Emmanouil Stylianos Brilakis MD FACC, FAHA, FSCAI, FESC

Interventional Cardiology

Director of the Center for Complex Coronary Interventions at the Minneapolis Heart Institute and Chairman of the Center for Coronary Artery Disease at the Minneapolis Heart Institute Foundation.

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800 E 28th StMinneapolis, MN 55407
Phone+1 612-863-3900
Fax+1 612-863-5667

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Summary

Dr. Emmanouil Brilakis is a cardiologist in Minneapolis, MN and is affiliated with Abbott Northwestern Hospital. He received his medical degree from University of Athens and has been in practice 22 years. He specializes in interventional cardiology and is experienced in interventional cardiology.
Dr. Brilakis leads a large clinical trial group investigating treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, prevention and management of complications, intracoronary imaging, antiplatelet treatment optimization post coronary stenting, radiation safety in the catheterization laboratory, lipid lowering strategies, and implementation of novel technologies in healthcare.

Dr. Brilakis has authored or co-authored over 600 manuscripts and has written the Manual of Percutaneous Coronary Interventions and the Manual of CTO Interventions, now in its 2nd edition. He created the Manual of CTO interventions (https://www.ctomanual.org/ ) and Manual of PCI (https://www.pcimanual.org/) youtube series and websites. He is on the Board of the Cardiovascular Innovations Foundation, an associate editor for Circulation and an editorial board member and reviewer for several journals and grant agencies. He is lecturing and proctoring at several institutions in the United States and abroad.

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Interventional Cardiology, 2003 - 2004
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2000 - 2003
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1997 - 2000
University of AthensClass of 1995

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Certifications & Licensure

AZ State Medical License 2000 - Present
GA State Medical License 2011 - 2028
MN State Medical License 2016 - 2027
TX State Medical License 2004 - 2027
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Interventional Cardiology

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

The SOS (Stenting Of Saphenous Vein Grafts) Trial
COMPLETED
PHASE3
Study of Optimal Clopidogrel Duration in Patients Receiving Drug Eluting Stents (SCORE Trial) Start of enrollment: 2008 Sep 11
COMPLETED
NA
Study Comparing Two Methods of Expanding Stents Placed in Legs of Diabetics With Peripheral Vascular Disease
COMPLETED
NA

Publications & Presentations

PubMed

Antegrade dissection and re-entry vs retrograde strategy in chronic total occlusion percutaneous coronary intervention: Rationale and design of the ADRENALINE randomiz...
Maksymilian P Opolski, Mateusz Spiewak, Filip Machaj, Hubert Borzuta, Grzegorz Sobieszek
American Heart Journal. 2026-11-01
Temporal trends in retrograde crossing of epicardial collaterals in chronic total occlusion percutaneous coronary intervention.
Theodoros Vichos, Dimitrios Strepkos, Michaella Alexandrou, Pedro E P Carvalho, Ayman Fath
International Journal of Cardiology. 2026-09-15
Drug-Coated Balloons Versus Drug-Eluting Stents Following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-analysis.
Ricardo F O Suruagy-Motta, Leonardo Dexheimer da Silva, Caio Rodrigues Rosa, Gabriel Lima Vieira Barbosa, Lucas Ferreira Paz Silva
The American Journal of Cardiology. 2026-09-01

Journal Articles

Prevalence, Trends, and Outcomes of Higher Risk Percutaneous Coronary Interventions Among Patients Without Acute Coronary Syndromes☆☆☆
Ivan Chavez, M Nicholas Burke, Daniel Lips, Jay Traverse, Emmanouil S Brilakis, Anil Poulose, Michael Mooney, Paul Sorajja, Yale Wang, ScienceDirect
Meta‐Analysis of the Impact of Successful Chronic Total Occlusion Percutaneous Coronary Intervention on Left Ventricular Systolic Function and Reverse Remodeling
Ivan Chavez, Yale Wang, Emmanouil S Brilakis, Louis P Kohl, Daniel Lips, Michael Mooney, Paul Sorajja, Anil Poulose, M Nicholas Burke, Jay Traverse, Journal of Interventional Cardiology

Books/Book Chapters

Manual of Percutaneous Coronary Interventions
Emmanouil BrilakisElsevier, New YorkEdition 1st,2020
Manual of Coronary Chronic Total Occlusion Interventions
Chapter: ISBN: 9780124201293 eBook ISBN: 9780128004326
Emmanouil BrilakisElsevierEdition 2nd,2017

Lectures

Late Coronary Bypass Graft Failure: Rational Approaches
CRF Transcatheter Cardiovascular Therapeutics - Annual Symposium 2019 - Miami, FL - 9/27/2019
Con: Non-Invasive = Non-Informative. Functional Assessment Is Not Necessary to Treat the Patient
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
CTO The Hybrid Algorithm and Approaches to Radiation Dose Reduction
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019

Authored Content

Sleep Deprivation in Interventional Cardiology: A Necessary Evil or an Opportunity for Improvement?September 2018
Sleep Deprivation in Interventional Cardiology: A Necessary Evil or an Opportunity for Improvement?September 2018
A New Treatment Strategy for Saphenous Vein Graft Lesions? Letting It GoApril 2018

Press Mentions

Economic Barriers to IC Care for Adults and Children with CHD and Potential Policy Solutions: A SCAI Policy StatementNovember 26th, 2025
Comparative Effectiveness of 2 Next-Generation Scatter Radiation Shielding SystemsNovember 25th, 2025
The Ringer Study: Clinical Experience with a Novel Perfusion Balloon Catheter in CAPNovember 24th, 2025