EstherAObengMD

PubMed

• 2 citations
  SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation.
  Martina Cusan, Haifeng Shen, Bo Zhang, Aijun Liao, Lu Yang, Meiling Jin, Mike Fernandez, Prajish Iyer, Yiming Wu, Kevyn Hart, Catherine Gutierrez, Sara Nik, Shondra M ...> ;The Journal of Clinical Investigation. 2023 Sep 1
• Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
  Jennifer L Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W Lam, Elizabeth A R Garfinkle, Pratima Nallagatla, Amelia M R Smith, Sharnise Mitchel...> ;Nature Communications. 2023 Mar 9
• 6 citations
  Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
  Jennifer L Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W Lam, Elizabeth A R Garfinkle, Pratima Nallagatla, Amelia M R Smith, Sharnise Mitchel...> ;Nature Communications. 2023 Feb 13
• Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
  Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillam...> ;Nature Cancer. 2023 Jan 1
• Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis.
  LaShanale Wallace, Obeng, E.> ;Frontiers in Molecular Biosciences. 2023 Jan 1
• 27 citations
  An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
  Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillam...> ;Nature Cancer. 2023 Jan 1
• 21 citations
  Engineering naturally occurring CD7- T cells for the immunotherapy of hematological malignancies.
  Velasquez, P., Velasquez, P., Abdullah Freiwan, Jaquelyn T Zoine, Jeremy Chase Crawford, Abishek Vaidya, Stefan A Schattgen, Jacquelyn A Myers, Sagar L Patil, Mahsa Kh...> ;Blood. 2022 Dec 22
• 1 citations
  Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.
  Potts, K., Cameron, R., Metidji, A., Ghazale, N., Wallace, L., Leal-Cervantes, A., Palumbo, R., Barajas, J., Gupta, V., Aluri, S., Pradhan, K., Myers, J., McKinstry, M...> ;Cell Reports. 2022 Dec 13
• The development of therapy related myeloid neoplasms in childhood cancer survivors.
  Esther A Obeng, Tanja A Gruber> ;Trends in Cancer. 2022 Oct 1
• 18 citations
  Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors.
  Miguel Ganuza, Trent Hall, Jacquelyn Myers, Chris Nevitt, Raúl Sánchez-Lanzas, Ashley Chabot, Juan Ding, Emilia Kooienga, Claire Caprio, David Finkelstein, Guolian Kan...> ;Nature Cell Biology. 2022 Oct 1
• 12 citations
  Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth.
  Trent D Hall, Hyunjin Kim, Mahmoud Dabbah, Jacquelyn A Myers, Jeremy Chase Crawford, Antonio Morales-Hernandez, Claire E Caprio, Pramika Sriram, Emilia Kooienga, Marta...> ;Nature Communications. 2022 Sep 15
• 16 citations
  Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.
  Maarten Fornerod, Jing Ma, Sanne Noort, Yu Liu, Michael P. Walsh, Lei Shi, Stephanie Nance, Yanling Liu, Yuanyuan Wang, Guangchun Song, Tamara Lamprecht, John Easton, ...> ;Blood Cancer Discovery. 2021 Sep 9
• 3 citations
  Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia.
  John W Figg, Juan Martin Barajas, Esther A. Obeng> ;Current Opinion in Hematology. 2021 Mar 1
• 22 citations
  Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations.
  Abigael Cheruiyot, Shan Li, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Yuhao Chen, Delphine Lemaçon, Ying Li, Zheng Yang, Brian A. Wadugu, Wayne A. Warner, Shondra M...> ;Cancer Research. 2021 Jul 2
• 9 citations
  Clones assemble! The clonal complexity of blood during ontogeny and disease.
  Miguel Ganuza, Trent Hall, Esther A. Obeng, Shannon McKinney-Freeman> ;Experimental Hematology. 2020 Mar 1
• 76 citations
  Altered RNA Processing in Cancer Pathogenesis and Therapy
  Esther A. Obeng, Connor Stewart, Omar Abdel-Wahab> ;Cancer Discovery. 2019 Oct 14
• 23 citations
  Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.
  Nour J. Abdulhay, Claudia Fiorini, Jeffrey M. Verboon, Leif S. Ludwig, Jacob C. Ulirsch, Barbara Zieger, Caleb A. Lareau, Xiaoli Mi, Anindita Roy, Esther A. Obeng, Mir...> ;The Journal of Experimental Medicine. 2019 May 6
• 27 citations
  Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice
  Inga Hofmann, Mitchell J. Geer, Timo Vögtle, Andrew Crispin, Dean R. Campagna, Alastair J. Barr, Monica L. Calicchio, Silke Heising, Johanna P. van Geffen, Marijke J.E...> ;Blood. 2018 Sep 27
• 132 citations
  Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
  Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eun Jung Jang, Esther A. Obeng, Sydney X. Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Ji...> ;Cancer Cell. 2018 Aug 13
• 55 citations
  Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.
  Brenton R. Paolella, William J. Gibson, Laura M. Urbanski, John A. Alberta, Travis I. Zack, Pratiti Bandopadhayay, Caitlin A. Nichols, Pankaj K. Agarwalla, Meredith Br...> ;Elife. 2017 Feb 8
• 265 citations
  Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.
  Esther A. Obeng, Ryan J. Chappell, Michael Seiler, Michelle C. Chen, Dean R. Campagna, Paul J. Schmidt, Rebekka K. Schneider, Allegra M. Lord, Lili Wang, Rutendo Gambe...> ;Cancer Cell. 2016 Sep 12
• 8 citations
  A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients
  Adam L. Green, Joanna Yi, Natalie Susan Bezler, Yana Pikman, Venée N. Tubman, Esther A. Obeng, Teresa O'Neil, Robert Mersereau, Lisa Morrissey, Amy L. Billett> ;Pediatric Blood & Cancer. 2016 Jan 1
• 8 citations
  Charting the “Splice” Routes to MDS
  Esther A. Obeng, Benjamin L. Ebert> ;Cancer Cell. 2015 May 11
• 36 citations
  Pediatric Heparin-Induced Thrombocytopenia: Prevalence, Thrombotic Risk, and Application of the 4Ts Scoring System
  Esther A. Obeng, Kathy M. Harney, Thomas Moniz, Alana Arnold, Ellis J. Neufeld, Cameron C. Trenor> ;The Journal of Pediatrics. 2015 Jan 1
• 867 citations
  Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.
  Esther A. Obeng, Louise M. Carlson, Delia Gutman, William J. Harrington, Kelvin P. Lee, Lawrence H. Boise> ;Blood. 2006 Jun 15
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Lectures

• Blood Building: How to Make a Red Cell 
  60th American Society of Hematology Annual Meeting - 12/1/2018