EdwardMUchioMDFACS

PubMed

• ATPase copper transporting beta (ATP7B) is a novel target for improving the therapeutic efficacy of docetaxel by disulfiram/copper in human prostate cancer.
  Song, L., Nguyen, V., Xie, J., JIa, S., Chang, C., Zi, X., Uchio, E.> ;Molecular Cancer Therapeutics. 2024 Feb 28
• 1 citations
  The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ra...
  Zhongbo Liu, Noriko N Yokoyama, Liankun Song, Jun Xie, Zhina Sadeghi, Yi Xi Wu, Sarah Yee, Xue-Ru Wu, Beverly Wang, Edward Uchio, Xiaolin Zi> ;Cancers. 2023 Jun 7
• 1 citations
  Aquablation Therapy in Large Prostates (80-150 mL) for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Final WATER II 5-Year Clinical Trial Results.
  Naeem Bhojani, Mo Bidair, Eugene Kramolowsky, Mihir Desai, Leo Doumanian, Kevin C Zorn, Dean Elterman, Ronald P Kaufman Jr, Gregg Eure, Gopal Badlani, Mark Plante, Edw...> ;The Journal of Urology. 2023 Jul 1
• 1 citations
  Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation.
  Xia Xu, Xuejiao Tian, Liankun Song, Jun Xie, Joseph C Liao, Joshua J Meeks, Xue-Ru Wu, Greg E Gin, Beverly Wang, Edward Uchio, Xiaolin Zi> ;Biomolecules. 2023 Mar 13
• 3 citations
  Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism.
  Zhongbo Liu, Liankun Song, Jun Xie, Xue-Ru Wu, Greg E Gin, Beverly Wang, Edward Uchio, Xiaolin Zi> ;Molecules. 2023 Feb 9
• 2 citations
  A Phase 2, Double-blind, Randomized Controlled Trial of PROSTVAC in Prostate Cancer Patients on Active Surveillance.
  J Kellogg Parsons, Peter A Pinto, Christian P Pavlovich, Edward Uchio, Mike N Nguyen, Hyung L Kim, James L Gulley, Houssein Abdul Sater, Christina Jamieson, Chiu-Hsieh...> ;European Urology Focus. 2023 May 1
• 14 citations
  Aquablation therapy in large prostates (80-150 cc) for lower urinary tract symptoms due to benign prostatic hyperplasia: WATER II 3-year trial results.
  Kevin C Zorn, Mohamed Bidair, Andrew Trainer, Andrew Arther, Eugene Kramolowsky, Mihir Desai, Leo Doumanian, Dean Elterman, Ronald P Kaufman Jr, James Lingeman, Amy Kr...> ;BJUI Compass. 2022 Mar 1
• 8 citations
  Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice.
  Zhongbo Liu, Liankun Song, Jun Xie, Anne R Simoneau, Edward Uchio, Xiaolin Zi> ;Pharmaceutics. 2022 Feb 24
• 20 citations
  Prostate cancer immunotherapy: a review of recent advancements with novel treatment methods and efficacy.
  Ian Wang, Liankun Song, Beverly Y Wang, Arash Rezazadeh Kalebasty, Edward Uchio, Xiaolin Zi> ;American Journal of Clinical and Experimental Urology. 2022 Jan 1
• 2 citations
  Use of immunotherapy in clinical management of genitourinary cancers - a review.
  Edward Uchio, Arash Rezazadeh Kalebasty, Mar, N.> ;Cancer Treatment and Research Communications. 2022 Jan 1
• 5 citations
  Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer.
  Liankun Song, Merci Mino, Jana Yamak, Vyvyan Nguyen, Derron Lopez, Victor Pham, Ali Fazelpour, Vinh Le, Dongjun Fu, Matthew Tippin, Edward Uchio, Xiaolin Zi> ;Frontiers in Oncology. 2022 Jan 1
• 11 citations
  A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer.
  Eric Zhuang, Edward Uchio, Michael B. Lilly, Xiaolin Zi, John P. Fruehauf> ;Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2021 Sep 24
• 1 citations
  Comparison of Perioperative Outcomes for Radical Nephrectomy Based on Surgical Approach for Masses Greater than 10cm
  Logan Grimaud, Felix V Chen, Jenny Chang, Argyrios Ziogas, John P. Sfakianos, Ketan K. Badani, Edward Uchio, Hoda Anton-Culver, Greg Gin> ;Journal of Endourology. 2021 Jun 19
• 187 citations
  Pembrolizumab monotherapy for the treatment of high-risk non-muscle-invasive bladder cancer unresponsive to BCG (KEYNOTE-057): an open-label, single-arm, multicentre, ...
  Arjun Vasant Balar, Ashish M. Kamat, Girish S. Kulkarni, Edward Uchio, Joost L. Boormans, Mathieu Roumiguié, Laurence Eliot Miles Krieger, Eric A. Singer, Dean F. Bajo...> ;The Lancet. Oncology. 2021 Jul 1
• 258 citations
  Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, ...
  Thomas Powles, Tibor Csőszi, Mustafa Ozguroglu, Nobuaki Matsubara, Lajos Géczi, Susanna Y-S Cheng, Yves Fradet, Stéphane Oudard, Christof Vulsteke, Rafael Morales Barr...> ;The Lancet. Oncology. 2021 Jul 1
• 7 citations
  Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1.
  Xuesen Li, Liankun Song, Shan Xu, Matthew Tippin, Shuan Meng, Jun Xie, Edward Uchio, Xiaolin Zi> ;Journal of Translational Genetics and Genomics. 2021 Jan 1
• 26 citations
  A 3D-2D Hybrid U-Net Convolutional Neural Network Approach to Prostate Organ Segmentation of Multiparametric MRI
  Alexander Ushinsky, Michelle Bardis, Justin Glavis-Bloom, Edward Uchio, Chanon Chantaduly, Michael Nguyentat, Daniel S. Chow, Peter Chang, Roozbeh Houshyar> ;AJR. American Journal of Roentgenology. 2021 Jan 1
• 5 citations
  Management of Advanced Prostate Cancer in Clinical Practice: Real-World Answers to Challenging Dilemmas
  Nataliya Mar, Arash Rezazadeh Kalebasty, Edward Uchio> ;JCO Oncology Practice. 2020 Dec 10
• 14 citations
  Veterans Affairs Cooperative Studies Program Study #553: Chemotherapy After Prostatectomy for High-risk Prostate Carcinoma: A Phase III Randomized Study.
  Daniel W. Lin, Mei Chiung Shih, William J. Aronson, Joseph W. Basler, Tomasz M. Beer, Mary Brophy, Matthew R. Cooperberg, Mark Garzotto, W. Kevin Kelly, Kelvin K. Lee,...> ;European Urology. 2020 May 1
• 18 citations
  Aquablation for benign prostatic hyperplasia in large prostates (80-150 cc): 2-year results
  Mihir M. Desai, Mo Bidair, Naeem Bhojani, Andrew Trainer, Andrew Arther, Eugene V. Kramolowsky, Leo Doumanian, Dean Elterman, Ronald P. Kaufman, James E. Lingeman, Amy...> ;The Canadian Journal of Urology. 2020 Apr 1
• 43 citations
  Predictors of Recurrence, and Progression-Free and Overall Survival following Open versus Robotic Radical Cystectomy: Analysis from the RAZOR Trial with a 3-Year Follo...
  Vivek Venkatramani, Isildinha M. Reis, Erik P. Castle, Mark L. Gonzalgo, Michael Woods, Robert S. Svatek, Alon Z. Weizer, Badrinath R. Konety, Mathew Tollefson, Tracey...> ;The Journal of Urology. 2020 Mar 1
• 4 citations
  PI-RADS Version 2 Is an Excellent Screening Tool for Clinically Significant Prostate Cancer as Designated by the Validated International Society of Urological Patholog...
  Mitchell Daun, Sara Fardin, Alexander Ushinsky, Sahil Batra, Michael Nguyentat, Thomas K. Lee, Edward Uchio, Chandana Lall, Roozbeh Houshyar> ;Current Problems in Diagnostic Radiology. 2020 Nov 1
• 30 citations
  Aquablation for benign prostatic hyperplasia in large prostates (80–150 mL): 6-month results from the WATER II trial
  Mihir M. Desai, Mo Bidair, Kevin C. Zorn, Andrew Trainer, Andrew Arther, Eugene V. Kramolowsky, Leo Doumanian, Dean Elterman, Ronald P. Kaufman, James E. Lingeman, Amy...> ;BJU International. 2019 Aug 1
• 34 citations
  Aquablation for Benign Prostatic Hyperplasia in Large Prostates (80-150 cc): 1-Year Results
  Naeem Bhojani, Mohamed Bidair, Kevin C. Zorn, Andrew Trainer, Andrew Arther, Eugene V. Kramolowsky, Leo Doumanian, Dean Elterman, Ronald P. Kaufman, James E. Lingeman,...> ;Urology. 2021 Jun 1
• 21 citations
  Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation.
  Xuesen Li, Victor Pham, Matthew Tippin, Dong-Jun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang, Xiaolin Zi> ;Cell Communication and Signaling. 2019 Mar 18
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Journal Articles

• Effects of androgen deprivation on cerebral morphometry in prostate cancer patients – an exploratory study  
  Choa HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS, PLoS One, 8/1/2013
• Effects of androgen deprivation on brain function in prostate cancer patients - a prospective observational cohort analysis  
  Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS, BMC Cancer, 8/1/2012
• Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival  
  Guo X, Schmitz JC, Kenney BC, Uchio EM, Kulkarni S, Cha CH, Cancer Sci, 8/1/2012
• Laparoscopic repair of inguinal cystocele using cystoscopic light test  
  Uchio EM, Calderon JS, Hwang JJ, Urology, 3/1/2012
• Poliomyelitis following injection of basement membrane matrix contaminated with lactate dehydrogenase-elevating virus (LDV) in MuLV-infected ICR-SCID mice  
  Carlson Scholz JA, Garg R, Compton S, Allore HG, Zeiss C, Uchio EM, Comp Med, 10/1/2011
• Improving Urinary Continence after Radical Prostatectomy: Review of Surgical Modifications  
  Hwang JJ, Kim BY, Uchio EM, The Korean Journal of Urology, 10/1/2009
• Molecular Markers and Death From Prostate Cancer  
  Concato J, Jain D, Uchio EM, Risch HA, Li WW, Wells CK, Ann of Int Med, 5/1/2009
• Downregulation of surviving is associated with reductions in TNF receptors' mRNA and protein and alterations in nuclear factor kappa B signaling in urothelial cancer c...  
  Takizawa BT, Uchio EM, Cohen JJ, Wheeler MA, Weiss RM., Cancer Invest, 12/1/2007
• SiRNA-Mediated Gene Silencing in colorectal Cancer: A Novel Anti-angiogenic Targeted Therapy  
  Mulkeen A, Silva T, Schmitz J, Uchio E, Chu E, Cha C, Archives of Surgery, 1/1/2006
• Follow up Strategies and Management of Recurrence in Urologic Oncology – Renal Cancer – Familial Hereditary Kidney Cancer  
  Hwang JJ, Uchio EM, Linehan WM, Walther MM, Urol Clin North Am, 11/1/2003
• Diagnostic Localization of Extra-adrenal Pheochromocytoma Using 6-[18F] Flourodopamine Positron Emission Tomography  
  Hwang JJ, Uchio EM, Patel SV, Linehan WM, Walther MM, Pacek C, J Urol, 1/1/2003
• Physiologic studies of male sexual dysfunction in multiple sclerosis  
  Yang CC, Bowen JD, Kraft GH, Uchio EM, Kromm BG, Mult Scler, 8/1/2001
• Cortical Evoked Responses from the Perineal Nerve  
  Uchio EM, Yang CC, Bradley WE, Annals of Neurology, 9/1/1999
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Books/Book Chapters

• Principles and Practice of Geriatric Surgery 
  Chapter: Renal and Bladder Neoplasms in the Elderly. 
  Uchio, EMEditors: R Rosenthal, M Zenilman, and M. Katlic.Springer-Verlag, New York, NYEdition 2nd,2009

Abstracts/Posters

• “The Role of Met Receptor Expression in Prostate Cancer.”
  Uchio EM, Cha C, Calderon J, Hwang J, Walker J, Sener A, Pautler, S, Annual AUA Meeting, Chicago, IL, 1/1/2009
• “The Clinical Utility of Urine Cytology and Fluorescence in situ Hybridization (FISH) for Detecting Transitional Cell Carcinoma (TCC) in a Veterans Population.”
  Uchio EM, Calderon J, Neto A, Taylor J, Hwang J, Concato J, Annual AUA Meeting, Chicago, IL, 1/1/2009
• “Molecular Markers and Long-term Prognosis in Prostate Cancer.”
  Uchio EM, Jain D, Risch H, Li W, Wells CK, Concato J, Annual AUA Meeting, Chicago, IL, 1/1/2009
• “Tissue Microarray Analysis of 622 Patients with Colorectal Adenocarcinoma: High Expression of HuR Predicts Poor Survival.”
  Yoo PS, Gao WL, Kiang S, Uchio E, Chu E, Dardik A, Chung G, Cha, CH, Society of Surgical Oncology, Chicago, IL, 1/1/2008
• “Aging Effects on the von Hippel Lindau (VHL) Tumor Suppressor Pathway in Renal Carcinoma.”
  Garg R, Li Y, Cha CH, Marottoli R, Schmitz J, Walker C, Hwang JJ, Chu E, Uchio EM, Annual Academic Surgical Congress, Huntington Beach, CA, 1/1/2008
• “Development of age-dependent poliomyelitis (ADPM) in SCID mice following injection of tumor suspension matrix contaminated with lactate dehydrogenase-elevating virus ...
  Scholz JA, Garg R, Compton S, Allore H, Zeiss C and Uchio EM, 59th AALAS National Meeting, Indianapolis, IN, 1/1/2008
• "The Role of MET Receptor Expression in Prostate Cancer Cell Lines.”
  Garg R, Li Y, Cha CH, Walker C, Sener A, Hwang JJ, Walker J, Pautler S, Uchio EM, Annual AVAS Meeting, 1/1/2007
• “RNA-Binding Protein HuR regulates expression of VEGF in pancreatic adenocarcinoma cells”
  Yoo, P, Mulkeen A, Schmitz J, Uchio E, Chu E, Cha C, Association of Academic Surgeons, Phoenix, AZ, 1/1/2007
• "The Use of Spectral And Spatial Analysis to Improve The Utility of Urine Cytology in the Diagnosis of Transitional Cell Carcinoma (TCC) Of The Bladder."
  Uchio EM, Li Y, Angeletti C, Li Y, Renzulli J, Walker C, Rimm D, Annual FAMRI Foundation Research Meeting, Miami, FL, 1/1/2007
• "The Use of Spectral And Spatial Analysis to Improve The Utility of Urine Cytology in the Diagnosis of Transitional Cell Carcinoma (TCC) Of The Bladder."
  Garg R, Li Y, Angeletti C, Li Y, Renzulli J, Walker C, Rimm D, Uchio EM, Annual AUA Meeting, Anaheim, CA, 1/1/2007
• “A Novel in vitro model of lymphatic metastasis in colorectal cancer.”
  Yoo PS, Mulkeen AL, Schmitz Sr. J, Uchio EM, Chu E, Cha CH, Association for Academic Surgery. Academic Surgical Congress, Phoenix, AZ, 1/1/2007
• “Angiogenic proliferation in colon cancer cells is mediated by RNA-binding protein HuR.”
  Yoo PS, Mulkeen AL, Schmitz JC, Uchio E, Chu E, Longo WE, Cha, CH, Society of University Surgeons. Academic Surgical Congress, Phoenix, AZ, 1/1/2007
• “Improved Assessment of Prognosis in Prostate Cancer.”
  Uchio EM, Concato J, Jain D, Li WW, Risch HA, Wells CK, ASCO Prostate Cancer Symposium, San Francisco, CA, 1/1/2006
• An autocrine VEGF pathway mediates proliferation in the RKO colorectal cancer cell line.
  Silva T, Mulkeen A, Schmitz J, Uchio E, Chu E, Cha C, American Association for Cancer Research, Washington, DC, 1/1/2006
• “RNA-Binding protein HuR regulates VEGF expression in human colorectal cancer cells.”
  Yoo PS, Mulkeen AL, Silva T, Schmitz J, Tai N, Uchio EM, Chu E, Cha CH, Association for Academic Surgeons, Academic Surgical Congress, San Diego, CA, 1/1/2006
• “Expression of GRO-alpha, an Oncogenic Chemokine, in the Prostate Epithelium: Role in Normal and Malignant Tissues.”
  Hwang JJ, Uchio EM, Phillips J, Linehan WM, AUA Annual Meeting, Atlanta, GA, 1/1/2006
• “Minimally Invasive Sural Nerve Harvest for Cavernous Nerve Reconstruction in Non-nerve-sparing Radical Retropubic Prostatectomy.”
  Uchio EM, Hwang JJ, Narayan D, AUA Annual Meeting, Video Session, Atlanta, GA, 1/1/2006
• “Aging Effects on the von Hippel Lindau (VHL) Tumor Suppressor Pathway in Renal Carcinoma.”
  Uchio EM, Garg R, Li Y, Cha CH, Marottoli R, Schmitz J, Chu E, AUA Annual Meeting, Atlanta, GA, 1/1/2006
• "The Use of Spectral And Spatial Analysis to Improve The Utility of Urine Cytology in the Diagnosis of Transitional Cell Carcinoma (TCC) Of The Bladder."
  Garg R, Li Y, Angeletti C, Li Y, Renzulli J, Walker C, Rimm D, Uchio EM, 75th Annual Meeting New England Section Annual AUA meeting, Providence, RI, 1/1/2006
• "The Role of MET Receptor Expression in Prostate Cancer Cell Lines.”
  Garg R, Li Y, Cha CH, Walker C, Sener A, Hwang JJ, Walker J, Pautler S, Uchio EM, 75th Annual Meeting New England Section Annual AUA meeting, Providence, RI, 1/1/2006
• Post-transcriptional Regulation of VEGF: Potential for novel therapies
  Cha C, Mulkeen AL, Yoo PS, Silva T, Schmitz JC, Chu E, Uchio E, Surgical Forum of the American College of Surgeons, Chicago, IL, 1/1/2006
• Effects of Aging on Tumor Angiogenesis in GI Malignancy.
  Mulkeen A, Silva T, Schmitz J, Uchio E, Cha C, American Geriatrics Society, Orlando, FL, 1/1/2005
• “Aging Effects on the von Hippel Lindau (VHL) Tumor Suppressor Pathway in Renal Carcinoma.”
  Uchio EM, Garg R, Li Y, Cha CH, Schmitz J, Chu E, American Geriatrics Society Annual Scientific Meeting, Orlando, FL, 1/1/2005
• SiRNA-Mediated Gene Silencing in Colorectal Cancer: A Novel Anti-angiogenic Targeted Therapy.
  Mulkeen A, Silva T, Schmitz J, Uchio E, Chu E, Cha C, New England Surgical Society Annual Meeting, Mt. Washington, NH, 1/1/2005
• SiRNA-Mediated Gene Silencing in Colorectal Cancer: A Novel Anti-angiogenic Targeted Therapy.
  Mulkeen A, Silva T, Schmitz J, Uchio E, Chu E, Cha C, New England Surgical Society Resident’s Forum, Boston, MA, 1/1/2005
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Lectures

• “UCI Department of Urology Focus Event” 
  Irvine, CA - 1/1/2013
• “XTANDI (enzalutamide) capsules: Inhibiting the Androgen Receptor Signaling Pathway at Multiple Steps” 
  Monterey, CA - 1/1/2013
• “New Prostate Screening Guidelines and Advances in Treatment of Prostate Cancer Utilizing Cyberknife Stereotactic Radiation” 
  Riverside Community Hospital, Riverside, CA - 1/1/2013
• “The Evolving Role of the Urologist in Oncology" 
  Orange, CA - 1/1/2013
• “The Clinical Experience with AML and TSC, the Role of Affinitor” 
  Phoenix, AZ - 1/1/2013
• “Robotic Technology at the VACT Healthcare System: Technique and Outcomes” 
  West Haven, CT - 1/1/2009
• “Robotic Technology in the VA System” 
  Boston, MA - 1/1/2009
• “Minimally Invasive Treatment for Genitourinary Tumors” 
  West Haven, CT - 1/1/2008
• “New Technology in the Treatment of Prostate Cancer” 
  1/1/2008
• “Complications of Robotic Radical Prostatectomy” 
  Georgetown University, Washington, DC - 1/1/2008
• “Robotic Surgery in Prostate Cancer” 
  Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA - 1/1/2007
• “Aging Effects on the von Hippel Lindau (VHL) Tumor Suppressor Pathway in Renal Carcinoma” 
  University of Connecticut, School of Medicine, Farmington, CT - 1/1/2007
• “Laparoscopic Renal Surgery” (Lecturer and Surgical Instructor) 
  Robert Wood Johnson UMDNJ, New Brunswick, NJ - 1/1/2005
• “Molecular Basis of Renal Cell Carcinoma” 
  Robert Wood Johnson UMDNJ, New Brunswick, NJ - 1/1/2004
• “New Advances in the Treatment of Renal Cell Carcinoma” 
  St. Mary’s Medical Center, Waterbury, CT - 1/1/2004
• “Physiologic Studies of Male Sexual Dysfunction in Multiple Sclerosis” 
  Toronto, Canada - 1/1/2001
• “Urologic Problems in the Pregnant Patient” 
  Seattle, WA - 1/1/2000
• “Gene Therapy in Urologic Malignancies” 
  Seattle, WA - 1/1/2000
• “Recent Advances in Neurourology” 
  Virginia Mason Clinic, Seattle, WA - 1/1/1999
• “The Neurourology of Erection” 
  University of Washington, Seattle, WA - 1/1/1999
• “Defining Normal Serum Creatinines in the Quadriplegic Patient” 
  University of Washington, Seattle, WA - 1/1/1999
• “Cortical Evoked Responses from the Perineal Nerve” 
  University of Washington, Seattle, WA - 1/1/1999
• “Unilateral Cortical Evoked Responses from the Dorsal Nerve of the Penis” 
  University of Washington, Seattle, WA - 1/1/1999
• “The Role of Penile Somatosensory Innervation in Psychogenic Erections” 
  University of Washington, Seattle, WA - 1/1/1999
• “Renal Infarction: Diagnosis and Management” 
  University of Washington, Seattle, WA - 1/1/1998
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Other

• “Cancer Answers” 
  Uchio EM, Connecticut WNPR Radio Show, New Haven, CT
  1/1/2008
• “Innovations in Kidney Cancer” 
  Uchio EM, Connecticut WNPR Radio Show, New Haven, CT
  1/1/2008