EmmanuelPayeBessayMD

PubMed

• 4 citations
  Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil.
  Jackie D. Corbin, Teri-Lee Foster, Emmanuel P. Bessay, Jennifer L. Busch, Mitsi A. Blount, Sharron H. Francis> ;Cellular Signalling. 2011 May 1
• 14 citations
  Phosphorylation Increases Affinity of the Phosphodiesterase-5 Catalytic Site for Tadalafil
  Emmanuel P. Bessay, Mitsi A. Blount, Roya Zoraghi, Alfreda Beasley, Kennard A. Grimes, Sharron H. Francis, Jackie D. Corbin> ;The Journal of Pharmacology and Experimental Therapeutics. 2008 Apr 1
• 21 citations
  Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.
  Mitsi A. Blount, Roya Zoraghi, Emmanuel P. Bessay, Alfreda Beasley, Sharron H. Francis, Jackie D. Corbin> ;The Journal of Pharmacology and Experimental Therapeutics. 2007 Nov 1
• 15 citations
  Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.
  Emmanuel P. Bessay, Roya Zoraghi, Mitsi A. Blount, Kennard A. Grimes, Alfreda Beasley, Sharron H. Francis, Jackie D. Corbin> ;Frontiers in Bioscience. 2007 Jan 1
• 26 citations
  A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 d...
  Mitsi A. Blount, Roya Zoraghi, Hengming Ke, Emmanuel P. Bessay, Jackie D. Corbin, Sharron H. Francis> ;Molecular Pharmacology. 2006 Nov 1
• 14 citations
  Correlation of seasonal acclimatization in metabolic enzyme activity with preferred body temperature in the Eastern red spotted newt (Notophthalmus viridescens virides...
  Nancy J. Berner, Emmanuel P. Bessay> ;Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 2006 Aug 1
• 75 citations
  Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation
  Roya Zoraghi, Emmanuel P. Bessay, Jackie D. Corbin, Sharron H. Francis> ;The Journal of Biological Chemistry. 2005 Mar 25
• 141 citations
  Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation
  Mitsi A. Blount, Alfreda Beasley, Roya Zoraghi, Konjeti R. Sekhar, Emmanuel P. Bessay, Sharron H. Francis, Jackie D. Corbin> ;Molecular Pharmacology. 2004 Jul 1
• 71 citations
  Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity.
  Sharron H. Francis, Emmanuel P. Bessay, Jun Kotera, Kennard A. Grimes, Li Liu, W. Joseph Thompson, Jackie D. Corbin> ;The Journal of Biological Chemistry. 2002 Dec 6
• 33 citations
  A Conserved Serine Juxtaposed to the Pseudosubstrate Site of Type I cGMP-dependent Protein Kinase Contributes Strongly to Autoinhibition and Lower cGMP Affinity
  Jennifer L. Busch, Emmanuel P. Bessay, Sharron H. Francis, Jackie D. Corbin> ;The Journal of Biological Chemistry. 2002 Sep 13
• Join now to see all