EdwinKarlKuffnerJr.MD

PubMed

• 2 citations
  JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients un...
  Cathy K Gelotte, Amy M Vakil, Brenda A Zimmerman, Peter Zannikos, Rajesh Mishra, Gary Eichenbaum, Edwin K Kuffner, Christopher M Flores> ;Regulatory Toxicology and Pharmacology. 2023 Aug 23
• 1 citations
  Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
  Heng-Keang Lim, Jie Chen, Wing Lam, Yong Gong, Laurent Leclercq, Jose Silva, Rhys Salter, Joris Berwaerts, Cathy K Gelotte, Amy M Vakil, Gary E Eichenbaum, Edwin K Kuf...> ;Regulatory Toxicology and Pharmacology. 2023 Mar 16
• 1 citations
  Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
  Junguo Zhou, Sandra De Jonghe, Ellen E Codd, Sandy Weiner, David Gallacher, Paul Stahle, Michael F Kelley, Edwin K Kuffner, Christopher M Flores, Gary E Eichenbaum> ;Regulatory Toxicology and Pharmacology. 2023 Jan 4
• 3 citations
  First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.
  Cathy K Gelotte, Amy M Vakil, Joris Berwaerts, Brenda A Zimmerman, Gary E Eichenbaum, Christopher M Flores, Edwin K Kuffner> ;Regulatory Toxicology and Pharmacology. 2022 Oct 1
• 18 citations
  Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential
  Hartmut Jaeschke, F. Jay Murray, Andrew D. Monnot, David Jacobson-Kram, Samuel M. Cohen, Jerry F. Hardisty, Evren Atillasoy, Anne Hermanowski-Vosatka, Edwin Kuffner, D...> ;Regulatory Toxicology and Pharmacology. 2021 Jan 1
• 8 citations
  Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
  Gary Eichenbaum, Kyunghee Yang, Yeshitila Gebremichael, Brett A. Howell, F. Jay Murray, David Jacobson-Kram, Hartmut Jaeschke, Edwin Kuffner, Cathy K. Gelotte, John C....> ;Regulatory Toxicology and Pharmacology. 2020 Oct 22
• 3 citations
  A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential
  F. Jay Murray, Andrew D. Monnot, David Jacobson-Kram, Samuel M. Cohen, Jerry F. Hardisty, Suren B. Bandara, Michael Kovochich, Milind Deore, Suresh Kumar Pitchaiyan, C...> ;Regulatory Toxicology and Pharmacology. 2020 Oct 9
• 4 citations
  Comparison of the Efficacy and Safety of 2 Acetaminophen Dosing Regimens in Febrile Infants and Children: A Report on 3 Legacy Studies.
  Anthony R. Temple, Brenda Zimmerman, Cathy K. Gelotte, Edwin Kuffner> ;The Journal of Pediatric Pharmacology and Therapeutics. 2017 Mar 6
• 23 citations
  Dosing and antipyretic efficacy of oral acetaminophen in children.
  Anthony R. Temple, Brigham R. Temple, Edwin K. Kuffner> ;Clinical Therapeutics. 2013 Sep 1
• The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study.
  Dart, R. C., Green, J. L., Kuffner, E. K., Heard, K., Sproule, B., Brands, B.> ;Aliment Pharmacol Ther. 2010 Aug
• 8 citations
  Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature.
  Edwin Kuffner, Mitesh Patel> ;The American Journal of Forensic Medicine and Pathology. 2010 Mar 1
• AASLD public policy statement should be evidence-based
  Edwin K. Kuffner, Jeffrey S. Baggish> ;Hepatology. 2008 Mar 1
• 54 citations
  The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients – a multicenter randomized study
  Edwin K. Kuffner, Jody L. Green, Greg Bogdan, Pat C. Knox, Rob B. Palmer, Kennon Heard, J.T. Slattery, Richard C. Dart> ;BMC Medicine. 2007 May 30
• 36 citations
  Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials
  Edwin K. Kuffner, Anthony R. Temple, Kimberly M. Cooper, Jeffrey S. Baggish, Dennis L Parenti> ;Current Medical Research and Opinion. 2006 Sep 28
• 72 citations
  Clinical policy: Critical issues in the evaluation and management of adult patients presenting with suspected pulmonary embolism
  Francis M. Fesmire, Jeffrey A. Kline, Stephen J. Wolf, William C. Dalsey, Andy Jagoda, Wyatt W. Decker, Steven A. Godwin, John M. Howell, J.Stephen Huff, Edwin K. Kuff...> ;Annals of Emergency Medicine. 2003 Feb 1
• 4 citations
  Alcohol and Acetaminophen Hepatotoxicity
  Richard C. Dart, Edwin K. Kuffner> ;Archives of Internal Medicine. 2003 Jan 27
• New perspectives on acetaminophen and alcohol use.
  Kuffner, E. K.> ;Am J Manag Care. 2001 Dec
• 2 citations
  Acetaminophen use in patients who drink alcohol: current study evidence.
  Edwin K. Kuffner, Richard C. Dart> ;The American Journal of Managed Care. 2001 Dec 1
• 85 citations
  Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: A randomized, double-blind, placebo-controlled trial
  Edwin K. Kuffner, Richard C. Dart, Gregory M. Bogdan, Robert E. Hill, Edmund Casper, Lisa Darton> ;Archives of Internal Medicine. 2001 Oct 8
• 3 citations
  Use of acetaminophen in alcoholic patients: comment on the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarth...
  Richard C. Dart, Edwin K. Kuffner> ;Arthritis and Rheumatism. 2001 Oct 1
• 70 citations
  Clinical policy: Critical issues in the evaluation and management of patients presenting with syncope
  Stephen A Colucciello, Barbara A Murphy, Thomas P Martin, M. S. Radeos, Stephen V. Cantrill, William C. Dalsey, Mark Campbell, Wyatt W. Decker, Francis M. Fesmire, E. ...> ;Annals of Emergency Medicine. 2001 Jan 1
• 59 citations
  Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.
  Richard C. Dart, Edwin K. Kuffner, Barry H. Rumack> ;American Journal of Therapeutics. 2000 Mar 1
• 51 citations
  Clinical policy: Critical issues for the initial evaluation and management of patients presenting with a chief complaint of nontraumatic acute abdominal pain
  E. J. Gallagher, Thomas W. Lukens, Stephen A Colucciello, David L. Morgan, Stephen V. Cantrill, Melody Campbell, William C. Dalsey, Wyatt W. Decker, Francis M. Fesmire...> ;Annals of Emergency Medicine. 2000 Jan 1
• 58 citations
  Clinical policy: Critical issues in the evaluation and management of adult patients presenting with suspected acute myocardial infarction or unstable angina
  Francis M. Fesmire, Mark Campbell, Wyatt W. Decker, John M. Howell, Jeffrey A. Kline, Stephen V. Cantrill, Stephen A Colucciello, William C. Dalsey, Andy Jagoda, S Jr ...> ;Annals of Emergency Medicine. 2000 Jan 1
• 24 citations
  Ingestion of low-concentration hydrofluoric acid: an insidious and potentially fatal poisoning.
  Wei Fong Kao, Richard C Dart, Edwin K. Kuffner, Greg Bogdan> ;Annals of Emergency Medicine. 1999 Jul 1
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