EmmanouilStylianosBrilakisMDFACC, FAHA, FSCAI, FESC

Interventional Cardiology

Director of the Center for Complex Coronary Interventions at the Minneapolis Heart Institute and Chairman of the Center for Coronary Artery Disease at the Minneapolis Heart Institute Foundation.

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Office
920 E 28th Street
#300
Minneapolis, MN 55407
Phone+1 612-863-4204
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Summary

Dr. Emmanouil Brilakis is a cardiologist in Minneapolis, MN and is affiliated with Abbott Northwestern Hospital. He received his medical degree from University of Athens and has been in practice 22 years. He specializes in interventional cardiology and is experienced in interventional cardiology.
Dr. Brilakis leads a large clinical trial group investigating treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, prevention and management of complications, intracoronary imaging, antiplatelet treatment optimization post coronary stenting, radiation safety in the catheterization laboratory, lipid lowering strategies, and implementation of novel technologies in healthcare.

Dr. Brilakis has authored or co-authored over 600 manuscripts and has written the Manual of Percutaneous Coronary Interventions and the Manual of CTO Interventions, now in its 2nd edition. He created the Manual of CTO interventions (https://www.ctomanual.org/ ) and Manual of PCI (https://www.pcimanual.org/) youtube series and websites. He is on the Board of the Cardiovascular Innovations Foundation, an associate editor for Circulation and an editorial board member and reviewer for several journals and grant agencies. He is lecturing and proctoring at several institutions in the United States and abroad.

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Interventional Cardiology, 2003 - 2004
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2000 - 2003
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1997 - 2000
University of AthensClass of 1995

Certifications & Licensure

AZ State Medical License 2000 - Present
TX State Medical License 2004 - 2025
GA State Medical License 2011 - 2024
MN State Medical License 2016 - 2024
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Interventional Cardiology

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

The SOS (Stenting Of Saphenous Vein Grafts) Trial Start of enrollment: 2005 May 01
Completed
Phase 3
Study of Optimal Clopidogrel Duration in Patients Receiving Drug Eluting Stents (SCORE Trial) Start of enrollment: 2008 Sep 11
Completed
Not Applicable
Study Comparing Two Methods of Expanding Stents Placed in Legs of Diabetics With Peripheral Vascular Disease Start of enrollment: 2008 Nov 01
Completed
Not Applicable
Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions Start of enrollment: 2009 May 01
Completed
Phase 4
AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study Start of enrollment: 2009 Nov 01
Completed
Phase 4
Cardiac CAtheterization for Bypass Graft Patency Rate Optimization: the CABG-PRO Randomized-controlled Pilot Study Start of enrollment: 2010 Feb 01
Unknown status
Phase 3
Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty Start of enrollment: 2012 Jan 11
Completed
Phase 4
Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis Start of enrollment: 2010 Oct 01
Completed
Phase 2
Use of Optical Coherence Tomography to Determine the Optimal Management of Patients With Drug-eluting Stents Who Need Non-cardiac Surgery Start of enrollment: 2011 Jan 01
Terminated
Phase 4
RADIAL Versus Femoral Access for Coronary Artery Bypass Graft Angiography and Intervention (RADIAL-CABG) Trial Start of enrollment: 2011 Oct 01
Completed
Phase 3
Prevention of Serious Adverse Events Following Angiography Start of enrollment: 2013 Oct 07
Completed
Phase 3
Effect of a Real Time Radiation Monitoring Device on Radiation Exposure During Cardiac Catheterization Start of enrollment: 2012 Jan 01
Completed
Phase 3
Prasugrel for Prevention of Early Saphenous Vein Graft Thrombosis Start of enrollment: 2013 Feb 01
Completed
Phase 3
Functional Change in Endothelium After Cardiac cAtheterization, With and Without Music Therapy Start of enrollment: 2012 Jun 01
Completed
Phase 4
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention Start of enrollment: 2012 Jan 01
Recruiting
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease Start of enrollment: 2014 Aug 25
Active, not recruiting
Not Applicable
ORACLE-NIRS: Lipid cORe Plaque Association With CLinical Events: a Near-InfraRed Spectroscopy Study Start of enrollment: 2014 Sep 01
Withdrawn
Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial Start of enrollment: 2015 Sep 01
Completed
Phase 4
Randomized-controlled Trial of a Combined vs. Conventional Percutaneous Intervention for Near-Infrared Spectroscopy Defined High-Risk Native Coronary Artery Lesions Start of enrollment: 2015 Nov 01
Terminated
Phase 4
The SHINE-CTO Trial Start of enrollment: 2016 May 01
Withdrawn
Not Applicable
Increasing Exercise Adherence After Percutaneous Coronary Intervention With the Fitbit Charge HR Device Start of enrollment: 2016 May 01
Unknown status
Not Applicable
Physiologic Assessment of Coronary Stenosis Following PCI Start of enrollment: 2017 Jun 20
Completed
The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial Start of enrollment: 2018 Aug 04
Terminated
Phase 4
Radial vs. State-Of-The-Art Femoral Access for Bleeding and Access Site Complication Reduction in Cardiac Catheterization (REBIRTH) Start of enrollment: 2019 Nov 15
Recruiting
Not Applicable
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Publications & Presentations

PubMed

Validation of the BCIS CHIP Score in chronic total occlusion percutaneous coronary intervention.
Athanasios Rempakos, Michaella Alexandrou, Deniz Mutlu, James W Choi, Paul Poommipanit, Jaikirshan J Khatri, Laura Young, Brian Jefferson, Sevket Gorgulu, Farouc A Jaf...> ;Catheterization and Cardiovascular Interventions. 2024 Apr 17
Interventional cardiologists' perspectives and knowledge towards artificial intelligence.
Michaella Alexandrou, Athanasios Rempakos, Deniz Mutlu, Ahmed Al Ogaili, Bavana V Rangan, Olga C Mastrodemos, Anastasios Milkas, M Nicholas Burke, Yiannis S Chatzizisi...> ;The Journal of Invasive Cardiology. 2024 Apr 8
The Role of Retrograde Crossing in Short Coronary Chronic Total Occlusions.
Deniz Mutlu, Emmanouil S Brilakis> ;The American Journal of Cardiology. 2024 Apr 5
Retrograde chronic total occlusion percutaneous coronary intervention via ipsilateral collaterals.
Ahmed Al-Ogaili, Michaella Alexandrou, Athanasios Rempakos, Deniz Mutlu, James W Choi, Paul Poommipanit, Jaikirshan J Khatri, Khaldoon Alaswad, Mir B Basir, Raj H Chan...> ;Catheterization and Cardiovascular Interventions. 2024 Apr 2
Early vs. Delayed Mechanical Circulatory Support in Patients with Acute Myocardial Infarction and Cardiogenic Shock.
Kevin G Buda, Katarzyna Hryniewicz, Peter M Eckman, Mir B Basir, Jennifer A Cowger, Khaldoon Alaswad, Srini Mukundan, Yader Sandoval, Andrea Elliott, Emmanouil S Brila...> ;European Heart Journal. Acute Cardiovascular Care. 2024 Mar 19
Self-Apposing Stents in Coronary Chronic Total Occlusions: A Pilot Study.
Ahmed Elborae, Mohamed Hassan, Mohammed Abdel Meguid, Karim Bakry, Ahmad Samir, Emmanouil Brilakis, Hossam Kandil, Ahmed ElGuindy> ;Heart, Lung & Circulation. 2024 Mar 5
Use of plaque modification microcatheters during percutaneous coronary interventions for chronic total occlusion: insights from the PROGRESS-CTO Registry.
Deniz Mutlu, Athanasios Rempakos, Michaella Alexandrou, Ahmed Al-Ogaili, Farouc A Jaffer, Khaldoon Alaswad, Jaikirshan J Khatri, Laura Young, Mir B Basir, Oleg Krestya...> ;The Journal of Invasive Cardiology. 2024 Mar 4
Editorial: The critical intersection of chronic total occlusion and non-ST elevation myocardial infarction.
Michaella Alexandrou, Emmanouil S Brilakis> ;Cardiovascular Revascularization Medicine. 2024 Mar 3
Guide catheter extension use are associated with higher procedural success in chronic total occlusion percutaneous coronary interventions.
Evandro M Filho, Gustavo N Araujo, Guilherme P Machado, Lucio Padilla, João E T de Paula, Antonio C Botelho, Carlos M Campos, Franklin L H Quesada, Marco Alcantara, Ri...> ;Catheterization and Cardiovascular Interventions. 2024 Mar 1
Update on chronic total occlusion percutaneous coronary intervention.
Mutlu, D., Rempakos, A., Alexandrou, M., Al-Ogaili, A., Yamane, M., Alaswad, K., Basir, M., Davies, R., Choi, J., Gagnor, A., Garbo, R., Goktekin, O., Gorgulu, S., Kha...> ;The Journal of Invasive Cardiology. 2024 Mar 1
Racial disparities in chronic total occlusion percutaneous coronary interventions: insights from the PROGRESS-CTO registry.
Allana, S., Rempakos, A., Alexandrou, M., Mutlu, D., Alaswad, K., Azzalini, L., Kearney, K., Krestyaninov, O., Khelimskii, D., Gorgulu, S., Chandwaney, R., Jaffer, F.,...> ;The Journal of Invasive Cardiology. 2024 Mar 1
Emergency coronary artery bypass surgery after chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry.
Deniz Mutlu, Athanasios Rempakos, Michaella Alexandrou, Ahmed Al-Ogaili, Sevket Gorgulu, James W Choi, Basem Elbarouni, Jaikirshan J Khatri, Farouc Jaffer, Robert Rile...> ;International Journal of Cardiology. 2024 Mar 2
Iso-osmolar vs low-osmolar contrast agents for coronary optical coherence tomography: a blinded prospective randomized controlled study.
Kostantinis, S., Mastrodemos, O., Stanberry, L., Mutlu, D., Rempakos, A., Alexandrou, M., Okeson, B., Burke, M., Rangan, B., Sandoval, Y., Allana, S., Simsek, B., Kara...> ;The Journal of Invasive Cardiology. 2024 Feb 29
Predictors of successful primary antegrade wiring in chronic total occlusion percutaneous coronary intervention.
Rempakos, A., Alexandrou, M., Mutlu, D., Choi, J., Poommipanit, P., Khatri, J., Young, L., Dattilo, P., Sadek, Y., Davies, R., Gorgulu, S., Jaffer, F., Chandwaney, R.,...> ;The Journal of Invasive Cardiology. 2024 Feb 29
Use of the Indigo CAT RX aspiration system during percutaneous coronary intervention.
Sydney Peng, Athanasios Rempakos, Olga C Mastrodemos, Bavana V Rangan, Michaella Alexandrou, Salman Allana, Ahmed Al-Ogaili, Deniz Mutlu, Judit Karacsonyi, Seth Bergst...> ;Catheterization and Cardiovascular Interventions. 2024 Apr 1
Validation of the J-Channel Score for retrograde channel crossing in the PROGRESS-CTO registry.
Mutlu, D., Rempakos, A., Alexandrou, M., Gorgulu, S., Burke, M., Al-Ogaili, A., Khatri, J., Alaswad, K., Sandoval, Y., Brilakis, E.> ;The Journal of Invasive Cardiology. 2024 Feb 26
Burnout in cardiology: a narrative review.
Alexandrou, M., Rempakos, A., Kostantinis, S., Rangan, B., Mastrodemos, O., Rao, S., Egred, M., Milkas, A., Burke, M., Simsek, B., Karacsonyi, J., Allana, S., Linzer, ...> ;The Journal of Invasive Cardiology. 2024 Feb 26
Radiation dose during contemporary percutaneous coronary interventions for chronic total occlusion: insights from the PROGRESS-CTO registry.
Deniz Mutlu, Athanasios Rempakos, Michaella Alexandrou, Ahmed Al-Ogaili, Bavana V Rangan, Olga C Mastrodemos, Yader Sandoval, M Nicholas Burke, Emmanouil S Brilakis> ;The Journal of Invasive Cardiology. 2024 Apr 1
Equipment entrapment/loss during chronic total occlusion percutaneous coronary intervention.
Michaella Alexandrou, Athanasios Rempakos, Deniz Mutlu, Ahmed Al Ogaili, James W Choi, Paul Poommipanit, Khaldoon Alaswad, Mir Babar Basir, Rhian Davies, Farouc A Jaff...> ;The Journal of Invasive Cardiology. 2024 Apr 1
Chronic total occlusion percutaneous coronary intervention: the next chapter.
Brilakis, E., Al-Ogaili, A.> ;Eurointervention. 2024 Feb 5
Sex differences in the well-being of interventional cardiologists.
Alexandrou, M., Simsek, B., Rempakos, A., Kostantinis, S., Karacsonyi, J., Rangan, B., Mastrodemos, O., Kirtane, A., Bortnick, A., Jneid, H., Azzalini, L., Milkas, A.,...> ;The Journal of Invasive Cardiology. 2024 Feb 1
Life After Chronic Total Occlusion Percutaneous Coronary Intervention.
Athanasios Rempakos, Emmanouil S Brilakis> ;The American Journal of Cardiology. 2024 Apr 1
Comparative Analysis of Polymer Versus Non-Polymer Jacketed Wires in Chronic Total Occlusion Percutaneous Coronary Intervention.
Alexandrou, M., Rempakos, A., Mutlu, D., Ogaili, A., Choi, J., Poommipanit, P., Alaswad, K., Basir, M., Davies, R., Benton, S., Jaffer, F., Chandwaney, R., Kearney, K....> ;The American Journal of Cardiology. 2024 Mar 15
Modes of failure of guide catheter extensions: Insights from the MAUDE database.
Shaukat, S., Lodhi, H., Khan, H., Desai, A., Luna, M., Brilakis, E., Khalili, H.> ;The Journal of Invasive Cardiology. 2024 Jan 1
Lesion complexity and procedural outcomes associated with ostial chronic total occlusions: Insights from the PROGRESS-CTO Registry.
Allana, S., Kostantinis, S., Simsek, B., Karacsonyi, J., Rempakos, A., Alaswad, K., Krestyaninov, O., Khelimskii, D., Karmpaliotis, D., Jaffer, F., Khatri, J., Poommip...> ;The Journal of Invasive Cardiology. 2023 Dec 1
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Journal Articles

Prevalence, Trends, and Outcomes of Higher Risk Percutaneous Coronary Interventions Among Patients Without Acute Coronary Syndromes☆☆☆
Ivan Chavez, M Nicholas Burke, Daniel Lips, Jay Traverse, Emmanouil S Brilakis, Anil Poulose, Michael Mooney, Paul Sorajja, Yale Wang, ScienceDirect
Meta‐Analysis of the Impact of Successful Chronic Total Occlusion Percutaneous Coronary Intervention on Left Ventricular Systolic Function and Reverse Remodeling
Ivan Chavez, Yale Wang, Emmanouil S Brilakis, Louis P Kohl, Daniel Lips, Michael Mooney, Paul Sorajja, Anil Poulose, M Nicholas Burke, Jay Traverse, Journal of Interventional Cardiology

Books/Book Chapters

Manual of Percutaneous Coronary Interventions
Emmanouil BrilakisElsevier, New YorkEdition 1st,2020
Manual of Coronary Chronic Total Occlusion Interventions
Chapter: ISBN: 9780124201293 eBook ISBN: 9780128004326
Emmanouil BrilakisElsevierEdition 2nd,2017

Lectures

Late Coronary Bypass Graft Failure: Rational Approaches
CRF Transcatheter Cardiovascular Therapeutics - Annual Symposium 2019 - Miami, FL - 9/27/2019
Patient Outcomes Matter: Contemporary Management of Heart Disease to Complete Revascularization
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Con: Non-Invasive = Non-Informative. Functional Assessment Is Not Necessary to Treat the Patient
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
CTO The Hybrid Algorithm and Approaches to Radiation Dose Reduction
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Stay Away From the Light: Emotional Experiences in the Cath Lab
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
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Authored Content

Sleep Deprivation in Interventional Cardiology: A Necessary Evil or an Opportunity for Improvement?September 2018
Sleep Deprivation in Interventional Cardiology: A Necessary Evil or an Opportunity for Improvement?September 2018
A New Treatment Strategy for Saphenous Vein Graft Lesions? Letting It GoApril 2018
A New Treatment Strategy for Saphenous Vein Graft Lesions? Letting It GoApril 2018
Mid-Term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention with Subadventitial vs. Intraplaque Crossing: A Systematic Review and Meta-AnalysisJanuary 2018
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Press Mentions

Clinical and Procedural Outcomes of Radial Versus Femoral Access for CTO PCI Evaluated in the PROGRESS-CTO RegistryAugust 31st, 2022
Late-Breaking Clinical Research Reveals Advances in Chronic Total Occlusion (CTO) Care and Outcomes Based on Data from More Than 10,000 Patients WorldwideMay 20th, 2022
Late-Breaking Clinical Research Reveals Advances in Chronic Total Occlusion (CTO) Care and Outcomes Based on Data from More Than 10,000 Patients WorldwideMay 20th, 2022
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