ElliotMarkEpnerMDPhD Genetics

PubMed

• 9 citations
  Mantle cell lymphoma management trends and novel agents: where are we going?
  Jeffrey J Pu, Malvi Savani, Nick Huang, Elliot M Epner> ;Therapeutic Advances in Hematology. 2022 Jan 1
• Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma.
  Francis R LeBlanc, Zainul S Hasanali, August Stuart, Sara Shimko, Kamal Sharma, Violetta V Leshchenko, Samir Parekh, Haiqing Fu, Ya Zhang, Melvenia M Martin, Mark Kest...> ;Oncotarget. 2022 Jan 1
• 16 citations
  Phase 1-2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B-cell non-Hodgkin lymphoma and previously untreated mantle cell lymphoma.
  Stephen E. Spurgeon, Kamal Sharma, David F. Claxton, Christopher Ehmann, Jeffrey J. Pu, Sara Shimko, August Stewart, N. Subbiah, Gundula Palmbach, Francis LeBlanc, Emi...> ;British Journal of Haematology. 2019 Sep 1
• 25 citations
  Mantle cell lymphoma and its management: where are we now?
  Abdullah Ladha, Jianzhi Zhao, Elliot M. Epner, Jeffrey J. Pu> ;Experimental Hematology & Oncology. 2019 Jan 30
• 3 citations
  Combination epigenetic and immunotherapy overcomes resistance to monoclonal antibodies in hematologic malignancies: A new therapeutic approach
  Elliot M. Epner, Bikramajit Singh Saroya, Zainul Hasanali, Thomas P. Loughran> ;Experimental Hematology. 2016 Mar 1
• 38 citations
  Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia
  Zainul Hasanali, Bikramajit Singh Saroya, August Stuart, Sara Shimko, Juanita J. Evans, Mithun Vinod Shah, Kamal Sharma, Violetta V. Leshchenko, Samir Parekh, Thomas P...> ;Science Translational Medicine. 2015 Jun 24
• 5 citations
  Vorinostat Downregulates CD30 and Decreases Brentuximab Vedotin Efficacy in Human Lymphocytes
  Zainul Hasanali, Elliot M. Epner, David J. Feith, Thomas P. Loughran, Clare E. Sample> ;Molecular Cancer Therapeutics. 2014 Dec 1
• 99 citations
  A phase II multicenter trial of hyperCVAD MTX/Ara-C and rituximab in patients with previously untreated mantle cell lymphoma; SWOG 0213
  Steven H. Bernstein, Elliot M. Epner, Joseph M. Unger, Michael LeBlanc, Erin Cebula, Richard Burack, Lisa M. Rimsza, Thomas P. Miller, Richard I. Fisher> ;Annals of Oncology. 2013 Jun 1
• G-CSF mobilized vs conventional donor lymphocytes for therapy of relapse or incomplete engraftment after allogeneic hematopoietic transplantation.
  Abbi, K. K.,Zhu, J.,Ehmann, W. C.,Epner, E.,Carraher, M.,Mierski, J.,Talamo, G.,Lucas, K.,Rybka, W.,Claxton, D.> ;Bone Marrow Transplant.. 2013 Mar
• 5 citations
  Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma.
  Vikas Ghai, Kamal Sharma, Kamal Kant Singh Abbi, Sara Shimko, Elliot M. Epner> ;Advances in Experimental Medicine and Biology. 2013 Jan 1
• 23 citations
  Marginal zone lymphoma: old, new, targeted, and epigenetic therapies
  Monika Joshi, Hassan Sheikh, Kamal Kant Singh Abbi, Sarah Long, Kamal Sharma, Mark Tulchinsky, Elliot M. Epner> ;Therapeutic Advances in Hematology. 2012 Jul 16
• 12 citations
  Flipping the cyclin D1 switch in mantle cell lymphoma
  Zainul Hasanali, Kamal Sharma, Elliot M. Epner> ;Best Practice & Research. Clinical Haematology. 2012 Jun 1
• 32 citations
  Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma
  Stephen E. Spurgeon, Talia Pindyck, Craig Okada, Yiyi Chen, Zunqiu Chen, Elana Mater, Kamal Kant Singh Abbi, Elliot M. Epner> ;Leukemia & Lymphoma. 2011 Jul 14
• 57 citations
  Beyond the CRAB Symptoms: A Study of Presenting Clinical Manifestations of Multiple Myeloma
  Giampaolo Talamo, Umar Farooq, Maurizio Zangari, Jason Liao, Nathan G. Dolloff, Thomas P. Loughran, Elliot M. Epner> ;Clinical Lymphoma, Myeloma & Leukemia. 2010 Dec 1
• 16 citations
  Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients
  Cedar J. Fowler, Jennifer Dunlap, Darcy Troyer, Peter Stenzel, Elliot M. Epner, Richard T. Maziarz> ;Advances in Hematology. 2010 Jun 16
• 41 citations
  Cladribine: not just another purine analogue?
  Stephen E. Spurgeon, Margaret K. Yu, John D. Phillips, Elliot M Epner> ;Expert Opinion on Investigational Drugs. 2009 Jul 15
• 267 citations
  Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE study
  Andre Goy, Steven H. Bernstein, Brad S. Kahl, Benjamin Djulbegovic, Michael J. Robertson, S. de Vos, Elliot M. Epner, Amrita Krishnan, John P. Leonard, Sagar Lonial, S...> ;Annals of Oncology. 2008 Jan 1
• 25 citations
  Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma
  Hui Liu, Jing Huang, Jin Wang, Shuguang Jiang, Alexis S. Bailey, Devorah C. Goldman, Markus Welcker, Victoria Bedell, Marilyn L. Slovak, Bruce E. Clurman, Mathew J. Th...> ;The Journal of Experimental Medicine. 2008 Aug 4
• 108 citations
  Reduced-Intensity Conditioning followed by Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Myelodysplastic Syndrome and Myeloproliferative Disorders
  Ginna G. Laport, Brenda M. Sandmaier, Barry E. Storer, Bart L. Scott, Monic J. Stuart, Thoralf Lange, Michael B. Maris, Edward Agura, Thomas R. Chauncey, Ruby M. Wong,...> ;Biology of Blood and Marrow Transplantation. 2008 Feb 1
• 6 citations
  The epigenetics of mantle cell lymphoma.
  Margaret K. Yu, Elliot M. Epner> ;Current Treatment Options in Oncology. 2007 Oct 1
• 139 citations
  Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
  Christoph Kahl, Barry E. Storer, Brenda M. Sandmaier, Marco Mielcarek, Michael B. Maris, Karl G. Blume, Dietger Niederwieser, Thomas R. Chauncey, Stephen J. Forman, Ed...> ;Blood. 2007 Oct 1
• 587 citations
  Multicenter Phase II Study of Bortezomib in Patients With Relapsed or Refractory Mantle Cell Lymphoma
  Richard I. Fisher, Steven H. Bernstein, Brad S. Kahl, Benjamin Djulbegovic, Michael J. Robertson, Sven de Vos, Elliot M. Epner, Amrita Krishnan, John P. Leonard, Sagar...> ;Journal of Clinical Oncology. 2006 Oct 20
• Bortezomib in patients with relapsed or refractory mantle cell lymphoma (MCL): Preliminary results of the PINNACLE study.
  Goy A, Bernstein S, Kahl B, Epner E, Leonard JP, Stadtmauer E, Morgan D, Belt R, Baidas S, Fisher RI> ;J. Clin. Oncol.. 2005-06-01
• 3 citations
  Targeted Deletion of the Chicken β-Globin Regulatory Elements Reveals a Cooperative Gene Silencing Activity
  Jin Wang, Hui Liu, Chi Mei Lin, Mirit I. Aladjem, Elliot M. Epner> ;The Journal of Biological Chemistry. 2005 Jun 17
• 90 citations
  Sox6 directly silences epsilon globin expression in definitive erythropoiesis.
  Zanhua Yi, Orit Cohen-Barak, Nobuko Hagiwara, Paul D. Kingsley, Deborah Fuchs, Drew T. Erickson, Elliot M. Epner, James Palis, Murray H. Brilliant> ;Plos Genetics. 2005 Jan 1
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Journal Articles

• The Beta-Globin LCR is not Required for an Open Chromatin Structure or Low Level Transcription of the Mouse Beta-Globin Locus.  
  Epner,E, Reik, A, Cimbora, D, Telling, A, Fiering, S, Keller, G, and Groudine, M, Molecular Cell
• Short-term impact of a robot-assisted laparoscopic prostatectomy 'mini-residency' experience on postgraduate urologists' practice patterns.  
  McDougall EM, Corica FA, Chou DS, Abdelshehid CS, Uribe CA, Stoliar G, Sala LG, Khonsari SS, Eichel L, Boker JR, Ahlering TE, Clayman RV, Int J Med Robot
• The locus control region is necessary for beta-globin gene expression but not for the maintenance of an open chromatin structure in erythroid cells.  
  Reik, A, Telling, A, Zitnik, G, Epner, E and Groudine, M, Mol. Cell Biol
• Comparison of basic elements of human performance scores between urologists with various extents of experience.  
  McDougall EM, Corica FA, Chou DS, Uribe CA, Abdelshehid CS, Boker JR, Khonsari SS, Eichel L, Lee D, Finley DS, Hogg D, Cadeddu JA, Pearle MS, Clayman RV, J Endourol
• A Multicenter Phase II Study of Bortezomib in Patients with Relapsed or Refractory Mantle Cell Lymphoma.  
  Fisher,R, Bernstein S, Kahl, B, Djulbegovic, B, Robertson M, De Vos S, Epner, E, Krishnan A, Leonard J, Lonial S, Stadtmauer E, Oconnor O, Shi, H, Boral A, and Goy A, Journal of Clinical Oncology
• Third Prize: Comparison of radical nephrectomy, laparoscopic microwave thermotherapy, cryotherapy, and radiofrequency ablation for destruction of experimental VX-2 ren...  
  Eichel L, Kim IY, Uribe C, Khonsari S, Basillote J, Steward E, Coad J, Bischof J, Rudie E, Kluge S, McDougall EM, Clayman RV, J Endourol
• Initial impact of a dedicated postgraduate laparoscopic mini-residency on clinical practice patterns.  
  Chou DS, Abdelshehid CS, Uribe CA, Khonsari SS, Eichel L, Boker JR, Shanberg AM, Ahlering TE, Clayman RV, McDougall EM, J Endourol
• Oncogene Addiction/ Substitution In Cyclin D1 Deregulated B Cell Malignancies.  
  Stuart., A Huang, J. Ragland, A, Liu, H, Sharma, K and Elliot Epner, Plos One, in revision
• The Epigenetics of Gastrointestinal Malignanicies.  
  Hasanali Z, Stuart, A, Yee, N, Sharma K, and Epner E, Curr Colorectal Cancer Rep
• Platelet-activating factor and the production of human interferon-gamma.  
  Yousefi S, Vaziri N, Carandang G, Villanueva JL, Khonsari S, Ocariz J, Cesario TC, J Interferon Cytokine Res
• What does the human beta-globin locus control region actually control?  
  Epner, E, Kim, C, Groudine, M, Current Biology
• The regulation of Hemoglobin Switching.  
  Fiering, S, Epner, E, Groudine, M, eds. Stamatoyannopoulos, G., Nienhuis, A.W, The Johns Hopkins Univ
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Books/Book Chapters

• Structure and replication of the human beta-globin domain. 
  Chapter: Molecular Mechanisms of Hemoglobin Switching 
  Groudine, M, Forrester, W, Novak, U, Epner, EEditors: Stamatoyannopoulos, G, Neinhuis, A, Liss, A.New York
• Revoltella et. al., Murine erythroleukemia cell differentiation: The relationship of commitment to terminal cell division. Globin mRNA synthesis and cell cycle related effects of inducer. 
  Chapter: Expression of Differentiated Functions in Cancer Cells 
  Marks, P, Chen, Z, Epner, E, Banks, J, Gambari, R, Rifkind, REditors: R. Revoltella.Raven Press, New York
• Chromatin structure and DNA replication patterns in normal and mutant beta-globin gene loci. 
  Chapter: The regulation of Hemoglobin Switching 
  Page 153 - 177Epner, E, Forrester, WC, Kim, C, Telling, A, Enver, T, Brice, M, Papayannopoulou, T, Groudine, MEditors: Stamatoyannopoulos, G., Nienhuis, A.W.The Johns Hopkins Univ, Baltimore and London

Abstracts/Posters

• Desferroxamine: An anti-cyclin D1 agent cytotoxic against cyclin D1 (+) mantle cell lymphoma and multiple myeloma cell lines.
  Epner, E, American Association of Cancer Research
• Long distance deregulation of cyclin D1 expression in B cell malignancy is accompanied by local promoter DNA demethylation and histone hyperacetylation.
  Liu H, Wang J, Epner E, American Association of Cancer Research
• Cyclin D1 Gene Expression is not required for in vitro growth or in vivo tumorigenicity of mantle cell lymphoma lines.
  Wang J, Rangland A, Lui H, Grogan T, Epner E, American Association of Cancer Research
• Desferroxamine: An anti-cyclin D1 agent cytoxic against cyclin D1 (+) mantle cell lymphoma and multiple myeloma cell lines.
  Epner E, Wright H, DeAngelis K, Wang J, Liu H, Clurman B, American Society of Hematology
• Immunoablative Transplantation for Lymphoid Malignancies.
  Briggs A, Safah H, List A, Epner E, Weiner R, Rink J, Miller A, American Society of Bone Marrow Transplant
• Linezolid Use in Patients Prior to or During Stem Cell Transplantation for Vancomycin Resistant Enterococcus Infections: An Effective Nontoxic Therapy.
  Epner E, Shapiro T, Graham M, American Society of Hematology
• Gene Targeting Mediated Ablation Of IgH Deregulated Genes in Human B Cell Lines Reveals that Cyclin D3 can Substitute for Cyclin D1 in Mantle Cell Lymphoma and Multipl...
  Ragland A Liu H, Liu X, Epner E, American Society of Hematology
• Gene Targeting Studies of Cyclin D1 Deregulation in U266 Multiple Myeloma Cells.
  Liu X, Lowe M, Ragland A, Brenneman J, Liu H, and Epner E, American Society of Hematology
• Cyclin D1 Gene Expression Is not Required for In Vitro Growth or In Vivo Tumorigenicity of Mantle Cell Lymphoma Cell Lines.
  Lowe M, Ragland A, Brenneman J, Liu H, Liu X, Stadheim C, List A, Grogan T, Clurman B and Epner E, American Society of Hematology
• Deregulation of Cyclin D1 Expression in B Cell Malignancy Is Accompanied by Promoter DNA Hypomethylation and Histone Hyperacetylation.
  Liu H, Lowe M, Liu X, and Epner E, American Society of Hematology
• Cyclin D1 Deregulation in Mantle Cell Lymphoma and Multiple Myeloma Is Accompanied by Local Promoter Histone Hyperacetylation.
  Liu H, Lowe M, and Epner E, American Society of Hematology
• Initiation of DNA Replication from Multiple Replicators in the Murine Beta-Globin Locus.
  Aladjem M, Cimbora D, Telling A, Wahl G and Groudine M and Epner E, American Society of Hematology
• Deregulation of Cyclin D1 Expression in B Cell Malignancy Is Accompanied by Reversible Local Promoter Histone Hyperacetylation.
  Liu H, Lowe MC, Epner E, American Association of Cancer Research
• Suppression of Cyclin D1 Gene Expression in a Mantle Cell Lymphoma Cell Line by Targeted Insertion of the Eu Intronic Enhancer and a Selectable Marker Gene into the Ma...
  Epner E, Brenneman J, Lowe M, Liu H, Ragland A, Stadheim C and List A, American Association of Cancer Research
• The Beta-Globin LCR Is not Necessary for the Initiation or Maintenance of an Open Chromatin Structure, Replication, or Transcription of the Mouse Beta-Globin Locus.
  Epner E, Reik A, Cimbora D, Telling A,. Bender MA, Aladjem M, Wahl G and Groudine M, American Society of Hematology
• experience with robotic assisted pyeloplasty.
  Khonsari S, Eichel L, Lee D, McDougall EM, Clayman RV, J Endourol, Montreal, QC, Canada
• The Nature of the Inducing Agent Influences the Predominant Production of Either Th1 or Th2 Cytokines.
  Khonsari S, Cesario TC, UCI Journal of Undergraduate Research in the Biological Sciences, University of CA at Irvine Student Center
• Cladribine plus rituximab for the initial treatment of mantle cell lymphoma.
  Talia Pindyck, Stephen E.F. Spurgeon, Marc M. Loriaux, Craig Okada, Yiyi Chen, Zunqiu Chen, Elana Mater, Elliot M. Epner, American Society of Clinical Oncology Annual Meeting
• Targeting the epigenome in B-cell malignancies: A phase I/II study of vorinostat (SAHA), cladribine (2-CdA), and rituximab (R) in B-cell malignancies.
  Stephen E Spurgeon, Craig Y. Okada, Gundula Palmbach, Nan Subbiah, Jing Huang, John D. Phillips, Elliot M. Epner, American Society of Clinical Oncology Annual Meeting
• Hematopoietic Stem Cell Transplantation following Reduced Intensity Conditioning for High Risk Patients with Paroxysmal Nocturnal Hemoglobinuria.
  Agata Mikolajewska, Haifa Kathrin Al-Ali, Nadezda Basara, Elliot Epner, Ernst Holler, Laura Johnston, Dietger Niederwieser, and Thoralf Lange, Blood American Society of Hematology Annual Meeting
• CTCF and Nucleophosmin Participate in Long Distance Cyclin D1 Deregulation in Mantle Cell Lymphoma.
  Elliot M. Epner, Jing Huang, Hui Liu, Jin Wang, Shugiang Liang, and William H. Fleming, CTCF and Nucleophosmin Participate in Long Distance Cyclin D1 Deregulation in Mantle Cell Lymphoma
• A Multi Center Trial of hyperCVAD+Rituxan in Patients with Newly Diagnosed Mantle Cell Lymphoma.
  Elliot M. Epner, Joseph Unger, Thomas Miller, Lisa Rimzsa, Catherine Spier, Michael Leblanc, and Richard Fisher, Blood American Society of Hematology Annual Meeting
• Applying the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) in Myeloablative MUD Transplants Predicts NRM and OS Using a Modified 2-Tier Scoring System.
  Tibor Kovacsovics, Byung Park, Brandon Hayes-Lattin, Jose F. Leis, Peter T. Curtin, Gabrielle Meyers, Elliot Epner, and Richard T. Maziarz, Blood American Society of Hematology Annual Meeting
• Transvection Mediated by the Translocated Cyclin D1 Locus in B Cell Malignancies.
  Elliot Epner, Jing Huang, Hui Liu, Jin Wang, and W.H. Fleming, Blood American Society of Hematology Annual Meeting
• Has a Single-Agent Response Rate of 21% in Patients with Refractory or Recurrent Systemic Anaplastic Large Cell Lymphoma (ALCL).
  Andres Forero-Torres, Steven H. Bernstein, Ajay Gopal, Francine Foss, John P. Leonard, Joseph D. Rosenblatt, Nancy L. Bartlett, Bruce D. Cheson, Elliot Epner, Francisc..., Blood American Society of Hematology Annual Meeting
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Lectures

• Traumatic Brain Injury. 
  University of CA, Irvine Department
• Rehabilitation Issues in Parkinson’s Disease. 
  Huntington Parkinson’s Support Group
• Bladder Function and Dysfunction. 
  Casa Colina Centers for Rehabilitation Stroke Symposium
• Regarding pain and treatment options for pain 
  La Fetra Senior Center, Glendora Community Services, Glendora, CA
• Traumatic Brain Injury Recovery. 
  Ontario, CA
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Other

• Recombination-proficient avian/mammalian microcell hybrids. 
  Epner E
• Targeting nucleophosmin in mantle cell lymphoma. 
  Epner E
• Therapeutic drug combinations for the treatment of B Cell Malignancies. 
  Epner E
• Therapeutic drug combinations using epigenetic and monoclonal antibody therapy in human malignancies. 
  Epner E
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