EfratDotanMD

Oncology • Philadelphia, PA

Gastrointestinal Cancer, Hematologic Oncology

Assistant Professor, Program Director, Hematology/Oncology Fellowship Program

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Office
333 Cottman Avenue
Fox Chase Cancer Center
Philadelphia, PA 19111
Phone+1 215-728-6900

Fax+1 215-728-3639
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Summary

I specialize in treatment of patients with gastrointestinal cancers with various chemotherapies. My goal is to provide each patient with cutting age therapy for therapy for their cancer, and supportive care necessary for tolerating treatment. I am specifically interested in caring for older adults with gastrointestinal cancers, while focusing on other factors that are not related to their cancer and complicates their care.

Education & Training

Temple University HospitalFellowship, Hematology and Medical Oncology, 2007 - 2010
Zucker School of Medicine at Hofstra/Northwell at Lenox Hill HospitalResidency, Internal Medicine, 2003 - 2006
Technion-Israel Inst of Technology Faculty of MedicineClass of 2002

Certifications & Licensure

PA State Medical License 2007 - 2024
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer Start of enrollment: 2010 Oct 01
Terminated
Phase 1
The Hurria Older PatiEnts (HOPE) With Breast Cancer Study Start of enrollment: 2011 Sep 09
Active, not recruiting
Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer Start of enrollment: 2013 Feb 12
Terminated
Phase 1, Phase 2
Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy Start of enrollment: 2013 Oct 01
Terminated
Dose Escalation Study of OMP-54F28 in Combination With Nab-Paclitaxel and Gemcitabine in Patients With Previously Untreated Stage IV Pancreatic Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 1
Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver Start of enrollment: 2016 Jan 29
Terminated
Phase 1
Regorafenib in Metastatic Colorectal Cancer Start of enrollment: 2015 Mar 01
Completed
Phase 2
Improving the Approach to and Management of the Older Metastatic Breast Cancer Patient Start of enrollment: 2016 Nov 01
Completed
Not Applicable
Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread Start of enrollment: 2020 Aug 26
Active, not recruiting
Phase 2
Improving the Approach to and Management of the Older Patient With Metastatic Gastric Cancer Start of enrollment: 2020 Sep 22
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
PHL Treatment in Pancreatic Cancer Start of enrollment: 2021 Oct 20
Recruiting
Early Phase 1
Roles: Contact, Principal Investigator
Redefining FOLFIORINOX in Older Pancreatic Cancer Patients Start of enrollment: 2022 Apr 22
Recruiting
Phase 2
Roles: Principal Investigator, Contact
A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations Start of enrollment: 2022 Apr 18
Active, not recruiting
Phase 1
Roles: Contact
A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) Start of enrollment: 2023 Jan 09
Recruiting
Phase 2, Phase 3
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

HSR24-137: Does Routine Clinical Assessment of Older Adults With Gastroesophageal Cancer Tell the Whole Story?
Lauren Laderman, Meghan Connors, Caitlin R Meeker, Elizabeth A Handorf, Kelly A Filchner, Grant R Williams, Arthur Winer, Mohamedtaki A Tejani, Sukeshi P Arora, Namrat...> ;Journal of the National Comprehensive Cancer Network. 2024 Apr 5
Disparities in care of older adults of color with cancer: A narrative review.
Efrat Dotan, Shannon M Lynch, Joanne C Ryan, Edith P Mitchell> ;Cancer Medicine. 2024 Feb 1
Falls prechemotherapy and toxicity-related hospitalization during adjuvant chemotherapy for breast cancer in older women: Results from the prospective multicenter HOPE...
Jingran Ji, Marie Bae, Can-Lan Sun, Tanya M Wildes, Rachel A Freedman, Allison Magnuson, Tracey O'Connor, Beverly Moy, Heidi D Klepin, Andrew E Chapman, William P Tew,...> ;Cancer. 2024 Mar 15
Validation of a Molecular Diagnostic Test for Circulating Tumor DNA by Next-Gen Sequencing.
Sandra V Fernandez, Yin Fei Tan, Shilpa Rao, Patricia Fittipaldi, Fathima Sheriff, Hossein Borghaei, Efrat Dotan, Jennifer S Winn, Martin J Edelman, Joseph Treat, Juli...> ;International Journal of Molecular Sciences. 2023 Oct 30
Evidence-Based Care of Older Adults With Metastatic Colorectal Cancer: Insights From Landmark Clinical Trials.
Dina Ioffe, Efrat Dotan> ;Journal of Clinical Oncology. 2023 Dec 1
2 citations
A phase 1 study of nivolumab in combination with interferon-gamma for patients with advanced solid tumors.
Matthew Zibelman, Alexander W MacFarlane 4th, Kimberly Costello, Thomas McGowan, John O'Neill, Rutika Kokate, Hossein Borghaei, Crystal S Denlinger, Efrat Dotan, Danie...> ;Nature Communications. 2023 Jul 27
Cancer rarely travels alone: Addressing the accumulation of risk and early mortality for older adults with advanced lung cancer.
Carolyn J Presley, Megan Baumgart, Balazs Halmos, Efrat Dotan> ;Journal of Geriatric Oncology. 2023 Jul 8
9 citations
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
E Gabriela Chiorean, Marco Del Chiaro, Margaret A Tempero, Mokenge P Malafa, Al B Benson, Dana B Cardin, Jared A Christensen, Vincent Chung, Brian Czito, Mary Dillhoff...> ;Journal of the National Comprehensive Cancer Network. 2023 Jul 1
Paclitaxel With or Without Cixutumumab as Second-Line Treatment of Metastatic Esophageal or Gastroesophageal Junction Cancer: A Randomized Phase II ECOG-ACRIN Trial.
Shannon Stockton, Paul Catalano, Steven J Cohen, Barbara A Burtness, Edith P Mitchell, Efrat Dotan, Sam J Lubner, Pankaj Kumar, Mary F Mulcahy, George A Fisher, Theodo...> ;The Oncologist. 2023 Sep 7
Guidance for Treating the Older Adults with Colorectal Cancer.
Dina Ioffe, Efrat Dotan> ;Current Treatment Options in Oncology. 2023 Jun 1
The GIANT trial (ECOG-ACRIN EA2186) methods paper: A randomized phase II study of gemcitabine and nab-paclitaxel compared with 5-fluorouracil, leucovorin, and liposoma...
Efrat Dotan, Paul Catalano, Leon Lenchik, Robert Boutin, Xin Yao, Helga S Marques, Dina Ioffe, David B Zhen, Daneng Li, Lynne I Wagner, Melissa A Simon, Terence Z Wong...> ;Journal of Geriatric Oncology. 2023 Apr 1
3 citations
Venous thromboembolism in metastatic pancreatic cancer.
Lauren Laderman, Krishnalatha Sreekrishnanilayam, Ramesh K Pandey, Elizabeth Handorf, Aryeh Blumenreich, Kristen A Sorice, Shannon M Lynch, Khadija Cheema, Lavanya Nag...> ;European Journal of Haematology. 2023 Jun 1
1 citations
Psychosocial needs of older patients with metastatic breast cancer treated at community centers.
Khyati H Somayaji, Elizabeth Handorf, Caitlin R Meeker, Bianca Lewis, Kelly Filchner, Lori J Goldstein, Efrat Dotan> ;Journal of Geriatric Oncology. 2023 Mar 1
Understanding the Challenges Faced by Esophageal and Gastroesophageal Junction Cancer Survivors.
Erin McGillivray, Rishi Jain, Chethan Ramamurthy, Jennifer Y Sheng, Evgenia Granina, Daohai Yu, Xiaoning Lu, Abbas E Abbas, Efrat Dotan, Joshua E Meyer, Carolyn Y Fang...> ;Journal of Patient Experience. 2023 Jan 1
6 citations
Trial Design Considerations to Increase Older Adult Accrual to National Cancer Institute Clinical Trials.
Jennifer Le-Rademacher, Supriya Mohile, Joseph Unger, Matthew F Hudson, Jared Foster, Stuart Lichtman, Jane Perlmutter, Efrat Dotan, Martine Extermann, Kevin Dodd, Wil...> ;Journal of the National Cancer Institute. Monographs. 2022 Dec 15
5 citations
Low-Intensity Adjuvant Chemotherapy for Breast Cancer in Older Women: Results From the Prospective Multicenter HOPE Trial.
Mina S Sedrak, Can-Lan Sun, Jingran Ji, Harvey J Cohen, Cary P Gross, William P Tew, Heidi D Klepin, Tanya M Wildes, Efrat Dotan, Rachel A Freedman, Tracey O'Connor, S...> ;Journal of Clinical Oncology. 2023 Jan 10
7 citations
A Phase II Study Investigating Cabozantinib in Patients with Refractory Metastatic Colorectal Cancer (AGICC 17CRC01).
Aaron J Scott, Atrayee Basu Mallick, Efrat Dotan, Steven J Cohen, Philip J Gold, Howard S Hochster, Somasundaram Subramaniam, Afsaneh Barzi, George S Watts, Patrick J ...> ;Cancer Research Communications. 2022 Oct 1
2 citations
Assessing Oncologists' Adoption of Biomarker Testing in Metastatic Colorectal Cancer Using Real-World Data.
Pritish Iyer, Mengying Deng, Elizabeth A Handorf, Shazia Nakhoda, Efrat Dotan> ;JNCI Cancer Spectrum. 2022 Nov 1
1 citations
Paraneoplastic limbic encephalitis following treatment with single-agent pembrolizumab for advanced gastroesophageal adenocarcinoma.
Lauren Laderman, Omer Naveed, Carla LoPinto-Khoury, Efrat Dotan, Benjamin Miron> ;BMJ Case Reports. 2022 May 24
28 citations
Circulating Tumor DNA in Precision Oncology and Its Applications in Colorectal Cancer.
Maria F Arisi, Efrat Dotan, Sandra V Fernandez> ;International Journal of Molecular Sciences. 2022 Apr 18
9 citations
Impact of the COVID-19 Pandemic on Treatment Patterns for Patients With Metastatic Solid Cancer in the United States.
Ravi B Parikh, Samuel U Takvorian, Daniel Vader, E Paul Wileyto, Amy S Clark, Daniel J Lee, Gaurav Goyal, Gabrielle B Rocque, Efrat Dotan, Daniel M Geynisman, Pooja Ph...> ;Journal of the National Cancer Institute. 2022 Apr 11
Prospective Comparison of Geriatric Assessment and Provider's Assessment of Older Adults With Metastatic Breast Cancer in the Community.
Rino S Seedor, Caitlin R Meeker, Bianca Lewis, Elizabeth A Handorf, Kelly A Filchner, Ramya Varadarajan, Jack Hensold, Aruna Padmanabhan, Benjamin Negin, Kenneth Blank...> ;The Oncologist. 2022 Mar 4
3 citations
Impact of Immunoscore on the Management of Stage II Colon Cancer Patients: A Physician Survey.
Anup Kasi, Efrat Dotan, Graham M. Poage, Aurelie Catteau, Dewi Vernerey, Manju George, Afsaneh Barzi> ;Cancers. 2021 Oct 30
7 citations
Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
Dina Ioffe, Pooja Phull, Efrat Dotan> ;Cancer Management and Research. 2021 Oct 27
3 citations
Treatment Paradigms for Older Adults with Pancreatic Cancer: a Nuanced Approach.
Arthur Winer, Efrat Dotan> ;Current Treatment Options in Oncology. 2021 Oct 1
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