EmmanuelJohnBotzolakisMDPhD

Radiology • Mooresville, NC

Neuroradiology

Physician

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Office
118 Gateway Blvd
Ste E
Mooresville, NC 28117
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Education & Training

University of Pennsylvania Health SystemFellowship, Neuroradiology, 2016 - 2017
University of Pennsylvania Health SystemFellowship, Neuroradiology, 2015 - 2016
University of Pennsylvania Health SystemResidency, Radiology-Diagnostic, 2011 - 2015
Albert Einstein Healthcare NetworkResidency, Internal Medicine, 2010 - 2011
Vanderbilt University School of MedicineClass of 2010

Certifications & Licensure

SC State Medical License 2017 - 2025
NC State Medical License 2017 - 2024
PA State Medical License 2010 - 2018
NJ State Medical License 2016 - 2017
American Board of Radiology Diagnostic Radiology
American Board of Radiology Neuroradiology

Publications & Presentations

PubMed

2 citations
Brain MRI Deep Learning and Bayesian Inference System Augments Radiology Resident Performance.
Jeffrey D. Rudie, Jeffrey T. Duda, Michael Tran Duong, Po-Hao Chen, Long Xie, Robert M. Kurtz, Jeffrey B. Ware, Joshua Choi, Raghav R. Mattay, Emmanuel J. Botzolakis, ...> ;Journal of Digital Imaging. 2021 Jun 15
11 citations
Subspecialty-Level Deep Gray Matter Differential Diagnoses with Deep Learning and Bayesian Networks on Clinical Brain MRI: A Pilot Study
Jeffrey D. Rudie, Andreas M. Rauschecker, Long Xie, Jiancong Wang, Michael Tran Duong, Emmanuel J. Botzolakis, Asha M Kovalovich, John M. Egan, Tessa S. Cook, R. Nick ...> ;Radiology. Artificial Intelligence. 2020 Sep 23
57 citations
Artificial Intelligence System Approaching Neuroradiologist-level Differential Diagnosis Accuracy at Brain MRI.
Andreas M. Rauschecker, Jeffrey D. Rudie, Long Xie, Jiancong Wang, Michael Tran Duong, Emmanuel J. Botzolakis, Asha M Kovalovich, John M. Egan, Tessa C Cook, R. Nick B...> ;Radiology. 2020 Apr 7
21 citations
Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHI...
Emmanuel J. Botzolakis, Katharine N. Gurba, Andre H. Lagrange, Hua-Jun Feng, Aleksandar K. Stanic, Ningning Hu, Robert L. Macdonald> ;The Journal of Biological Chemistry. 2016 Sep 23
26 citations
GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).
Emily Todd, Katharine N. Gurba, Emmanuel J. Botzolakis, Aleksandar K. Stanic, Robert L. Macdonald> ;Neurobiology of Disease. 2014 Sep 1
24 citations
The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1.
Emmanuel J. Botzolakis, Jiali Zhao, Katharine N. Gurba, Robert L. Macdonald, Peter Hedera> ;Molecular and Cellular Neurosciences. 2011 Jan 1
29 citations
GABAA Receptor α1 Subunit Mutation A322D Associated with Autosomal Dominant Juvenile Myoclonic Epilepsy Reduces the Expression and Alters the Composition of Wild Type ...
Li Ding, Hua-Jun Feng, Robert L. Macdonald, Emmanuel J. Botzolakis, Ningning Hu, Martin J. Gallagher> ;The Journal of Biological Chemistry. 2010 Aug 20
43 citations
Relation of Melatonin to Sleep Architecture in Children with Autism
Roberta M. Leu, Liya Beyderman, Emmanuel J. Botzolakis, Kyla Surdyka, Lily Wang, Beth A. Malow> ;Journal of Autism and Developmental Disorders. 2011 Apr 1
29 citations
Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
Matt T. Bianchi, Emmanuel J. Botzolakis> ;BMC Pharmacology. 2010 Mar 2
31 citations
Benzodiazepine modulation of GABAA receptor opening frequency depends on activation context: A patch clamp and simulation study
Matt T. Bianchi, Emmanuel J. Botzolakis, Andre H. Lagrange, Robert L. Macdonald> ;Epilepsy Research. 2009 Aug 1
13 citations
Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics.
Emmanuel J. Botzolakis, A. Maheshwari, Hua-Jun Feng, Andre H. Lagrange, J.H. Shaver, N.J. Kassebaum, Raghav Venkataraman, Franz J. Baudenbacher, Robert L. Macdonald> ;Journal of Neuroscience Methods. 2009 Mar 15
12 citations
Context-dependent modulation of αβγ and αβδ GABAA receptors by penicillin: Implications for phasic and tonic inhibition
Hua-Jun Feng, Emmanuel J. Botzolakis, Robert L. Macdonald> ;Neuropharmacology. 2009 Jan 1
33 citations
Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a ...
Jiali Zhao, Dawn Signor Matthies, Emmanuel J. Botzolakis, Robert L. Macdonald, Randy D. Blakely, Peter Hedera> ;The Journal of Neuroscience. 2008 Dec 17
33 citations
A Conserved Cys-loop Receptor Aspartate Residue in the M3-M4 Cytoplasmic Loop Is Required for GABAA Receptor Assembly
Wen-yi Lo, Emmanuel J. Botzolakis, Xin Tang, Robert L. Macdonald> ;The Journal of Biological Chemistry. 2008 Oct 31
31 citations
Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.
Matt T. Bianchi, Emmanuel J. Botzolakis, Kevin F. Haas, Janet L. Fisher, Robert L. Macdonald> ;The Journal of Physiology. 2007 Nov 1
68 citations
Enhanced macroscopic desensitization shapes the response of α4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA
Andre H. Lagrange, Emmanuel J. Botzolakis, Robert L. Macdonald> ;The Journal of Physiology. 2007 Feb 1
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Hospital Affiliations

Novant Health Huntersville Medical CenterHuntersville, North Carolina