ElifOralMD

Endocrinology • Ann Arbor, MI

Diabetes, Lipid Metabolism

Endocrinologist, Metabolism Endocrinology Diabetes & Podiatry Clinic

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Office
24 Frank Lloyd Wright Dr
Lobby C Suite 1300
Ann Arbor, MI 48105
Phone+1 734-998-2450
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Education & Training

National Institutes of Health Clinical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1996 - 1999
Detroit Medical Center/Wayne State UniversityResidency, Internal Medicine, 1993 - 1996
Istanbul University FomClass of 1992

Certifications & Licensure

MI State Medical License 1993 - 2024

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Fellow (FACE) American Association of Clinical Endocrinology

Clinical Trials

Recombinant Leptin Therapy for Treatment of Nonalcoholic Steatohepatitis (NASH) Start of enrollment: 2006 Feb 01
Completed
Phase 2
Effect of Macrocomposition on Nonalcoholic Fatty Liver Disease (NAFLD) in Bariatric Surgery Candidates Start of enrollment: 2009 Apr 01
Completed
Not Applicable
Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus Start of enrollment: 2010 Jun 18
Completed
Phase 3
Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy Start of enrollment: 2012 Oct 08
Completed
Phase 2
Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese Start of enrollment: 2012 Dec 01
Terminated
Not Applicable
Amlexanox for Type 2 Diabetes and Obesity Start of enrollment: 2013 Jul 19
Terminated
Phase 2
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients Start of enrollment: 2014 Jan 01
Completed
Phase 2
A 12-Week Study to Assess the Efficacy Safety and Tolerability of Gemcabene in Subjects With Severe Hypertriglyceridemia Start of enrollment: 2016 Dec 01
Completed
Phase 2
Study of Gemcabene in Adults With FPLD Start of enrollment: 2018 Mar 13
Completed
Phase 1, Phase 2
Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy Start of enrollment: 2018 Nov 14
Active, not recruiting
Phase 4
Evaluation of Safety and Efficiency of Metreleptin Treatment for Patients With Multiple Symmetric Lipomatosis (MSL) Start of enrollment: 2023 Aug 01
Enrolling by invitation
Phase 1
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

2 citations
Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia.
Alexander, V., Karwatowska-Prokopczuk, E., Prohaska, T., Li, L., Geary, R., Gouni-Berthold, I., Hegele, R., Stroes, E., Oral, E., Witztum, J., Tsimikas, S.> ;The New England Journal of Medicine. 2024 Feb 1
Efficacy and Safety of Glucagon-Like Peptide 1 Agonists in a Retrospective Study of Patients With Familial Partial Lipodystrophy.
Maria C Foss-Freitas, Salman Imam, Adam Neidert, Anabela Dill Gomes, David T Broome, Elif A Oral> ;Diabetes Care. 2024 Apr 1
1 citations
Letter to the Editor From Taylor et al "Type B Insulin Resistance Syndrome: A Rare Cause of Hypoglycemia".
Shahidzadeh Yazdi, Z., Taylor, S., Oral, E.> ;JCEM Case Reports. 2024 Feb 1
Metabolic and other morbid complications in congenital generalized lipodystrophy type 4.
Akinci, G., Alyaarubi, S., Patni, N., Alhashmi, N., Al-Shidhani, A., Prodam, F., Gagne, N., Babalola, F., Al Senani, A., Muniraj, K., Elsayed, S., Beghini, M., Saydam,...> ;American Journal of Medical Genetics. Part A. 2024 Jan 17
A Very-Low-Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy.
Maria C Foss-Freitas, Özge Besci, Rasimcan Meral, Adam Neidert, Thomas L Chenevert, Oral, E., Rothberg, A.> ;Obesity Facts. 2024 Jan 1
1 citations
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Judith Y Altarejos, Jeffrey Pangilinan, Simona Podgrabinska, Baris Akinci, Maria Foss-Freitas, Adam H Neidert, Yonaton Ray, Wenjun Zheng, Steven Kim, Vishal Kamat, Mei...> ;Science Translational Medicine. 2023 Nov 22
Impact of Nonalcoholic Fatty Liver Disease (NAFLD) on Weight Loss After Bariatric Surgery.
Mohammed Abu-Rumaileh, Raad A Haddad, Matheos Yosef, Nazanene H Esfandiari, Andrew Kraftson, Shafaq Khairi, Corey Lager, Jordan Bushman, Shoukoufeh Khalatbari, Monica ...> ;Obesity Surgery. 2023 Dec 1
Deciphering the Clinical Presentations in LMNA-related Lipodystrophy: Report of 115 Cases and a Systematic Review.
Ozge Besci, Maria Christina Foss de Freitas, Natália Rossin Guidorizzi, Merve Celik Guler, Donatella Gilio, Jessica N Maung, Rebecca L Schill, Keegan S Hoose, Bonje N ...> ;The Journal of Clinical Endocrinology and Metabolism. 2024 Feb 20
1 citations
Impact of diabetes on weight loss outcomes after bariatric surgery: Experience from 5-year follow-up of Michigan Bariatric Surgery Cohort.
Yingying Luo, Raad A Haddad, Mehmet Selman Ontan, Abdel Wahab Jalal Eldin, Mohammed Abu-Rumaileh, Matheos Yosef, Shokoufeh Khalatbari, Oliver Varban, Andrew Kraftson, ...> ;Clinical Endocrinology. 2023 Sep 1
3 citations
Clinical features of generalized lipodystrophy in Turkey: A cohort analysis.
Ilgin Yildirim Simsir, Beyhan Tuysuz, Mehmet Nuri Ozbek, Seher Tanrikulu, Merve Celik Guler, Asuman Nur Karhan, Yasemin Denkboy Ongen, Nilay Gunes, Utku Erdem Soyaltin...> ;Diabetes, Obesity & Metabolism. 2023 Jul 1
2 citations
A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.
Özge Besci, Sevde Nur Fırat, Samim Özen, Semra Çetinkaya, Leyla Akın, Yılmaz Kör, Zafer Pekkolay, Şervan Özalkak, Elif Özsu, Şenay Savaş Erdeve, Şükran Poyrazoğlu, Mer...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Aug 18
1 citations
Pelvis Magnetic Resonance Imaging to Diagnose Familial Partial Lipodystrophy.
Suleyman Cem Adiyaman, Canan Altay, Berfu Y Kamisli, Emre Ruhat Avci, Isil Basara, Ilgin Yildirim Simsir, Tahir Atik, Mustafa Secil, Elif A Oral, Baris Akinci> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Jul 14
2 citations
Predicting Early Weight Loss Failure Using a Bariatric Surgery Outcomes Calculator and Weight Loss Curves.
Andrew Kraftson, Anne H Cain-Nielsen, Amy Lockwood, Yingying Luo, Colleen Buda, Corey Lager, Nazanene H Esfandiari, Elif Oral, Oliver A Varban> ;Obesity Surgery. 2022 Dec 1
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge, UK, 7-8 April 2022.
Héléna Mosbah, Baris Akinci, David Araújo-Vilar, Juan Carrion Tudela, Giovanni Ceccarini, Philippe Collas, I Sadaf Farooqi, Antía Fernández-Pombo, Isabelle Jéru, Fredr...> ;Annales D'endocrinologie. 2022 Dec 1
12 citations
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN stud...
Elif A Oral, Abhimanyu Garg, Joseph Tami, Eric A Huang, Louis St L O'Dea, Hartmut Schmidt, Anatoly Tiulpakov, Ann Mertens, Veronica J Alexander, Lynnetta Watts, Eunju ...> ;Journal of Clinical Lipidology. 2022 Sep 22
10 citations
Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
Caleigh Mandel-Brehm, Sara E Vazquez, Christopher Liverman, Mickie Cheng, Zoe Quandt, Andrew F Kung, Audrey Parent, Brenda Miao, Emmanuel Disse, Christine Cugnet-Ancea...> ;Diabetes. 2023 Jan 1
9 citations
Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-co...
Maria C Foss-Freitas, Baris Akinci, Adam Neidert, Victoria J Bartlett, Eunju Hurh, Ewa Karwatowska-Prokopczuk, Elif A Oral> ;Lipids in Health and Disease. 2021 Dec 5
5 citations
Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients with Partial Lipodystrophy.
Rasimcan Meral, Noemi Malandrino, Mary Walter, Adam H. Neidert, Ranganath Muniyappa, Elif A. Oral, Rebecca J. Brown> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Oct 22
Iron parameters in patients with partial lipodystrophy and impact of exogenous leptin therapy.
Efe Yagiz Akinci, Sabine Boutros, Benjamin J. Ryan, Pinar Sargin, Baris Akinci, Adam H. Neidert, Rita Hench, Jeffrey F. Horowitz, Elif A. Oral> ;BMJ Open Diabetes Research & Care. 2021 Aug 1
8 citations
Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings
Baris Akinci, Angela Subauste, Nevin Ajluni, Nazanene H. Esfandiari, Rasimcan Meral, Adam H. Neidert, Akin Eraslan, Rita Hench, Diana Rus, Barbara J. McKenna, Hero K. ...> ;Med. 2021 Jul 9
12 citations
Adipocyte-specific deletion of lamin A/C largely models human familial partial lipodystrophy type 2.
Callie A.S. Corsa, Carolyn M. Walsh, Devika P. Bagchi, Maria Cristina Foss de Freitas, Ziru Li, Julie Hardij, Katrina Granger, Hiroyuki Mori, Rebecca L. Schill, Kennet...> ;Diabetes. 2021 Jun 4
12 citations
Effect of metformin on outcomes of catheter ablation for atrial fibrillation
Amrish Deshmukh, Michael Ghannam, Jackson J. Liang, Mohammed Saeed, Ryan Cunnane, Hamid Ghanbari, Rakesh Latchamsetty, Thomas Crawford, Syeda Atiqa Batul, Eugene Chung...> ;Journal of Cardiovascular Electrophysiology. 2021 May 1
11 citations
Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis
Keziah Cook, Omer A. Ali, Baris Akinci, Maria Cristina Foss de Freitas, Renan Magalhães Montenegro, Virgínia Oliveira Fernandes, Deepshekhar Gupta, Kai-Jye Lou, Edward...> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Apr 2
2 citations
Risk factors for diabetic foot ulcers in metreleptin naïve patients with lipodystrophy.
O Saydam, B Ozgen Saydam, Suleyman Cem Adiyaman, M Sonmez Ince, Mehmet Eren, Fatma Ela Keskin, Habib Bilen, M Dagdeviren, Sukru Kaya, Gulcin Akinci, Ali Balci, Canan A...> ;Clinical Diabetes and Endocrinology. 2021 Mar 31
5 citations
The Metabolic Equivalent BMI in Patients with Familial Partial Lipodystrophy (FPLD) Compared with Those with Severe Obesity.
Eden Koo, Maria C Foss-Freitas, Rasimcan Meral, Muhammet Ozer, Abdelwahab Jalal Eldin, Baris Akinci, Nicole Miller, Amy E. Rothberg, Elif A. Oral> ;Obesity. 2021 Feb 1
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Journal Articles

Metabolic Parameters, Weight Loss, and Comorbidities 4 Years After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy
Elif A Oral, Nazanene H Esfandiari, Colleen M Buda, Corey J Lager, Oliver A Varban, Andrew T Kraftson, Obesity Surgery

Press Mentions

New Potential Therapy for Fatty Liver DiseaseJune 7th, 2021
Gemphire Announces Termination of Phase 2a Clinical Trial of Gemcabene in Pediatric NAFLDAugust 10th, 2018
Michigan Medicine's Division of Metabolism, Endocrinology and Diabetes Showcases New Research at Endocrine Society's ENDO 2018March 17th, 2018
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