B., Farson, D..Wiley-Blackwell, Weinheim, Germany2014
• The intervertebral disc: Molecular and structural studies of the disc in health and disease 
  Chapter: Intervertebral disc herniation: Pathophysiology and emerging therapies 
  Winkelstein, B.A., K.D. Allen, and L.A. SettonEditors: I.M. Shapiro and M.V. Risbud.Springer-Verlag, Wein, Austria2014
• Pathy's Principles and Practice of Geriatric Medicine 
  Chapter: Chapter 78- Drug development and Alzheimer’s disease 
  Delrieu, J., A. Piau, and B. VellasEditors: A.J. Sinclair, J.E. Morley, and B. Vellas.John Wiley & Sons, West Sussex, UK2012
• Rehabilitation Medicine 
  Chapter: Stroke Rehabilitation 
  Kim, C.T.Editors: C.T. Kim.InTech2012
• Advances in Alzheimer’s Disease Management 
  Chapter: New Drugs Under Development for Alzheimer’s Disease 
  Ooi, L. and e. al.Editors: S. Gauthier and P. Rosa-Neto.2012
• Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders 
  Chapter: Chapter 7- Historical perspectives on the discovery and development of drugs to treat neurological disorders 
  Williams, M. and J.T. CoyleEditors: J.E. Barrett, J.T. Coyle, and M. Williams.Cambridge University Press, New York, N.Y.2012
• The Handbook of Alzheimer’s Disease and Other Dementias 
  Chapter: Chapter 10- Rational therapeutics for Alzheimer’s disease and other dementias 
  Kowall, N.W.Editors: A.E. Budson and N.W. Kowall.Blackwell Publishing, West Sussex, UK2011
• Encyclopedia of Clinical Neuropsychology 
  Chapter: F-A-S test 
  Patterson, JEditors: J.S. Kreutzer, J. DeLuca, and B. Caplan.Springer Science+Business Media, New York, N.Y.2011
• Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders 
  Chapter: Chapter 15- The Neuroimmunology of Cortical Disease (Dementia, Epilepsy, and Autoimmune Encephalopathies) 
  Roth, J.L., B.R. Ott, J.N. Gaitanis, and A.S. BlumEditors: S.A. Rizvi and P.K. Coyle.Springer Science+Business Media, New York, N.Y.2011
• The Lumbar Intervertebral Disc 
  Chapter: Chapter 5- The Mechanisms of Pain from Intervertebral Discs 
  Alamin, T.F. and V. AgarwalEditors: F.M. Phillips and C. Lauryssen.Thieme Medical Publishers2010
• Handbook of Psychiatric Drug Therapy 
  Chapter: Chapter 8- Drugs for the treatment of dementia 
  Labbate, L.A., J.F. Rosenbaum, M. Fava, and G.W. AranaEditors: L.A. Labbate, et al..Lippincott Williams & Wilkins/Wolters Kluwer Health, Philadelphia, PA2010
• Translational Pain Research: From Mouse to Man 
  Chapter: Chapter 8- Cytokines in pain 
  Shubayev, V.I., K. Kato, and R.R. MyersEditors: L. Kruger and A.R. Light.CRC Press/Taylor & Francis, Boca Raton, FL2010
• Human Neuroanatomy: A Text Brain Atlas, and Laboratory Dissection Guide 
  Chapter: Chapter 4- Blood Supply of the Nervous System 
  Bruni, J.E. and D.G. MontemurroEditors: J.E. Bruni and D.G. Montemurro.Oxford University Press, New York, N.Y.2009
• Cytokines and the Brain 
  Chapter: Cytokines in Synaptic Function 
  Ignatowski, T.A. and R.N. SpenglerEditors: I. Berczi and A. Szentivanyi.Elsevier, Amsterdam, Netherlands2008
• Cytokines in the Genesis and Treatment of Cancer 
  Chapter: Chapter 4- TNF and Cancer 
  DeWitte, M., D.J. Shealy, M.T. Nakada, and G.M. AndersonEditors: M.A. Caligiuri and M.T. Lotze.Humana Press, Totowa, NJ2007
• Neuroinflammation in Neuronal Death and Repair 
  Chapter: Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function-Based and Target-Based Discovery Approaches 
  Van Eldik, L.J., W.L. Thompson, H.R. Ranaivo, H.A. Behanna, et al.Editors: G. Bagetta, M.T. Corasaniti, and S.A. Liption.Elsevier2007
• Skin Surgery, A Practical Guide 
  Usatine R, Tobinick E, Moy R,Siegel DMosby1998
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Abstracts/Posters

• Neuroinflammation as a new therapeutic target in neurology
  Tobinick E, Medical Staff CME Lecture, University Hospital, Tamarac, FL, 1/10/2011
• TNF antagonists for neurological disorders: from concept to the clinic
  Tobinick E, GTC bio’s 5th Modern Drug Discovery & Development Conference, San Diego, CA, 1/14/2009
• Perispinal etanercept for Alzheimer’s Disease
  Tobinick E, Restauracion Neurologica 2009 International Conference, Havana, Cuba, 1/11/2009
• TNF modulation for treatment of Alzheimer’s disease
  Tobinick E, Inaugural Targeting Alzheimer’s with Novel Therapeutics Conference at the World Pharmaceutical Congress, Philadelphia, PA, 1/11/2009
• Perispinal etanercept produces rapid improvement in primary progressive aphasia
  Tobinick E, 11th International Conference on Alzheimer’s Disease, Chicago, IL, 1/30/2008
• Repurposing of Enbrel for Alzheimer’s Disease
  Tobinick E, Third Annual Drug Repositioning Summit, Boston, MA, 1/6/2008
• Perispinal etanercept for treatment of Alzheimer’s Disease
  Tobinick E, 7th International Conference on Alzheimer’s Disease Drug Discovery; Best Practices in the Continuum of Care: Advances in Alzheimer’s Disease Management conference, University of Arkansas for Medical Sciences, Little Rock, AR, 2008, 1/1/2008
• TNF Modulation for Treatment of Alzheimer’s Disease: Effects on Verbal Function
  Tobinick E, Shirinyan D, Gross H, Days of Molecular Medicine Conference, Karolinska Institutet, Stockholm, Sweden, 1/27/2006
• Perispinal TNF-alpha inhibition for discogenic pain
  Tobinick E, 2nd Annual Restauracion Neurologica 2004 International Conference, Havana, Cuba, 1/27/2004
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Lectures

• TNF inhibition for aphasia after stroke or brain injury 
  Fort Lauderdale, FL - 1/30/2015