ElineTLuning PrakMD

PubMed

• 6 citations
  Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
  Allan Feng, Emily Y Yang, Andrew Reese Moore, Shaurya Dhingra, Sarah Esther Chang, Xihui Yin, Ruoxi Pi, Elisabeth Km Mack, Sara Völkel, Reinhard Geßner, Margrit Gündis...> ;JCI Insight. 2023 Feb 8
• 37 citations
  Tissue adaptation and clonal segregation of human memory T cells in barrier sites.
  Maya M L Poon, Daniel P Caron, Zicheng Wang, Steven B Wells, David Chen, Wenzhao Meng, Peter A Szabo, Nora Lam, Masaru Kubota, Rei Matsumoto, Adeeb Rahman, Eline T Lun...> ;Nature Immunology. 2023 Feb 1
• 26 citations
  BTK inhibition limits B-cell-T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy.
  Rui Li, Hao Tang, Jeremy C Burns, Brian T Hopkins, Carole Le Coz, Bo Zhang, Isabella Peixoto de Barcelos, Neil Romberg, Amy C Goldstein, Brenda L Banwell, Eline T Luni...> ;Acta Neuropathologica. 2022 Apr 1
• 9 citations
  No increase in inflammation in late-life major depression screened to exclude physical illness.
  Eline T Luning Prak, Thomas Brooks, Walid Makhoul, Joanne C Beer, Ling Zhao, Tommaso Girelli, Carsten Skarke, Yvette I Sheline> ;Translational Psychiatry. 2022 Mar 24
• 5 citations
  Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections.
  Allan Feng, Emily Yang, Andrew Moore, Shaurya Dhingra, Sarah Chang, Xihui Yin, Ruoxi Pi, Elisabeth Mack, Sara Völkel, Reinhard Geßner, Margrit Gundisch, Andreas Neubau...> ;Research Square. 2022 Jan 20
• 2 citations
  AIRR Community Guide to Planning and Performing AIRR-Seq Experiments.
  Anne Eugster, Magnolia L Bostick, Nidhi Gupta, Encarnita Mariotti-Ferrandiz, Gloria Kraus, Wenzhao Meng, Cinque Soto, Johannes Trück, Ulrik Stervbo, Eline T Luning Prak> ;Methods in Molecular Biology. 2022 Jan 1
• 2 citations
  Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis.
  Susanna Marquez, Lmar Babrak, Victor Greiff, Kenneth B Hoehn, William D Lees, Eline T Luning Prak, Enkelejda Miho, Aaron M Rosenfeld, Chaim A Schramm, Ulrik Stervbo> ;Methods in Molecular Biology. 2022 Jan 1
• 2 citations
  Bulk gDNA Sequencing of Antibody Heavy-Chain Gene Rearrangements for Detection and Analysis of B-Cell Clone Distribution: A Method by the AIRR Community.
  Aaron M Rosenfeld, Wenzhao Meng, Kalisse I Horne, Elaine C Chen, Davide Bagnara, Ulrik Stervbo, Eline T Luning Prak> ;Methods in Molecular Biology. 2022 Jan 1
• 28 citations
  Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex.
  Maya M.L. Poon, Eve Byington, Wenzhao Meng, Masaru Kubota, Rei Matsumoto, Alba Grifoni, Daniela Weiskopf, Pranay Dogra, Nora Lam, Peter A. Szabo, Basak Burcu Ural, Ste...> ;Cell Reports. 2021 Nov 30
• 39 citations
  A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia.
  Katharine J. Bar, Pamela A. Shaw, Grace H Choi, Nicole A. Aqui, Andrew D. Fesnak, Jasper B Yang, Haideliza Soto-Calderon, Lizette Grajales, Julie Starr, Michelle Andro...> ;The Journal of Clinical Investigation. 2021 Nov 17
• 211 citations
  Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
  Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Younoss Soliman, Matthew Pi...> ;Immunity. 2021 Nov 4
• 11 citations
  Transcriptome and unique cytokine microenvironment of Castleman disease.
  Anna Wing, Jason Xu, Wenzhao Meng, Aaron M. Rosenfeld, Elizabeth Y. Li, Gerald Wertheim, Michele Paessler, Adam Bagg, Dale Frank, Kai Tan, David T. Teachey, Megan S. L...> ;Modern Pathology. 2021 Oct 22
• 498 citations
  mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
  Rishi R. Goel, Mark M Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld, Kendall A. Lundgreen, Arnold Reynaldi, David S. Khoury, Ajinkya...> ;Science. 2021 Oct 14
• 11 citations
  Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.
  Sita Awasthi, James J. Knox, Angela Desmond, Mohamad-Gabriel Alameh, Brian T. Gaudette, John M. Lubinski, Alexis Naughton, Lauren M. Hook, Kevin P. Egan, Ying K. Tam, ...> ;The Journal of Clinical Investigation. 2021 Oct 7
• 168 citations
  Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.
  Sokratis A. Apostolidis, Mihir Kakara, Mark M Painter, Rishi R. Goel, Divij Mathew, Kerry Lenzi, Ayman Rezk, Kristina R. Patterson, Diego A. Espinoza, Jessy C. Kadri, ...> ;Nature Medicine. 2021 Sep 14
• 163 citations
  New-onset IgG autoantibodies in hospitalized patients with COVID-19.
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Communications. 2021 Sep 14
• 7 citations
  BLyS neutralization results in selective anti-HLA alloantibody depletion without successful desensitization.
  Divyansh Agarwal, Eline T. Luning Prak, Tina Bharani, Matthew Everly, Thi-Sau Migone, Michael P. Cancro, David Allman, Insuk Choe, Jane Kearns, Jennifer Trofe-Clark, A...> ;Transplant Immunology. 2021 Dec 1
• 47 citations
  mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern
  Rishi R. Goel, Mark M Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld, Kendall A. Lundgreen, Arnold Reynaldi, David S. Khoury, Ajinkya...> ;Biorxiv. 2021 Aug 23
• 39 citations
  Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.
  Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov,...> ;Nature Communications. 2021 Aug 10
• 4 citations
  TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.
  Mayara Garcia de Mattos Barbosa, Adam R. Lefferts, Daniel Huynh, Hui Liu, Yu Zhang, Beverly Fu, Jenna Barnes, Milagros Samaniego, Richard J. Bram, Raif S. Geha, Ariell...> ;JCI Insight. 2021 Sep 8
• 26 citations
  Maintenance of the human memory T cell repertoire by subset and tissue site.
  Michelle Miron, Wenzhao Meng, Aaron M. Rosenfeld, Shirit Dvorkin, Maya Meimei Li Poon, Nora Lam, Brahma V Kumar, Yoram Louzoun, Eline T. Luning Prak, Donna L. Farber> ;Genome Medicine. 2021 Jun 14
• 11 citations
  Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling.
  Johannes Trück, Anne Eugster, Pierre Barennes, Christopher M. Tipton, Eline T. Luning Prak, Davide Bagnara, Cinque Soto, Jacob S. Sherkow, Aimee S. Payne, Marie-Paule ...> ;Elife. 2021 May 26
• 19 citations
  Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency
  Bryanna Reinhardt, Omar Habib, Kit L. Shaw, Elizabeth Garabedian, Denise A. Carbonaro-Sarracino, Dayna Terrazas, Beatriz Campo Fernandez, Satiro N. De Oliveira, Theodo...> ;Blood. 2021 Oct 14
• 27 citations
  Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation.
  Jianing Fu, Julien Zuber, Brittany Shonts, Aleksandar Obradovic, Wang Z, Kristjana Frangaj, Wenzhao Meng, Aaron M. Rosenfeld, Elizabeth E. Waffarn, Peter Liou, Sai-Pin...> ;The Journal of Clinical Investigation. 2021 Apr 15
• 438 citations
  Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination.
  Rishi R. Goel, Sokratis A. Apostolidis, Mark M Painter, Divij Mathew, Ajinkya Pattekar, Oliva Kuthuru, Sigrid Gouma, Philip Hicks, Wenzhao Meng, Aaron M. Rosenfeld, Sa...> ;Science Immunology. 2021 Apr 15
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Journal Articles

• B cell development in chromosome 22q112 deletion syndrome  
  Derfalvi, B., Maurer, K., McDonald, D.M., Zackai, E., Meng, W., Luning Prak, E.T. and K.E. Sullivan, Clinical Immunology, 1/1/2016
• Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus  
  Walter, J.E., Lo, M., Kis-Toth, K., Tirosh, I., Frugoni, F., Lee, Y.N., Abraham, R.S., Chen, K., Pillai, S., Dunham, J., Tsokos, G., Luning Prak, E.T. and L.D. Notaren..., Journal of Allergy and Clinical Immunology, 1/1/2015
• Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich Syndrome  
  Kolhatkar, N.S., Brahmandam, A., Thouvenel, C., Becker-Herman, S., Jacobs, H.M., Schwartz, M.A., Khim, S., Panigrahi, A.K., Luning Prak, E.T., Thrasher, A.J., Notarang..., Journal of Experimental Medicine, 1/1/2015
• Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases  
  Li, Y.R., Li, J., Zhao, S.D., Bradfield, J.P., Mentch, F.D., Maggadottir, S.M., Hou, C., Abrams, D.J., Chang, D., Gao, F., Guo, Y., Wei, Z., Connolly, J.J., Cardinale,..., Nature Medicine, 1/1/2015
• Genetic Sharing and Heritability of Pediatric Age of Onset Autoimmune Diseases  
  Li, Y.R., Zhao, S., Mohebnasab, M., Li, J., Bradfield, J., Steel, L., Abrams, D., Kobie, J., Mentch, F., Glessner, J., Guo, Y., Wei, Z., Cardinale, C., Bakay, M., Conn..., Nature Communications, 1/1/2015
• Can immune thrombocytopenia be cured with medical therapy?  
  Cuker, A., Luning Prak, E.T. and D. B. Cines, Seminars in Thrombosis and Hemostasis, 1/1/2015
• Invited Review: the analysis of clonal expansions in normal and autoimmune B cell repertoires  
  Uri Hershberg and Eline T. Luning Prak, Phil. Trans. B, 1/1/2015
• RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of "alternative NHEJ"  
  V. Gigi, S. Lewis, O. Shestova, M. Mijuskovic, L. Deriano, W. Meng, E. T. Luning Prak and D. B. Roth, Nucleic Acids Research, 1/1/2014
• Improvement in beta-cell secretory capacity following human islet transplantation according to the CIT07 protocol  
  Rickels, M., Liu, C., Shlansky-Goldberg, R., Soleimanpour, S., Vivek, K., Kamoun, M., Min, Z., Markmann, E., Palangian, M., Dalton-Bakes, C., Fuller, C., Chiou, A., Ba..., Diabetes, 1/1/2013
• Antibodies that bind complex glycosaminoglycans accumulate in the golgi  
  Radic, M., Weigert, M., Khan, S.N., Han, J., Kalinina, O. and E.T. Luning Prak, Proc Natl Acad Sci USA, 1/1/2013
• Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity  
  Andrews, S., Zhang, Q., Lim, S., Li, L., Lee, J-H, Zheng, N. Y., Huang, M., Taylor, W., Farris, A. D., Ni, D., Meng, W., Luning Prak, E. T. and P. Wilson, Journal of Experimental Medicine, 1/1/2013
• DH reading frame usage in the expressed human antibody repertoire is selected based upon amino acid content  
  . Benichou, J., Glanville, J., Luning Prak, E.T., Azran, R., Kuo, T.C., Pons, J., Desmarais, C., Tsaban, L. and Y. Louzoun, J. Immunol, 1/1/2013
• TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells Yet is Also Required for Their Activation  
  Nickerson, K.M., Christensen, S.R., Cullen, J.L., Meng, W., Luning Prak, E. T. and M. J. Shlomchik, J. Immunol, 1/1/2013
• Rituximab Therapy for Primary Sjogren's Syndrome: An Open-Label Clinical Trial and Mechanistic Analysis  
  St. Clair, E.W., Levesque, M.C., Luning Prak, E.T., Vivino, F.B., Alappatt, C.J., Spychala, M.E., Wedgwood, J., McNamara, J., Moser Sivils, K.L., Fisher, L. and P. Cohen, Arthritis and Rheumatism, 1/1/2013
• Altered B cell homeostasis is associated with Type I diabetes and carriers of the PTPN22 allelic variant  
  Habib, T., Funk, A., Rieck, M., Brahmandam, A., Dai, X., Panigrahi, A., Luning Prak, E., Meyer-Bahlburg, A., Sanda, S., Greenbaum, C., Rawlings, D. and J. Buckner, J. Immunol, 1/1/2012
• B-cell tolerance defects in the B6Aec1/2 mouse model of Sjogren's syndrome  
  Meng, W., Li, Y., Xue, E., Satoh, M., Peck, A.B., Cohen, P.L., Eisenberg, R.A. and E. T. Luning Prak, Journal of Clinical Immunology, 1/1/2012
• Sullivan: Rituximab-treated patients have a poor response to influenza vaccination  
  Eisenberg, R.A., Jawad, A.F., Boyer, J., Maurer, K., McDonald, K., Luning Prak, E.T. and K.E, J. Clin. Immunol, 1/1/2012
• Adoptive transfer of autologous T cells improves T cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma  
  Grupp, S.A., Luning Prak, E.T., Boyer, J., McDonald, K.R., Shusterman, S., Thompson, E., Callahan, C., Jawad, A.F., Levine, B.L., June, C.H. and K.E. Sullivan, Clinical Cancer Research, 1/1/2012
• Lenalidomide therapy in treatment refractory cutaneous lupus erythematosus: Histologic and circulating leukocyte profile and potential risk of a systemic lupus flare  
  Braunstein, I., Goodman, N.G., Rosenbach, M., Okawa, J., Shah, A., Krathen, M., Kovarik, C., Luning Prak, E.T. and V.P. Werth, Journal of the American Academy of Dermatology, 1/1/2012
• Restoring balance to B cells in ADA deficiency  
  Eline T. Luning Prak, J. Clin. Invest. Kathryn Claiborn, 1/1/2012
• Age-Related Trends in Pediatric B cell Subsets  
  Luning Prak, E.T., Ross, J., Sutter, J. and K. E. Sullivan, Pediatric and Developmental Pathology, 1/1/2011
• A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22qdel112 deletion syndrome (DiGeorge Sy...  
  Jawad, A.F., Luning Prak, E., Boyer, J., McDonald-McGinn, D., Zackai, E., McDonald, K. and K. Sullivan, J. Clin. Immunol, 1/1/2011
• Selection of individual VH genes occurs at the pro-B to pre-B cell transition  
  Meng, W., Yunk, L., Wang, L-S, Maganty, A., Xue, E., Cohen, P.L., Eisenberg, R.A., Weigert, M.G., Mancini, S.J.C. and E.T. Luning Prak, J. Immunol, 1/1/2011
• Circulating lymphocyte subsets in normal adults are variable and can be clustered into sub-groups  
  Sekiguchi, D.R., Smith, S.B., Sutter, J.A., Goodman, N.G., Propert,K.J., Louzoun, Y., Rogers, W. and E.T. Luning Prak, Cytometry Part B, 1/1/2011
• Caspase-activated DNase is required to maintain tolerance to lupus nuclear autoantigens  
  Jog, N.R., Frisoni, L., Shi, Q., Monestier, M., Hernandez, S., Craft, J., Luning Prak, E.T. and R. Caricchio, Arthritis and Rheumatism, 1/1/2011
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Books/Book Chapters

• Arthritis Research and Therapy 
  Chapter: Persistence and selection of an expanded B cell clone in the setting of rituximab therapy for Sjogren's syndrome 
  Hershberg, U., Meng, W., Zhang, B., Haff, N., St. Clair, EW, Cohen, PL, McNair, PD, Li, L, Levesque, MC and ET Luning PrakEditors: Peter Lipsky.BioMed Central2014
• Frontiers in Immunology 
  Chapter: Trials and Tribulations with VH Replacement 
  W. Meng, S. Jayaraman, B. Zhang, G.W. Schwartz, R. Daber, U. Hershberg, A. Garfall, C. Carlson and E. T. Luning PrakEditors: Jason Zhang.Frontiers Medicine and Engineering2014
• Clinical Transplantation 
  Chapter: Antibody-mediated rejection in heart transplant recipients: potential efficacy of B cell depletion and antibody removal 
  Page 489 - 496Charlene Bierl, Barry Miller, Eline T. Luning Prak, Alison Gasiewski, Jane Kearns, Mariell Jessup and Malek KamounEditors: Terasaki.2006
• Clinical Transplants 
  Chapter: B cell monitoring of transplant patients treated with anti-CD20 
  Page 427 - 437Khaled O. Abdallah and Eline T. Luning PrakEditors: Terasaki.2006
• The Handbook of Transfusion Medicine 
  Chapter: Approach to the Platelet-Refractory Patient 
  Page 209 - 219Luning Prak, EAcademic Press, San Diego, CA2001
• Essentials of Basic Science in Surgery 
  Chapter: Nutrition. Essentials of Basic Science 
  Page 384 - 390Luketich, J. , D. Rigberg and E. Luning PrakEditors: Savage, Fishman and Miller.J.B. Lippincott & Co., Philadelhpia, PA1993
• Essentials of Basic Science in Surgery 
  Chapter: Biochemistry of Metabolism 
  Page 7 - 24Luketich, J. and E. Luning PrakEditors: Savage, Fishman and Miller.J.B. Lippincott & Co, Philadelhpia, PA1993
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Lectures

• B cells, antibodies and antibody repertoires 
  1/1/2016
• Immunodiagnostic lab testing and implications for the rheumatologist 
  Philadelphia, PA - 1/1/2015
• B cell autoimmunity 
  Spring House, PA - 1/1/2015
• Antibody repertoire profiling in health and disease 
  Philadelphia, PA - 1/1/2015
• B cell development and antibody production 
  Spring House, PA - 1/1/2014
• Persistence and selection of an expanded B cell clone in the setting of rituximab therapy for Sjogren's Syndrome 
  Philadelphia, PA - 1/1/2013
• Genetics of the antibody repertoire in autoimmunity 
  Luebbeck, Germany - 1/1/2013
• Advances in Targeting of B cell Survival Factors 
  Washington, DC - 1/1/2012
• Immunology Studies on CIT patients at the University of Pennsylvania 
  Washington, DC - 1/1/2011
• Lymphocyte subset profiling in patients with autoimmunity 
  1/1/2011
• B cell tolerance checkpoints 
  Philadelphia, PA - 1/1/2011
• Systemic Lupus Erythematosus: that's how B cells lose tolerance! 
  1/1/2007
• CAMB 510 
• B-cell development and antibodies 
• Laboratory Measurements course directed by Bruce Sachais 
• CAMB510 B cell tolerance and autoimmunity 
• High throughput sequencing of antibody genes 
  Philadelphia, PA
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