ElizabethMatthewsBruntMD

Pathology • Saint Louis, MO

Anatomic Pathology, Clinical Pathology

Professor, Pathology & Immunology, Washington University School of Medicine

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Office
Emeritus Professor Pathology
Saint Louis, MO 63110
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Education & Training

Mercy Hospital (St Louis)Residency, Pathology-Anatomic and Clinical, 1992 - 1994
Washington University/B-JH/SLCH ConsortiumResidency, Pathology-Anatomic and Clinical, 1983 - 1986
Washington University/B-JH/SLCH ConsortiumResidency, Neurological Surgery, 1982 - 1983
Washington University/B-JH/SLCH ConsortiumInternship, Transitional Year, 1981 - 1982
University of Texas Medical Branch School of MedicineClass of 1981

Certifications & Licensure

MO State Medical License 1987 - 2026
IL State Medical License 2014 - 2017
TX State Medical License 1981 - 1998
American Board of Pathology Anatomic Pathology
American Board of Pathology Clinical Pathology

Clinical Trials

Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS) Start of enrollment: 2005 Jan 01
Completed
Phase 3
Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC) Start of enrollment: 2005 Sep 01
Completed
Phase 3
Registry Study of Neoadjuvant Chemoradiation & Transplant for Cholangiocarcinoma Patients Start of enrollment: 2005 Aug 12
Terminated
Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children Start of enrollment: 2012 Jun 01
Completed
Phase 2, Phase 3
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Publications & Presentations

PubMed

Liver pathology in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: vasculopathic disease beyond nodular regenerative hyperplasia.
Pooja Khonde, Deyali Chatterjee, Madonna Bogacki, M Kathryn Liszewski, Andria L Ford, John P Atkinson, Elizabeth M Brunt, Miner, J., Jonathan J Miner> ;Human Pathology. 2023 May 1
2 citations
Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers.
Zachary L Skidmore, Jason Kunisaki, Yiing Lin, Kelsy C Cotto, Erica K Barnell, Jasreet Hundal, Kilannin Krysiak, Vincent Magrini, Lee Trani, Jason R Walker, Robert Ful...> ;Cancer Genetics. 2022 Jun 1
57 citations
Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD.
Elizabeth M Brunt, Andrew D Clouston, Zachary Goodman, Cynthia Guy, David E Kleiner, Carolin Lackner, Dina G Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine ...> ;Journal of Hepatology. 2022 May 1
4 citations
Improved pathology reporting in NAFLD/NASH for clinical trials.
Caitlin Rose Langford, Marc H Goldinger, Darren Treanor, Clare McGenity, Jonathan R. Dillman, Daniela S. Allende, Robert D. Goldin, Elizabeth M. Brunt, Kurt Zatloukal,...> ;Journal of Clinical Pathology. 2021 Nov 9
19 citations
Banff consensus recommendations for steatosis assessment in donor livers.
Desley Neil, Marta I. Minervini, Maxwell L. Smith, Stefan G. Hubscher, Elizabeth M. Brunt, A. Jake Demetris> ;Hepatology. 2021 Oct 22
3 citations
Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis
Yan Xie, Elizabeth P. Newberry, Elizabeth M. Brunt, Samuel Ballentine, Saeed Soleyman-Jahi, Elizabeth A. Molitor, Nicholas O. Davidson> ;Journal of Lipid Research. 2021 Jan 1
3 citations
Hepatocellular adenomas: the expanding epidemiology.
Elizabeth M. Brunt, Christine Sempoux, Paulette Bioulac-Sage> ;Histopathology. 2021 Jul 1
49 citations
Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer
Elizabeth P. Newberry, Zoe Hall, Yan Xie, Elizabeth A. Molitor, Peter O. Bayguinov, Gregory W. Strout, James A.J. Fitzpatrick, Elizabeth M. Brunt, Julian L. Griffin, N...> ;Hepatology. 2021 Sep 1
226 citations
From NAFLD to MAFLD: Implications of a Premature Change in Terminology.
Zobair M. Younossi, Mary E. Rinella, Arun J. Sanyal, Stephen A. Harrison, Elizabeth M. Brunt, Zachary Goodman, David E. Cohen, Rohit Loomba> ;Hepatology. 2021 Mar 1
17 citations
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer
Valerie Blanc, Jesse D. Riordan, Saeed Soleyman-Jahi, Joseph H. Nadeau, ILKe Nalbantoglu, Yan Xie, Elizabeth A. Molitor, Blair B. Madison, Elizabeth M. Brunt, Jason C....> ;The Journal of Clinical Investigation. 2021 Jan 4
58 citations
NAFLD: Reporting Histologic Findings in Clinical Practice.
Elizabeth M. Brunt, David E. Kleiner, Danielle Carpenter, Mary E. Rinella, Stephen A. Harrison, Rohit Loomba, Zobair M. Younossi, Brent A. Neuschwander-Tetri, Arun J. ...> ;Hepatology. 2021 May 1
24 citations
Deep learning quantification of percent steatosis in donor liver biopsy frozen sections.
Lulu Sun, Jon N. Marsh, Matthew K. Matlock, Ling Chen, Joseph P. Gaut, Elizabeth M. Brunt, S. Joshua Swamidass, Ta-Chiang Liu> ;Ebiomedicine. 2020 Sep 24
10 citations
Liver biopsy reliability in clinical trials: Thoughts from a liver pathologist.
Elizabeth M. Brunt> ;Journal of Hepatology. 2020 Sep 2
39 citations
Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice
Stavra A. Xanthakos, Joel E. Lavine, Katherine P. Yates, Jeffrey B. Schwimmer, Jean P. Molleston, Philip J. Rosenthal, Karen F. Murray, Miriam B. Vos, Ajay Jain, Ann O...> ;Gastroenterology. 2020 Jul 23
Fifty years of impact on liver pathology: a history of the Gnomes
Michael Torbenson, Valeer Desmet, Helmut Denk, Francesco Callea, Alastair D. Burt, Stefan G. Hubscher, Luigi Terracciano, Hans Peter Dienes, Zachary Goodman, Pierre Be...> ;Virchows Archiv. 2021 Feb 1
6 citations
Correction: Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial (PLoS ONE (2019) 14:9 (e0221683) DOI: ...
Victor J. Navarro, Steven H. Belle, Massimo D’Amato, Nezam H. Afdhal, Elizabeth M. Brunt, Michael Fried, K. Rajender Reddy, Abdus S. Wahed, Stephen C. Harrison> ;Plos One. 2019 Jan 1
199 citations
Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease
David E. Kleiner, Elizabeth M. Brunt, Laura Wilson, Cynthia Behling, Cynthia D. Guy, Melissa J. Contos, Oscar W. Cummings, Matthew M. Yeh, Ryan M. Gill, Naga Chalasani...> ;JAMA Network Open. 2019 Oct 2
127 citations
Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.
Mohammad S. Siddiqui, Goro Yamada, Raj Vuppalanchi, Mark L. Van Natta, Rohit Loomba, Cynthia D. Guy, Danielle Brandman, James Tonascia, Naga Chalasani, Brent A. Neusch...> ;Clinical Gastroenterology and Hepatology. 2019 Aug 1
33 citations
Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial.
Victor J Navarro, Steven H Belle, Massimo D'Amato, Nezam Adfhal, Elizabeth M Brunt, Michael W Fried, K Rajender Reddy, Abdus S Wahed, Stephen Harrison> ;Plos One. 2019 Jan 1
81 citations
Improvements in Histologic Features and Diagnosis Associated With Improvement in Fibrosis in Nonalcoholic Steatohepatitis: Results From the Nonalcoholic Steatohepatiti...
Elizabeth M. Brunt, David E. Kleiner, Laura A. Wilson, Arun J. Sanyal, Brent A. Neuschwander-Tetri> ;Hepatology. 2018 Dec 14
Hepatocellular carcinoma: Where are we in 2018?
William C. Chapman, Kevin M. Korenblat, Kathryn J. Fowler, Nael Saad, Adeel S. Khan, Vijay Subramanian, Maria B. Doyle, Leigh Anne Dageforde, Benjamin R. Tan, Patrick ...> ;Current Problems in Surgery. 2018 Nov 1
10 citations
Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease.
Erin E. Elbel, Joel E. Lavine, Michael Downes, Mark L. Van Natta, Ruth T. Yu, Jeffrey B. Schwimmer, Cynthia Behling, Elizabeth M. Brunt, James Tonascia, Ronald M. Evans> ;Hepatology Communications. 2018 Sep 27
41 citations
Systemic Therapy for Combined Hepatocellular-Cholangiocarcinoma: A Single-Institution Experience.
Nikolaos A. Trikalinos, Amy Zhou, Maria B. Doyle, Kathryn J. Fowler, Ashley Morton, Neeta Vachharajani, Manik Amin, Jesse Keller, William C. Chapman, Elizabeth M. Brun...> ;Journal of the National Comprehensive Cancer Network. 2018 Oct 1
46 citations
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm.
Nancy M. Joseph, Elizabeth M. Brunt, Celia Marginean, ILKe Nalbantoglu, Dale C. Snover, Swan N. Thung, Matthew M. Yeh, Sarah E. Umetsu, Linda D. Ferrell, Ryan M. Gill> ;The American Journal of Surgical Pathology. 2018 Sep 1
9 citations
Genetic Variants Associated With Obesity and Insulin Resistance in Hispanic Boys With Nonalcoholic Fatty Liver Disease.
John C. Rausch, Joel E. Lavine, Naga Chalasani, Xiuqing Guo, Soonil Kwon, Jeffrey B. Schwimmer, Jean P. Molleston, Rohit Loomba, Elizabeth M. Brunt, Yii-Der Ida Chen, ...> ;Journal of Pediatric Gastroenterology and Nutrition. 2018 May 1
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Journal Articles

Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease
Joel E Lavine, Cynthia Behling, Jeffrey B Schwimmer, Elizabeth M Brunt, Hepatology Communications

Lectures

Surgical Pathology for the Practicing Pathologist
Harvard Medical School, Fort Myers, Florida - 3/14/2013

Press Mentions

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients with Nonalcoholic SteatohepatitisApril 13th, 2020
Struggling to Find a Foothold with NAFLDMarch 1st, 2020